23 results on '"Vick GW 3rd"'
Search Results
2. Analysis of multigenerational families with thoracic aortic aneurysms and dissections due to TGFBR1 or TGFBR2 mutations.
- Author
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Tran-Fadulu V, Pannu H, Kim DH, Vick GW 3rd, Lonsford CM, Lafont AL, Boccalandro C, Smart S, Peterson KL, Hain JZ, Willing MC, Coselli JS, LeMaire SA, Ahn C, Byers PH, and Milewicz DM
- Subjects
- Adolescent, Adult, Chi-Square Distribution, Cohort Studies, Family Health, Female, Genetic Predisposition to Disease, Humans, Kaplan-Meier Estimate, Magnetic Resonance Angiography, Male, Middle Aged, Pedigree, Receptor, Transforming Growth Factor-beta Type I, Receptor, Transforming Growth Factor-beta Type II, Aortic Dissection genetics, Aortic Aneurysm, Thoracic genetics, Mutation, Missense, Protein Serine-Threonine Kinases genetics, Receptors, Transforming Growth Factor beta genetics
- Abstract
Background: Mutations in the transforming growth factor beta receptor type I and II genes (TGFBR1 and TGFBR2) cause Loeys-Dietz syndrome (LDS), characterised by thoracic aortic aneurysms and dissections (TAAD), aneurysms and dissections of other arteries, craniosynostosis, cleft palate/bifid uvula, hypertelorism, congenital heart defects, arterial tortuosity, and mental retardation. TGFBR2 mutations can also cause TAAD in the absence of features of LDS in large multigenerational families, yet only sporadic LDS cases or parent-child pairs with TGFBR1 mutations have been reported to date., Methods: The authors identified TGFBR1 missense mutations in multigenerational families with TAAD by DNA sequencing. Clinical features of affected individuals were assessed and compared with clinical features of previously described TGFBR2 families., Results: Statistical analyses of the clinical features of the TGFBR1 cohort (n = 30) were compared with clinical features of TGFBR2 cohort (n = 77). Significant differences were identified in clinical presentation and survival based on gender in TGFBR1 families but not in TGFBR2 families. In families with TGFBR1 mutations, men died younger than women based on Kaplan-Meier survival curves. In addition, men presented with TAAD and women often presented with dissections and aneurysms of arteries other than the ascending thoracic aorta. The data also suggest that individuals with TGFBR2 mutations are more likely to dissect at aortic diameters <5.0 cm than individuals with TGFBR1 mutations., Conclusion: This study is the first to demonstrate clinical differences between patients with TGFBR1 and TGFBR2 mutations. These differences are important for the clinical management and outcome of vascular diseases in these patients.
- Published
- 2009
- Full Text
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3. Anomalous right coronary artery from the pulmonary artery: noninvasive diagnosis and serial evaluation.
- Author
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Su JT, Krishnamurthy R, Chung T, Vick GW 3rd, and Kovalchin JP
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- Adult, Coronary Vessel Anomalies surgery, Diagnosis, Differential, Female, Humans, Coronary Vessel Anomalies diagnosis, Magnetic Resonance Imaging methods, Pulmonary Artery abnormalities
- Abstract
Isolated anomalous origin of the right coronary artery from the main pulmonary artery (ARCAPA) is a rare congenital cardiac malformation. We reviewed the current literature and found only 31 patients with ARCAPA. We report the first case that was diagnosed and followed on a noninvasive basis with cardiovascular magnetic resonance after surgical re-implantation. This report of a patient with ARCAPA showed resolving coronary artery sizes secondary to decreased pulmonary steal. Cardiovascular magnetic resonance is an accurate and reliable imaging modality that allows serial noninvasive follow up in patients with coronary artery anomalies.
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- 2007
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4. Quantitation and localization of matrix metalloproteinases and their inhibitors in human carotid endarterectomy tissues.
