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1. Serum zonulin and colorectal cancer risk

Author

Marino, Mirko, Mignozzi, Silvia, Michels, Karin B., Cintolo, Marcello, Penagini, Roberto, Gargari, Giorgio, Ciafardini, Clorinda, Ferraroni, Monica, Patel, Linia, Del Bo’, Cristian, Leone, Pierfrancesco, Airoldi, Aldo, Vecchi, Maurizio, Bonzi, Rossella, Oreggia, Barbara, Carnevali, Pietro, Vangeli, Marcello, Mutignani, Massimiliano, Guglielmetti, Simone, Riso, Patrizia, La Vecchia, Carlo, and Rossi, Marta

Published
2024
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2. Gastrointestinal Ultrasound in Infectious Diseases: A Comprehensive Review.

Author

Aprile, Francesca, Vangeli, Marcello, Allocca, Mariangela, Zilli, Alessandra, Argollo, Marjorie Costa, D'amico, Ferdinando, Parigi, Tommaso Lorenzo, Danese, Silvio, and Furfaro, Federica

Subjects
GASTROINTESTINAL diseases, PARASITIC diseases, ULTRASONIC imaging, COMMUNICABLE diseases, SYMPTOMS
Abstract

Infectious diseases affecting the gastrointestinal tract often present diagnostic challenges due to the variability in clinical manifestations and overlapping symptoms. Ultrasound imaging has emerged as a valuable tool in the assessment of gastrointestinal pathologies, offering non-invasive and real-time visualization of anatomical structures. This review aims to explore the role of ultrasound in the diagnosis and management of infectious diseases involving the gastrointestinal tract. We discuss the imaging features of various infectious etiologies, such as bacterial, viral, and parasitic infections, highlighting characteristic findings on ultrasound scans. Additionally, we provide insights into the utility of ultrasound for the assessment of treatment response. Through a comprehensive analysis of existing literature and clinical case studies, this review underscores the significance of ultrasound imaging as a frontline modality in the diagnosis and management of infectious diseases affecting the gastrointestinal tract. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Flavonoid Intake in Relation to Colorectal Cancer Risk and Blood Bacterial DNA

Author

Speciani, Michela Carola, primary, Cintolo, Marcello, additional, Marino, Mirko, additional, Oren, Maya, additional, Fiori, Federica, additional, Gargari, Giorgio, additional, Riso, Patrizia, additional, Ciafardini, Clorinda, additional, Mascaretti, Federica, additional, Parpinel, Maria, additional, Airoldi, Aldo, additional, Vangeli, Marcello, additional, Leone, Pierfrancesco, additional, Cantù, Paolo, additional, Lagiou, Pagona, additional, Del Bo’, Cristian, additional, Vecchi, Maurizio, additional, Carnevali, Pietro, additional, Oreggia, Barbara, additional, Guglielmetti, Simone, additional, Bonzi, Rossella, additional, Bonato, Giulia, additional, Ferraroni, Monica, additional, La Vecchia, Carlo, additional, Penagini, Roberto, additional, Mutignani, Massimiliano, additional, and Rossi, Marta, additional

Published
2022
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4. Blood Bacterial DNA Load and Profiling Differ in Colorectal Cancer Patients Compared to Tumor-Free Controls

Author

Mutignani, Massimiliano, primary, Penagini, Roberto, additional, Gargari, Giorgio, additional, Guglielmetti, Simone, additional, Cintolo, Marcello, additional, Airoldi, Aldo, additional, Leone, Pierfrancesco, additional, Carnevali, Pietro, additional, Ciafardini, Clorinda, additional, Petrocelli, Giulio, additional, Mascaretti, Federica, additional, Oreggia, Barbara, additional, Dioscoridi, Lorenzo, additional, Cavalcoli, Federica, additional, Primignani, Massimo, additional, Pugliese, Francesco, additional, Bertuccio, Paola, additional, Soru, Pietro, additional, Magistro, Carmelo, additional, Ferrari, Giovanni, additional, Speciani, Michela C., additional, Bonato, Giulia, additional, Bini, Marta, additional, Cantù, Paolo, additional, Caprioli, Flavio, additional, Vangeli, Marcello, additional, Forti, Edoardo, additional, Mazza, Stefano, additional, Tosetti, Giulia, additional, Bonzi, Rossella, additional, Vecchi, Maurizio, additional, La Vecchia, Carlo, additional, and Rossi, Marta, additional

