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The tilt-to-length coupling during the LISA Pathfinder mission has been numerically and analytically modeled for particular timespans. In this work, we investigate the long-term stability of the coupling coefficients of this noise. We show that they drifted slowly (by 1\,$\mu$m/rad and 6$\times10^{-6}$ in 100 days) and strongly correlated to temperature changes within the satellite (8\,$\mu$m/rad/K and 30$\times10^{-6}$/K). Based on analytical TTL coupling models, we attribute the temperature-driven coupling changes to rotations of the test masses and small distortions in the optical setup. Particularly, we show that LISA Pathfinder's optical baseplate was bent during the cooldown experiment, which started in late 2016 and lasted several months.

A precise characterization of the magnetic properties of LISA Pathfinder free falling test-masses is of special interest for future gravitational wave observatory in space. Magnetic forces have an important impact on the instrument sensitivity in the low frequency regime below the millihertz. In this paper we report on the magnetic injection experiments performed throughout LISA Pathfinder operations. We show how these experiments allowed a high precision estimate of the instrument magnetic parameters. The remanent magnetic moment was found to have a modulus of $(0.245\pm0.081)\,\rm{nAm}^2$, the x-component of the background magnetic field within the test masses position was measured to be $(414 \pm 74)$ nT and its gradient had a value of $(-7.4\pm 2.1)\,\mu$T/m. Finally, we also measured the test mass magnetic susceptibility to be $(-3.35\pm0.15)\times$10$^{-5}$ in the low frequency regime. All results are in agreement with on-ground estimates.

LISA Pathfinder was a mission designed to test key technologies required for gravitational wave detection in space. Magnetically driven forces play a key role in the instrument sensitivity in the low-frequency regime, which corresponds to the measurement band of interest for future space-borne gravitational wave observatories. Magnetic-induced forces couple to the test mass motion, introducing a contribution to the relative acceleration noise between the free falling test masses. In this Letter we present the first complete estimate of this term of the instrument performance model. Our results set the magnetic-induced acceleration noise during the February 2017 noise run of $\rm 0.25_{-0.08}^{+0.15}\,fm\,s^{-2}/\sqrt{Hz}$ at 1 mHz and $\rm 1.01_{-0.24}^{+0.73}\, fm\,s^{-2}/\sqrt{Hz}$ at 0.1 mHz. We also discuss how the non-stationarities of the interplanetary magnetic field can affect these values during extreme space weather conditions.

We present an in-depth analysis of the LISA Pathfinder differential acceleration performance over the entire course of its science operations, spanning approximately 500 days. We find that: 1) the evolution of the Brownian noise that dominates the acceleration amplitude spectral density (ASD), for frequencies $f\gtrsim 1\,\text{mHz}$, is consistent with the decaying pressure due to the outgassing of a single gaseous species. 2) between $f=36\,\mu\text{Hz}$ and $1\,\text{mHz}$, the acceleration ASD shows a $1/f$ tail in excess of the Brownian noise of almost constant amplitude, with $\simeq 20\%$ fluctuations over a period of a few days, with no particular time pattern over the course of the mission; 3) at the lowest considered frequency of $f=18\,\mu\text{Hz}$, the ASD significantly deviates from the $1/f$ behavior, because of temperature fluctuations that appear to modulate a quasi-static pressure gradient, sustained by the asymmetries of the outgassing pattern. We also present the results of a projection of the observed acceleration noise on the potential sources for which we had either a direct correlation measurement, or a quantitative estimate from dedicated experiments. These sources account for approximately $40\%$ of the noise power in the $1/f$ tail. Finally, we analyze the possible sources of the remaining unexplained fraction, and identify the possible measures that may be taken to keep those under control in LISA.

