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This is an Open Access article, published by EDP Sciences, under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited., Context. Stellar occultations have become one of the best techniques to gather information about the physical properties of trans-Neptunian objects (TNOs), which are critical objects for understanding the origin and evolution of our Solar System. Aims. The purpose of this work is to determine, with better accuracy, the physical characteristics of the TNO (84922) 2003 VS2 through the analysis of the multichord stellar occultation on 2019 October 22 and photometric data collected afterward. Methods. We predicted, observed, and analyzed the multichord stellar occultation of the Second Gaia Data Release (Gaia DR2) source 3449076721168026624 (mυ = 14.1 mag) by the plutino object 2003 VS2 on 2019 October 22. We performed aperture photometry on the images collected and derived the times when the star disappeared and reappeared from the observing sites that reported a positive detection. We fit the extremities of such positive chords to an ellipse using a Monte Carlo method. We also carried out photometric observations to derive the rotational light curve amplitude and rotational phase of 2003 VS2 during the stellar occultation. Combining the results and assuming a triaxial shape, we derived the 3D shape of 2003 VS2. Results. Out of the 39 observatories involved in the observational campaign, 12 sites, located in Bulgaria (one), Romania (ten), and Serbia (one), reported a positive detection; this makes it one of the best observed stellar occultations by a TNO so far. Considering the rotational phase of 2003 VS2 during the stellar occultation and the rotational light curve amplitude derived (Am = 0.264 ± 0.017 mag), we obtained a mean area-equivalent diameter of DAeq = 545 ± 13 km and a geometric albedo of 0.134 ± 0.010. By combining the rotational light curve information with the stellar occultation results, we derived the best triaxial shape for 2003 VS2, which has semiaxes a = 339 ± 5 km, b = 235 ± 6 km, and c = 226 ± 8 km. The derived aspect angle of 2003 VS2 is θ = 59° ± 2° or its supplementary θ = 121° ± 2°, depending on the north-pole position of the TNO. The spherical-volume equivalent diameter is DVeq = 524 ± 7 km. If we consider large albedo patches on its surface, the semi-major axis of the ellipsoid could be ~ 10 km smaller. These results are compatible with the previous ones determined from the single-chord 2013 and four-chord 2014 stellar occultations and with the effective diameter and albedo derived from Herschel and Spitzer data. They provide evidence that 2003 VS2’s 3D shape is not compatible with a homogeneous triaxial body in hydrostatic equilibrium, but it might be a differentiated body and/or might be sustaining some stress. No secondary features related to rings or material orbiting around 2003 VS2 were detected. © M. Vara-Lubiano et al. 2022., We acknowledge financial support from the State Agency for Research of the Spanish MCIU through the “Center of Excellence Severo Ochoa” award to the Instituto de Astrofísica de Andalucía (SEV-2017-0709). Funding from Spanish projects PID2020-112789GB-I00 from AEI and Proyecto de Excelencia de la Junta de Andalucía PY20-01309 is acknowledged. Part of the research leading to these results has received funding from the European Research Council under the European Community’s H2020 (2014-2020/ERC Grant Agreement no. 669416 “LUCKY STAR”). M.V-L. acknowledges funding from Spanish project AYA2017-89637-R (FEDER/MICINN). P.S-S. acknowledges financial support by the Spanish grant AYA-RTI2018-098657-J-I00 “LEO-SBNAF”. Part of the work of M.P. was financed by a grant of the Romanian National Authority for Scientific Research and Innovation, CNCS – UEFIS– CDI, PN-III-P1-1.1-TE-2019-1504. E.F.-V. acknowledges financial support from the Florida Space Institute and the Space Research Initiative. The following authors acknowledge the respective CNPq grants: F.B-R 309578/2017-5; B.E.M. 150612/2020-6; RV-M 304544/2017-5, 401903/2016-8; J.I.B.C. 308150/2016-3 and 305917/2019-6; M.A 427700/2018-3, 310683/2017-3 and 473002/2013-2. D.I. and O.V. acknowledge funding provided by the Ministry of Education, Science, and Technological Development of the Republic of Serbia (contracts 451-039/2021-14/200104, 451-03-9/2021-14/200002). D.I. acknowledges the support of the Alexander von Humboldt Foundation. M.H. thanks the Slovak Academy of Sciences (VEGA No. 2/0059/22) and the Slovak Research and Development Agency under the Contract No. APVV-19-0072. This work has also been supported by the VEGA grant of the Slovak Academy of Sciences No. 2/0031/18. A.P., R.S. and C.K. acknowledge the grant of K-138962 of National Research, Development and Innovation Office (Hungary). This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001 and the National Institute of Science and Technology of the e-Universe project (INCT do e-Universo, CNPq grant 465376/2014-2). This work has made use of data from the European Space Agency (ESA) mission Gaia (https://www.cosmos.esa.int/gaia), processed by the Gaia Data Processing and Analysis Consortium (DPAC, https://www.cosmos.esa.int/web/gaia/dpac/consortium). Funding for the DPAC has been provided by national institutions, in particular the institutions participating in the Gaia Multilateral Agreement. This research is partially based on observations collected at the Centro Astronómico Hispano-Alemán (CAHA) at Calar Alto, operated jointly by Junta de Andalucía and Consejo Superior de Investigaciones Científicas (IAA-CSIC). This research is also partially based on observations carried out at the Observatorio de Sierra Nevada (OSN) operated by Instituto de Astrofísica de Andalucía (CSIC). This article is also based on observations made in the Observatorios de Canarias del IAC with the Liverpool Telescope operated on the island of La Palma by the Instituto de Astrofísica de Canarias in the Roque de los Muchachos Observatory.