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Choudhary S, Higgins CL, Chen IY, Reardon M, Lawrie G, Vick GW 3rd, Karmonik C, Via DP, and Morrisett JD
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- Carotid Arteries pathology, Contrast Media, Enzyme-Linked Immunosorbent Assay, Humans, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Magnetic Resonance Imaging, Tissue Distribution, Carotid Arteries metabolism, Endarterectomy, Carotid, Matrix Metalloproteinase 2 metabolism, Matrix Metalloproteinase 9 metabolism, Tissue Inhibitor of Metalloproteinase-1 metabolism, Tissue Inhibitor of Metalloproteinase-2 metabolism
- Abstract
Background: Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) play a central role in arterial wall remodeling, affecting stability of fibrous caps covering atherosclerotic plaques. The objective of this study was to determine the spatial distribution of TIMP mass and MMP mass and activity of carotid endarterectomy (CEA) tissues and relate it to the distribution of atherosclerotic lesions., Methods and Results: Fresh CEA tissues were imaged by multicontrast MRI to generate 3D reconstructions. Tissue segments were cut transversely from the common, bifurcation, internal, and external regions. Segments were subjected to total protein extractions and analyzed by ELISA for MMP-2 and -9 and TIMP-1 and -2 mass and by zymography for gelatinase activity. Segments at or near the bifurcation with highly calcified lesions contained higher MMP levels and activity than segments distant from the bifurcation; highly fibrotic or necrotic plaque contained lower MMP levels and activity and higher TIMP levels. Fatty streak, fibroatheroma with hemorrhage and calcification, and fully occluded lesions were enriched in MMP-2, MMP-9, and TIMP-1 and TIMP-2, respectively., Conclusions: The spatial distribution of MMPs and TIMPs in carotid atherosclerotic lesions is highly heterogeneous, reflecting lesion location, size, and composition. This study provides the first semi-quantitative maps of differential distribution of MMPs and TIMPs over atherosclerotic plaques.
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- 2006
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5. Bilateral symmetry of human carotid artery atherosclerosis.
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Adams GJ, Simoni DM, Bordelon CB Jr, Vick GW 3rd, Kimball KT, Insull W Jr, and Morrisett JD
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- Aged, Aged, 80 and over, Calcinosis diagnostic imaging, Calcinosis pathology, Carotid Arteries diagnostic imaging, Carotid Artery Diseases diagnostic imaging, Humans, Magnetic Resonance Imaging methods, Middle Aged, Predictive Value of Tests, Reproducibility of Results, Tomography, X-Ray Computed, Carotid Arteries pathology, Carotid Artery Diseases pathology
- Abstract
Background and Purpose: Atherosclerosis is a principal cause of stroke and myocardial infarction. The carotid arteries provide a site at which progression of atherosclerosis can be monitored reproducibly and noninvasively. This study was conducted to determine the similarity of atherosclerotic plaques in the left and right carotid arteries. This question was explored with the use of perfusion-fixed cadaveric carotid arteries and 2 noninvasive clinical imaging techniques, MRI and electron-beam CT., Methods: Fifty pairs of carotid arteries from cadaveric donors (aged 48 to 98 years) were imaged with MRI and electron-beam CT. Thirty-eight of the pairs met the criteria for rigorous analysis. Carotid artery wall volumes were measured from the MRI images, and calcification scores were computed from the electron-beam CT images., Results: Total wall volumes of the left (972.5+/-241.6 mm3) and right (1016.3+/-275.0 mm3) carotid arteries were moderately correlated (concordance correlation coefficient [r(c)]=0.71). Calcification scores were highly correlated, with r(c)=0.95 for the Agatston scores and r(c)=0.94 for the calcium volume scores., Conclusions: Total wall volume and plaque calcification in the left and right human carotid arteries are substantially similar. These results suggest that atherosclerosis of the human carotid arteries is generally a bilaterally symmetrical disease. This evidence of symmetry suggests that diagnostic information about atherosclerotic plaque in one carotid artery can be used to infer information about the composition and volume of atherosclerotic plaque in the contralateral artery.
- Published
- 2002
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6. Meandering right pulmonary vein to the left atrium and inferior vena cava: the first case with associated anomalies.
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Tortoriello TA, Vick GW 3rd, Chung T, Bezold LI, and Vincent JA
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- Child, Coronary Vessel Anomalies complications, Heart Atria pathology, Humans, Magnetic Resonance Angiography, Magnetic Resonance Imaging, Male, Pulmonary Veins pathology, Radiography, Scimitar Syndrome complications, Vena Cava, Inferior pathology, Coronary Vessel Anomalies diagnosis, Heart Atria abnormalities, Heart Atria diagnostic imaging, Pulmonary Veins abnormalities, Pulmonary Veins diagnostic imaging, Scimitar Syndrome diagnosis, Vena Cava, Inferior abnormalities, Vena Cava, Inferior diagnostic imaging
- Abstract
We report a case of a healthy, asymptomatic 6-year-old boy in whom an anomalous right pulmonary vein was noted to drain into both the inferior vena cava and left atrium in association with findings consistent with scimitar syndrome. The anomalous pulmonary vein took a very circuitous route through the lungs before draining into the left atrium, a condition previously termed "meandering pulmonary vein." To aid in the diagnosis, cardiovascular magnetic resonance imaging and magnetic resonance angiography were used to delineate this complex course and the connection of the anomalous pulmonary vein. To our knowledge, this is the 1st reported case of a meandering pulmonary vein with dual drainage to the inferior vena cava and left atrium in association with other anomalies.