Electrostatic force actuation is a key component of the system of geodesic reference test masses (TM) for the LISA orbiting gravitational wave observatory and in particular for performance at low frequencies, below 1 mHz, where the observatory sensitivity is limited by stray force noise. The system needs to apply forces of order 10$^{-9}$ N while limiting fluctuations in the measurement band to levels approaching 10$^{-15}$ N/Hz$^{1/2}$. We present here the LISA actuation system design, based on audio-frequency voltage carrier signals, and results of its in-flight performance test with the LISA Pathfinder test mission. In LISA, TM force actuation is used to align the otherwise free-falling TM to the spacecraft-mounted optical metrology system, without any forcing along the critical gravitational wave-sensitive interferometry axes. In LISA Pathfinder, on the other hand, the actuation was used also to stabilize the TM along the critical $x$ axis joining the two TM, with the commanded actuation force entering directly into the mission's main differential acceleration science observable. The mission allowed demonstration of the full compatibility of the electrostatic actuation system with the LISA observatory requirements, including dedicated measurement campaigns to amplify, isolate, and quantify the two main force noise contributions from the actuation system, from actuator gain noise and from low frequency ``in band'' voltage fluctuations. These campaigns have shown actuation force noise to be a relevant, but not dominant, noise source in LISA Pathfinder and have allowed performance projections for the conditions expected in the LISA mission.

We present a study of the tilt-to-length coupling noise during the LISA Pathfinder mission and how it depended on the system's alignment. Tilt-to-length coupling noise is the unwanted coupling of angular and lateral spacecraft or test mass motion into the primary interferometric displacement readout. It was one of the major noise sources in the LISA Pathfinder mission and is likewise expected to be a primary noise source in LISA. We demonstrate here that a recently derived and published analytical model describes the dependency of the LISA Pathfinder tilt-to-length coupling noise on the alignment of the two freely falling test masses. This was verified with the data taken before and after the realignments performed in March (engineering days) and June 2016, and during a two-day experiment in February 2017 (long cross-talk experiment). The latter was performed with the explicit goal of testing the tilt-to-length coupling noise dependency on the test mass alignment. Using the analytical model, we show that all realignments performed during the mission were only partially successful and explain the reasons why. In addition to the analytical model, we computed another physical tilt-to-length coupling model via a minimising routine making use of the long cross-talk experiment data. A similar approach could prove useful for the LISA mission.

A comprehensive summary of the measurements made to characterize test mass charging due to the space environment during the LISA Pathfinder mission is presented. Measurements of the residual charge of the test mass after release by the grabbing and positioning mechanism, show that the initial charge of the test masses was negative after all releases, leaving the test mass with a potential in the range $-12$ mV to $-512$ mV. Variations in the neutral test mass charging rate between $21.7$ e s$^{-1}$ and $30.7$ e s$^{-1}$ were observed over the course of the 17-month science operations produced by cosmic ray flux changes including a Forbush decrease associated with a small solar energetic particle event. A dependence of the cosmic ray charging rate on the test mass potential between $-30.2$ e s$^{-1}$ V$^{-1}$ and $-40.3$ e s$^{-1}$ V$^{-1}$ was observed and this is attributed to a contribution to charging from low-energy electrons emitted from the gold surfaces of the gravitational reference sensor. Data from the on-board particle detector show a reliable correlation with the charging rate and with other environmental monitors of the cosmic ray flux. This correlation is exploited to extrapolate test mass charging rates to a 20-year period giving useful insight into the expected range of charging rate that may be observed in the LISA mission., Comment: 17 pages, 10 figures

LISA Pathfinder (LPF) has been a space-based mission designed to test new technologies that will be required for a gravitational wave observatory in space. Magnetically driven forces play a key role in the instrument sensitivity in the low-frequency regime (mHz and below), the measurement band of interest for a space-based observatory. The magnetic field can couple to the magnetic susceptibility and remanent magnetic moment from the test masses and disturb them from their geodesic movement. LISA Pathfinder carried on-board a dedicated magnetic measurement subsystem with noise levels of 10 $ \rm nT \ Hz^{-1/2}$ from 1 Hz down to 1 mHz. In this paper we report on the magnetic measurements throughout LISA Pathfinder operations. We characterise the magnetic environment within the spacecraft, study the time evolution of the magnetic field and its stability down to 20 $\mu$Hz, where we measure values around 200 $ \rm nT \ Hz^{-1/2}$ and identify two different frequency regimes, one related to the interplanetary magnetic field and the other to the magnetic field originating inside the spacecraft. Finally, we characterise the non-stationary component of the fluctuations of the magnetic field below the mHz and relate them to the dynamics of the solar wind., Comment: 16 pages, 17 figures. MNRAS LaTeX style file version 3.0

