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Your search keyword '"Tsai, Ching-Hui"' showing total 37 results
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6. Serum polyfluoroalkyl concentrations, asthma outcomes, and immunological markers in a case-control study of Taiwanese children

Author

Dong, Guang-Hui, Tung, Kuan-Yen, Tsai, Ching-Hui, Liu, Miao-Miao, Wang, Da, Liu, Wei, Jin, Yi-He, Hsieh, Wu-Shiun, Lee, Yungling Leo, and Chen, Pau-Chung

Subjects
Asthma in children -- Surveys -- Case studies, Environmental health -- Research, Pollutants -- Health aspects, Public health -- Research, Environmental issues, Health
Abstract

BACKGROUND: Perfluorinated compounds (PFCs) are ubiquitous pollutants. Experimental data suggest that they may be associated with adverse health outcomes, including asthma. However, there is little supporting epidemiological evidence. METHODS: A [...]

Published
2013

7. Shallow gas hydrates off southwest Taiwan and their mechanisms

Author

Huang, Yin-sheng, Hsu, Shu-kun, Su, Chih-chieh, Lin, Andrew Tien-shun, Yu, Pai-sen, Babonneau, Nathalie, Ratzov, Gueorgui, Lallemand, Serge, Huang, Pi-chuen, Lin, Shiao-shan, Lin, Jing-yi, Wei, Kuo-yen, Chang, Yuan-pin, Yu, Neng-ti, Tsai, Ching-hui, Huang, Yin-sheng, Hsu, Shu-kun, Su, Chih-chieh, Lin, Andrew Tien-shun, Yu, Pai-sen, Babonneau, Nathalie, Ratzov, Gueorgui, Lallemand, Serge, Huang, Pi-chuen, Lin, Shiao-shan, Lin, Jing-yi, Wei, Kuo-yen, Chang, Yuan-pin, Yu, Neng-ti, and Tsai, Ching-hui

Abstract

We have collected two shallow gas hydrate samples at two sites having different geological settings off southwest Taiwan during the cruise MD214 in 2018. The first core site, MD18-3542, is on the South Yuan-An East Ridge at ~ 1200 m water deep, where a structural unconformity covered by fine-silt sediments appears at ~ 5.5 m below the seafloor. The second core site, MD18-3543, is close to the Good-Weather Ridge at ~ 1100 m water deep, where a gas-related pockmark structure and authigenic carbonates are present at shallow strata with fine-silt sediments near the seafloor. Sediment properties of core MD18-3542 are distinctively different above and below the layer corresponding to the unconformity. Both cores show obvious gaps or voids in the lower core halves. The core features could be linked to the dissociated methane upward migrating from deep strata. Core site settings with upwelling methane would favor the formation of shallow gas hydrates. At site MD18-3542, the shallow hydrate could be formed due to high concentration methane kept beneath the unconformity covered by fine-silt sediments. At site MD18-3543, the shallow hydrate could be formed due to an extremely high flux of upwelling methane trapped either beneath the authigenic carbonates or fine-silt sediments.

Published
2021
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13. Household environmental tobacco smoke and risks of asthma, wheeze and bronchitic symptoms among children in Taiwan

Author

Hwang Bing-Fang, Huang Jiun-Hau, Tsai Ching-Hui, and Lee Yungling L

Subjects
Diseases of the respiratory system, RC705-779
Abstract

Abstract Background Although studies show that maternal smoking during pregnancy increases the risks of respiratory outcomes in childhood, evidence concerning the effects of household environmental tobacco smoke (ETS) exposure remains inconsistent. Methods We conducted a population-based study comprised of 5,019 seventh and eighth-grade children in 14 Taiwanese communities. Questionnaire responses by parents were used to ascertain children's exposure and disease status. Logistic regression models were fitted to estimate the effects of ETS exposures on the prevalence of asthma, wheeze, and bronchitic symptoms. Results The lifetime prevalence of wheeze was 11.6% and physician-diagnosed asthma was 7.5% in our population. After adjustment for potential confounders, in utero exposure showed the strongest effect on all respiratory outcomes. Current household ETS exposure was significantly associated with increased prevalence of active asthma, ever wheeze, wheeze with nighttime awakening, and bronchitis. Maternal smoking was associated with the increased prevalence of a wide range of wheeze subcategories, serious asthma, and chronic cough, but paternal smoking had no significant effects. Although maternal smoking alone and paternal smoking alone were not independently associated with respiratory outcomes, joint exposure appeared to increase the effects. Furthermore, joint exposure to parental smoking showed a significant effect on early-onset asthma (OR, 2.01; 95% CI, 1.00-4.02), but did not show a significant effect on late-onset asthma (OR, 1.17; 95% CI, 0.36-3.87). Conclusion We concluded that prenatal and household ETS exposure had significant adverse effects on respiratory health in Taiwanese children.