- Published
- 2002
7. Review of new techniques in echocardiography and magnetic resonance imaging as applied to patients with congenital heart disease.
- Author
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Sahn DJ and Vick GW 3rd
- Subjects
- Coronary Circulation, Echocardiography, Doppler, Color, Echocardiography, Transesophageal, Female, Heart Defects, Congenital physiopathology, Humans, Magnetic Resonance Angiography, Myocardial Contraction, Myocardium pathology, Oximetry methods, Pregnancy, Prenatal Diagnosis methods, Regional Blood Flow, Echocardiography methods, Heart Defects, Congenital diagnosis, Magnetic Resonance Imaging methods
- Published
- 2001
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8. Right aortic arch and coarctation: delineation by three dimensional magnetic resonance angiogram.
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McMahon CJ, Vick GW 3rd, and Nihill MR
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- Adolescent, Female, Humans, Magnetic Resonance Angiography, Aorta, Thoracic abnormalities, Aortic Coarctation diagnosis
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- 2001
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9. Double aortic arch in D-transposition of the great arteries: confirmation of dominant arch by magnetic resonance imaging.
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McMahon CJ, Bezold LI, and Vick GW 3rd
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- Aorta, Thoracic pathology, Female, Humans, Infant, Newborn, Transposition of Great Vessels diagnosis, Aorta, Thoracic abnormalities, Magnetic Resonance Imaging, Transposition of Great Vessels complications
- Abstract
We report the case of a female infant who had the rare combination of double aortic arch and D-transposition of the great arteries. The double aortic arch was diagnosed at the time of her arterial switch procedure. Magnetic resonance imaging identified the left arch as dominant, and the right arch was successfully ligated.
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- 2000
10. Update on new technologies in pediatric echocardiography.
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Bezold LI, Lewin MB, Vick GW 3rd, and Pignatelli R
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- Cardiotonic Agents, Child, Dobutamine, Heart Defects, Congenital diagnostic imaging, Heart Diseases diagnostic imaging, Humans, Image Processing, Computer-Assisted methods, Echocardiography methods, Echocardiography trends, Echocardiography, Doppler methods, Echocardiography, Doppler trends
- Abstract
Advances in ultrasound technology will continue to expand the utility of echocardiography in the assessment of structural and functional cardiac disease in children. Tissue Doppler imaging and dobutamine stress echocardiography are 2 promising clinical applications that are expected to become increasingly used with time. Advances in data compression technology, including JPEG and MPEG techniques, will significantly affect digital archival and transmission of echocardiograms, which also have clinical implications, particularly in the expanding use of telemedicine. Continued research and clinical experience will further define the ultimate roles of these technologies in the future.
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- 1997
11. Intraoperative transesophageal echocardiography in congenital heart surgery. The Texas Children's Hospital experience.
- Author
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Bezold LI, Pignatelli R, Altman CA, Feltes TF, Gajarski RJ, Vick GW 3rd, and Ayres NA
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- Adolescent, Adult, Child, Child, Preschool, Echocardiography, Transesophageal instrumentation, Evaluation Studies as Topic, Humans, Infant, Infant, Newborn, Intraoperative Period, Middle Aged, Retrospective Studies, Treatment Outcome, Echocardiography, Transesophageal methods, Heart Defects, Congenital diagnostic imaging, Heart Defects, Congenital surgery
- Published
- 1996
12. Use of intravascular stents in systemic venous and systemic venous baffle obstructions. Short-term follow-up results.
