1,338 results on '"Wood, Matthew"'
Search Results
2. The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science
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Lilly, Jena V, Rokita, Jo Lynne, Mason, Jennifer L, Patton, Tatiana, Stefankiewiz, Stephanie, Higgins, David, Trooskin, Gerri, Larouci, Carina A, Arya, Kamnaa, Appert, Elizabeth, Heath, Allison P, Zhu, Yuankun, Brown, Miguel A, Zhang, Bo, Farrow, Bailey K, Robins, Shannon, Morgan, Allison M, Nguyen, Thinh Q, Frenkel, Elizabeth, Lehmann, Kaitlin, Drake, Emily, Sullivan, Catherine, Plisiewicz, Alexa, Coleman, Noel, Patterson, Luke, Koptyra, Mateusz, Helili, Zeinab, Van Kuren, Nicholas, Young, Nathan, Kim, Meen Chul, Friedman, Christopher, Lubneuski, Alex, Blackden, Christopher, Williams, Marti, Baubet, Valerie, Tauhid, Lamiya, Galanaugh, Jamie, Boucher, Katie, Ijaz, Heba, Cole, Kristina A, Choudhari, Namrata, Santi, Mariarita, Moulder, Robert W, Waller, Jonathan, Rife, Whitney, Diskin, Sharon J, Mateos, Marion, Parsons, Donald W, Pollack, Ian F, Goldman, Stewart, Leary, Sarah, Caporalini, Chiara, Buccoliero, Anna Maria, Scagnet, Mirko, Haussler, David, Hanson, Derek, Firestein, Ron, Cain, Jason, Phillips, Joanna J, Gupta, Nalin, Mueller, Sabine, Grant, Gerald, Monje-Deisseroth, Michelle, Partap, Sonia, Greenfield, Jeffrey P, Hashizume, Rintaro, Smith, Amy, Zhu, Shida, Johnston, James M, Fangusaro, Jason R, Miller, Matthew, Wood, Matthew D, Gardner, Sharon, Carter, Claire L, Prolo, Laura M, Pisapia, Jared, Pehlivan, Katherine, Franson, Andrea, Niazi, Toba, Rubin, Josh, Abdelbaki, Mohamed, Ziegler, David S, Lindsay, Holly B, Stucklin, Ana Guerreiro, Gerber, Nicolas, Vaske, Olena M, Quinsey, Carolyn, Rood, Brian R, Nazarian, Javad, Raabe, Eric, Jackson, Eric M, Stapleton, Stacie, Lober, Robert M, Kram, David E, Koschmann, Carl, Storm, Phillip B, Lulla, Rishi R, Prados, Michael, Resnick, Adam C, and Waanders, Angela J
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Neurosciences ,Pediatric Cancer ,Brain Disorders ,Pediatric Research Initiative ,Pediatric ,Brain Cancer ,Rare Diseases ,Cancer ,Good Health and Well Being ,Adult ,Humans ,Child ,Quality of Life ,Brain Neoplasms ,Collaborative international research infrastructure ,Pediatric brain tumors ,Multi-omic data ,Longitudinal clinical data ,Biospecimens ,Molecular clinical trials ,Clinical Sciences ,Oncology & Carcinogenesis - Abstract
Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential years of life lost compared to adult cancers. Moreover, survivors frequently suffer long-term side effects, including secondary cancers. The Children's Brain Tumor Network (CBTN) is a multi-institutional international clinical research consortium created to advance therapeutic development through the collection and rapid distribution of biospecimens and data via open-science research platforms for real-time access and use by the global research community. The CBTN's 32 member institutions utilize a shared regulatory governance architecture at the Children's Hospital of Philadelphia to accelerate and maximize the use of biospecimens and data. As of August 2022, CBTN has enrolled over 4700 subjects, over 1500 parents, and collected over 65,000 biospecimen aliquots for research. Additionally, over 80 preclinical models have been developed from collected tumors. Multi-omic data for over 1000 tumors and germline material are currently available with data generation for > 5000 samples underway. To our knowledge, CBTN provides the largest open-access pediatric brain tumor multi-omic dataset annotated with longitudinal clinical and outcome data, imaging, associated biospecimens, child-parent genomic pedigrees, and in vivo and in vitro preclinical models. Empowered by NIH-supported platforms such as the Kids First Data Resource and the Childhood Cancer Data Initiative, the CBTN continues to expand the resources needed for scientists to accelerate translational impact for improved outcomes and quality of life for children with brain and spinal cord tumors.
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- 2023
3. Design and Performance of the Prototype Schwarzschild-Couder Telescope Camera
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Adams, Colin B., Ambrosi, Giovanni, Ambrosio, Michelangelo, Aramo, Carla, Arlen, Timothy, Benbow, Wystan, Bertucci, Bruna, Bissaldi, Elisabetta, Biteau, Jonathan, Bitossi, Massimiliano, Boiano, Alfonso, Bonavolontà, Carmela, Bose, Richard, Bouvier, Aurelien, Buscemi, Mario, Brill, Aryeh, Brown, Anthony M., Buckley, James H., Canestrari, Rodolfo, Capasso, Massimo, Caprai, Mirco, Coppi, Paolo, Covault, Corbin E., Depaoli, Davide, Di Venere, Leonardo, Errando, Manel, Fegan, Stephen, Feng, Qi, Fiandrini, Emanuele, Furniss, Amy, Garczarczyk, Markus, Gent, Alasdair, Giglietto, Nicola, Giordano, Francesco, Giro, Enrico, Halliday, Robert, Hervet, Olivier, Hughes, Gareth, Incardona, Simone, Humensky, Thomas B., Ionica, Maria, Jin, Weidong, Johnson, Caitlin A., Kieda, David, Krennrich, Frank, Kuznetsov, Andrey, Lapington, Jon, Licciulli, Francesco, Loporchio, Serena, Marsella, Giovanni, Masone, Vincenzo, Meagher, Kevin, Meures, Thomas, Mode, Brent A. W., Mognet, Samuel A. I., Mukherjee, Reshmi, Okumura, Akira, Pantaleo, Francesca R., Paoletti, Riccardo, Di Pierro, Federico, Ribeiro, Deivid, Riitano, Luca, Roache, Emmet, Ross, Duncan, Rousselle, Julien, Rugliancich, Andrea, Santander, Marcos, Schneider, Michael, Schoorlemmer, Harm, Shang, Ruo-Yu, Stevenson, Brandon, Stiaccini, Leonardo, Tajima, Hiroyasu, Taylor, Leslie P., Thornhill, Julian, Tosti, Luca, Tripodo, Giovanni, Vagelli, Valerio, Valentino, Massimo, Vandenbroucke, Justin, Vassiliev, Vladimir V., Wakely, Scott P., Watson, Jason J., White, Richard, Wilcox, Patrick, Williams, David A., Wood, Matthew, Yu, Peter, and Zink, Adrian
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Astrophysics - Instrumentation and Methods for Astrophysics ,Physics - Instrumentation and Detectors - Abstract
The prototype Schwarzschild-Couder Telescope (pSCT) is a candidate for a medium-sized telescope in the Cherenkov Telescope Array. The pSCT is based on a novel dual mirror optics design which reduces the plate scale and allows for the use of silicon photomultipliers as photodetectors. The prototype pSCT camera currently has only the central sector instrumented with 25 camera modules (1600 pixels), providing a 2.68$^{\circ}$ field of view (FoV). The camera electronics are based on custom TARGET (TeV array readout with GSa/s sampling and event trigger) application specific integrated circuits. Field programmable gate arrays sample incoming signals at a gigasample per second. A single backplane provides camera-wide triggers. An upgrade of the pSCT camera is in progress, which will fully populate the focal plane. This will increase the number of pixels to 11,328, the number of backplanes to 9, and the FoV to 8.04$^{\circ}$. Here we give a detailed description of the pSCT camera, including the basic concept, mechanical design, detectors, electronics, current status and first light.