We report on the results of the LISA Pathfinder (LPF) free-fall mode experiment, in which the control force needed to compensate the quasistatic differential force acting on two test masses is applied intermittently as a series of "impulse" forces lasting a few seconds and separated by roughly 350 s periods of true free fall. This represents an alternative to the normal LPF mode of operation in which this balancing force is applied continuously, with the advantage that the acceleration noise during free fall is measured in the absence of the actuation force, thus eliminating associated noise and force calibration errors. The differential acceleration noise measurement presented here with the free-fall mode agrees with noise measured with the continuous actuation scheme, representing an important and independent confirmation of the LPF result. An additional measurement with larger actuation forces also shows that the technique can be used to eliminate actuation noise when this is a dominant factor.

LISA Pathfinder (LPF) was a technology pioneering mission designed to test key technologies required for gravitational wave detection in space. In the low frequency regime (milli-Hertz and below), where space-based gravitational wave observatories will operate, temperature fluctuations play a crucial role since they can couple into the interferometric measurement and the test masses' free-fall accuracy in many ways. A dedicated temperature measurement subsystem, with noise levels in 10$\,\mu$K$\,$Hz$^{-1/2}$ down to $1\,$mHz was part of the diagnostics unit on board LPF. In this paper we report on the temperature measurements throughout mission operations, characterize the thermal environment, estimate transfer functions between different locations and report temperature stability (and its time evolution) at frequencies as low as 10$\,\mu$Hz, where typically values around $1\,$K$\,$Hz$^{-1/2}$ were measured., Comment: 13 pages, 16 figures. MNRAS LaTeX style file version 3.0

The zodiacal dust complex, a population of dust and small particles that pervades the Solar System, provides important insight into the formation and dynamics of planets, comets, asteroids, and other bodies. Here we present a new set of data obtained using a novel technique: direct measurements of momentum transfer to a spacecraft from individual particle impacts. This technique is made possible by the extreme precision of the instruments flown on the LISA Pathfinder spacecraft, a technology demonstrator for a future space-based gravitational wave observatory that operated near the first Sun-Earth Lagrange point from early 2016 through Summer of 2017. Using a simple model of the impacts and knowledge of the control system, we show that it is possible to detect impacts and measure properties such as the transferred momentum (related to the particle's mass and velocity), direction of travel, and location of impact on the spacecraft. In this paper, we present the results of a systematic search for impacts during 4348 hours of Pathfinder data. We report a total of 54 candidates with momenta ranging from 0.2$\,\mu\textrm{Ns}$ to 230$\,\mu\textrm{Ns}$. We furthermore make a comparison of these candidates with models of micrometeoroid populations in the inner solar system including those resulting from Jupiter-family comets, Oort-cloud comets, Hailey-type comets, and Asteroids. We find that our measured population is consistent with a population dominated by Jupiter-family comets with some evidence for a smaller contribution from Hailey-type comets. This is in agreement with consensus models of the zodiacal dust complex in the momentum range sampled by LISA Pathfinder., Comment: 22 pages, 14 figures, accepted in ApJ

Non-recurrent short term variations of the galactic cosmic-ray (GCR) flux above 70 MeV n$^{-1}$ were observed between 2016 February 18 and 2017 July 3 aboard the European Space Agency LISA Pathfinder (LPF) mission orbiting around the Lagrange point L1 at 1.5$\times$10$^6$ km from Earth. The energy dependence of three Forbush decreases (FDs) is studied and reported here. A comparison of these observations with others carried out in space down to the energy of a few tens of MeV n$^{-1}$ shows that the same GCR flux parameterization applies to events of different intensity during the main phase. FD observations in L1 with LPF and geomagnetic storm occurrence is also presented. Finally, the characteristics of GCR flux non-recurrent variations (peaks and depressions) of duration $<$ 2 days and their association with interplanetary structures are investigated. It is found that, most likely, plasma compression regions between subsequent corotating high-speed streams cause peaks, while heliospheric current sheet crossing cause the majority of the depressions.