- Author
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Ward CJ, Mullins CE, Nihill MR, Grifka RG, and Vick GW 3rd
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- Adolescent, Adult, Angiography, Child, Child, Preschool, Follow-Up Studies, Humans, Infant, Stents, Thrombophlebitis diagnosis, Veins physiopathology, Thrombophlebitis surgery
- Abstract
Background: Balloon-expandable intravascular stents are well accepted in the management of arterial obstructions. This study was undertaken to detail the immediate and short-term results of intravascular stent implantation in systemic venous and systemic venous baffle obstructions in children., Methods and Results: Between September 1991 and June 1994, 12 patients had 21 stents implanted in 13 systemic venous obstructions, 1 patient having stents placed in 2 separate obstructions. In the baffle group, 4 of 13 obstructions were at the superior vena cava/right atrial junction after atrial baffling for transposition of the great arteries. One of 4 patients had complete obstruction requiring transseptal needle perforation before stent implantation. There was an immediate gradient reduction from 12 +/- 8.4 mm Hg (range, 4 to 20 mm Hg) to 1.3 +/- 1.9 mm Hg (range, 0 to 4 mm Hg, P = .05). The obstructed segment diameter increased from 3.5 +/- 3.9 mm (range, 0 to 8.5 mm) to 16 +/- 2.7 mm (range, 14 to 20 mm, P = .002). In the central vein group, 9 of 13 obstructions were in large central veins. Three of 9 patients had complete obstruction requiring transseptal needle perforation before stent implantation. There was an immediate gradient reduction from 10.3 +/- 8.5 mm Hg (range, 0 to 20 mm Hg) to 0.8 +/- 1.1 mm Hg (range, 0 to 3 mm Hg, P = .005). The obstructed segment diameter increased from 1.3 +/- 1.1 mm (range, 0 to 2.8 mm) to 9.4 +/- 1.7 mm (range, 7.6 to 12 mm, P < .001). There were no acute complications in either group. In the follow-up group, patients were scheduled for clinical follow-up at 3, 6, and 12 months with echocardiography or magnetic resonance imaging (MRI) at 3 or 6 months and for repeat cardiac catheterization at 12 months. All stents were patent by echocardiography or MRI when studied at follow-up. Cardiac catheterization in 6 of 12 patients, 2 to 13 months after stent, demonstrated that all stents remained patent without compression or fracture. Follow-up and immediate poststent gradients were not significantly different (1 +/- 1.6 versus 0.7 +/- 1.2 mm Hg, P = NS). Neointimal hyperplasia (5 of 6 patients) reduced the stent lumen only from 12.5 +/- 4.7 mm (range, 8 to 20 mm) to 10.6 +/- 4.7 mm (range, 4.5 to 17.7 mm, P = NS). No stents required redilation. One of 18 stents placed in series had "unlocked" and rotated in the venous lumen but remained fully patent to flow., Conclusions: Balloon-expandable intravascular stents can be safely and effectively used to relieve systemic venous and systemic venous baffle obstructions, even when obstruction is complete. Short-term follow-up suggests excellent continued patency, but further follow-up is required to observe for progression of neointimal hyperplasia. We postulate that balloon-expandable intravascular stents will become the treatment of choice for the relief of selected systemic venous and venous baffle obstructions in the pediatric population.
- Published
- 1995
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13. Role of spin echo and cine magnetic resonance imaging in presurgical planning of heterotaxy syndrome. Comparison with echocardiography and catheterization.
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Geva T, Vick GW 3rd, Wendt RE, and Rokey R
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- Abdomen, Child, Child, Preschool, Female, Heart Defects, Congenital complications, Humans, Infant, Male, Motion Pictures, Prospective Studies, Thorax, Abnormalities, Multiple diagnosis, Abnormalities, Multiple surgery, Cardiac Catheterization, Echocardiography, Magnetic Resonance Imaging methods
- Abstract
Background: Patients with heterotaxy syndrome frequently have complex congenital cardiac and noncardiac malformations requiring detailed diagnostic evaluation by noninvasive as well as invasive imaging modalities for management planning. Recent advances in magnetic resonance imaging (MRI) techniques allow detailed delineation of cardiovascular anatomy and blood flow in young infants with rapid heart rates. The present study was undertaken to prospectively evaluate the role of MRI in the presurgical evaluation of patients with heterotaxy syndrome., Methods and Results: Between January 1 and December 31, 1992, 14 consecutive patients with heterotaxy syndrome and complex congenital heart disease were enrolled in a prospective protocol. After evaluation by echocardiography and cardiac catheterization, a tentative management plan was recorded. Subsequently, a MRI study was performed and surgical planning was reevaluated. MRI was found to be comparable to echocardiography in terms of length of examination and sedation requirements. Surgical planning was altered in four patients because MRI provided additional data not evident on echocardiography and catheterization. Comparison of diagnostic yield between echocardiography, catheterization, and MRI showed that MRI is superior to echocardiography and often to catheterization in delineation of systemic and pulmonary venous anatomy and their relation to mediastinal structures. When the anatomic and hemodynamic data obtained by echocardiography and MRI were considered together, cardiac catheterization data were necessary only to determination of pulmonary vascular resistance before Fontan operation., Conclusions: MRI provides excellent anatomic and functional information that in some patients was not available by echocardiography or catheterization. Combined with echocardiography, MRI provides the high-quality diagnostic information necessary for management planning in most patients with heterotaxy syndrome. Cardiac catheterization is indicated when determination of pulmonary vascular resistance is necessary for decision making or when an interventional procedures is indicated.