Published
2021
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5. Long-term albumin administration in decompensated cirrhosis (ANSWER): an open-label randomised trial

Author

Caraceni, Paolo, Riggio, Oliviero, Angeli, Paolo, Alessandria, Carlo, Neri, Sergio, Foschi, Francesco G, Levantesi, Fabio, Airoldi, Aldo, Boccia, Sergio, Svegliati-Baroni, Gianluca, Fagiuoli, Stefano, Romanelli, Roberto G, Cozzolongo, Raffaele, Di Marco, Vito, Sangiovanni, Vincenzo, Morisco, Filomena, Toniutto, Pierluigi, Tortora, Annalisa, De Marco, Rosanna, Angelico, Mario, Cacciola, Irene, Elia, Gianfranco, Federico, Alessandro, Massironi, Sara, Guarisco, Riccardo, Galioto, Alessandra, Ballardini, Giorgio, Rendina, Maria, Nardelli, Silvia, Piano, Salvatore, Elia, Chiara, Prestianni, Loredana, Cappa, Federica Mirici, Cesarini, Lucia, Simone, Loredana, Pasquale, Chiara, Cavallin, Marta, Andrealli, Alida, Fidone, Federica, Ruggeri, Matteo, Roncadori, Andrea, Baldassarre, Maurizio, Tufoni, Manuel, Zaccherini, Giacomo, Bernardi, Mauro, Domenicali, Marco, Giannone, Ferdinando A, Merli, Manuela, Gioia, Stefania, Fasolato, Silvano, Sticca, Antonietta, Campion, Daniela, Risso, Alessandro, Saracco, Giorgio M, Maiorca, Daniela, Rizzotto, Agostino, Lanzi, Arianna, Neri, Elga, Visani, Anna, Mastroianni, Antonio, Alberti, Alberto B, Mazzarelli, Chiara, Vangeli, Marcello, Marzioni, Marco, Capretti, Francesca, Kostandini, Alba, Magini, Giulia, Colpani, Maria, Laffi, Giacomo, Gabbani, Tommaso, Marsico, Maria, Zappimbulso, Marianna, Petruzzi, Josè, Calvaruso, Vincenza, Parrella, Giovanni, Caporaso, Nicola, Auriemma, Francesco, Guarino, Maria, Pugliese, Fabio, Gasbarrini, Antonio, Leo, Pietro, De Leonardis, Francesco, Pecchioli, Alessandra, Rossi, Piera, Raimondo, Giovanni, Negri, Elisa, Dallio, Marcello, Loguercio, Carmelina, Conte, Dario, Celli, Natascia, Bringiotti, Roberto, Castellaneta, Nicola M, Salerno, Francesco, ANSWER Study Investigators, Caraceni, Paolo, Riggio, Oliviero, Angeli, Paolo, Alessandria, Carlo, Neri, Sergio, Foschi, Francesco G, Levantesi, Fabio, Airoldi, Aldo, Boccia, Sergio, Svegliati-Baroni, Gianluca, Fagiuoli, Stefano, Romanelli, Roberto G, Cozzolongo, Raffaele, Di Marco, Vito, Sangiovanni, Vincenzo, Morisco, Filomena, Toniutto, Pierluigi, Tortora, Annalisa, De Marco, Rosanna, Angelico, Mario, Cacciola, Irene, Elia, Gianfranco, Federico, Alessandro, Massironi, Sara, Guarisco, Riccardo, Galioto, Alessandra, Ballardini, Giorgio, Rendina, Maria, Nardelli, Silvia, Piano, Salvatore, Elia, Chiara, Prestianni, Loredana, Cappa, Federica Mirici, Cesarini, Lucia, Simone, Loredana, Pasquale, Chiara, Cavallin, Marta, Andrealli, Alida, Fidone, Federica, Ruggeri, Matteo, Roncadori, Andrea, Baldassarre, Maurizio, Tufoni, Manuel, Zaccherini, Giacomo, Bernardi, Mauro, Domenicali, Marco, Giannone, Ferdinando A, Merli, Manuela, Gioia, Stefania, Fasolato, Silvano, Sticca, Antonietta, Campion, Daniela, Risso, Alessandro, Saracco, Giorgio M, Maiorca, Daniela, Rizzotto, Agostino, Lanzi, Arianna, Neri, Elga, Visani, Anna, Mastroianni, Antonio, Alberti, Alberto B, Mazzarelli, Chiara, Vangeli, Marcello, Marzioni, Marco, Capretti, Francesca, Kostandini, Alba, Magini, Giulia, Colpani, Maria, Laffi, Giacomo, Gabbani, Tommaso, Marsico, Maria, Zappimbulso, Marianna, Petruzzi, Josè, Calvaruso, Vincenza, Parrella, Giovanni, Caporaso, Nicola, Auriemma, Francesco, Guarino, Maria, Pugliese, Fabio, Gasbarrini, Antonio, Leo, Pietro, De Leonardis, Francesco, Pecchioli, Alessandra, Rossi, Piera, Raimondo, Giovanni, Negri, Elisa, Dallio, Marcello, Loguercio, Carmelina, Conte, Dario, Celli, Natascia, Bringiotti, Roberto, Castellaneta, Nicola