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Your search keyword '"Uquillas, Carlos A."' showing total 15 results
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15 results on '"Uquillas, Carlos A."'

1. MRI Features That Contribute to Decision-Making for Treatment of Capitellar OCD Lesions: An Expert Consensus Using the Delphi Method.

Author

Kostyun, Regina O., Nguyen, Jie C., Chhabra, Bobby, Todd R. Lawrence, J., Polousky, John D., Saper, Michael, Uquillas, Carlos, Nissen, Carl W., Albright, Jay, Bae, Donald, Bohn, Deb, Chan, Charles, Crepeau, Allison, Edmonds, Eric, Fabricant, Peter, Ganley, Theodore, Little, Kevin, Lee Pace, James, Pacicca, Donna, and Pennock, Andrew

Published
2024
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15. Ubiquitination by TOPORS Regulates the Prostate Tumor Suppressor NKX3.1.

Author

Bin Guan, Pooja Pungaliya, Xiang Li, Uquillas, Carlos, Mutton, Laura N., Rubin, Eric H., and Bieberich, Charles J.

Subjects
*PROSTATE cancer, *TUMOR suppressor proteins, *UBIQUITIN, *CANCER cells, *PROTEOLYTIC enzymes
Abstract

The NKX3.1 gene located at 8p21.2 encodes a homeodomain-containing transcription factor that acts as a haploinsufficient tumor suppressor in prostate cancer. Diminished protein expression of NKX3.1 has been observed in prostate cancer precursors and carcinomas. TOPORS is a ubiquitously expressed E3 ubiquitin ligase that can ubiquitinate tumor suppressor p53. Here we report interaction between NKX3.1 and TOPORS. NKX3.1 can be ubiquitinated by TOPORS in vitro and in vivo, and overexpression of TOPORS leads to NKX3.1 proteasomal degradation in prostate cancer cells. Conversely, small interfering RNA-mediated knockdown of TOPORS leads to an increased steady-state level and prolonged half-life of NKX3.1. These data establish TOPORS as a negative regulator of NKX3.1 and implicate TOPORS in prostate cancer progression. [ABSTRACT FROM AUTHOR]

Published
2008
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