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12 results on '"Tonani, Ludmilla"'

1. Antagonistic Interactions in Onychomycosis: Antifungal Activity of Extracts from Pure and Mixed Cultures of Candida parapsilosis and Trichophyton spp.

Author

Lemes, Thiago Henrique, primary, Nascentes, Julyanna Andrade Silva, additional, Regasini, Luis Octávio, additional, Siqueira, João Paulo Zen, additional, Rigotto, Glaucia, additional, Tonani, Ludmilla, additional, von Zeska Kress, Marcia Regina, additional, and de Almeida, Margarete Teresa Gottardo, additional

Published
2024
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4. Virulence potential of Salmonella 1,4, [5],12:i:- strains isolated during decades from different sources in the Southeast region of Brazil

Author

Pereira, Giovana do Nascimento, primary, Seribelli, Amanda Aparecida, additional, Gomes, Carolina Nogueira, additional, Vilela, Felipe Pinheiro, additional, Tonani, Ludmilla, additional, Tiba-Casas, Monique Ribeiro, additional, Medeiros, Marta Inês Cazentini, additional, Rodrigues, Dália dos Prazeres, additional, Kress, Márcia Regina von Zeska, additional, and Falcão, Juliana Pfrimer, additional

Published
2023
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6. Virulence potential of Salmonella1,4, [5],12:i:- strains isolated during decades from different sources in the Southeast region of Brazil

Author

Pereira, Giovana do Nascimento, Seribelli, Amanda Aparecida, Gomes, Carolina Nogueira, Vilela, Felipe Pinheiro, Tonani, Ludmilla, Tiba-Casas, Monique Ribeiro, Medeiros, Marta Inês Cazentini, Rodrigues, Dália dos Prazeres, Kress, Márcia Regina von Zeska, and Falcão, Juliana Pfrimer

Abstract

Salmonella1,4, [5],12:i:- is one of the most prevalent serovars associated with gastroenteritis in several countries, including Brazil. However, few studies have analyzed the virulence potential of this variant in this country. Therefore, this study aimed to characterize S.1,4, [5],12:i:- strains isolated in Southeast Brazil. To this end, 113 S.1,4, [5],12:i:- strains isolated from different sources between 1983 and 2020 were analyzed. For all strains, the frequencies of 11 virulence genes were investigated using PCR and the molecular typing was performed using pulsed-field gel electrophoresis (PFGE). Furthermore, 40 strains isolated from human and non-human sources were characterized by survival under acid and oxidative stress, and virulence analysis in Galleria mellonellawas performed for 20 selected strains. All virulence genes were detected in more than 91% of the strains. The studied strains were grouped into four clusters using PFGE. Most strains were present in one cluster, named PFGE-A, with a genetic similarity of ≥ 79.5%. All 40 strains survived acid stress after 10 min and 1 h of exposure. Under oxidative stress, all 40 strains survived after 10 min, and 36 survived after 1 h of exposure. In the G. mellonellaassay, nine isolates from non-human sources and six isolates from human showed high-to-intermediate virulence profiles. In conclusion, the pathogenic potential of the strains studied was corroborated by the high frequency of all the virulence genes identified. The PFGE results suggested that most strains belonged to one main cluster that has been prevailing in the São Paulo State, Brazil. The S. 1,4, [5],12:i:- strains isolated from human and non-human sources successfully survived the unfavorable conditions in the human gastrointestinal tract. Finally, strains isolated from non-human sources showed a higher proportion of isolates with high to intermediate virulence profiles in G. mellonellathan in human isolates, suggesting a possible difference between isolates from different origins.

Published
2023
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8. The Lung Microbiome of Three Young Brazilian Patients With Cystic Fibrosis Colonized by Fungi

Author

de Almeida, Otávio Guilherme Gonçalves, primary, Capizzani, Carolina Paulino da Costa, additional, Tonani, Ludmilla, additional, Grizante Barião, Patrícia Helena, additional, da Cunha, Anderson Ferreira, additional, De Martinis, Elaine Cristina Pereira, additional, Torres, Lidia Alice Gomes Monteiro Marin, additional, and von Zeska Kress, Marcia Regina, additional

Published
2020
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11. The Immune Interplay between the Host and the Pathogen in Aspergillus fumigatus Lung Infection

Author

Sales-Campos, Helioswilton, Tonani, Ludmilla, Cardoso, Cristina Ribeiro Barros, and Kress, Márcia Regina Von Zeska

Subjects
Article Subject
Abstract

The interplay between Aspergillus fumigatus and the host immune response in lung infection has been subject of studies over the last years due to its importance in immunocompromised patients. The multifactorial virulence factors of A. fumigatus are related to the fungus biological characteristics, for example, structure, ability to grow and adapt to high temperatures and stress conditions, besides capability of evading the immune system and causing damage to the host. In this context, the fungus recognition by the host innate immunity occurs when the pathogen disrupts the natural and chemical barriers followed by the activation of acquired immunity. It seems clear that a Th1 response has a protective role, whereas Th2 reactions are often associated with higher fungal burden, and Th17 response is still controversial. Furthermore, a fine regulation of the effector immunity is required to avoid excessive tissue damage associated with fungal clearance, and this role could be attributed to regulatory T cells. Finally, in this work we reviewed the aspects involved in the complex interplay between the host immune response and the pathogen virulence factors, highlighting the immunological issues and the importance of its better understanding to the development of novel therapeutic approaches for invasive lung aspergillosis.

Published
2013
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