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4. Real-time PCR detection of mixed Plasmodium ovale curtisi and wallikeri infections in human and mosquito hosts

Author

Potlapalli, Varun R., primary, Muller, Meredith S., additional, Ngasala, Billy, additional, Ali, Innocent Mbulli, additional, Na, Yu Bin, additional, Williams, Danielle R., additional, Kharabora, Oksana, additional, Chhetri, Srijana, additional, Liu, Mei S., additional, Carey-Ewend, Kelly, additional, Lin, Feng-Chang, additional, Mathias, Derrick, additional, Tarimo, Brian B., additional, Juliano, Jonathan J., additional, Parr, Jonathan B., additional, and Lin, Jessica T., additional

Published
2023
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9. Proceedings of an expert workshop on community agreement for gene drive research in Africa - Co-organised by KEMRI, PAMCA and Target Malaria

Author

Thizy, Delphine, primary, Pare Toe, Lea, additional, Mbogo, Charles, additional, Matoke-Muhia, Damaris, additional, Alibu, Vincent Pius, additional, Barnhill-Dilling, S. Kathleen, additional, Chantler, Tracey, additional, Chongwe, Gershom, additional, Delborne, Jason, additional, Kapiriri, Lydia, additional, Nassonko Kavuma, Esther, additional, Koloi-Keaikitse, Sethlomo, additional, Kormos, Ana, additional, Littler, Katherine, additional, Lwetoijera, Dickson, additional, Vargas de Moraes, Roberta, additional, Mumba, Noni, additional, Mutengu, Lilian, additional, Mwichuli, Sylvia, additional, Nabukenya, Silvia Elizabeth, additional, Nakigudde, Janet, additional, Ndebele, Paul, additional, Ngara, Carolyne, additional, Ochomo, Eric, additional, Odiwuor Ondiek, Simon, additional, Rivera, Stephany, additional, Roberts, Aaron J., additional, Robinson, Benjamin, additional, Sambakunsi, Rodrick, additional, Saxena, Abha, additional, Sykes, Naima, additional, Tarimo, Brian B., additional, Tiffin, Nicki, additional, and Tountas, Karen H., additional

Published
2021
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10. Cytochrome P450/ABC transporter inhibition simultaneously enhances ivermectin pharmacokinetics in the mammal host and pharmacodynamics in Anopheles gambiae

Author

Chaccour, Carlos J., primary, Hammann, Felix, additional, Alustiza, Marta, additional, Castejon, Sandra, additional, Tarimo, Brian B., additional, Abizanda, Gloria, additional, Irigoyen Barrio, Ángel, additional, Martí Soler, Helena, additional, Moncada, Rafael, additional, Bilbao, José Ignacio, additional, Aldaz, Azucena, additional, Maia, Marta, additional, and Del Pozo, José Luis, additional

Published
2017
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13. The Nonartemisinin Sesquiterpene Lactones Parthenin and Parthenolide Block Plasmodium falciparumSexual Stage Transmission

Author

Balaich, Jared N., Mathias, Derrick K., Torto, Baldwyn, Jackson, Bryan T., Tao, Dingyin, Ebrahimi, Babak, Tarimo, Brian B., Cheseto, Xavier, Foster, Woodbridge A., and Dinglasan, Rhoel R.

Abstract

ABSTRACTParthenin and parthenolide are natural products that are closely related in structure to artemisinin, which is also a sesquiterpene lactone (SQL) and one of the most important antimalarial drugs available. Parthenin, like artemisinin, has an effect on Plasmodiumblood stage development. We extended the evaluation of parthenin as a potential therapeutic for the transmissible stages of Plasmodium falciparumas it transitions between human and mosquito, with the aim of gaining potential mechanistic insight into the inhibitory activity of this compound. We posited that if parthenin targets different biological pathways in the parasite, this in turn could pave the way for the development of druggable compounds that could prevent the spread of artemisinin-resistant parasites. We examined parthenin's effect on male gamete activation and the ookinete-to-oocyst transition in the mosquito as well as on stage V gametocytes that are present in peripheral blood. Parthenin arrested parasite development for each of the stages tested. The broad inhibitory properties of parthenin on the evaluated parasite stages may suggest different mechanisms of action between parthenin and artemisinin. Parthenin's cytotoxicity notwithstanding, its demonstrated activity in this study suggests that structurally related SQLs with a better safety profile deserve further exploration. We used our battery of assays to test parthenolide, which has a more compelling safety profile. Parthenolide demonstrated activity nearly identical to that of parthenin against P. falciparum, highlighting its potential as a possible transmission-blocking drug scaffold. We discuss the context of the evidence with respect to the next steps toward expanding the current antimalarial arsenal.

Published
2016
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