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- 1994
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14. The long QT syndrome in children. An international study of 287 patients.
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Garson A Jr, Dick M 2nd, Fournier A, Gillette PC, Hamilton R, Kugler JD, van Hare GF 3rd, Vetter V, and Vick GW 3rd
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- Adrenergic beta-Antagonists therapeutic use, Child, Death, Sudden, Cardiac epidemiology, Defibrillators, Implantable, Electrocardiography, Female, Follow-Up Studies, Humans, Long QT Syndrome therapy, Male, Pacemaker, Artificial, Propranolol therapeutic use, Retrospective Studies, Risk Factors, Long QT Syndrome epidemiology
- Abstract
Background: The Pediatric Electrophysiology Society studied children with the long QT syndrome (LQTS) to describe the features of LQTS in patients less than 21 years old, define potential "low-risk" and "high-risk" subpopulations, and determine optimal treatment., Methods and Results: Patients less than 21 years old were included if either QTc was more than 0.44; they had unexplained syncope, seizures, or cardiac arrest preceded by emotion or exercise; or family history of LQTS. We found 287 patients from 26 centers in seven countries. Mean +/- SD age at presentation was 6.8 +/- 5.6; 9% presented with cardiac arrest, 26% with syncope, and 10% with seizures. Of those with symptoms, 67% had symptoms related to exercise. Family history was positive for long QT interval in 39% and for sudden death in 31%. Hearing loss was present in 4.5%. A normal QTc was present in 6%, and QTc of more than 0.60 was in 13%. Atrioventricular block occurred in 5%, but 13 of 15 patients had second-degree atrioventricular block (2:1), and only two of 287 had complete atrioventricular block. Ventricular arrhythmias were found on 16% of initial routine ECGs: 4% uniform premature ventricular contractions, 5% multiform premature ventricular contractions, 1% monomorphic ventricular tachycardia, and 6% torsade de pointes. Overall, treatment was effective for symptoms in 76% and for ventricular arrhythmias in 60%. There was no difference between propranolol and other beta-blockers in effective treatment. Left stellectomy was performed in nine patients, and defibrillators were implanted in four; no sudden death occurred in these 13 patients. In follow-up (duration, 5.0 +/- 4 years; age, 10.9 +/- 6.3 years), 5% had cardiac arrest, 4% had syncope, and 1% had seizures. The two multivariate predictors of symptoms at follow-up were symptoms at presentation and propranolol failure. Sudden death occurred in 8%; multivariate predictors of sudden death were length of QTc at presentation of more than 0.60 and medication noncompliance., Conclusions: The appearance of 2:1 atrioventricular block, multiform premature ventricular contractions, and torsade de pointes are relatively more common in children with LQTS than other children and should raise the index of suspicion for LQTS. Because 9% of patients presented with cardiac arrest and no preceding symptoms, perhaps prophylactic treatment in asymptomatic children is indicated. Asymptomatic patients with normal QTc and positive family history may be a low-risk group. Patients with QTc of more than 0.60 are at particularly high risk for sudden death, and if treatment is not effective, consideration should be given to cardiac sympathetic denervation, pacemaker implantation, and perhaps implantation of a defibrillator.
- Published
- 1993
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15. Transient neonatal tricuspid regurgitation: possible relation with premature closure of the ductus arteriosus.
- Author
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Huhta JC, Vick GW 3rd, Carpenter RA, and Gutgesell HP
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- Female, Humans, Infant, Newborn, Pregnancy, Prenatal Diagnosis, Ultrasonography, Ductus Arteriosus embryology, Tricuspid Valve Insufficiency congenital
- Published
- 1984
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16. Echocardiographic evaluation of the postoperative tetralogy of Fallot patient.
- Author
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Vick GW 3rd and Serwer GA
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- Adolescent, Angiocardiography, Cardiac Catheterization, Child, Child, Preschool, Cineangiography, Follow-Up Studies, Heart Septum physiopathology, Humans, Infant, Myocardial Contraction, Tetralogy of Fallot physiopathology, Echocardiography, Heart physiopathology, Tetralogy of Fallot surgery
- Published
- 1978
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17. Double balloon technique for dilation of valvular or vessel stenosis in congenital and acquired heart disease.