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- 2022
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4. Molecular profiling of pre- and post-treatment pediatric high-grade astrocytomas reveals acquired increased tumor mutation burden in a subset of recurrences
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Wood, Matthew D., Beadling, Carol, Neff, Tanaya, Moore, Steve, Harrington, Christina A., Baird, Lissa, and Corless, Christopher
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- 2023
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5. Variations in small-scale movements of, Rousettus aegyptiacus, a Marburg virus reservoir across a seasonal gradient
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Wood, Matthew R., de Vries, J. Low, Epstein, Jonathan H., and Markotter, Wanda
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- 2023
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6. Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis
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Obeidat, Alia M., Wood, Matthew J., Adamczyk, Natalie S., Ishihara, Shingo, Li, Jun, Wang, Lai, Ren, Dongjun, Bennett, David A., Miller, Richard J., Malfait, Anne-Marie, and Miller, Rachel E.
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- 2023
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7. SP56. Effects Of Systemic T Cell Modulation On Nerve Regeneration After Segmental Injury
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Pinni, Sai L., Finnan, Michael J., Schellhardt, Lauren, Snyder-Warwick, Alison K., Mackinnon, Susan E., and Wood, Matthew D.
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- 2024
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8. Unreasoned, Nondeliberative, or Temporally Uncertain? Elaborating Time-Calibrated Entrepreneurial Action.
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Wood, Matthew S., Bakker, Rene M., and Fisher, Greg
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ENTREPRENEURSHIP ,BUSINESSPEOPLE ,REASONING - Abstract
This article is a response to a continuing discussion on the original article by Wood, Bakker, and Fisher “Back to the Future: A Time Calibrated Theory of Entrepreneurial Action” and a commentary on it by Professors Van Lent, Hunt, and Lerner. This article, written by the authors of the original article, comments on Van Lent, Hunt and Lerner’s ideas concerning entrepreneurial action theory.
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- 2024
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9. Peptide-conjugated antimiRs improve myotonic dystrophy type 1 phenotypes by promoting endogenous MBNL1 expression
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González-Martínez, Irene, Cerro-Herreros, Estefanía, Moreno, Nerea, García-Rey, Andrea, Espinosa-Espinosa, Jorge, Carrascosa-Sàez, Marc, Piqueras-Losilla, Diego, Arzumanov, Andrey, Seoane-Miraz, David, Jad, Yahya, Raz, Richard, Wood, Matthew J., Varela, Miguel A., Llamusí, Beatriz, and Artero, Rubén
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- 2023
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10. Glioblastomas with primitive neuronal component harbor a distinct methylation and copy-number profile with inactivation of TP53, PTEN, and RB1
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Suwala, Abigail K, Stichel, Damian, Schrimpf, Daniel, Maas, Sybren LN, Sill, Martin, Dohmen, Hildegard, Banan, Rouzbeh, Reinhardt, Annekathrin, Sievers, Philipp, Hinz, Felix, Blattner-Johnson, Mirjam, Hartmann, Christian, Schweizer, Leonille, Boldt, Henning B, Kristensen, Bjarne Winther, Schittenhelm, Jens, Wood, Matthew D, Chotard, Guillaume, Bjergvig, Rolf, Das, Anirban, Tabori, Uri, Hasselblatt, Martin, Korshunov, Andrey, Abdullaev, Zied, Quezado, Martha, Aldape, Kenneth, Harter, Patrick N, Snuderl, Matija, Hench, Jürgen, Frank, Stephan, Acker, Till, Brandner, Sebastian, Winkler, Frank, Wesseling, Pieter, Pfister, Stefan M, Reuss, David E, Wick, Wolfgang, von Deimling, Andreas, Jones, David TW, and Sahm, Felix
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Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Brain Disorders ,Human Genome ,Brain Cancer ,Neurosciences ,Cancer ,Rare Diseases ,Genetics ,2.1 Biological and endogenous factors ,Aetiology ,Brain Neoplasms ,Chromosomes ,Human ,Pair 1 ,Chromosomes ,Human ,Pair 7 ,Cohort Studies ,Cyclin-Dependent Kinase Inhibitor p16 ,DNA Copy Number Variations ,DNA Methylation ,Female ,Gene Deletion ,Glial Fibrillary Acidic Protein ,Glioblastoma ,Humans ,Male ,Middle Aged ,Neuroectodermal Tumors ,Primitive ,PTEN Phosphohydrolase ,Retinoblastoma Binding Proteins ,Tumor Suppressor Protein p53 ,Ubiquitin-Protein Ligases ,GBM ,PNET ,DNA methylation ,Phenotype ,Classification ,Plasticity ,Neurology & Neurosurgery - Abstract
Glioblastoma IDH-wildtype presents with a wide histological spectrum. Some features are so distinctive that they are considered as separate histological variants or patterns for the purpose of classification. However, these usually lack defined (epi-)genetic alterations or profiles correlating with this histology. Here, we describe a molecular subtype with overlap to the unique histological pattern of glioblastoma with primitive neuronal component. Our cohort consists of 63 IDH-wildtype glioblastomas that harbor a characteristic DNA methylation profile. Median age at diagnosis was 59.5 years. Copy-number variations and genetic sequencing revealed frequent alterations in TP53, RB1 and PTEN, with fewer gains of chromosome 7 and homozygous CDKN2A/B deletions than usually described for IDH-wildtype glioblastoma. Gains of chromosome 1 were detected in more than half of the cases. A poorly differentiated phenotype with frequent absence of GFAP expression, high proliferation index and strong staining for p53 and TTF1 often caused misleading histological classification as carcinoma metastasis or primitive neuroectodermal tumor. Clinically, many patients presented with leptomeningeal dissemination and spinal metastasis. Outcome was poor with a median overall survival of only 12 months. Overall, we describe a new molecular subtype of IDH-wildtype glioblastoma with a distinct histological appearance and genetic signature.