M, Salerno, Francesco, Caraceni P1, Riggio O2, Angeli P3, Alessandria C4, Neri S5, Foschi FG6, Levantesi F7, Airoldi A8, Boccia S9, Svegliati-Baroni G10, Fagiuoli S11, Romanelli RG12, Cozzolongo R13, Di Marco Vito, Sangiovanni V15, Morisco F16, Toniutto P17, Tortora A18, De Marco R19, Angelico M20, Cacciola I21, Elia G22, Federico A23, Massironi S24, Guarisco R25, Galioto A26, Ballardini G27, Rendina M28, Nardelli S2, Piano S3, Elia C4, Prestianni L5, Cappa FM6, Cesarini L8, Simone L9, Pasquale C2, Cavallin M3, Andrealli A4, Fidone F5, Ruggeri M29, Roncadori A30, Baldassarre M1, Tufoni M1, Zaccherini G1, Bernardi M31, Domenicali M, Giannone FA, Merli M, Gioia S, Fasolato S, Sticca A, Campion D, Risso A, Saracco GM, Maiorca D, Rizzotto A, Lanzi A, Neri E, Visani A, Mastroianni A, Alberti AB, Mazzarelli C, Vangeli M, Marzioni M, Capretti F, Kostandini A, Magini G, Colpani M, Laffi G, Gabbani T, Marsico M, Zappimbulso M, Petruzzi J, Calvaruso Vincenza, Parrella G, Caporaso N, Auriemma F, Guarino M, Pugliese F, Gasbarrini A, Leo P, De Leonardis F, Pecchioli A, Rossi P, Raimondo G, Negri E, Dallio M, Loguercio C, Conte D, Celli N, Bringiotti R, Castellaneta NM, Salerno F., Caraceni P, Riggio O, Angeli P, Alessandria C, Neri S, Foschi FG, Levantesi F, Airoldi A, Boccia S, Svegliati-Baroni G, Fagiuoli S, Romanelli RG, Cozzolongo R, Di Marco V, Sangiovanni V, Morisco F, Toniutto P, Tortora A, De Marco R, Angelico M, Cacciola I, Elia G, Federico A, Massironi S, Guarisco R, Galioto A, Ballardini G, Rendina M, Nardelli S, Piano S, Elia C, Prestianni L, Cappa FM, Cesarini L, Simone L, Pasquale C, Cavallin M, Andrealli A, Fidone F, Ruggeri M, Roncadori A, Baldassarre M, Tufoni M, Zaccherini G, Bernardi M, Domenicali M, Giannone FA, Merli M, Gioia S, Fasolato S, Sticca A, Campion D, Risso A, Saracco GM, Maiorca D, Rizzotto A, Lanzi A, Neri E, Visani A, Mastroianni A, Alberti AB, Mazzarelli C, Vangeli M, Marzioni M, Capretti F, Kostandini A, Magini G, Colpani M, Laffi G, Gabbani T, Marsico M, Zappimbulso M, Petruzzi J, Calvaruso V, Parrella G, Caporaso N, Auriemma F, Guarino M, Pugliese F, Gasbarrini A, Leo P, De Leonardis F, Pecchioli A, Rossi P, Raimondo G, Negri E, Dallio M, Loguercio C, Conte D, Celli N, Bringiotti R, Castellaneta NM, Salerno F., Caraceni, P, Riggio, O, Angeli, P, Alessandria, C, Neri, S, Foschi, F, Levantesi, F, Airoldi, A, Boccia, S, Svegliati-Baroni, G, Fagiuoli, S, Romanelli, R, Cozzolongo, R, Di Marco, V, Sangiovanni, V, Morisco, F, Toniutto, P, Tortora, A, De Marco, R, Angelico, M, Cacciola, I, Elia, G, Federico, A, Massironi, S, Guarisco, R, Galioto, A, Ballardini, G, Rendina, M, Nardelli, S, Piano, S, Elia, C, Prestianni, L, Cappa, F, Cesarini, L, Simone, L, Pasquale, C, Cavallin, M, Andrealli, A, Fidone, F, Ruggeri, M, Roncadori, A, Baldassarre, M, Tufoni, M, Zaccherini, G, Bernardi, M, Domenicali, M, Giannone, F, Merli, M, Gioia, S, Fasolato, S, Sticca, A, Campion, D, Risso, A, Saracco, G, Maiorca, D, Rizzotto, A, Lanzi, A, Neri, E, Visani, A, Mastroianni, A, Alberti, A, Mazzarelli, C, Vangeli, M, Marzioni, M, Capretti, F, Kostandini, A, Magini, G, Colpani, M, Laffi, G, Gabbani, T, Marsico, M, Zappimbulso, M, Petruzzi, J, Calvaruso, V, Parrella, G, Caporaso, N, Auriemma, F, Guarino, M, Pugliese, F, Gasbarrini, A, Leo, P, De Leonardis, F, Pecchioli, A, Rossi, P, Raimondo, G, Negri, E, Dallio, M, Loguercio, C, Conte, D, Celli, N, Bringiotti, R, Castellaneta, N, and Salerno, F