The Space Technology 7 Disturbance Reduction System (ST7-DRS) is a NASA technology demonstration payload that operated from January 2016 through July of 2017 on the European Space Agency's LISA Pathfinder spacecraft. The joint goal of the NASA and ESA missions was to validate key technologies for a future space-based gravitational wave observatory targeting the source-rich milliHertz band. The two primary components of ST7-DRS are a micropropulsion system based on colloidal micro-Newton thrusters (CMNTs) and a control system that simultaneously controls the attitude and position of the spacecraft and the two free-flying test masses (TMs). This paper presents our main experimental results and summarizes the overall the performance of the CMNTs and control laws. We find that the CMNT performance to be consistent with pre-flight predictions, with a measured system thrust noise on the order of $100\,\textrm{nN}/\sqrt{\textrm{Hz}}$ in the $1\,\textrm{mHz}\leq f \leq 30\,\textrm{mHz}$ band. The control system maintained the TM-spacecraft separation with an RMS error of less than 2$\,$nm and a noise spectral density of less than $3\,\textrm{nm}/\sqrt{\textrm{Hz}}$ in the same band. Thruster calibration measurements yield thrust values consistent with the performance model and ground-based thrust-stand measurements, to within a few percent. We also report a differential acceleration noise between the two test masses with a spectral density of roughly $3\,\textrm{fm}/\textrm{s}^2/\sqrt{\textrm{Hz}}$ in the $1\,\textrm{mHz}\leq f \leq 30\,\textrm{mHz}$ band, slightly less than twice as large as the best performance reported with the baseline LISA Pathfinder configuration and below the current requirements for the Laser Interferometer Space Antenna (LISA) mission.

The LISA Pathfinder charge management device was responsible for neutralising the cosmic ray induced electric charge that inevitably accumulated on the free-falling test masses at the heart of the experiment. We present measurements made on ground and in-flight that quantify the performance of this contactless discharge system which was based on photo-emission under UV illumination. In addition, a two-part simulation is described that was developed alongside the hardware. Modelling of the absorbed UV light within the Pathfinder sensor was carried out with the GEANT4 software toolkit and a separate MATLAB charge transfer model calculated the net photocurrent between the test masses and surrounding housing in the presence of AC and DC electric fields. We confront the results of these models with observations and draw conclusions for the design of discharge systems for future experiments like LISA that will also employ free-falling test masses.

LISA Pathfinder (LPF) was a European Space Agency mission with the aim to test key technologies for future space-borne gravitational-wave observatories like LISA. The main scientific goal of LPF was to demonstrate measurements of differential acceleration between free-falling test masses at the sub-femto-g level, and to understand the residual acceleration in terms of a physical model of stray forces, and displacement readout noise. A key step toward reaching the LPF goals was the correct calibration of the dynamics of LPF, which was a three-body system composed by two test-masses enclosed in a single spacecraft, and subject to control laws for system stability. In this work, we report on the calibration procedures adopted to calculate the residual differential stray force per unit mass acting on the two test-masses in their nominal positions. The physical parameters of the adopted dynamical model are presented, together with their role on LPF performance. The analysis and results of these experiments show that the dynamics of the system was accurately modeled and the dynamical parameters were stationary throughout the mission. Finally, the impact and importance of calibrating system dynamics for future space-based gravitational wave observatories is discussed.

Galactic cosmic-ray (GCR) energy spectra observed in the inner heliosphere are modulated by the solar activity, the solar polarity and structures of solar and interplanetary origin. A high counting rate particle detector (PD) aboard LISA Pathfinder (LPF), meant for subsystems diagnostics, was devoted to the measurement of galactic cosmic-ray and solar energetic particle integral fluxes above 70 MeV n$^{-1}$ up to 6500 counts s$^{-1}$. PD data were gathered with a sampling time of 15 s. Characteristics and energy-dependence of GCR flux recurrent depressions and of a Forbush decrease dated August 2, 2016 are reported here. The capability of interplanetary missions, carrying PDs for instrument performance purposes, in monitoring the passage of interplanetary coronal mass ejections (ICMEs) is also discussed.