Published
2010
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14. Seabed gas emissions and submarine landslides off SW Taiwan

Author

Hsu, Shu-Kun, primary, Lin, Shiao-Shan, additional, Wang, Shiou-Ya, additional, Tsai, Ching-Hui, additional, Doo, Wen-Bin, additional, Chen, Song-Chuen, additional, Lin, Jing-Yi, additional, Yeh, Yi-Ching, additional, Wang, Hsueh-Fen, additional, and Su, Cheng-Wei, additional

Published
2018
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19. A simple prediction tool for inhaled corticosteroid response in asthmatic children.

Author

Yi-Fan Wu, Ming-Wei Su, Bor-Luen Chiang, Yao-Hsu Yang, Ching-Hui Tsai, Yungling L. Lee, Wu, Yi-Fan, Su, Ming-Wei, Chiang, Bor-Luen, Yang, Yao-Hsu, Tsai, Ching-Hui, and Lee, Yungling L

Subjects
CORTICOSTEROIDS, ASTHMA in children, ASTHMA, DRUGS, DEMOGRAPHIC surveys
Abstract

Background: Inhaled corticosteroids are recommended as the first-line controller medication for childhood asthma owing to their multiple clinical benefits. However, heterogeneity in the response towards these drugs remains a significant clinical problem.Methods: Children aged 5 to 18 years with mild to moderate persistent asthma were recruited into the Taiwanese Consortium of Childhood Asthma Study. Their responses to inhaled corticosteroids were assessed based on their improvements in the asthma control test and peak expiratory flow. The predictors of responsiveness were demographic and clinical features that were available in primary care settings. We have developed a prediction model using logistic regression and have simplified it to formulate a practical tool. We assessed its predictive performance using the area under the receiver operating characteristic curve.Results: Of the 73 asthmatic children with baseline and follow-up outcome measurements for inhaled corticosteroids treatment, 24 (33%) were defined as non-responders. The tool we have developed consisted of three predictors yielding a total score between 0 and 5, which are comprised of the following parameters: the age at physician-diagnosis of asthma, sex, and exhaled nitric oxide. Sensitivity and specificity of the tool for prediction of inhaled corticosteroids non-responsiveness, for a score of 3, were 0.75 and 0.69, respectively. The areas under the receiver operating characteristic curve for the prediction tool was 0.763.Conclusions: Our prediction tool represents a simple and low-cost method for predicting the response of inhaled corticosteroids treatment in asthmatic children. [ABSTRACT FROM AUTHOR]

Published
2017
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21. Training Effectiveness from Guanxi Perspective in Mentoring System

Author

Tsai Ching-Hui, Tsai Ching-Yi, and Cheng-Hua Tsai

Subjects
Medical education, Hospitality, business.industry, Perspective (graphical), Pedagogy, Psychology, business, Guanxi, Training (civil), Focus group
Abstract

This research is seeking to discuss how Guanxi influence training effectiveness between mentor and mentee. Two steps methods were used, first steps, from mentee to mentor using questionnaire, there are 150 questionnaire sent out 87 come back, sent to the hotel and hospitality department students. Second steps, focus group interviews were conducted with 5 informants in semi-structured, in-depth format and lasted approximately 120 minutes. From mentor to mentee using focus group interview, there are 5 different chef de cuisine. They have the classes with these students and also the students were by group went to the restaurant for practical training. The result shows Guanxi influence trainees’ reaction to training, it changes in job-related behavior and performance that result from training.