Observations of metal absorption systems in the spectra of distant quasars allow to constrain a possible variation of the fine-structure constant throughout the history of the Universe. Such a test poses utmost demands on the wavelength accuracy and previous studies were limited by systematics in the spectrograph wavelength calibration. A substantial advance in the field is therefore expected from the new ultra-stable high-resolution spectrograph Espresso, recently installed at the VLT. In preparation of the fundamental physics related part of the Espresso GTO program, we present a thorough assessment of the Espresso wavelength accuracy and identify possible systematics at each of the different steps involved in the wavelength calibration process. Most importantly, we compare the default wavelength solution, based on the combination of Thorium-Argon arc lamp spectra and a Fabry-P\'erot interferometer, to the fully independent calibration obtained from a laser frequency comb. We find wavelength-dependent discrepancies of up to 24m/s. This substantially exceeds the photon noise and highlights the presence of different sources of systematics, which we characterize in detail as part of this study. Nevertheless, our study demonstrates the outstanding accuracy of Espresso with respect to previously used spectrographs and we show that constraints of a relative change of the fine-structure constant at the $10^{-6}$ level can be obtained with Espresso without being limited by wavelength calibration systematics., Comment: 27 pages, accepted for publication in A&A

The aim of this study is to explore the role of labial minor salivary gland (LMSG) focus score (FS) in stratifying Sjögren's Syndrome (SS) patients, lymphoma development prediction and to facilitate early lymphoma diagnosis. Ιn an integrated cohort of 1997 patients, 618 patients with FS ≥ 1 and at least one-year elapsing time interval from SS diagnosis to lymphoma diagnosis or last follow up were identified. Clinical, laboratory and serological features were recorded. A data driven logistic regression model was applied to identify independent lymphoma associated risk factors. Furthermore, a FS threshold maximizing the difference of time interval from SS until lymphoma diagnosis between high and low FS lymphoma subgroups was investigated, to develop a follow up strategy for early lymphoma diagnosis. Of the 618 patients, 560 were non-lymphoma SS patients while the other 58 had SS and lymphoma. FS, cryoglobulinemia and salivary gland enlargement (SGE) were proven to be independent lymphoma associated risk factors. Lymphoma patients with FS ≥ 4 had a statistically significant shorter time interval from SS to lymphoma diagnosis, compared to those with FS < 4 (4 vs 9 years, respectively, p = 0,008). SS patients with FS ≥ 4 had more frequently B cell originated manifestations and lymphoma, while in patients with FS < 4, autoimmune thyroiditis was more prevalent. In the latter group SGE was the only lymphoma independent risk factor. A second LMSG biopsy is patients with a FS ≥ 4, 4 years after SS diagnosis and in those with FS < 4 and a history of SGE, at 9-years, may contribute to an early lymphoma diagnosis. Based on our results we conclude that LMSG FS, evaluated at the time of SS diagnosis, is an independent lymphoma associated risk factor and may serve as a predictive biomarker for the early diagnosis of SS-associated lymphomas. © 2021 Elsevier Ltd