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- 2021
11. The optimum composition for endurance sports drinks
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Hopkins, W. G. and Wood, Matthew R
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- 2006
12. Papillary tumor of the pineal region: analysis of DNA methylation profiles and clinical outcomes in 76 cases
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Wu, Zhichao, Dazelle, Karen, Abdullaev, Zied, Chung, Hye-Jung, Dahiya, Sonika, Wood, Matthew, Lee, Han, Lucas, Calixto-Hope G., Mao, Qinwen, Robinson, Lorraina, Fernandes, Igor, McCord, Matthew, Pytel, Peter, Conway, Kyle S., Yoda, Rebecca, Eschbacher, Jennifer M., Maher, Ossama M., Hasselblatt, Martin, Mobley, Bret C., Raisanen, Jack M., Hatanpaa, Kimmo J., Byers, Joshua, Lehman, Norman L., Cimino, Patrick J., Pratt, Drew, Quezado, Martha, and Aldape, Kenneth
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- 2024
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13. Modeling protective action decision-making in earthquakes by using explainable machine learning and video data
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Zhang, Xiaojian, Zhao, Xilei, Baldwin, Dare, McBride, Sara, Bellizzi, Josephine, Cochran, Elizabeth S., Luco, Nicholas, Wood, Matthew, and Cova, Thomas J.
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- 2024
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14. Limited Nerve Regeneration across Acellular Nerve Allografts (ANAs) Coincides with Changes in Blood Vessel Morphology and the Development of a Pro-Inflammatory Microenvironment
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Acevedo Cintrón, Jesús A., primary, Hunter, Daniel A., additional, Schellhardt, Lauren, additional, Pan, Deng, additional, Mackinnon, Susan E., additional, and Wood, Matthew D., additional
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- 2024
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15. Comprehensive analysis of diverse low-grade neuroepithelial tumors with FGFR1 alterations reveals a distinct molecular signature of rosette-forming glioneuronal tumor
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Lucas, Calixto-Hope G, Gupta, Rohit, Doo, Pamela, Lee, Julieann C, Cadwell, Cathryn R, Ramani, Biswarathan, Hofmann, Jeffrey W, Sloan, Emily A, Kleinschmidt-DeMasters, Bette K, Lee, Han S, Wood, Matthew D, Grafe, Marjorie, Born, Donald, Vogel, Hannes, Salamat, Shahriar, Puccetti, Diane, Scharnhorst, David, Samuel, David, Cooney, Tabitha, Cham, Elaine, Jin, Lee-way, Khatib, Ziad, Maher, Ossama, Chamyan, Gabriel, Brathwaite, Carole, Bannykh, Serguei, Mueller, Sabine, Kline, Cassie N, Banerjee, Anu, Reddy, Alyssa, Taylor, Jennie W, Clarke, Jennifer L, Oberheim Bush, Nancy Ann, Butowski, Nicholas, Gupta, Nalin, Auguste, Kurtis I, Sun, Peter P, Roland, Jarod L, Raffel, Corey, Aghi, Manish K, Theodosopoulos, Philip, Chang, Edward, Hervey-Jumper, Shawn, Phillips, Joanna J, Pekmezci, Melike, Bollen, Andrew W, Tihan, Tarik, Chang, Susan, Berger, Mitchel S, Perry, Arie, and Solomon, David A
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Biological Sciences ,Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Cancer ,Rare Diseases ,Genetics ,Human Genome ,Aetiology ,2.1 Biological and endogenous factors ,Adolescent ,Adult ,Aged ,Brain Neoplasms ,Child ,Female ,Humans ,Male ,Middle Aged ,Mutation ,Neoplasms ,Neuroepithelial ,Receptor ,Fibroblast Growth Factor ,Type 1 ,Spinal Cord Neoplasms ,Young Adult ,Rosette-forming glioneuronal tumor ,Extraventricular neurocytoma ,Dysembryoplastic neuroepithelial tumor ,Pilocytic astrocytoma ,FGFR1 ,PIK3CA ,Molecular neuropathology ,DNA methylation profiling ,PIK3R1 ,Biochemistry and Cell Biology ,Neurosciences ,Biochemistry and cell biology - Abstract
The FGFR1 gene encoding fibroblast growth factor receptor 1 has emerged as a frequently altered oncogene in the pathogenesis of multiple low-grade neuroepithelial tumor (LGNET) subtypes including pilocytic astrocytoma, dysembryoplastic neuroepithelial tumor (DNT), rosette-forming glioneuronal tumor (RGNT), and extraventricular neurocytoma (EVN). These activating FGFR1 alterations in LGNET can include tandem duplication of the exons encoding the intracellular tyrosine kinase domain, in-frame gene fusions most often with TACC1 as the partner, or hotspot missense mutations within the tyrosine kinase domain (either at p.N546 or p.K656). However, the specificity of these different FGFR1 events for the various LGNET subtypes and accompanying genetic alterations are not well defined. Here we performed comprehensive genomic and epigenomic characterization on a diverse cohort of 30 LGNET with FGFR1 alterations. We identified that RGNT harbors a distinct epigenetic signature compared to other LGNET with FGFR1 alterations, and is uniquely characterized by FGFR1 kinase domain hotspot missense mutations in combination with either PIK3CA or PIK3R1 mutation, often with accompanying NF1 or PTPN11 mutation. In contrast, EVN harbors its own distinct epigenetic signature and is characterized by FGFR1-TACC1 fusion as the solitary pathogenic alteration. Additionally, DNT and pilocytic astrocytoma are characterized by either kinase domain tandem duplication or hotspot missense mutations, occasionally with accompanying NF1 or PTPN11 mutation, but lacking the accompanying PIK3CA or PIK3R1 mutation that characterizes RGNT. The glial component of LGNET with FGFR1 alterations typically has a predominantly oligodendroglial morphology, and many of the pilocytic astrocytomas with FGFR1 alterations lack the biphasic pattern, piloid processes, and Rosenthal fibers that characterize pilocytic astrocytomas with BRAF mutation or fusion. Together, this analysis improves the classification and histopathologic stratification of LGNET with FGFR1 alterations.