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Mullins CE, Nihill MR, Vick GW 3rd, Ludomirsky A, O'Laughlin MP, Bricker JT, and Judd VE
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- Adolescent, Adult, Aged, Angioplasty, Balloon instrumentation, Child, Child, Preschool, Constriction, Pathologic therapy, Coronary Disease etiology, Humans, Infant, Middle Aged, Vascular Diseases therapy, Venae Cavae, Angioplasty, Balloon methods, Coronary Disease therapy, Heart Defects, Congenital complications, Heart Diseases complications, Heart Valve Diseases therapy
- Abstract
Despite the generally excellent success with balloon dilation for the stenotic lesions of congenital and acquired heart disease, technical difficulties sometimes prevent satisfactory results. Such technical difficulties include: a large diameter of the anulus of the stenotic lesion relative to available balloon diameter, difficulty in the insertion or removal of the larger balloon catheters, and permanent damage to or obstruction of the femoral vessels by the redundant deflated balloon material of the large balloons. A double balloon technique was initiated to resolve these difficulties. With this method, percutaneous balloon angioplasty catheters were inserted in right and left femoral vessels, placed side by side across the stenotic lesion and inflated simultaneously. Dilation procedures using the two balloon technique were performed in 41 patients: 18 with pulmonary valve stenosis, 14 with aortic valve stenosis, 5 with mitral valve stenosis, 3 with vena caval obstruction following the Mustard or Senning procedure and 1 with tricuspid valve stenosis. Patient ages ranged from 1 to 75 years (mean 17.8) and patient weights ranged from 8.9 to 89 kg (mean 42.3). Balloon catheter sizes ranged from 10 to 20 mm in diameter. Average maximal pressure gradient in mm Hg before dilation was 61 in pulmonary stenosis, 68 in aortic stenosis, 21 in mitral stenosis, 12 in tricuspid stenosis and 25 in vena caval stenosis. Average maximal valvular pressure gradient after dilation was 13 in pulmonary stenosis, 24 in aortic stenosis, 4 in mitral stenosis, 0 in tricuspid stenosis, and 1 in vena caval stenosis. No major complications were encountered with the procedures.(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1987
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18. Hypoplastic left heart syndrome: is echocardiography accurate enough to guide surgical palliation?
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Bash SE, Huhta JC, Vick GW 3rd, Gutgesell HP, and Ott DA
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- Aorta abnormalities, Aortic Valve abnormalities, Autopsy, Heart Defects, Congenital pathology, Heart Ventricles abnormalities, Humans, Infant, Newborn, Mitral Valve abnormalities, Palliative Care, Pulmonary Artery abnormalities, Syndrome, Echocardiography, Heart Defects, Congenital surgery
- Abstract
Two-dimensional echocardiography can diagnose hypoplastic left heart syndrome. However, with the advent of the possibility of palliative open heart surgery, complete anatomic diagnosis is necessary. The anatomic findings of 15 neonates with hypoplastic left heart syndrome (age 1 to 10 days, mean 4.1) who had two-dimensional Doppler echocardiographic studies were compared with the results obtained by angiography (6 cases), surgery (11 cases) and autopsy (8 cases). Complete two-dimensional echocardiographic examination of the aortic arch, pulmonary and systemic venous return, atrial septum, ductus arteriosus and proximal coronary arteries was possible in all 15 neonates and correctly diagnosed hypoplastic left heart syndrome in each. Anatomic two-dimensional echocardiographic assessment was accurate in 13 (86%) of the 15 neonates and there were no false positive results. Undiagnosed associated abnormalities were hypoplasia of a left pulmonary artery in one patient and left superior vena cava in another. Accurate quantitation of the size of the tricuspid valve anulus, ascending aorta, pulmonary anulus and right and left pulmonary arteries was possible. Doppler examination was performed in seven patients and confirmed retrograde aortic arch flow and right to left systolic shunting in the patent ductus arteriosus. In selected neonates, surgical palliation can be attempted without angiography.
- Published
- 1986
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19. Assessment of the ductus arteriosus in preterm infants utilizing suprasternal two-dimensional/Doppler echocardiography.