ESPRESSO is the new high-resolution spectrograph of ESO's Very-Large Telescope (VLT). It was designed for ultra-high radial-velocity precision and extreme spectral fidelity with the aim of performing exoplanet research and fundamental astrophysical experiments with unprecedented precision and accuracy. It is able to observe with any of the four Unit Telescopes (UT) of the VLT at a spectral resolving power of 140,000 or 190,000 over the 378.2 to 788.7 nm wavelength range, or with all UTs together, turning the VLT into a 16-m diameter equivalent telescope in terms of collecting area, while still providing a resolving power of 70,000. We provide a general description of the ESPRESSO instrument, report on the actual on-sky performance, and present our Guaranteed-Time Observation (GTO) program with its first results. ESPRESSO was installed on the Paranal Observatory in fall 2017. Commissioning (on-sky testing) was conducted between December 2017 and September 2018. The instrument saw its official start of operations on October 1st, 2018, but improvements to the instrument and re-commissioning runs were conducted until July 2019. The measured overall optical throughput of ESPRESSO at 550 nm and a seeing of 0.65 arcsec exceeds the 10% mark under nominal astro-climatic conditions. We demonstrate a radial-velocity precision of better than 25 cm/s during one night and 50 cm/s over several months. These values being limited by photon noise and stellar jitter show that the performanceis compatible with an instrumental precision of 10 cm/s. No difference has been measured across the UTs neither in throughput nor RV precision. The combination of the large collecting telescope area with the efficiency and the exquisite spectral fidelity of ESPRESSO opens a new parameter space in RV measurements, the study of planetary atmospheres, fundamental constants, stellar characterisation and many other fields., 26 pages, 28 figures

We present the IBIS2.0 project, which aims to upgrade and to install the Interferometric BIdimensional Spectrometer at the solar Vacuum Tower Telescope (Tenerife, Spain) after its disassembling from the Dunn Solar Telescope (New Mexico, USA). The instrument is undergoing a hardware and software revision that will allow it to perform new spectropolarimetric measurements of the solar atmosphere at high spatial, spectral and temporal resolution in coordination with other ground- and space-based instruments. Here we present the new opto-mechanical layout and control system designed for the instrument, and describe future steps....

Toledo-Padrón, B. et al., Context. An accurate characterization of the known exoplanet population is key to understanding the origin and evolution of planetary systems. Determining true planetary masses through the radial velocity (RV) method is expected to experience a great improvement thanks to the availability of ultra-stable echelle spectrographs. Aims. We took advantage of the extreme precision of the new-generation echelle spectrograph ESPRESSO to characterize the transiting planetary system orbiting the G2V star K2-38 located at 194 pc from the Sun with V 11.4. This system is particularly interesting because it could contain the densest planet detected to date. Methods. We carried out a photometric analysis of the available K2 photometric light curve of this star to measure the radius of its two known planets, K2-38b and K2-38c, with Pb = 4.01593 ± 0.00050 d and Pc = 10.56103 ± 0.00090 d, respectively. Using 43 ESPRESSO high-precision RV measurements taken over the course of 8 months along with the 14 previously published HIRES RV measurements, we modeled the orbits of the two planets through a Markov chain Monte Carlo analysis, significantly improving their mass measurements. Results. Using ESPRESSO spectra, we derived the stellar parameters, Teff = 5731 ± 66, log g = 4.38 ± 0.11 dex, and [Fe/H] = 0.26 ± 0.05 dex, and thus the mass and radius of K2-38, Ma = 1.03-0.02+0.04 MaS and Ra = 1.06-0.06+0.09 RaS. We determine new values for the planetary properties of both planets. We characterize K2-38b as a super-Earth with RP = 1.54 ± 0.14 RaS and Mp = 7.3-1.0+1.1 MaS, and K2-38c as a sub-Neptune with RP = 2.29 ± 0.26 RaS and Mp = 8.3-1.3+1.3 MaS. Combining the radius and mass measurements, we derived a mean density of ρp = 11.0-2.8+4.1 g cm-3 for K2-38b and ρp = 3.8-1.1+1.8 g cm-3 for K2-38c, confirming K2-38b as one of the densest planets known to date. Conclusions. The best description for the composition of K2-38b comes from an iron-rich Mercury-like model, while K2-38c is better described by a rocky-model with H2 envelope. The maximum collision stripping boundary shows how giant impacts could be the cause for the high density of K2-38b. The irradiation received by each planet places them on opposite sides of the radius valley. We find evidence of a long-period signal in the RV time-series whose origin could be linked to a 0.25-3 MJ planet or stellar activity., With funding from the Spanish government through the "María de Maeztu Unit of Excellence" accreditation (MDM-2017-0737)

