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8 results on '"Szaumkessel, Marcin"'

2. Combined deletion and DNA methylation result in silencing of FAM107A gene in laryngeal tumors

Author

Kiwerska, Katarzyna, primary, Szaumkessel, Marcin, additional, Paczkowska, Julia, additional, Bodnar, Magdalena, additional, Byzia, Ewa, additional, Kowal, Ewelina, additional, Kostrzewska-Poczekaj, Magdalena, additional, Janiszewska, Joanna, additional, Bednarek, Kinga, additional, Jarmuż-Szymczak, Małgorzata, additional, Kalinowicz, Ewelina, additional, Wierzbicka, Małgorzata, additional, Grenman, Reidar, additional, Szyfter, Krzysztof, additional, Marszałek, Andrzej, additional, and Giefing, Maciej, additional

Published
2017
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3. Recurrent epigenetic silencing of the PTPRD tumor suppressor in laryngeal squamous cell carcinoma

Author

Szaumkessel, Marcin, primary, Wojciechowska, Sonia, additional, Janiszewska, Joanna, additional, Zemke, Natalia, additional, Byzia, Ewa, additional, Kiwerska, Katarzyna, additional, Kostrzewska-Poczekaj, Magdalena, additional, Ustaszewski, Adam, additional, Jarmuz-Szymczak, Malgorzata, additional, Grenman, Reidar, additional, Wierzbicka, Malgorzata, additional, Bartochowska, Anna, additional, Szyfter, Krzysztof, additional, and Giefing, Maciej, additional

Published
2017
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5. Global miRNA Expression Profiling Identifies miR-1290 as Novel Potential oncomiR in Laryngeal Carcinoma

Author

Janiszewska, Joanna, primary, Szaumkessel, Marcin, additional, Kostrzewska-Poczekaj, Magdalena, additional, Bednarek, Kinga, additional, Paczkowska, Julia, additional, Jackowska, Joanna, additional, Grenman, Reidar, additional, Szyfter, Krzysztof, additional, Wierzbicka, Malgorzata, additional, Giefing, Maciej, additional, and Jarmuz-Szymczak, Malgorzata, additional

Published
2015
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8. Downregulation of CEACAM6 gene expression in laryngeal squamous cell carcinoma is an effect of DNA hypermethylation and correlates with disease progression.

Author

Bednarek K, Kostrzewska-Poczekaj M, Szaumkessel M, Kiwerska K, Paczkowska J, Byzia E, Ustaszewski A, Janiszewska J, Bartochowska A, Grenman R, Wierzbicka M, Szyfter K, Giefing M, and Jarmuz-Szymczak M

Abstract

We have turned our attention to CEACAM6 gene, already described as deregulated in various types of cancer. By using the expression microarrays performed on the set of 16 laryngeal squamous cell carcinoma (LSCC) samples: 11 cell lines and 5 primary tumors we have shown downregulation of CEACAM6 gene as compared to non cancer controls from head and neck region. CEACAM6 gene downregulation, further confirmed by quantitative PCR on 25 LSCC cell lines, was observed in cell lines derived from recurrent tumors in comparison to controls. A significant gene downregulation was observed in cell lines derived from advanced, high grade tumors in comparison to controls. Intrigued by the recurrent transcriptional loss of CEACAM6 we searched for the mechanism potentially responsible for its downregulation and hence we analyzed DNA copy number changes (a-CGH), promoter DNA methylation status and occurrence of gene mutations ( in silico ). Neither the analysis of gene copy number, nor the mutation screen has shown recurrent deletions or mutations, that could contribute to the observed downregulation of the gene. However, by using bisulfite pyrosequencing, we have shown DNA hypermethylation (mean DNA methylation > 78%) of CEACAM6 promoter region in 9/25 (36%) LSCC cell lines. Importantly, the 5-aza-2-deoxycytidine-induced inhibition of DNA methylation resulted in restoration of CEACAM6 expression in the two LSCC cell lines on mRNA level. In summary, we have shown that recurrent downregulation of CEACAM6 in LSCC is dependent on the gene's promoter DNA methylation and is observed predominantly in large, poorly differentiated tumors and recurrences., Competing Interests: None.

Published
2018

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