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Vick GW 3rd, Huhta JC, and Gutgesell HP
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- Aortography, Ductus Arteriosus, Patent physiopathology, Humans, Infant, Infant, Newborn, Pulmonary Artery physiopathology, Sternum, Ductus Arteriosus, Patent diagnosis, Echocardiography methods, Infant, Premature
- Abstract
Evaluation for patent ductus arteriosus by both Doppler examination and direct two-dimensional echocardiographic visualization has been reported in infants and children. However, visualization of a patent ductus arteriosus in preterm infants with lung disease has been difficult. Using a recently developed 7.5 MHz mechanical scanner with interfaced two-dimensional directed pulsed Doppler ultrasonography, 36 examinations were performed from a suprasternal approach in 27 patients (age range 1 day to 3 months, mean 18 days; weight range 490 to 2,500 g, mean 1,260). Complete imaging for evaluation of patency of the ductus arteriosus was successful in 33 (92%) of 36 examinations, and imaging of the pulmonary end of the ductus arteriosus was successful in all. In 18 examinations, the ductus arteriosus was closed by both two-dimensional echocardiography and Doppler examination. In four cases the ductus arteriosus was widely patent by both two-dimensional echocardiography and Doppler examination. Eleven echocardiographic examinations revealed a narrowed ductus arteriosus, and of these, 10 (91%) showed Doppler findings of patent ductus arteriosus. It is concluded that combined two-dimensional/Doppler echocardiographic assessment allows confident detection of both a large unrestrictive and a small, stenotic patent ductus arteriosus in preterm infants with lung disease.
- Published
- 1985
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20. Pulmonary venous and systemic ventricular inflow obstruction in patients with congenital heart disease: detection by combined two-dimensional and Doppler echocardiography.
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Vick GW 3rd, Murphy DJ Jr, Ludomirsky A, Morrow WR, Morriss MJ, Danford DA, and Huhta JC
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- Adolescent, Adult, Child, Child, Preschool, Heart Defects, Congenital surgery, Humans, Infant, Infant, Newborn, Mitral Valve abnormalities, Mitral Valve Stenosis physiopathology, Mitral Valve Stenosis surgery, Transposition of Great Vessels physiopathology, Transposition of Great Vessels surgery, Coronary Circulation, Echocardiography methods, Heart Defects, Congenital physiopathology, Pulmonary Veins physiopathology
- Abstract
Obstruction to pulmonary venous return may be associated with a number of congenital cardiovascular abnormalities occurring both before and after surgery. Hemodynamic assessment by cardiac catheterization is often difficult. A noninvasive method for detection and quantitation of obstruction to systemic ventricular inflow would be clinically useful. Two-dimensionally directed pulsed and continuous wave Doppler echocardiography was performed before cardiac catheterization in 31 patients thought clinically to have possible obstruction to left ventricular inflow or pulmonary venous return. Primary diagnoses included transposition of the great arteries after the Mustard or Senning procedure in nine patients, total anomalous pulmonary venous connection in nine (in two after surgical repair), cor triatriatum in eight (in four after surgical repair), congenital mitral stenosis in four (in one after surgical repair) and mitral atresia in one. Severe obstruction was defined as a mean pressure gradient at catheterization of greater than or equal to 16 mm Hg at any level of the pulmonary venous return or of the systemic ventricular inflow. Severe obstruction was predicted if Doppler examination measured a flow velocity of greater than or equal to 2 m/s across any area of inflow obstruction. At catheterization, 12 patients (39%) had severe obstruction to left ventricular inflow or pulmonary venous return and all obstructions were correctly detected by Doppler echocardiography. The site of pulmonary venous obstruction was localized by two-dimensionally directed pulsed Doppler study. Patients with a lesser degree of obstruction had a lower Doppler velocity, but none had a maximal Doppler velocity of greater than or equal to 2 ms/s.(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1987
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21. Implantation of balloon-expandable intravascular grafts by catheterization in pulmonary arteries and systemic veins.
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Mullins CE, O'Laughlin MP, Vick GW 3rd, Mayer DC, Myers TJ, Kearney DL, Schatz RA, and Palmaz JC
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- Animals, Constriction, Pathologic surgery, Dogs, Female, Male, Prostheses and Implants, Stainless Steel, Blood Vessel Prosthesis, Catheterization instrumentation, Pulmonary Artery, Vascular Diseases surgery
- Abstract
The purpose of this investigation was to evaluate the efficacy and safety of implanting expandable intravascular stents in pulmonary arteries and systemic veins. Twenty-seven balloon-expandable grafts were placed in 13 mongrel dogs under anesthesia. A long sheath was introduced over a wire and catheter or dilator into the pulmonary artery or target vein. A collapsed stainless steel expandable mesh stent was placed over the balloon of an angioplasty catheter. The catheter with the mounted stent was advanced through the sheath. The stent expanded to the diameter of the balloon as the balloon was inflated, and remained expanded as the balloon was deflated. The stent was expanded further with a larger balloon in 11 instances. Eleven stents were placed successfully in pulmonary arteries (out of thirteen attempted), and 11 of 14 were installed in tributaries of the precava or postcava. Three inadvertent embolizations of the devices occurred. All three devices that embolized lodged in the pulmonary arteries and did not obstruct flow. Seven dogs were recatheterized at intervals ranging from 56 to 278 days. Twelve stents were patent and nonobstructive, and two were malpositioned, one of which was obstructed. Three animals were killed 2 months (two dogs) and 9 months (one dog) after the implantations. The stents (four in the pulmonary arteries and two in veins) were completely covered with neointima and were patent, without thrombosis. These stents hold promise for definitive dilation of congenital or postoperative vessel stenoses.