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- 2020
16. Perceptions of accountability and trust in the regulatory governance of wood burning stove sustainability: Survey evidence from the post-Brexit UK
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Wood, Matthew, Wood, Chantelle, Styring, Peter, Jones, Christopher R., Smith, Jeffery K., Day, Marianne, Chakraborty, Rohit, and Mensah, Gloria
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- 2023
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17. Investigating Eukaryotic Elongation Factor 2 Kinase/Eukaryotic Translation Elongation Factor 2 Pathway Regulation and Its Role in Protein Synthesis Impairment during Disuse-Induced Skeletal Muscle Atrophy
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Vilchinskaya, Natalia, Lim, Wooi Fang, Belova, Svetlana, Roberts, Thomas C., Wood, Matthew J.A., and Lomonosova, Yulia
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- 2023
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18. PATH-22. COMPREHENSIVE ANALYSIS OF DIVERSE LOW-GRADE NEUROEPITHELIAL TUMORS WITH FGFR1 ALTERATIONS REVEALS A DISTINCT MOLECULAR SIGNATURE OF ROSETTE-FORMING GLIONEURONAL TUMOR
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Lucas, Calixto-Hope G, Gupta, Rohit, Doo, Pamela, Wood, Matthew, Grafe, Marjorie, Lee, Han, Kleinschmidt-Demasters, BK, Bush, Nancy Ann Oberheim, Taylor, Jennie, Clarke, Jennifer, Butowski, Nicholas, Kline, Cassie, Reddy, Alyssa, Banerjee, Anurhada, Mueller, Sabine, Hervey-Jumper, Shawn, Aghi, Manish, Chang, Edward, Theodosopoulos, Philip, Roland, Jarod, Auguste, Kurtis, Sun, Peter, Raffel, Corey, Gupta, Nalin, Lee, Julieann, Phillips, Joanna, Pekmezci, Melike, Bollen, Andrew, Tihan, Tarik, Chang, Susan, Berger, Mitchel, Perry, Arie, and Solomon, David
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Neurosciences ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
Abstract The FGFR1 gene encoding fibroblast growth factor receptor 1 has emerged as a frequently altered oncogene in the pathogenesis of multiple low-grade neuroepithelial tumor (LGNET) subtypes including pilocytic astrocytoma (PA), dysembryoplastic neuroepithelial tumor (DNT), rosette-forming glioneuronal tumor (RGNT), and extraventricular neurocytoma (EVN). These activating FGFR1 alterations in LGNET can include tandem duplication of the exons encoding the intracellular tyrosine kinase domain, in-frame gene fusions most often with TACC1 as the partner, or hotspot missense mutations within the tyrosine kinase domain (either p.N546 or p.K656). However, the specificity of these different FGFR1 events for the various LGNET subtypes and accompanying genetic alterations are not well defined, nor are the histopathologic features of pilocytic astrocytomas with FGFR1 alterations versus those harboring the more common BRAF mutations or fusions. Here we performed comprehensive genomic and epigenomic characterization on a diverse cohort of 30 LGNET with FGFR1 alterations. We identified that RGNT harbors a distinct epigenetic signature compared to other LGNET with FGFR1 alterations, and is uniquely characterized by FGFR1 kinase domain hotspot missense mutations in combination with either PIK3CA or PIK3R1 mutation, often with accompanying NF1 or PTPN11 mutation. In contrast, EVN harbors its own distinct epigenetic signature and is characterized by FGFR1-TACC1 fusion as the solitary pathogenic alteration. Additionally, DNT and PA are characterized by either kinase domain tandem duplication or hotspot missense mutations, occasionally with accompanying NF1 or PTPN11 mutation, but lacking the accompanying PIK3CA or PIK3R1 mutation that characterizes RGNT. The glial component of LGNET with FGFR1 alterations typically has a predominantly oligodendroglial morphology, and many of the pilocytic astrocytomas with FGFR1 alterations lack the biphasic pattern, piloid processes, and Rosenthal fibers that characterize pilocytic astrocytomas with BRAF mutation or fusion. Together, this analysis refines the classification and histopathologic spectrum of LGNET with FGFR1 alterations.
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- 2020
19. All-sky Medium Energy Gamma-ray Observatory: Exploring the Extreme Multimessenger Universe
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McEnery, Julie, Barrio, Juan Abel, Agudo, Ivan, Ajello, Marco, Álvarez, José-Manuel, Ansoldi, Stefano, Anton, Sonia, Auricchio, Natalia, Stephen, John B., Baldini, Luca, Bambi, Cosimo, Baring, Matthew, Barres, Ulisses, Bastieri, Denis, Beacom, John, Beckmann, Volker, Bednarek, Wlodek, Bernard, Denis, Bissaldi, Elisabetta, Bloser, Peter, Blumer, Harsha, Boettcher, Markus, Boggs, Steven, Bolotnikov, Aleksey, Bottacini, Eugenio, Bozhilov, Vladimir, Bozzo, Enrico, Briggs, Michael, Buckley, Jim, Burns, Eric, Buson, Sara, Campana, Riccardo, Caputo, Regina, Cardillo, Martina, Caroli, Ezio, Castro, Daniel, Cenko, S. Brad, Charles, Eric, Chen, Wenlei, Cheung, Teddy, Ciprini, Stefano, Coppi, Paolo, da Silva, Rui Curado, Cutini, Sara, D'Ammando, Filippo, De Angelis, Alessandro, De Becker, Michaël, De Nolfo, Georgia, Del Sordo, Stefano, Di Mauro, Mattia, Di Venere, Leonardo, Dietrich, Stefano, Digel, Seth, Dominguez, Alberto, Doro, Michele, Ferrara, Elizabeth, Fields, Brian, Finke, Justin, Foffano, Luca, Fryer, Chris, Fukazawa, Yasushi, Funk, Stefan, Gasparrini, Dario, Gelfand, Joseph, Georganopoulos, Markos, Giordano, Francesco, Giuliani, Andrea, Gouiffes, Christian, Grefenstette, Brian, Grenier, Isabelle, Griffin, Sean, Grove, Eric, Guiriec, Sylvain, Harding, Alice, Harding, Pat, Hartmann, Dieter, Hays, Elizabeth, Hernanz, Margarita, Hewitt, Jack, Holder, Jamie, Hui, Michelle, Inglis, Andrew, Johnson, Robert, Jones, Sam, Kanbach, Gottfried, Kargaltsev, Oleg, Kaufmann, Sarah, Kerr, Matthew, Kierans, Carolyn, Kislat, Fabian, Klimenko, Alexei V., Knodlseder, Jurgen, Kocveski, Daniel, Kopp, Joachim, Krawczynsiki, Henric, Krizmanic, John, Kubo, Hidetoshi, Neilson, Naoko Kurahashi, Laurent, Philippe, Lenain, Jean-Philippe, Li, Hui, Lien, Amy, Linden, Tim, Lommler, Jan, Longo, Francesco, Lovellette, Michael, López, Marcos, Manousakis, Antonios, Marcotulli, Lea, Marcowith, Alexandre, Martinez, Manel, McConnell, Marc, Metcalfe, Jessica, Meyer, Eileen, Meyer, Manuel, Mignani, Roberto, Mitchell, John, Mizuno, Tsunefumi, Moiseev, Alexander, Morcuende, Daniel, Moskalenko, Igor, Moss, Michael, Nakazawa, Kazuhiro, Mazziotta, M. Nicola, Oberlack, Uwe, Ohno, Masanori, Oikonomou, Foteini, Ojha, Roopesh, Omodei, Nicola, Orlando, Elena, Otte, Nepomuk, Paliya, Vaidehi S, Parker, Lucas, Patricelli, Barbara, Perkins, Jeremy, Petropoulou, Maria, Pittori, Carlotta, Pohl, Martin, Porter, Troy, Prandini, Elisa, Prescod-Weinstein, Chanda, Racusin, Judith, Rando, Riccardo, Rani, Bindu, Ribó, Marc, Rodi, James, Sanchez-Conde, Miguel A., Parkinson, Pablo Saz, Schirato, Richard, Shawhan, Peter, Shrader, Chris, Smith, Jacob, Smith, Karl, Stamerra, Antonio, Stawarz, Lukasz, Strong, Andy, Stumke, Inga, Tajima, Hiro, Takahashi, Hiromitsu, Tanaka, Yasuyuki, Tatischeff, Vincent, The, Lih-Sin, Thompson, David, Tibaldo, Luigi, Tomsick, John, Uhm, Lucas, Venters, Tonia, Vestrand, Tom, Vianello, Giacomo, Wadiasingh, Zorawar, Walter, Roland, Wang, Xilu, Williams, David, Wilson-Hodge, Colleen, Wood, Matthew, Woolf, Richard, Wulf, Eric, Younes, George, Zampieri, Luca, Zane, Silvia, Zhang, Bing, Zhang, Haocheng, Zimmer, Stephan, Zoglauer, Andreas, and van der Horst, Alexander