Subjects
Liver Cirrhosis, Male, Time Factors, Cirrhosis, Kaplan-Meier Estimate, law.invention, ascites, 0302 clinical medicine, Hepatorenal syndrome, Randomized controlled trial, Furosemide, law, Ascites, Clinical endpoint, Paracentesis, Diuretics, albumin, decompensated cirrhosi, Mineralocorticoid Receptor Antagonists, Settore MED/12 - Gastroenterologia, Medicine (all), Hazard ratio, General Medicine, Middle Aged, Survival Rate, 030220 oncology & carcinogenesis, Drug Therapy, Combination, Female, 030211 gastroenterology & hepatology, Quality-Adjusted Life Years, medicine.symptom, Hyponatremia, medicine.medical_specialty, 03 medical and health sciences, Albumins, Internal medicine, medicine, Humans, Survival rate, albumin, Aged, business.industry, cirrhosis, medicine.disease, Clinical trial, albumin, cirrhosis, ascites, liver decompensation, Quality of Life, Hyperkalemia, business, Esophagus Varices, Portal Hypertension, Varicosis
Abstract

Background Evidence is scarce on the efficacy of long-term human albumin (HA) administration in patients with decompensated cirrhosis. The human Albumin for the treatmeNt of aScites in patients With hEpatic ciRrhosis (ANSWER) study was designed to clarify this issue. Methods We did an investigator-initiated multicentre randomised, parallel, open-label, pragmatic trial in 33 academic and non-academic Italian hospitals. We randomly assigned patients with cirrhosis and uncomplicated ascites who were treated with anti-aldosteronic drugs (≥200 mg/day) and furosemide (≥25 mg/day) to receive either standard medical treatment (SMT) or SMT plus HA (40 g twice weekly for 2 weeks, and then 40 g weekly) for up to 18 months. The primary endpoint was 18-month mortality, evaluated as difference of events and analysis of survival time in patients included in the modified intention-to-treat and per-protocol populations. This study is registered with EudraCT, number 2008–000625–19, and ClinicalTrials.gov, number NCT01288794. Findings From April 2, 2011, to May 27, 2015, 440 patients were randomly assigned and 431 were included in the modified intention-to-treat analysis. 38 of 218 patients died in the SMT plus HA group and 46 of 213 in the SMT group. Overall 18-month survival was significantly higher in the SMT plus HA than in the SMT group (Kaplan-Meier estimates 77% vs 66%; p=0·028), resulting in a 38% reduction in the mortality hazard ratio (0·62 [95% CI 0·40–0·95]). 46 (22%) patients in the SMT group and 49 (22%) in the SMT plus HA group had grade 3–4 non-liver related adverse events. Interpretation In this trial, long-term HA administration prolongs overall survival and might act as a disease modifying treatment in patients with decompensated cirrhosis. Funding Italian Medicine Agency. Copyright © 2018 Elsevier Ltd. All rights reserved.

