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18 results on '"Wiefels, Christiane"'

4. The Canadian Study of Arterial Inflammation in Patients with Diabetes and Recent Vascular Events, Evaluation of Colchicine Effectiveness (CADENCE): protocol for a randomised, double-blind, placebo-controlled trial

Author

Boczar, Kevin Emery, primary, Shin, Sheojung, additional, deKemp, Robert A, additional, Dowlatshahi, Dar, additional, Tavoosi, Anahita, additional, Wiefels, Christiane, additional, Liu, Peter, additional, Lochnan, Heather, additional, MacPherson, Paul A, additional, Chong, Aun Yeong, additional, Torres, Carlos, additional, Leung, Eugene, additional, Tawakol, Ahmed, additional, Ahmadi, Ali, additional, Garrard, Linda, additional, Lefebvre, Chantal, additional, Kelly, Cathy, additional, MacPhee, Poppy, additional, Tilokee, Everad, additional, Raggi, Paolo, additional, Wells, George A, additional, and Beanlands, Rob, additional

Published
2023
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6. Machine Learning Algorithms to Distinguish Myocardial Perfusion SPECT Polar Maps

Author

de Souza Filho, Erito Marques, primary, Fernandes, Fernando de Amorim, additional, Wiefels, Christiane, additional, de Carvalho, Lucas Nunes Dalbonio, additional, dos Santos, Tadeu Francisco, additional, dos Santos, Alair Augusto Sarmet M. D., additional, Mesquita, Evandro Tinoco, additional, Seixas, Flávio Luiz, additional, Chow, Benjamin J. W., additional, Mesquita, Claudio Tinoco, additional, and Gismondi, Ronaldo Altenburg, additional

Published
2021
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7. The Role of 18F-FDG PET/CT in Cardiac Sarcoidosis

Author

Wiefels,Christiane, Lamai,Olabimpe, Kandolin,Riina, Birnie,David, Leung,Eugene, Mesquita,Claudio Tinoco, and Beanlands,Rob

Subjects
Heart Failure, Sarcoidosis, Magnetic Resonance Imaging/diagnostic, Positron Emission Tomography Computed Tomography/diagnostic, Metabolism Disorders, Diagnostic, Imaging, Cardiomyopathies, Sudden Cardiac Death
Published
2020

9. Atrial Arrhythmias in Clinically Manifest Cardiac Sarcoidosis: Incidence, Burden, Predictors, and Outcomes

Author

Weng, Willy, primary, Wiefels, Christiane, additional, Chakrabarti, Santabhanu, additional, Nery, Pablo B., additional, Celiker-Guler, Emel, additional, Healey, Jeff S., additional, Hruczkowski, Tomasz W., additional, Quinn, F. Russell, additional, Promislow, Steven, additional, Medor, Maria C., additional, Spence, Stewart, additional, Odabashian, Roupen, additional, Alqarawi, Wael, additional, Juneau, Daniel, additional, de Kemp, Rob, additional, Leung, Eugene, additional, Beanlands, Rob, additional, and Birnie, David, additional

Published
2020
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11. The Current Role of Viability Imaging to Guide Revascularization and Therapy Decisions in Patients With Heart Failure and Reduced Left Ventricular Function

Author

Kandolin, Riina M., Wiefels, Christiane C., Mesquita, Claudio Tinoco, Chong, Aun-Yeong, Boland, Paul, Glineur, David, Sun, Louise, Beanlands, Rob S., Mielniczuk, Lisa M., HUS Heart and Lung Center, Kardiologian yksikkö, and University of Helsinki

Subjects
CHRONIC TOTAL OCCLUSIONS, POSITRON-EMISSION-TOMOGRAPHY, QUALITY-OF-LIFE, MYOCARDIAL VIABILITY, NATRIURETIC PEPTIDE, BYPASS-SURGERY, 3121 General medicine, internal medicine and other clinical medicine, HIBERNATING MYOCARDIUM, MAGNETIC-RESONANCE, CORONARY-ARTERY-DISEASE, CARDIAC RESYNCHRONIZATION THERAPY
Abstract

This review describes the current evidence and controversies for viability imaging to direct revascularization decisions and the impact on patient outcomes. Balancing procedural risks and possible benefit from revascularization is a key question in patients with heart failure of ischemic origin (IHF). Different stages of ischemia induce adaptive changes in myocardial metabolism and function. Viable but dysfunctional myocardium has the potential to recover after restoring blood flow. Modern imaging techniques demonstrate different aspects of viable myocardium; perfusion (single-photon emission computed tomography [SPECT], positron emission tomography [PET], cardiovascular magnetic resonance [CMR]), cell metabolism (PET), cell membrane integrity and mitochondrial function (201Tl and 99mTc-based SPECT), contractile reserve (stress echocardiography, CMR) and scar (CMR). Observational studies suggest that patients with IHF and significant viable myocardium may benefit from revascularization compared with medical treatment alone but that in patients without significant viability, revascularization appears to offer no survival benefit or could even worsen the outcome. This was not supported by 2 randomized trials (Surgical Treatment for Ischemic Heart Failure [STICH] and PET and Recovery Following Revascularization [PARR] -2) although post-hoc analyses suggest that benefit can be achieved if decisions had been strictly based on viability imaging recommendations. Based on current evidence, viability testing should not be the routine for all patients with IHF considered for revascularization but rather integrated with clinical data to guide decisions on revascularization of high-risk patients with comorbidities.