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
The All-sky Medium Energy Gamma-ray Observatory (AMEGO) is a probe class mission concept that will provide essential contributions to multimessenger astrophysics in the late 2020s and beyond. AMEGO combines high sensitivity in the 200 keV to 10 GeV energy range with a wide field of view, good spectral resolution, and polarization sensitivity. Therefore, AMEGO is key in the study of multimessenger astrophysical objects that have unique signatures in the gamma-ray regime, such as neutron star mergers, supernovae, and flaring active galactic nuclei. The order-of-magnitude improvement compared to previous MeV missions also enables discoveries of a wide range of phenomena whose energy output peaks in the relatively unexplored medium-energy gamma-ray band., Comment: Astro2020 APC White Paper Updated to make small change to author list in metadata
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- 2019
20. Engineered bacteria combined with doxorubicin nanoparticles suppress angiogenesis and metastasis in murine melanoma models
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Yang, Meiyang, Conceição, Mariana, Chen, Weijun, Yang, Fuwei, Zhao, Bingke, Wood, Matthew J.A., Qiu, Lipeng, and Chen, Jinghua
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- 2023
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21. An unusual recurrent high-grade glioneuronal tumor with MAP2K1 mutation and CDKN2A/B homozygous deletion
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Cheaney, Barry, Bowden, Stephen, Krause, Katie, Sloan, Emily A, Perry, Arie, Solomon, David A, Han, Seunggu Jude, and Wood, Matthew D
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Aged ,Brain Neoplasms ,Cyclin-Dependent Kinase Inhibitor p15 ,Cyclin-Dependent Kinase Inhibitor p16 ,Ganglioglioma ,Gene Deletion ,Homozygote ,Humans ,MAP Kinase Kinase 1 ,Male ,Mutation ,Neoplasm Grading ,Neoplasm Recurrence ,Local ,Glioneuronal tumor ,Anaplastic ,MAP2K1 mutation ,CDKN2A ,B homozygous deletion ,Multinodular and vacuolating neuronal tumor of the cerebrum ,Next-generation sequencing ,CDKN2A/B homozygous deletion ,Biochemistry and Cell Biology ,Clinical Sciences ,Neurosciences ,Biochemistry and cell biology - Published
- 2019
22. PATH-38. ROSETTE-FORMING GLIONEURONAL TUMOR IS DEFINED BY FGFR1 ACTIVATING ALTERATIONS WITH FREQUENT ACCOMPANYING PI3K AND MAPK PATHWAY MUTATIONS
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Calixto-Hope, Lucas, Lee, Julieann, Sloan, Emily, Hofmann, Jeffrey, Van Ziffle, Jessica, Onodera, Courtney, Grenert, James, Devine, Patrick, Kline, Cassie, Banerjee, Anu, Clarke, Jennifer, Taylor, Jennie, Ann Oberheim-Bush, Nancy, Buerki, Robin, Butowski, Nicholas, Chang, Susan, McDermott, Mike, Aghi, Manish, Theodosopoulos, Philip, Hervey-Jumper, Shawn, Berger, Mitchel, Raffel, Corey, Gupta, Nalin, Kleinschmidt-DeMasters, Bette, Wood, Matthew, Grafe, Marjorie, Guo, Hua, Sun, Peter, Torkildson, Joseph, Cooney, Tabitha, Fata, Cynthia, Scharnhorst, David, Samuel, David, Bannykh, Serguei, Khatib, Ziad, Maher, Ossama, Chamyan, Gabriel, Pelaez, Liset, Brathwaite, Carole, Jin, Lee-way, Lechpammer, Mirna, Born, Donald, Vogel, Hannes, Lee, Han, Phillips, Joanna, Pekmezci, Melike, Bollen, Andrew, Tihan, Tarik, Perry, Arie, and Solomon, David
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Neurosciences ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
Abstract BACKGROUND Rosette-forming glioneuronal tumor (RGNT) is an uncommon CNS tumor originally described in the fourth ventricle characterized by a low-grade glial neoplasm admixed with a rosette-forming neurocytic component. METHODS We reviewed clinicopathologic features of 42 patients with RGNT. Targeted next-generation sequencing was performed, and genome-wide methylation profiling is underway. RESULTS The 20 male and 22 female patients had a mean age of 25 years (range 3–47) at time of diagnosis. Tumors were located within or adjacent to the lateral ventricle (n=16), fourth ventricle (15), third ventricle (9), and spinal cord (2). All 31 tumors assessed to date contained FGFR1 activating alterations, either in-frame gene fusion, kinase domain tandem duplication, or hotspot missense mutation in the kinase domain (p.N546 or p.K656). While 7 of these 31 tumors harbored FGFR1 alterations as the solitary pathogenic event, 24 contained additional pathogenic alterations within PI3-kinase or MAP kinase pathway genes: 5 with additional PIK3CA and NF1 mutations, 4 with PIK3CA mutation, 3 with PIK3R1 mutation (one of which also contained focal RAF1 amplification), 5 with PTPN11 mutation (one with additional PIK3R1 mutation), and 2 with NF1 deletion. The other 5 cases demonstrated anaplastic features including hypercellularity and increased mitotic activity. Among these anaplastic cases, 3 harbored inactivating ATRX mutations and two harbored CDKN2A homozygous deletion, in addition to the FGFR1 alterations plus other PI3-kinase and MAP kinase gene mutations seen in those RGNT without anaplasia. CONCLUSION Independent of ventricular location, RGNT is defined by FGFR1 activating mutations or rearrangements, which are frequently accompanied by mutations involving PIK3CA, PIK3R1, PTPN11, NF1, and KRAS. Whereas pilocytic astrocytoma and ganglioglioma are characterized by solitary activating MAP kinase pathway alterations (e.g. BRAF fusion or mutation), RGNT are genetically more complex with dual PI3K-Akt-mTOR and Ras-Raf-MAPK pathway activation. Rare anaplastic examples may show additional ATRX and/or CDKN2A inactivation.