The FORS Upgrade project (FORS-Up) aims at bringing a new life to the highly demanded workhorse instrument attached to ESO's Very Large Telescope (VLT). FORS2 is a multimode optical instrument, which started regular science operations in 2000 and since then, together with its twin, FORS1, has been one of the most demanded and most productive instruments of the VLT. In order to ensure that a FORS shall remain operational for at least another 15 years, an upgrade has been planned. This is required as FORS2 is using technology and software that is now obsolete and cannot be put and maintained to the standards in use at the Observatory. The project - carried out as a collaboration between ESO and INAF-Astronomical Observatory of Trieste - aims at bringing to the telescope in 2023/2024 a refurbished instrument with a new scientific detector, an upgrade of the instrument control software and electronics, a new calibration unit, as well as additional filters and grisms. The new FORS will also serve as a test bench for the Extremely Large Telescope (ELT) standard technologies (among them the use of programmable logic controllers and of the features of the ELT Control Software). The project aims at minimising the downtime of the instrument by performing the upgrade on the currently decommissioned instrument FORS1 and retrofitting the Mask Exchange Unit and polarisation optics from FORS2 to FORS1., Comment: Author version of a paper presented at SPIE Ground-based and Airborne Instrumentation for Astronomy VIII; corrected one statement

Damasso, M. et al., Context. The bright star π Men was chosen as the first target for a radial velocity follow-up to test the performance of ESPRESSO, the new high-resolution spectrograph at the European Southern Observatory's Very Large Telescope. The star hosts a multi-planet system (a transiting 4 M· planet at ∼0.07 au and a sub-stellar companion on a ∼2100-day eccentric orbit), which is particularly suitable for a precise multi-technique characterization. Aims. With the new ESPRESSO observations, which cover a time span of 200 days, we aim to improve the precision and accuracy of the planet parameters and search for additional low-mass companions. We also take advantage of the new photometric transits of π Men c observed by TESS over a time span that overlaps with that of the ESPRESSO follow-up campaign. Methods. We analysed the enlarged spectroscopic and photometric datasets and compared the results to those in the literature. We further characterized the system by means of absolute astrometry with HIPPARCOS and Gaia. We used the high-resolution spectra of ESPRESSO for an independent determination of the stellar fundamental parameters. Results. We present a precise characterization of the planetary system around π Men. The ESPRESSO radial velocities alone (37 nightly binned data with typical uncertainty of 10 cm s-1) allow for a precise retrieval of the Doppler signal induced by π Men c. The residuals show a root mean square of 1.2 m s-1, which is half that of the HARPS data; based on the residuals, we put limits on the presence of additional low-mass planets (e.g. we can exclude companions with a minimum mass less than ∼2 M· within the orbit of π Men c). We improve the ephemeris of π Men c using 18 additional TESS transits, and, in combination with the astrometric measurements, we determine the inclination of the orbital plane of π Men b with high precision (ib =45.8-1.1+1.4 deg). This leads to the precise measurement of its absolute mass mb =14.1-0.4+0.5 MJup, indicating that π Men b can be classified as a brown dwarf. Conclusions. The π Men system represents a nice example of the extreme precision radial velocities that can be obtained with ESPRESSO for bright targets. Our determination of the 3D architecture of the π Men planetary system and the high relative misalignment of the planetary orbital planes put constraints on and challenge the theories of the formation and dynamical evolution of planetary systems. The accurate measurement of the mass of π Men b contributes to make the brown dwarf desert a bit greener., With funding from the Spanish government through the "María de Maeztu Unit of Excellence" accreditation (MDM-2017-0737)