Published
2018

6. Killer cell immunoglobulin-like receptor genotype and killer cell immunoglobulin-like receptor–human leukocyte antigen C ligand compatibility affect the severity of hepatitis C virus recurrence after liver transplantation

Author

de Arias, Alejandro Espadas, Haworth, Simone Elizabeth, Belli, Luca Saverio, Burra, Patrizia, Pinzello, Giovambattista, Vangeli, Marcello, Minola, Ernesto, Guido, Maria, Boccagni, Patrizia, De Feo, Tullia Maria, Torelli, Rosanna, Cardillo, Massimo, Scalamogna, Mario, and Poli, Francesca

Published
2009
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7. Liver transplantation for HCV cirrhosis: Improved survival in recent years and increased severity of recurrent disease in female recipients: Results of a long term retrospective study

Author

Belli, Luca S., Burroughs, Andrew K., Burra, Patrizia, Alberti, Alberto B., Samonakis, Dimitrios, Cammà, Calogero, Carlis, Luciano De, Minola, Ernesto, Quaglia, Alberto, Zavaglia, Claudio, Vangeli, Marcello, Patch, David, Dhillon, Amar, Cillo, Umberto, Guido, Maria, Fagiuoli, Stefano, Giacomoni, Alessandro, Slim, Omar A., Airoldi, Aldo, Boninsegna, Sara, Davidson, Brian R., Rolles, Keith, and Pinzello, Giovambattista

Published
2007
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10. Liver transplantation for HCV cirrhosis: Improved survival in recent years and increased severity of recurrent disease in female recipients: Results of a long term retrospective study

Author

Belli, L, Burroughs, A, Burra, P, Alberti, A, Samonakis, D, Cammà, C, De Carlis, L, Minola, E, Quaglia, A, Zavaglia, C, Vangeli, M, Patch, D, Dhillon, A, Cillo, U, Guido, M, Fagiuoli, S, Giacomoni, A, Slim, O, Airoldi, A, Boninsegna, S, Davidson, B, Rolles, K, Pinzello, G, Belli, Luca S., Burroughs, Andrew K., Burra, Patrizia, Alberti, Alberto B., Samonakis, Dimitrios, Cammà, Calogero, De Carlis, Luciano, Minola, Ernesto, Quaglia, Alberto, Zavaglia, Claudio, Vangeli, Marcello, Patch, David, Dhillon, Amar, Cillo, Umberto, Guido, Maria, Fagiuoli, Stefano, Giacomoni, Alessandro, Slim, Omar A., Airoldi, Aldo, Boninsegna, Sara, Davidson, Brian R., Rolles, Keith, Pinzello, Giovambattista, Belli, L, Burroughs, A, Burra, P, Alberti, A, Samonakis, D, Cammà, C, De Carlis, L, Minola, E, Quaglia, A, Zavaglia, C, Vangeli, M, Patch, D, Dhillon, A, Cillo, U, Guido, M, Fagiuoli, S, Giacomoni, A, Slim, O, Airoldi, A, Boninsegna, S, Davidson, B, Rolles, K, Pinzello, G, Belli, Luca S., Burroughs, Andrew K., Burra, Patrizia, Alberti, Alberto B., Samonakis, Dimitrios, Cammà, Calogero, De Carlis, Luciano, Minola, Ernesto, Quaglia, Alberto, Zavaglia, Claudio, Vangeli, Marcello, Patch, David, Dhillon, Amar, Cillo, Umberto, Guido, Maria, Fagiuoli, Stefano, Giacomoni, Alessandro, Slim, Omar A., Airoldi, Aldo, Boninsegna, Sara, Davidson, Brian R., Rolles, Keith, and Pinzello, Giovambattista