Published
2019

17. Renal dysfunction and anemia in patients with heart failure with reduced versus normal ejection fraction.

Author

Villacorta H, Saenz-Tello BF, Santos EB, Steffen R, Wiefels C, Lima LC, Sales AL, Soares P, and Mesquita ET

Subjects
Aged, Anemia diagnosis, Anemia etiology, Brazil epidemiology, Female, Heart Failure physiopathology, Humans, Male, Middle Aged, Prevalence, Prognosis, Prospective Studies, Renal Insufficiency diagnosis, Renal Insufficiency etiology, Sex Factors, Anemia epidemiology, Heart Failure complications, Renal Insufficiency epidemiology, Stroke Volume physiology
Abstract

Background: The presence of anemia and renal dysfunction grants a bad prognosis for patients with heart failure and reduced ejection fraction (HFREF). The impact on patients with heart failure and normal ejection fraction (HFNEF) is not widely studied., Objectives: To study the prevalence and the prognosis of anemia and renal dysfunction (RD) in patients with heart failure according to the type of ventricular dysfunction., Methods: A total of 209 patients with chronic and stable heart failure were prospectively studied. Individuals with ejection fraction <50% were considered as HFREF patients. Anemia was defined, based on WHO criteria, as hemoglobin <13 g/dl for men and <12 g/dl for women. Renal function was calculated by means of the Simplified Modified Diet Renal Disease (sMDRD) formula. Hospitalizations, emergency admittances and obit by cardiac causes were considered as cardiac events., Results: Ninety patients had HFREF and 119 had HFNEF. The glomerular filtration rate (GFR) was smaller in HFREF group (57.6 +/- 66.2 versus 94.8 +/- 36.6 ml/min/1.73m(2); p=0.01). There was no difference in the prevalence of anemia between groups (23.3% versus 18.5%; p=0.34). Moderate to severe RD prevalence was higher in HFREF group (32.2% versus 16.8%; p=0.01). RD was the only factor associated with anemia that was independently associated with cardiac events (HR 2.52; 95%CI=1.27-5.2; p=0.01)., Conclusion: RD was less prevalent in HFNEF, while the prevalence of anemia did not differ between groups. RD was predictor of cardiac events independently on ejection fraction.

Published
2010
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18. [Anemia and heart failure in a community-based cohort: comparison with a specialized outpatient clinic].

Author

Santos EB, Tello BS, Villacorta H, Sales AL, Wiefels C, Teixeira PS, Lima Filho LC, and Mesquita ET

Subjects
Ambulatory Care Facilities, Anemia blood, Anemia diagnosis, Brazil epidemiology, Creatinine blood, Epidemiologic Methods, Female, Humans, Male, Middle Aged, Primary Health Care, Urea blood, Anemia epidemiology, Heart Failure complications
Abstract

Background: Anemia is common in patients with heart failure (HF). Its prevalence in patients with HF from a community-based cohort is unknown in our country., Objective: evaluate the prevalence and characteristics of patients with anemia in a non-selected population with HF from a community-based cohort, comparing it with that of a HF population treated at a specialized outpatient clinic., Methods: This was a transversal, prospective, observational study, carried out from January 2006 to March 2007. The patients with HF met the Boston criteria, with a score > 8. Anemia was defined through the criteria of the World Health Organization as hemoglobin levels < 13 g/dL for men and <12 g/dl for women. Patients treated at a primary care program in the community were randomly selected, as well as patients treated at a Heart Failure Outpatient Clinic in a university hospital., Results: A total of 206 patients were assessed, with a mean age of 61.3+/-13.1 years, of which 53.4% were females. The prevalence of anemia in the community-based cohort (n=114) was 21% and at the outpatient clinic (n=92), of 25% (p=0.50). The patients from the community-based cohort presented a lower rate of kidney dysfunction (GFR<60 ml/min/1,73-5), predominance of HF with normal ejection fraction and female sex. Kidney function parameters (urea or creatinine) independently correlated with anemia in both populations., Conclusion: The prevalence of anemia was similar in the studied populations. Kidney function was the only factor that independently correlated with anemia in both populations.

Published
2010
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