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- 2019
23. A case of recurrent epilepsy‐associated rosette‐forming glioneuronal tumor with anaplastic transformation in the absence of therapy
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Halfpenny, Aaron, Ferris, Sean P, Grafe, Marjorie, Woltjer, Randy, Selden, Nathan, Nazemi, Kellie, Perry, Arie, Solomon, David A, Gultekin, Sakir H, Moore, Stephen, Olson, Susan, Lawce, Helen, Lucas, Lora, Corless, Christopher L, and Wood, Matthew D
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Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Neurosciences ,Clinical Research ,Cancer ,Neurodegenerative ,Genetics ,Brain Disorders ,Epilepsy ,Rare Diseases ,Aetiology ,2.1 Biological and endogenous factors ,Brain Neoplasms ,Cell Transformation ,Neoplastic ,Child ,Preschool ,Female ,Humans ,Mutation ,Neoplasm Recurrence ,Local ,Neoplasms ,Neuroepithelial ,Temporal Lobe ,X-linked Nuclear Protein ,1p ,19q-codeletion ,anaplastic transformation ,ATRX ,fibroblast growth factor receptor receptor 1 (FGFR1) kinase domain internal tandem duplication ,rosette-forming glioneuronal tumor ,1p/19q-codeletion ,Neurology & Neurosurgery ,Clinical sciences ,Biological psychology - Abstract
Rosette-forming glioneuronal tumor (RGNT) most commonly occurs adjacent to the fourth ventricle and therefore rarely presents with epilepsy. Recent reports describe RGNT occurrence in other anatomical locations with considerable morphologic and genetic overlap with the epilepsy-associated dysembryoplastic neuroepithelial tumor (DNET). Examples of RGNT or DNET with anaplastic change are rare, and typically occur in the setting of radiation treatment. We present the case of a 5-year-old girl with seizures, who underwent near total resection of a cystic temporal lobe lesion. Pathology showed morphologic and immunohistochemical features of RGNT, albeit with focally overlapping DNET-like patterns. Resections of residual or recurrent tumor were performed 1 year and 5 years after the initial resection, but no adjuvant radiation or chemotherapy was given. Ten years after the initial resection, surveillance imaging identified new and enhancing nodules, leading to another gross total resection. This specimen showed areas similar to the original tumor, but also high-grade foci with oligodendroglial morphology, increased cellularity, palisading necrosis, microvascular proliferation, and up to 13 mitotic figures per 10 high power fields. Ancillary studies the status by sequencing showed wild-type of the isocitrate dehydrogenase 1 (IDH1), IDH2, and human histone 3.3 (H3F3A) genes, and BRAF studies were negative for mutation or rearrangement. Fluorescence in situ hybridization (FISH) showed codeletion of 1p and 19q limited to the high-grade regions. By immunohistochemistry there was loss of nuclear alpha-thalassemia mental retardation syndrome, X-linked (ATRX) expression only in the high-grade region. Next-generation sequencing showed an fibroblast growth factor receptor receptor 1 (FGFR1) kinase domain internal tandem duplication in three resection specimens. ATRX mutation in the high-grade tumor was confirmed by sequencing which showed a frameshift mutation (p.R1427fs), while the apparent 1p/19q-codeletion by FISH was due to loss of chromosome arm 1p and only partial loss of 19q. Exceptional features of this case include the temporal lobe location, 1p/19q loss by FISH without true whole-arm codeletion, and anaplastic transformation associated with ATRX mutation without radiation or chemotherapy.
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- 2019
24. Extracellular vesicle-mediated promotion of myogenic differentiation is dependent on dose, collection medium composition, and isolation method
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Hanson, Britt, Vorobieva, Ioulia, Zheng, Wenyi, Conceição, Mariana, Lomonsova, Yulia, Mäger, Imre, Puri, Pier Lorenzo, Andaloussi, Samir EL., Wood, Matthew J.A., and Roberts, Thomas C.
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- 2023
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25. Clinical variants in Caenorhabditis elegans expressing human STXBP1 reveal a novel class of pathogenic variants and classify variants of uncertain significance
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Hopkins, Christopher E., McCormick, Kathryn, Brock, Trisha, Wood, Matthew, Ruggiero, Sarah, Mcbride, Kolt, Kim, Christine, Lawson, Jennifer A., Helbig, Ingo, and Bainbridge, Matthew N.
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- 2023
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26. The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science
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Lilly, Jena V., Rokita, Jo Lynne, Mason, Jennifer L., Patton, Tatiana, Stefankiewiz, Stephanie, Higgins, David, Trooskin, Gerri, Larouci, Carina A., Arya, Kamnaa, Appert, Elizabeth, Heath, Allison P., Zhu, Yuankun, Brown, Miguel A., Zhang, Bo, Farrow, Bailey K., Robins, Shannon, Morgan, Allison M., Nguyen, Thinh Q., Frenkel, Elizabeth, Lehmann, Kaitlin, Drake, Emily, Sullivan, Catherine, Plisiewicz, Alexa, Coleman, Noel, Patterson, Luke, Koptyra, Mateusz, Helili, Zeinab, Van Kuren, Nicholas, Young, Nathan, Kim, Meen Chul, Friedman, Christopher, Lubneuski, Alex, Blackden, Christopher, Williams, Marti, Baubet, Valerie, Tauhid, Lamiya, Galanaugh, Jamie, Boucher, Katie, Ijaz, Heba, Cole, Kristina A., Choudhari, Namrata, Santi, Mariarita, Moulder, Robert W., Waller, Jonathan, Rife, Whitney, Diskin, Sharon J., Mateos, Marion, Parsons, Donald W., Pollack, Ian F., Goldman, Stewart, Leary, Sarah, Caporalini, Chiara, Buccoliero, Anna Maria, Scagnet, Mirko, Haussler, David, Hanson, Derek, Firestein, Ron, Cain, Jason, Phillips, Joanna J., Gupta, Nalin, Mueller, Sabine, Grant, Gerald, Monje-Deisseroth, Michelle, Partap, Sonia, Greenfield, Jeffrey P., Hashizume, Rintaro, Smith, Amy, Zhu, Shida, Johnston, James M., Fangusaro, Jason R., Miller, Matthew, Wood, Matthew D., Gardner, Sharon, Carter, Claire L., Prolo, Laura M., Pisapia, Jared, Pehlivan, Katherine, Franson, Andrea, Niazi, Toba, Rubin, Josh, Abdelbaki, Mohamed, Ziegler, David S., Lindsay, Holly B., Stucklin, Ana Guerreiro, Gerber, Nicolas, Vaske, Olena M., Quinsey, Carolyn, Rood, Brian R., Nazarian, Javad, Raabe, Eric, Jackson, Eric M., Stapleton, Stacie, Lober, Robert M., Kram, David E., Koschmann, Carl, Storm, Phillip B., Lulla, Rishi R., Prados, Michael, Resnick, Adam C., and Waanders, Angela J.
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- 2023
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27. Distal femoral replacement for the treatment of periprosthetic distal femoral fractures around a total knee arthroplasty: a meta-analysis
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Wood, Matthew J, primary, Al-Jabri, Talal, additional, Stelzhammer, Thomas, additional, Brivio, Angela, additional, Donaldson, James, additional, Skinner, John A, additional, and Barrett, David, additional
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- 2024
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28. Dysregulation of Tweak and Fn14 in skeletal muscle of spinal muscular atrophy mice
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Meijboom, Katharina E., Sutton, Emma R., McCallion, Eve, McFall, Emily, Anthony, Daniel, Edwards, Benjamin, Kubinski, Sabrina, Tapken, Ines, Bünermann, Ines, Hazell, Gareth, Ahlskog, Nina, Claus, Peter, Davies, Kay E., Kothary, Rashmi, Wood, Matthew J. A., and Bowerman, Melissa
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- 2022
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29. An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides
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Baker, Ysobel R., Thorpe, Cameron, Chen, Jinfeng, Poller, Laura M., Cox, Lina, Kumar, Pawan, Lim, Wooi F., Lie, Lillian, McClorey, Graham, Epple, Sven, Singleton, Daniel, McDonough, Michael A., Hardwick, Jack S., Christensen, Kirsten E., Wood, Matthew J. A., Hall, James P., El-Sagheer, Afaf H., and Brown, Tom
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- 2022
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30. HOIL1 regulates group 2 innate lymphoid cell numbers and type 2 inflammation in the small intestine
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Wood, Matthew J., Marshall, Jeffrey N., Hartley, Victoria L., Liu, Ta-Chiang, Iwai, Kazuhiro, Stappenbeck, Thaddeus S., and MacDuff, Donna A.