Published
2014

26. Newborn genetic screening for hearing impairment: a population-based longitudinal study

Author

Wu, Chen-Chi, Tsai, Ching-Hui, Hung, Chia-Cheng, Lin, Yin-Hung, Lin, Yi-Hsin, Huang, Fang-Li, Tsao, Po-Nien, Su, Yi-Ning, Lee, Yungling Leo, Hsieh, Wu-Shiun, and Hsu, Chuan-Jen

Abstract

Purpose:The feasibility of genetic screening for deafness-causing mutations in newborns has been reported in several studies. The aim of this study was to investigate the long-term results in those who screened positive for deafness mutations; these results are crucial to determine the cost-effectiveness to justify population-wide genetic screening.Methods:We performed simultaneous hearing screening and genetic screening targeting four common deafness mutations (p.V37I and c.235delC of GJB2, c.919-2A>G of SLC26A4, and the mitochondrial m.1555A>G) in 5173 newborns at a tertiary hospital between 2009 and 2015. Serial audiometric results up to 6 years old were then analyzed in children with conclusive genotypes.Results:Newborn genetic screening identified 82 (1.6%) babies with conclusive genotypes, comprising 62 (1.2%) with GJB2 p.V37I/p.V37I, 16 (0.3%) with GJB2 p.V37I/c.235delC, and 4 (0.1%) with m.1555A>G. Of these, 46 (56.1%) passed hearing screening at birth. Long-term follow-up demonstrated progressive hearing loss in children with the GJB2 p.V37I/p.V37I and p.V37I/c.235delC genotypes; this hearing loss deteriorated by approximately 1 decibel hearing level (dBHL) per year.Conclusions:We delineated the longitudinal auditory features of the highly prevalent GJB2 p.V37I mutation on a general population basis and confirmed the utility of newborn genetic screening in identifying infants with late-onset or progressive hearing impairment undetectable by newborn hearing screening.Genet Med 19 1, 6–12.

Published
2017
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34. PD-L1 Enhanced by cis-Urocanic Acid on Langerhans Cells Inhibits Vg4+gdT17 Cells in Psoriatic Skin Inflammation

Author

Yeh, Chen-Yun, Su, Sheng-Han, Tan, Yeh Fong, Tsai, Tsen-Fang, Liang, Pi-Hui, Kelel, Musin, Weng, Hao-Jui, Hsiao, Yu-Ping, Lu, Chun-Hao, Tsai, Ching-Hui, Lee, Chih-Hung, Clausen, Björn E., Liu, Fu-Tong, and Lee, Yungling Leo

Abstract

Psoriasis is an IL-23/IL-17-mediated inflammatory autoimmune dermatosis, and UVB may contribute to immunosuppression and ameliorate associated symptoms. One of the pathophysiology underlying UVB therapy is the production of cis-urocanic acid (cis-UCA) by keratinocytes. However, the detailed mechanism is yet to be fully understood. In this study, we found FLG expression and serum cis-UCA levels were significantly lower in patients with psoriasis than in healthy controls. We also noted that cis-UCA application inhibited psoriasiform inflammation through the reduction of Vg4+gdT17 cells in murine skin and draining lymph nodes. Meanwhile, CCR6 was downregulated on gdT17 cells, which would suppress the inflammatory reaction at a distal skin site. We revealed that the 5-hydroxytryptamine receptor 2A, the known cis-UCA receptor, was highly expressed on Langerhans cells in the skin. cis-UCA also inhibited IL-23 expression and induced PD-L1 on Langerhans cells, leading to the attenuated proliferation and migration of gdT-cells. Compared to the isotype control, a-PD-L1 treatment in vivo could reverse the antipsoriatic effects of cis-UCA. PD-L1 expression on Langerhans cells was sustained through the cis-UCA-induced MAPK/ extracellular signal–regulated kinase pathway. These findings uncover the cis-UCA-induced PD-L1-mediated immunosuppression on Langerhans cells, which facilitates the resolution of inflammatory dermatoses.

Published
2023
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37. Gender-Dimorphic Impact of PXRGenotype and Haplotype on Hepatotoxicity During Antituberculosis Treatment

Author

Wang, Jann Yuan, Tsai, Ching Hui, Lee, Yungling Leo, Lee, Li Na, Hsu, Chia Lin, Chang, Hsiu Ching, Chen, Jong Ming, Hsu, Cheng An, Yu, Chong Jen, and Yang, Pan Chyr

Abstract

Women have a higher risk of drug-induced hepatotoxicity during antituberculosis treatment (HATT) than men. We hypothesized that single nucleotide polymorphism (SNP) genotype and derived haplotype of pregnane X receptor(PXR) gene, which could regulate the expression of phase I enzyme cytochrome P450 (CYP) 3A4, had a sex-specific influence on the risk of HATT.

Published
2015
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