Abstract

In recent years, a worsening outcome of hepatitis C virus (HCV)-positive recipients and a faster progression of recurrent disease to overt cirrhosis have been reported. Our aims were to 1) assess patient survival and development of severe recurrent disease (Ishak fibrosis score > 3) in different transplant years; and 2) model the effects of pre- and post-liver transplantation (LT) variables on the severity of recurrent disease. A multicenter retrospective analysis was conducted on 502 consecutive HCV-positive transplant recipients between January 1990 and December 2002. Protocol liver biopsies were obtained at 1, 3, 5, 7, and 10 yr post-LT ir almost 90% of the patients. All 502 patients were included in the overall survival analysis, while only the 354 patients with a follow-up longer than 1 yr were considered for the analysis of predictors of disease progression. The overall Kaplan-Meier survival rates were 78.7%, 66.3%, and 58.6%, at 12, 60, and 120 months, respectively, and a trend for a better patient survival over the years emerged from all 3 centers. The cumulative probability of developing HCV-related recurrent severe fibrosis (Ishak score 4-6) in the cohort of 354 patients who survived at least 1 yr remained unchanged over the years. Multivariate analysis indicated that older donors (P = 0.0001) and female gender of recipient (P = 0.02) were the 2 major risk factors for the development of severe recurrent disease, while the adoption of antilymphocytic preparations was associated with a less aggressive course (P = 0.03). Two of these prognostic factors, donor age and recipient gender, are easily available before LT and their combination showed an important synergy, such that a female recipient not only had a much higher probability of severe recurrent disease than a male recipient but her risk increased with the increasing age of the donor, reaching almost 100% when the age of the donor was 60 or older. In conclusion, a trend for a better patient survival

Published
2007

11. S1007 Genotype 2 and 3 Reccurent Hepatitis C After Liver Transplantation: Excellent Results with Suboptimal Doses of Antiviral Therapy

Author

Viganò, Raffaella, primary, Ponziani, Francesca R., additional, Belli, Luca S., additional, Vangeli, Marcello, additional, Pinzello, Giovambattista, additional, Gasbarrini, Antonio, additional, Pasulo, Luisa, additional, De Martin, Eleonora, additional, Burra, Patrizia, additional, Pompili, Maurizio, additional, Colledan, Michele, additional, Cillo, Umberto, additional, and Fagiuoli, Stefano, additional

Published
2009
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12. Combined therapy with interferon and low-dose ribavirin in posttransplantation recurrent hepatitis C: A pragmatic study

Author

Alberti, A, Belli, L, Airoldi, A, De Carlis, L, Rondinara, G, Minola, E, Vangeli, M, Cernuschi, A, D'Amico, M, Forti, D, Pinzello, G, Alberti, Alberto Battista, Belli, Luca Saverio, Airoldi, Aldo, De Carlis, Luciano, Rondinara, Gianfranco, Minola, Ernesto, Vangeli, Marcello, Cernuschi, Alessandra, D'Amico, Maria, Forti, Domenico, Pinzello, Giovambattista, Alberti, A, Belli, L, Airoldi, A, De Carlis, L, Rondinara, G, Minola, E, Vangeli, M, Cernuschi, A, D'Amico, M, Forti, D, Pinzello, G, Alberti, Alberto Battista, Belli, Luca Saverio, Airoldi, Aldo, De Carlis, Luciano, Rondinara, Gianfranco, Minola, Ernesto, Vangeli, Marcello, Cernuschi, Alessandra, D'Amico, Maria, Forti, Domenico, and Pinzello, Giovambattista