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- 2022
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31. Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19
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Ahern, David J, Ai, Zhichao, Ainsworth, Mark, Allan, Chris, Allcock, Alice, Angus, Brian, Ansari, M Azim, Arancibia-Cárcamo, Carolina, Aschenbrenner, Dominik, Attar, Moustafa, Baillie, J Kenneth, Barnes, Eleanor, Bashford-Rogers, Rachael, Bashyal, Archana, Beer, Sally, Berridge, Georgina, Beveridge, Amy, Bibi, Sagida, Bicanic, Tihana, Blackwell, Luke, Bowness, Paul, Brent, Andrew, Brown, Andrew, Broxholme, John, Buck, David, Burnham, Katie, Byrne, Helen, Camara, Susana, Ferreira, Ivan Candido, Charles, Philip, Chen, Wentao, Chen, Yi-Ling, Chong, Amanda, Clutterbuck, Elizabeth, Coles, Mark, Conlon, Christopher, Cornall, Richard, Cribbs, Adam, Curion, Fabiola, Davenport, Emma, Davidson, Neil, Davis, Simon, Dendrou, Calliope, Dequaire, Julie, Dib, Lea, Docker, James, Dold, Christina, Dong, Tao, Downes, Damien, Drakesmith, Hal, Dunachie, Susanna, Duncan, David, Eijsbouts, Chris, Esnouf, Robert, Espinosa, Alexis, Etherington, Rachel, Fairfax, Benjamin, Fairhead, Rory, Fang, Hai, Fassih, Shayan, Felle, Sally, Fernandez Mendoza, Maria, Ferreira, Ricardo, Fischer, Roman, Foord, Thomas, Forrow, Aden, Frater, John, Fries, Anastasia, Gallardo Sanchez, Veronica, Garner, Lucy, Geeves, Clementine, Georgiou, Dominique, Godfrey, Leila, Golubchik, Tanya, Gomez Vazquez, Maria, Green, Angie, Harper, Hong, Harrington, Heather, Heilig, Raphael, Hester, Svenja, Hill, Jennifer, Hinds, Charles, Hird, Clare, Ho, Ling-Pei, Hoekzema, Renee, Hollis, Benjamin, Hughes, Jim, Hutton, Paula, Jackson-Wood, Matthew, Jainarayanan, Ashwin, James-Bott, Anna, Jansen, Kathrin, Jeffery, Katie, Jones, Elizabeth, Jostins, Luke, Kerr, Georgina, Kim, David, Klenerman, Paul, Knight, Julian, Kumar, Vinod, Kumar Sharma, Piyush, Kurupati, Prathiba, Kwok, Andrew, Lee, Angela, Linder, Aline, Lockett, Teresa, Lonie, Lorne, Lopopolo, Maria, Lukoseviciute, Martyna, Luo, Jian, Marinou, Spyridoula, Marsden, Brian, Martinez, Jose, Matthews, Philippa, Mazurczyk, Michalina, McGowan, Simon, McKechnie, Stuart, Mead, Adam, Mentzer, Alexander, Mi, Yuxin, Monaco, Claudia, Montadon, Ruddy, Napolitani, Giorgio, Nassiri, Isar, Novak, Alex, O'Brien, Darragh, O'Connor, Daniel, O'Donnell, Denise, Ogg, Graham, Overend, Lauren, Park, Inhye, Pavord, Ian, Peng, Yanchun, Penkava, Frank, Pereira Pinho, Mariana, Perez, Elena, Pollard, Andrew, Powrie, Fiona, Psaila, Bethan, Quan, T Phuong, Repapi, Emmanouela, Revale, Santiago, Silva-Reyes, Laura, Richard, Jean-Baptiste, Rich-Griffin, Charlotte, Ritter, Thomas, Rollier, Christine, Rowland, Matthew, Ruehle, Fabian, Salio, Mariolina, Sansom, Stephen Nicholas, Sanches Peres, Raphael, Santos Delgado, Alberto, Sauka-Spengler, Tatjana, Schwessinger, Ron, Scozzafava, Giuseppe, Screaton, Gavin, Seigal, Anna, Semple, Malcolm, Sergeant, Martin, Simoglou Karali, Christina, Sims, David, Skelly, Donal, Slawinski, Hubert, Sobrinodiaz, Alberto, Sousos, Nikolaos, Stafford, Lizzie, Stockdale, Lisa, Strickland, Marie, Sumray, Otto, Sun, Bo, Taylor, Chelsea, Taylor, Stephen, Taylor, Adan, Thongjuea, Supat, Thraves, Hannah, Todd, John, Tomic, Adriana, Tong, Orion, Trebes, Amy, Trzupek, Dominik, Tucci, Felicia Anna, Turtle, Lance, Udalova, Irina, Uhlig, Holm, van Grinsven, Erinke, Vendrell, Iolanda, Verheul, Marije, Voda, Alexandru, Wang, Guanlin, Wang, Lihui, Wang, Dapeng, Watkinson, Peter, Watson, Robert, Weinberger, Michael, Whalley, Justin, Witty, Lorna, Wray, Katherine, Xue, Luzheng, Yuen Yeung, Hing, Yin, Zixi, Young, Rebecca, Youngs, Jonathan, Zhang, Ping, Zurke, Yasemin-Xiomara, Banning, Adrian, Antonopoulos, Alexios, Bajaj, Amrita, Kelion, Andrew, Deshpande, Aparna, Kardos, Attila, Hudson, Benjamin, Koo, Bon-Kwon, Shirodaria, Cheerag, Xie, Cheng, Kotanidis, Christos, Mahon, Ciara, Berry, Colin, Adlam, David, Newby, David, Connolly, Derek, Scaletta, Diane, Alexander, Donna, Nicol, Ed, McAlindon, Elisa, Oikonomou, Evangelos, Pugliese, Francesca, Pontone, Gianluca, Benedetti, Giulia, He, Guo-Wei, West, Henry, Kondo, Hidekazu, Benedek, Imre, Das, Intrajeet, Deanfield, John, Graby, John, Greenwood, John, Rodrigues, Jonathan, Ge, Junbo, Channon, Keith, Fabritz, Larissa, Fan, Li-Juan, Kingham, Lucy, Guglielmo, Marco, Lyasheva, Maria, Schmitt, Matthias, Beer, Meinrad, Anderson, Michelle, Desai, Milind, Marwan, Mohamed, Takahashi, Naohiko, Mehta, Nehal, Dai, Neng, Screaton, Nicholas, Sabharwal, Nikant, Maurovich-Horvat, Pál, Rao, Praveen, Kotronias, Rafail, Kharbanda, Rajesh, Preston, Rebecca, Wood, Richard, Blankstein, Ron, Rajani, Ronak, Mirsadraee, Saeed, Munir, Shahzad, Thomas, Sheena, Neubauer, Stefan, Klömpken, Steffen, Petersen, Steffen, Achenbach, Stephan, Anthony, Susan, Mak, Sze, Mittal, Tarun, Benedek, Theodora, Sharma, Vinoda, Lin, Wen-Hua, Kotanidis, Christos P, Rodrigues, Jonathan C L, O’Connor, Daniel, Siddique, Muhammad, Lockstone, Helen, Oikonomou, Evangelos K, Badi, Ileana, Lumley, Sheila F, Constantinides, Bede, Sanderson, Nicholas, Rodger, Gillian, Chau, Kevin K, Lodge, Archie, Tsakok, Maria, Gleeson, Fergus, Indrajeet, Das, Hudson, Benjamin J, Srivastava, Vivek, Farid, Shakil, Krasopoulos, George, Sayeed, Rana, Newby, David E, Channon, Keith M, and Antoniades, Charalambos
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- 2022
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32. Fake it ‘til you make it: Hazards of a cultural norm in entrepreneurship
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Wood, Matthew S., Scheaf, David J., and Dwyer, Sean M.
