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6. Usefulness of close surveillance for rectal cancer patients after neoadjuvant chemoradiotherapy

Author

Hsu Yu-Jen, Chern Yih-Jong, Lai I-Li, Chiang Sum-Fu, Liao Chun-Kai, Tsai Wen-Sy, Hung Hsin-Yuan, Hsieh Pao-Shiu, Yeh Chien-Yuh, Chiang Jy-Ming, Yu Yen-Lin, and You Jeng-Fu

Subjects
rectal cancer, chemoradiotherapy, complete response, watch and wait, salvage surgery, Medicine
Abstract

It is controversial whether patients who achieve clinical complete remission (cCR) of rectal cancer should be treated with the “watch and wait” (W&W) or radical resection (RR) strategy. Our study aimed to compare the survival outcomes and ostomy rate of the W&W and RR strategies. Between January 2008 and December 2015, we investigated 26 patients who achieved pathologic complete remission after undergoing RR and 36 patients who adopted the W&W strategy because of cCR. The tumor regrowth, salvage surgery, recurrence, disease-free, and overall survival (OS) rates were assessed. In our study, recurrences occurred in nine and two patients from the W&W and RR groups, respectively. Each patient in the RR group had a temporary or permanent ostomy, but only three (8.3%) had an ostomy in the W&W group. The 5-year recurrence rate was 25.0% in the W&W group and 7.7% in the RR group. Six patients (16.7%) had tumor regrowth in the W&W group, and all were resectable when regrowth. The 5-year OS rates between the two groups were nonsignificant. There is no specific risk factor for recurrence and OS. Under close surveillance, the W&W group achieved similar OS to the RR group and benefited from a lower ostomy rate.

Published
2022
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14. Association between personality types and low anterior resection syndrome in rectal cancer patients following surgery.

Author

Chiang, Ting‐Yu, Hsu, Yu‐Jen, Chern, Yih‐Jong, Liao, Chun‐Kai, Tsai, Wen‐Sy, Hsieh, Pao‐Shiu, Hsu, Hung‐Chih, Lin, Yu‐Fen, Lee, Hsiu‐Lan, and You, Jeng‐Fu

Subjects
RECTAL surgery, RECTAL cancer, PSYCHOLOGICAL typologies, CANCER patients, PERSONALITY questionnaires, PEARSON correlation (Statistics)
Abstract

Purpose: Low anterior resection syndrome (LARS) has had many impacts on the lives of patients and substantial differences in emotional and social functions. The aim of this study was to investigate the correlation analysis of different personality traits in rectal cancer patients with LARS after undergoing curative surgery. Methods: This study was designed as a prospective cohort study. The inclusion criteria included (1) participants diagnosed with rectal cancer who underwent surgical resection of malignant tumors and (2) ECOG 0–1. The primary outcome was the correlation between different personality traits and low anterior resection syndrome in rectal cancer patients after radical surgery. Low anterior resection syndrome incidence rates were estimated by questionnaires and personality groups by the Type A and Type D Scale‐14 Personality Inventory. Results: For all 161 participants in this study, the presence of a tumor at the lower anal verge and the receipt of neoadjuvant CCRT had a statistically significant positive correlation with the LARS score at 1 month, 6 months, and 1 year (Pearson correlation coefficient = −0.283, −0.374, and − 0.205, respectively), with a p value of less than 0.05. Personalities with Type A, Type D, and Type D‐SI scores had a statistically significant positive correlation with LARS score at 1 month (Pearson correlation coefficient = 0.172, 0.162, and 0,164, p value = 0.03, 0.04, and 0.04). Conclusion: Type A and Type D personalities are highly linked to LARS. Personalized support approaches can ultimately assist rectal cancer patients in overcoming difficulties after surgery and recovery and enhance their functional outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Perianal Basal Cell Carcinoma—A Systematic Review and Meta-Analysis of Real-World Data.

Author

Tsai, Tzong-Yun, Liao, Chun-Kai, Zhang, Bang-Yan, Huang, Yen-Lin, Tsai, Wen-Sy, You, Jeng-Fu, Yeh, Chien-Yuh, and Hsieh, Pao-Shiu

Subjects
BASAL cell carcinoma, SURGICAL excision, ANAL diseases, PATIENTS' attitudes, SURGICAL margin, SKIN cancer, ITCHING
Abstract