Abstract

Recurrent hepatitis C is a common problem after liver transplantation that can progress to liver cirrhosis of the graft. Preliminary reports of combination treatment with interferon (IFN) and ribavirin have been promising, but long-term follow-up data are not yet available. We report our experience with 1 year of combination therapy with IFN (3 million units thrice weekly) and low-dose ribavirin (600 mg/d), followed by long-term ribavirin monotherapy in 18 patients with moderate to severe recurrent hepatitis C and a median follow-up of 32 months after the completion of combined therapy. All patients were followed up clinically and histologically at regular intervals. Overall, in an intention-to-treat analysis, 15 patients had normal alanine aminotransferase levels (biochemical end-treatment response [ETR], 83%), and 8 patients were also hepatitis C virus RNA negative in serum (virological ETR, 44%) at the end of combined treatment. At last follow-up after the completion of combined therapy (median, 32 months; range, 18 to 73 months), 13 patients were biochemical responders (biochemical long term-sustained response [LT-SR], 72%), and 5 patients also maintained viral clearance (virological LT-SR, 27%). Comparison of liver biopsy specimens before and after 12 months of combined therapy showed improvement in grading scores of at least two points in the majority of the patients (73%). Notably, a trend toward fibrotic progression was only noted in nonresponders. Regarding side effects, despite the low dose of ribavirn, almost half the patients developed hemolytic anemia requiring dose reductions. In addition, long-term ribavirin monotherapy was not associated with iron accumulation. We conclude that combined therapy with low-dose ribavirin followed by long-term ribavirin monotherapy can be recommended because it favorably modifies the natural history of recurrent hepatitis C in most patients and possibly halts histological disease progression without causing iron accumula

Published
2001

13. W1245 Successful Induction of Clinical Response and Remission with Certolizumab Pegol in Crohn's Disease Patients Who Are Primary Non-Responders or Intolerant to Infliximab: A Real Life Multi-Center Experience of Compassionate Use

Author

Danese, Silvio, primary, Mocciaro, Filippo, additional, Guidi, Luisa, additional, Scribano, Maria Lia, additional, Comberlato, Michele, additional, Vangeli, Marcello, additional, Pulitanò, Raffaella, additional, Manca, Aldo, additional, Armuzzi, Alessandro, additional, Malesci, Alberto, additional, Prantera, Cosimo, additional, and Cottone, Mario, additional

Published
2008
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15. Hepatitis C virus recurrence after liver transplantation: a 10-year evaluation.

Author

Gitto S, Belli LS, Vukotic R, Lorenzini S, Airoldi A, Cicero AF, Vangeli M, Brodosi L, Panno AM, Di Donato R, Cescon M, Grazi GL, De Carlis L, Pinna AD, Bernardi M, and Andreone P

Subjects
Adult, Antiviral Agents adverse effects, Chi-Square Distribution, Drug Therapy, Combination, End Stage Liver Disease diagnosis, End Stage Liver Disease mortality, End Stage Liver Disease virology, Female, Hepacivirus drug effects, Hepacivirus growth & development, Hepatitis C complications, Hepatitis C diagnosis, Hepatitis C mortality, Humans, Italy, Kaplan-Meier Estimate, Logistic Models, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Proportional Hazards Models, Recurrence, Retrospective Studies, Risk Factors, Time Factors, Treatment Outcome, Virus Activation drug effects, Antiviral Agents therapeutic use, End Stage Liver Disease surgery, Hepatitis C drug therapy, Liver Transplantation adverse effects, Liver Transplantation mortality
Abstract

Aim: To evaluate the predictors of 10-year survival of patients with hepatitis C recurrence., Methods: Data from 358 patients transplanted between 1989 and 2010 in two Italian transplant centers and with evidence of hepatitis C recurrence were analyzed. A χ(2), Fisher's exact test and Kruskal Wallis' test were used for categorical and continuous variables, respectively. Survival analysis was performed at 10 years after transplant using the Kaplan-Meier method, and a log-rank test was used to compare groups. A P level less than 0.05 was considered significant for all tests. Multivariate analysis of the predictive role of different variables on 10-year survival was performed by a stepwise Cox logistic regression., Results: The ten-year survival of the entire population was 61.2%. Five groups of patients were identified according to the virological response or lack of a response to antiviral treatment and, among those who were not treated, according to the clinical status (mild hepatitis C recurrence, "too sick to be treated" and patients with comorbidities contraindicating the treatment). While the 10-year survival of treated and untreated patients was not different (59.1% vs 64.7%, P = 0.192), patients with a sustained virological response had a higher 10-year survival rate than both the "non-responders" (84.7% vs 39.8%, P < 0.0001) and too sick to be treated (84.7% vs 0%, P < 0.0001). Sustained virological responders had a survival rate comparable to patients untreated with mild recurrence (84.7% vs 89.3%). A sustained virological response and young donor age were independent predictors of 10-year survival., Conclusion: Sustained virological response significantly increased long-term survival. Awaiting the interferon-free regimen global availability, antiviral treatment might be questionable in selected subjects with mild hepatitis C recurrence.

Published
2015
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