The Astronomical Observatory of Trieste (OATs), part of the Italian Institute for Astrophysics (INAF), hosts a Celestron C14 telescope, equipped with a robotic Paramount ME equatorial mount, used for public outreach. The telescope is installed inside a dome, recently upgraded with a Beckhoff PLC control system, a SIEMENS inverter for the communication with the motor of the dome's roof, and further equipment to allow the complete automatization of the system. A peculiarity of the system is that, when operating, the telescope may exceed the height of the roof: due to this fact the telescope pointing is constrained by the full opening of the roof and, oppositely, the closing of the roof is allowed only when the telescope is in park position. Appropriate sensors are installed to monitor the position of the telescope to properly handle the complete opening or closing of the roof. Several emergency operations are also foreseen, for example in case of bad weather or lost connection with the user. The PLC software has been developed using TwinCAT software. An OPC-UA server is installed in the PLC and allows the communication with a web interface. The web GUI, developed in PHP and Javascript, allows the user to perform the remote operations like switching on all the instrumentations, open the dome's roof, park the telescope and view the status of the system. Furthermore through TheSkyX software it is possible to perform the pointing of the telescope and its set up. A dedicated script, interfaced with TheSkyX, have been implemented to perform a complete automated acquisition. An appropriate data storage system is foreseen. All these elements, that cooperate to create a fully remoted controlled system, are presented in this paper.

Departamento deFsica eAstronomia, Faculdade Cincias, Universidade do Porto,Rua das Estrelas, 4150-762PortugalReceived2013 Aug 29, accepted 2013 Nov1Published online 2014 Jan 15Keywords instrumentation: spectrographs –plantary systems –techniques: spectroscopicThe acronym ESPRESSO stems for Echelle SPectrograph for RockyExoplanets and Stable Spectroscopic Observations;this instrument will be the next VLThigh resolution spectrograph. The spectrograph will be installed at the Combined-CoudeL´ aboratory of the VLTand linked to the four 8.2mUnit Telescopes (UT) through four optical Coudet´ rains.ESPRESSO will combine efficiencyand extreme spectroscopic precision. ESPRESSO is foreseen to achieve again oftwomagnitudes with respect to its predecessor HARPS, and to improve the instrumental radial-velocity precision to reachthe 10 cms

The current E-ELT instrumentation plan foresees a High Resolution Spectrograph conventionally indicated as EELTHIRES whose Phase A study has started in March 2016. Since 2013 however, a preliminary study of a modular E-ELT instrument able to provide high-resolution spectroscopy (R 100,000) in a wide wavelength range (0.37-2.5 μm) has been already conducted by an international consortium (termed "HIRES initiative"). Taking into account the requirements inferred from this preliminary work in terms of both high-level operations as well as low-level control, we will present in this paper possible solutions for HIRES hardware and software architecture. The validity of the proposed architectural and hardware choices will be eventually discussed based also on the experience gained on a real-working instrument, ESPRESSO, the next generation high-stability spectrograph for the VLT and to certain extent the precursor of HIRES.

ESPRESSO, the Echelle SPectrograph for Rocky Exoplanet and Stable Spectroscopic Observations of the ESO - Very Large Telescope site, is now in its integration phase. The large number of functions of this complex instrument are fully controlled by a Beckhoff PLC based control electronics architecture. Four small and one large cabinets host the main electronic parts to control all the sensors, motorized stages and other analogue and digital functions of ESPRESSO. The Instrument Control Electronics (ICE) is built following the latest ESO standards and requirements. Two main PLC CPUs are used and are programmed through the TwinCAT Beckhoff dedicated software. The assembly, integration and verification phase of ESPRESSO, due to its distributed nature and different geographical locations of the consortium partners, is quite challenging. After the preliminary assembling and test of the electronic components at the Astronomical Observatory of Trieste and the test of some electronics and software parts at ESO (Garching), the complete system for the control of the four Front End Unit (FEU) arms of ESPRESSO has been fully assembled and tested in Merate (Italy) at the beginning of 2016. After these first tests, the system will be located at the Geneva Observatory (Switzerland) until the Preliminary Acceptance Europe (PAE) and finally shipped to Chile for the commissioning. This paper describes the integration strategy of the ICE workpackage of ESPRESSO, the hardware and software tests that have been performed, with an overall view of the experience gained during these project's phases.

