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17 results on '"Wondimu, Abrham"'

1. Inter-reviewer reliability of human literature reviewing and implications for the introduction of machine-assisted systematic reviews: a mixed-methods review

Author

Hanegraaf, Piet, primary, Wondimu, Abrham, additional, Mosselman, Jacob Jan, additional, de Jong, Rutger, additional, Abogunrin, Seye, additional, Queiros, Luisa, additional, Lane, Marie, additional, Postma, Maarten J, additional, Boersma, Cornelis, additional, and van der Schans, Jurjen, additional

Published
2024
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2. Economic evaluation of second measles containing vaccine (MCV) dose: a systematic review of available evidence.

Author

Bawa, Samuel, Wondimu, Abrham, Postma, Maarten J., Hutubessy, Raymond, and van Hulst, Marinus

Abstract

Introduction: The global measles incidence has decreased from 145 to 49 cases per 1 million population from 2000 to 2018, but evaluating the economic benefits of a second measles-containing vaccine (MCV2) is crucial. This study reviewed the evidence and quality of economic evaluation studies to guide MCV2 introduction. Methods: The systematic review of model-based economic evaluation studies was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The search yielded 2231 articles, with 876 duplicates removed and 1355 articles screened, with nine studies included for final analysis. Results: Six studies reported a positive benefit–cost ratio with one resulting in net savings of $11.6 billion, and two studies estimated a 2-dose MMR vaccination program would save $119.24 to prevent one measles case, and a second dose could prevent 9,200 cases at 18 months, saving $548.19 per case. The most sensitive variables were the discount rate and vaccination administration cost. Conclusions: Two MCV doses or a second opportunity with an additional dose of MCV were highly cost-beneficial and resulted in substantial cost savings compared to a single routine vaccine. But further research using high-quality model-based health economic evaluation studies of MCV2 should be made available to decision-makers. PROSPERO Registration: CRD42020200669 [ABSTRACT FROM AUTHOR]

Published
2024
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14. CANCER NANOTHERANOSTICS: A NEW PARADIGM OF SIMULTANEOUS DIAGNOSIS AND THERAPY

Author

Sisay, Berihun, Abrha, Solomon, Yilma, Zewdu, Assen, Admassu, Molla, Fantahun, Tadese, Ebisa, Wondimu, Abrham, Gebre-Samuel, Naod, Pattnaik, Gurudutta, Sisay, Berihun, Abrha, Solomon, Yilma, Zewdu, Assen, Admassu, Molla, Fantahun, Tadese, Ebisa, Wondimu, Abrham, Gebre-Samuel, Naod, and Pattnaik, Gurudutta

Abstract

Despite improvements in our understanding of cancer and the emerging concept of personalized medicine for the treatment of this disease, it is still one of the leading causes of death worldwide. Although, in recent years, significant advances have been achieved in cancer therapy, many tumors are still challenging to treat and novel strategies are required to effectively combat this deadly disease. Nanotheranostics is a burgeoning field which makes use of nanotechnology for diagnosis and therapy of cancer. The recent advancement in the area of nanotechnology has enabled a new generation of different types of nanomaterials composed of either inorganic or polymer based nanoparticles to be useful for nanotheranostics applications such as to diagnose and treat diseases and monitoring the therapeutic response in vivo at molecular level; to enhance the control, evaluation and optimization of drug delivery and release; to target the drug by conjugating theranostic nanoplatformes with biological ligands. This review, therefore, summarizes the various nanocarriers developed so far for the simultaneous imaging and therapy, strategies for their targeted delivery, their potential applications and the challenges in their development and application for cancer therapy.  Key words: Cancer; Cancer therapy; Nanoparticles; Nanotheranostics.

Published
2014

15. LITERATURE REVIEW ON ENSET STARCH: PHYSICO-CHEMICAL PROPERTIES AND PHARMACEUTICAL APPLICATIONS

Author

Wondimu, Abrham, Molla, Fantahun, Dinda, Subas Chandra, Gebre-Samuel, Naod, Tadese, Ebisa Tadese, Wondimu, Abrham, Molla, Fantahun, Dinda, Subas Chandra, Gebre-Samuel, Naod, and Tadese, Ebisa Tadese

Abstract

Enset (Ensete Ventricosum, Family Musaceae) is a plant indigenous to Ethiopia, it is often called ‘false banana” for its close resemblance to banana plant. The plant is the most important staple food for millions of people in the south and southwestern parts of Ethiopia. Enset plant contains starch as its major contents. The starch has been investigated for its physico-chemical properties including granule size, X-ray diffraction pattern, amylose content, gelatinization behavior, stability and various rhelogical properties of the gel. Based on its physico-chemical properties the starch was evaluated for various pharmaceutical applications such as in tablet binder and disintegrant. Several modifications were also attempted on the native enset starch so as to improve and modulate its physiochemical properties. Hence, this review aims to summarize the knowledge on the properties of enset starch and its pharmaceutical applications. Key words: Enset, Starch, properties, Pharmaceutical applicationÂ

Published
2014

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