(1) Background: BCC is a sporadic disease that develops in areas of the skin not exposed to the sun. Perianal BCC, which occurs in the anorectal region, accounts for less than 0.2% of all BCC cases. There have been only a few reported cases of the disease, with fewer than 200 cases reported in total. Given the diagnostic challenges and potential for misdiagnosis, we conducted a systematic review of perianal basal cell carcinoma using real-world data to provide comprehensive and detailed information on the disease. (2) Methods: The study was reported based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, 2020. Patients' clinical pathologic features, tumor characteristics, treatment modalities, and outcomes were presented. (3) Results: The results of 41 studies involving 140 patients were analyzed. The most common symptoms reported by patients at presentation were anorectal bleeding, pain, and pruritus. Ulceration was the most frequently observed tumor characteristic. The majority of patients underwent local excision as their primary treatment, with only eight patients experiencing a recurrence. Our analysis did not reveal any statistically significant differences in the outcomes of different treatment modalities. (4) Conclusions: Identifying perianal BCC poses a significant challenge as it closely resembles other anal diseases, thereby making it difficult to differentiate between the different conditions. However, a wide local excision with clear margins is considered an effective treatment option for most patients. Alternative treatments, such as radiotherapy, may be recommended for patients who are unable to undergo surgery. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Comprehensive functional genomic analyses link APC somatic mutation and mRNA-miRNA networks to the clinical outcome of stage-III colorectal cancer patients

Author

Chiang, Sum-Fu, primary, Huang, Heng-Hsuan, additional, Tsai, Wen-Sy, additional, Chin-Ming Tan, Bertrand, additional, Yang, Chia-Yu, additional, Huang, Po-Jung, additional, Yi-Feng Chang, Ian, additional, Lin, Jiarong, additional, Lu, Pei-Shan, additional, Chin, En, additional, Liu, Yu-Hao, additional, Yu, Jau-Song, additional, Chiang, Jy-Ming, additional, Hung, Hsin-Yuan, additional, You, Jeng-Fu, additional, and Liu, Hsuan, additional

Published
2022
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27. The impact of kidney function on colorectal cancer patients with localized and regional diseases: An observational study from Taiwan

Author

Chiang, Sum-Fu, Chen, Jinn-Shiun, Tang, Reiping, Yeh, Chien-Yuh, Hsieh, Pao-Shiu, Tsai, Wen-Sy, You, Jeng-Fu, Hung, Hsin-Yuan, Lai, Cheng-Chou, Lin, Jr-Rung, and Chiang, Jy-Ming

Subjects
Kidney -- Physiological aspects, Colorectal cancer -- Care and treatment, Cancer research, Kidney diseases, Medical research, Cancer patients, Health
Abstract

Byline: Sum-Fu. Chiang, Jinn-Shiun. Chen, Reiping. Tang, Chien-Yuh. Yeh, Pao-Shiu. Hsieh, Wen-Sy. Tsai, Jeng-Fu. You, Hsin-Yuan. Hung, Cheng-Chou. Lai, Jr-Rung. Lin, Jy-Ming. Chiang BACKGROUND: Impaired kidney function is associated with [...]

Published
2019

28. Association of Preoperative Physical Activity with Short- and Long-Term Outcomes in Patients Undergoing Palliative Resection for Metastatic Colorectal Cancer: An Inverse Probability of Treatment Weighting Analysis

Author

Cheng, Ching-Chung, primary, Lai, I-Li, additional, Huang, Shu-Huan, additional, Tsai, Wen-Sy, additional, Hsieh, Pao-Shiu, additional, Yeh, Chien-Yuh, additional, Chiang, Sum-Fu, additional, Hung, Hsin-Yuan, additional, and You, Jeng-Fu, additional

Published
2022
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30. Decreasing Postoperative Pulmonary Complication Following Laparoscopic Surgery in Elderly Individuals with Colorectal Cancer: A Competing Risk Analysis in a Propensity Score–Weighted Cohort Study

Author

Chern, Yih-Jong, primary, You, Jeng-Fu, additional, Cheng, Ching-Chung, additional, Jhuang, Jing-Rong, additional, Yeh, Chien-Yuh, additional, Hsieh, Pao-Shiu, additional, Tsai, Wen-Sy, additional, Liao, Chun-Kai, additional, and Hsu, Yu-Jen, additional

Published
2021
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34. A Prediction Model for Metachronous Peritoneal Carcinomatosis in Patients with Stage T4 Colon Cancer after Curative Resection

Author

Tsai, Tzong-Yun, primary, You, Jeng-Fu, additional, Hsu, Yu-Jen, additional, Jhuang, Jing-Rong, additional, Chern, Yih-Jong, additional, Hung, Hsin-Yuan, additional, Yeh, Chien-Yuh, additional, Hsieh, Pao-Shiu, additional, Chiang, Sum-Fu, additional, Lai, Cheng-Chou, additional, Chiang, Jy-Ming, additional, Tang, Reiping, additional, and Tsai, Wen-Sy, additional

Published
2021
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42. Targeted Sequencing of Circulating Tumor DNA to Monitor Genetic Variants and Therapeutic Response in Metastatic Colorectal Cancer