Sex steroid hormones contribute to the physiological regulation of bone turnover in males. To address this issue, we investigated serum estradiol (E2), total testosterone (T), and DHEAS concentrations, along with serum levels of carboxy-terminal telopeptide of type I collagen (sCTx), in a sample of 76 healthy men aged 23 to 87. The concentration of sCTx declined with age. Both T and DHEAS, at variance with E2, showed a significant age-related decline. T, DHEAS and sCTx significantly (p

At present current knowledges on OIT are controversial. We studied the effectiveness and the possible immunological mechanisms of this therapy. We followed a group of 56 children affected by allergic asthma due to Dermatophagoides during their treatment with OIT. Many clinical parameters were investigated and also immunoallergological and spirometric values in a subgroup. We observed a particularly satisfying clinical and respiratory improvement, while immunoallergological parameters did not suffer significant changes.

Ehrenreich, D.et al., Ultrahot giant exoplanets receive thousands of times Earth’s insolation. Their high-temperature atmospheres (greater than 2,000 kelvin) are ideal laboratories for studying extreme planetary climates and chemistry. Daysides are predicted to be cloud-free, dominated by atomic species and much hotter than nightsides. Atoms are expected to recombine into molecules over the nightside, resulting in different day and night chemistries. Although metallic elements and a large temperature contrast have been observed, no chemical gradient has been measured across the surface of such an exoplanet. Different atmospheric chemistry between the day-to-night (‘evening’) and night-to-day (‘morning’) terminators could, however, be revealed as an asymmetric absorption signature during transit. Here we report the detection of an asymmetric atmospheric signature in the ultrahot exoplanet WASP-76b. We spectrally and temporally resolve this signature using a combination of high-dispersion spectroscopy with a large photon-collecting area. The absorption signal, attributed to neutral iron, is blueshifted by −11 ± 0.7 kilometres per second on the trailing limb, which can be explained by a combination of planetary rotation and wind blowing from the hot dayside. In contrast, no signal arises from the nightside close to the morning terminator, showing that atomic iron is not absorbing starlight there. We conclude that iron must therefore condense during its journey across the nightside., With funding from the Spanish government through the "María de Maeztu Unit of Excellence" accreditation (MDM-2017-0737)

Two previously unreported nuyor pigments were found in the blue flowers of Tibouchina granulosa Cogn.: malvidin-3-(di-p-coumaroyl xyloside)-5-glucoside and malvidin-3-(p-coumaroyl xyloside)-5-glucoside. The first pigment is easily degraded to the second since the second p-coumaric acid molecule is quite labile. Two other pigments were present in trace amounts.

The Square Kilometer Array (SKA) project aims at building the world’s largest radio observatory to observe the sky with unprecedented sensitivity and collecting area. In the first phase of the project (SKA1), an array of dishes, SKA1-MID, will be built in South Africa. It will consist of 133 15m-dishes, which will include the MeerKAT array, for the 0.350-20 GHz frequency band observations. Each antenna will be provided with a local monitor and control system (LMC), enabling operations both to the Telescope Manager remote system, and to the engineers and maintenance staff; it provides different environment for the telescope control (positioning, pointing, observational bands), metadata collection for monitoring and database storaging, operational modes and functional states management for all the telescope capabilities. In this paper we present the LMC software architecture designed for the detailed design phase (DD), where we describe functional and physical interfaces with monitored and controlled sub-elements, and highlight the data flow between each LMC modules and its sub-element controllers from one side, and Telescope Manager on the other side. We also describe the complete Product Breakdown Structure (PBS) created in order to optimize resources allocation in terms of calculus and memory, able to perform required task for each element according to the proper requirements. Among them, time response and system reliability are the most important, considering the complexity of SKA dish network and its isolated placement. Performances obtained by software implementation using TANGO framework will be discussed, matching them with technical requirements derived by SKA science drivers.