Test mass charging caused by cosmic rays will be a significant source of acceleration noise for space-based gravitational wave detectors like LISA. Operating between December 2015 and July 2017, the technology demonstration mission LISA Pathfinder included a bespoke monitor to help characterise the relationship between test mass charging and the local radiation environment. The radiation monitor made in situ measurements of the cosmic ray flux while also providing information about its energy spectrum. We describe the monitor and present measurements which show a gradual 40% increase in count rate coinciding with the declining phase of the solar cycle. Modulations of up to 10% were also observed with periods of 13 and 26 days that are associated with co-rotating interaction regions and heliospheric current sheet crossings. These variations in the flux above the monitor detection threshold (approximately 70 MeV) are shown to be coherent with measurements made by the IREM monitor on-board the Earth orbiting INTEGRAL spacecraft. Finally we use the measured deposited energy spectra, in combination with a GEANT4 model, to estimate the galactic cosmic ray differential energy spectrum over the course of the mission.

Granuloma faciale is a rare, benign skin disease characterised by solitary or multiple papules, plaques or nodules, most often occurring on the face. The skin disorder is often associated with exacerbations and remissions; spontaneous resolution seldom occurs. The treatment of granuloma faciale is challenging. Various topical and systemic treatments, but also surgical and laser therapies have been administered. A spatially confined thermal destruction of the tissue is achieved by strong absorption of haemoglobin at 585 nm wavelength. Of note, none of the presently available therapeutic interventions are particularly successful. Moreover, Granuloma faciale has the tendency to recur after treatment. Here, we present a male patient with a treatment refractory Granuloma faciale on the right cheek who was successfully treated with the combination of surgery and pulsed-dye laser therapy. Besides the good aesthetic outcome, remission was maintained after almost 1 year of follow-up., Competing Interests: Ewan A. Langan is Editor‐in‐Chief of Skin Health and Disease., (© 2023 The Authors. Skin Health and Disease published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists.)

Biologic therapies are increasingly used to treat chronic inflammatory skin diseases such as psoriasis and atopic dermatitis. In clinical practice, scores based on evaluation of objective and subjective symptoms are used to assess disease severity, leading to evaluation of treatment goals with clinical decisions on treatment initiation, switch to another treatment modality or to discontinue current treatment. However, this visual-based scoring is relatively subjective and inaccurate due to inter- and intraobserver reliability. Optical coherence tomography (OCT) is a fast, high-resolution, in vivo imaging modality that enables the visualization of skin structure and vasculature. We evaluated the use of OCT for quantification and monitoring of skin inflammation to improve objective assessment of disease activity in patients with psoriasis and atopic dermatitis. We assessed the following imaging parameters including epidermal thickness, vascular density, plexus depth, vessel diameter, and vessel count. A total of four patients with psoriasis or atopic dermatitis were treated with biologic agents according to current treatment guidelines. OCT was used to monitor their individual treatment response in a target lesion representing disease activity for 52 weeks. Psoriatic and eczema lesions exhibited higher epidermal thickness, increased vascular density, and higher vessel count compared to uninvolved skin. An upward shift of the superficial vascular plexus accompanied by smaller vessel diameters was seen in psoriasis in contrast to atopic dermatitis, where larger vessels were observed. A response to biologic therapy was characterized by normalization of the imaging parameters in the target lesions in comparison to uninvolved skin during the observation period of 52 weeks. Optical coherence tomography potentially serves as an instrument to monitor biologic therapy in inflammatory skin diseases. Imaging parameters may enable objective quantification of inflammation in psoriasis or atopic dermatitis in selected representative skin areas. OCT may reveal persistent subclinical inflammation in atopic dermatitis beyond clinical remission., Competing Interests: Author DT declares being a consultant, investigator, speaker, and participating in scientific advisory boards for AbbVie, Almirall, Amgen, Biogen Idec, Eli Lilly, Galapagos, Janssen-Cilag, LEO Pharma, MSD, Novartis, Pfizer, Regeneron, Samsung, Sanofi, and UCB; and research/educational grants from AbbVie, LEO Pharma, and Novartis. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Ha-Wissel, Yasak, Huber, Zillikens, Ludwig, Thaçi and Hundt.)