Author

Hsu, Hung-Chih, primary, Lapke, Nina, additional, Wang, Chuang-Wei, additional, Lin, Pei-Yi, additional, You, Jeng Fu, additional, Yeh, Chien Yuh, additional, Tsai, Wen-Sy, additional, Hung, Hsin Yuan, additional, Chiang, Sum-Fu, additional, Chen, Hua-Chien, additional, Chen, Shu-Jen, additional, Hsu, An, additional, and Yang, Tsai Sheng, additional

Published
2018
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43. PTPRT and PTPRD Deleterious Mutations and Deletion Predict Bevacizumab Resistance in Metastatic Colorectal Cancer Patients

Author

Hsu, Hung-Chih, primary, Lapke, Nina, additional, Chen, Shu-Jen, additional, Lu, Yen-Jung, additional, Jhou, Ren-Shiang, additional, Yeh, Chien-Yuh, additional, Tsai, Wen-Sy, additional, Hung, Hsin-Yuan, additional, Hsieh, Jason, additional, Yang, Tsai-Sheng, additional, Thiam, Tan, additional, and You, Jeng-Fu, additional

Published
2018
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47. The impact of kidney function on colorectal cancer patients with localized and regional diseases: An observational study from Taiwan.

Author

Sum-Fu Chiang, Jinn-Shiun Chen, Reiping Tang, Chien-Yuh Yeh, Pao-Shiu Hsieh, Wen-Sy Tsai, Jeng-Fu You, Hsin-Yuan Hung, Cheng-Chou Lai, Jr-Rung Lin, Jy-Ming Chiang, Chiang, Sum-Fu, Chen, Jinn-Shiun, Tang, Reiping, Yeh, Chien-Yuh, Hsieh, Pao-Shiu, Tsai, Wen-Sy, You, Jeng-Fu, Hung, Hsin-Yuan, and Lai, Cheng-Chou

Subjects
COLORECTAL cancer, CANCER patients, PROPORTIONAL hazards models, RECEIVER operating characteristic curves
Abstract

Background: Impaired kidney function is associated with different diseases. However, its impact on colorectal cancer has not been clarified. In order to understand the effect of preoperative kidney function on the outcome of patients with cancer, we analyzed colorectal cancer patients with localized or regional diseases.Materials and Methods: In total, 3731 stage I to III colorectal cancer (CRC) patients were analyzed in Chang Gung Memorial Hospital. Modification of Diet in Renal Disease (MDRD) formula was used for estimated glomerular filtration rate (eGFR). Receiver operating characteristic (ROC) analysis for kidney function cut-off value; Chi-square method, independent t test, or analysis of variance (ANOVA) method for clinicopathological factors; Kaplan-Meier method for disease-free survival (DFS); Cox proportional hazard model for multivariate analysis.Results: Among colon cancer patients, low eGFR (MDRD <70) was associated with more male patients, T2 stage, patients without adjuvant chemotherapy, and patients with elevated creatinine level. Low eGFR is a significant risk factor only for stage III colon cancer (hazard ratio 1.70, 95% CI: 1.28-2.26; P < 0.001). Furthermore, postoperative adjuvant chemotherapy did not significantly increase 5-year DFS for both high and low eGFR groups in stage II patients (5 yrs DFS, 94.8% vs. 84.1%, P = 0.098 for high eGFR subgroup; and 75.0% vs. 75.8%, P = 0.379 for low eGFR subgroup). However, significant improvement of 5-yrs DFS after chemotherapy was found in low eGFR stage III colon cancer patients (64.7% vs. 39.4%, P < 0.001 for low eGFR subgroup). In contrast, no significant DFS difference was caused by chemotherapy for high eGFR stage III subgroup (70.5% vs. 63.9%, P = 0.110).Conclusions: Although low eGFR is an independent risk factor for stage III colon cancer. However, the adjuvant chemotherapy impacts on stage III colon cancer patients differently according to eGFR status. [ABSTRACT FROM AUTHOR]

Published
2019
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49. Circulating Tumor Cell Count Correlates with Colorectal Neoplasm Progression and Is a Prognostic Marker for Distant Metastasis in Non-Metastatic Patients

Author

Tsai, Wen-Sy, primary, Chen, Jinn-Shiun, additional, Shao, Hung-Jen, additional, Wu, Jen-Chia, additional, Lai, Jr-Ming, additional, Lu, Si-Hong, additional, Hung, Tsung-Fu, additional, Chiu, Yen-Chi, additional, You, Jeng-Fu, additional, Hsieh, Pao-Shiu, additional, Yeh, Chien-Yuh, additional, Hung, Hsin-Yuan, additional, Chiang, Sum-Fu, additional, Lin, Geng-Ping, additional, Tang, Reiping, additional, and Chang, Ying-Chih, additional

Published
2016
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