- Published
- 1988
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22. Balloon dilation of unoperated coarctation of the aorta: short- and intermediate-term results.
- Author
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Morrow WR, Vick GW 3rd, Nihill MR, Rokey R, Johnston DL, Hedrick TD, and Mullins CE
- Subjects
- Angiography, Aorta, Thoracic pathology, Aortic Coarctation complications, Blood Pressure, Child, Coronary Angiography, Follow-Up Studies, Humans, Magnetic Resonance Imaging, Recurrence, Time Factors, Angioplasty, Balloon, Aortic Coarctation therapy
- Abstract
Balloon dilation is effective in the immediate relief of obstruction due to unoperated coarctation of the aorta. However, the long-term benefits and complications of this procedure have not been established. Thirty-three patients underwent balloon dilation of unoperated coarctation using a percutaneous technique from November 1983 to December 1985. High quality biplane angiography was performed before and after dilation. Follow-up was obtained in 20 patients from 6 to 31 months following dilation. Angiography was performed at follow-up in 10, nuclear magnetic resonance (NMR) imaging in 10 and both NMR imaging and angiography in 3. Balloon dilation was successful in 31 of the 33 patients with a decrease in average systolic pressure gradient from 46 to 8 mm Hg. There was no significant change in gradient on follow-up physical examination and at recatheterization in 10 patients. In addition, there was no evidence of restenosis on follow-up angiography and NMR imaging. In two patients, a small aneurysm formed at the site of balloon dilation. Balloon dilation of unoperated coarctation is effective, providing lasting relief of coarctation gradient and no evidence of restenosis. However, because of the uncertain natural history of aneurysms after dilation, this procedure should be considered investigational until further follow-up on patients with and without an aneurysm is available.
- Published
- 1988
- Full Text
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23. Color Doppler detection of multiple ventricular septal defects.
- Author
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Ludomirsky A, Huhta JC, Vick GW 3rd, Murphy DJ Jr, Danford DA, and Morrow WR
- Subjects
- Adolescent, Adult, Child, Child, Preschool, Color, Echocardiography instrumentation, Evaluation Studies as Topic, Heart Septal Defects, Ventricular pathology, Heart Septum diagnostic imaging, Heart Septum pathology, Heart Ventricles diagnostic imaging, Heart Ventricles pathology, Humans, Infant, Radiography, Echocardiography methods, Heart Septal Defects, Ventricular diagnosis
- Abstract
Combined two-dimensional and Doppler echocardiography has a high sensitivity and specificity for detection of isolated perimembranous ventricular septal defects. However, muscular or multiple ventricular septal defects may be difficult to diagnose with noninvasive methods, particularly in older children, necessitating angiography for accurate diagnosis. Detection of single and multiple ventricular septal defects with two-dimensional color flow mapping was compared with detection by standard two-dimensional imaging and Doppler. Both techniques were compared with four-chamber left ventricular angiography. Fifty-one patients (age 3 months to 25 years, mean 5.6 years) were studied. Eighteen had solitary ventricular septal defects, 18 had multiple ventricular septal defects, and 15 patients with intact ventricular septum served as a control group. At least one ventricular septal defect was detected by color Doppler and two-dimensional/Doppler methods in all patients with ventricular septal defect proved by angiography with no false positives. In the detection of multiple ventricular septal defects, the sensitivity of color Doppler was 72% and that of two-dimensional/Doppler was 38% (100% specificity in both). Color Doppler failed to identify multiple ventricular septal defects in five patients (two weighing less than 4 kg and three with reduced pulmonary blood flow). However, no large additional muscular defects were missed by imaging and color Doppler. Color Doppler is useful for the detection of ventricular septal defects and has higher sensitivity than two-dimensional/Doppler for multiple ventricular septal defects. The contribution of color Doppler appears to be in the detection of additional small muscular ventricular septal defects.
- Published
- 1986
- Full Text
- View/download PDF
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