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- 2022
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33. Preliminary Results of the Fermi High-Latitude Extended Source Catalog
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Wood, Matthew, Biteau, Jonathan, Caputo, Regina, Di Mauro, Mattia, and Meyer, Manuel
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We report on preliminary results from the Fermi High-Latitude Extended Sources Catalog (FHES), a comprehensive search for spatially extended gamma-ray sources at high Galactic latitudes ($|b|>5^\circ$) based on data from the Fermi Large Area Telescope (LAT). While the majority of high-latitude LAT sources are extragalactic blazars that appear point-like within the LAT angular resolution, there are several physics scenarios that predict the existence of populations of spatially extended sources. If Dark Matter consists of Weakly Interacting Massive Particles, the annihilation or decay of these particles in subhalos of the Milky Way would appear as a population of unassociated gamma-ray sources with finite angular extent. Gamma-ray emission from blazars could also be extended (so-called pair halos) due to the deflection of electron-positron pairs in the intergalactic magnetic field (IGMF). The pairs are produced in the absorption of gamma rays in the intergalactic medium and subsequently up-scatter photons of background radiation fields to gamma-ray energies. Measurement of pair halos could provide constraints on the strength and coherence length scale of the IGMF. In a dedicated search, we find 21 extended sources and 16 sources not previously characterized as extended. Limits on the flux of the extended source components are used to derive constraints on the strength of the IGMF using spectral and spatial templates derived from Monte Carlo simulations of electromagnetic cascades. This allows us to constrain the IGMF to be stronger than $3\times10^{-16}\,$G for a coherence length $\lambda \gtrsim 10\,$kpc., Comment: Proc. 35th ICRC, Busan, South Korea, PoS(ICRC2017)647
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- 2017
34. Gammapy - A prototype for the CTA science tools
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Deil, Christoph, Zanin, Roberta, Lefaucheur, Julien, Boisson, Catherine, Khélifi, Bruno, Terrier, Régis, Wood, Matthew, Mohrmann, Lars, Chakraborty, Nachiketa, Watson, Jason, Coto, Rubén López, Klepser, Stefan, Cerruti, Matteo, Lenain, Jean-Philippe, Acero, Fabio, Djannati-Ataï, Arache, Pita, Santiago, Bosnjak, Zeljka, Ruiz, José Enrique, Trichard, Cyril, Vuillaume, Thomas, Donath, Axel, King, Johannes, Jouvin, Léa, Owen, Ellis, Arribas, Manuel Paz, Sipocz, Brigitta, Lennarz, Dirk, Voruganti, Arjun, and Spir-Jacob, Marion
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Gammapy is a Python package for high-level gamma-ray data analysis built on Numpy, Scipy and Astropy. It enables us to analyze gamma-ray data and to create sky images, spectra and lightcurves, from event lists and instrument response information, and to determine the position, morphology and spectra of gamma-ray sources. So far Gammapy has mostly been used to analyze data from H.E.S.S. and Fermi-LAT, and is now being used for the simulation and analysis of observations from the Cherenkov Telescope Array (CTA). We have proposed Gammapy as a prototype for the CTA science tools. This contribution gives an overview of the Gammapy package and project and shows an analysis application example with simulated CTA data., Comment: Proc. 35th ICRC, Busan, South Korea, PoS(ICRC2017)766
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- 2017
35. Business School Research
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Cornuel, Eric, Thomas, Howard, and Wood, Matthew
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Management education ,Business schools ,Business research impact ,Business school leadership ,Social impact ,Higher education ,Deans ,thema EDItEUR::K Economics, Finance, Business and Management::KC Economics ,thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJS Sales and marketing ,thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJU Organizational theory and behaviour ,thema EDItEUR::J Society and Social Sciences::JP Politics and government ,thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJM Management and management techniques::KJMB Management: leadership and motivation ,thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJM Management and management techniques::KJMV Management of specific areas::KJMV7 Sales and marketing management - Abstract
This second book in the EFMD Management Education series explores business schools’ increasing focus on, and search for, meaningful societal and economic research impact. This involves, in particular, co-operation and collaboration in both knowledge creation and implementation of the findings of academic research in practice. Business schools have a critical role to play in ‘rewiring’ our missions for research relevance, impact and reach, and in recognising needs and addressing real issues of society and economy. With cases from a range of international business schools, the book doesn’t simply highlight the need for the dominant research model in business schools to evolve, but illustrates how this can happen in practice. In so doing, it opens the discussion on how the business school can contribute in very real ways to solving global and complex challenges such as climate change, rising inequalities, international isolationism, eroding democratic systems, and the spread of fake news. These are goals that the EFMD has championed since its inception, and this book will be of value and interest to policy makers and business leaders seeking insight into how management education will be shaped to support business and wider society, as well as those working in business schools and higher education leaders. The Open Access version of this book, available at http://www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives (CC-BY-NC-ND) 4.0 license.
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- 2024
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36. Proof of concept of peptide-linked blockmiR-induced MBNL functional rescue in myotonic dystrophy type 1 mouse model
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Overby, Sarah J., Cerro-Herreros, Estefanía, González-Martínez, Irene, Varela, Miguel A., Seoane-Miraz, David, Jad, Yahya, Raz, Richard, Møller, Thorleif, Pérez-Alonso, Manuel, Wood, Matthew J., Llamusí, Beatriz, and Artero, Rubén
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- 2022
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37. Cellular and molecular heterogeneity in the synovial tissue of osteoarthritis patients
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Wood, Matthew John
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616.7 - Abstract
Osteoarthritis (OA) is the most common form of arthritis and one of the leading causes of disability globally. There are no disease modifying treatments, and for end stage disease, total joint replacement is the only therapeutic option. There is a major unmet clinical need for OA patients. Compared to peripheral blood and inflammatory arthritis (IA), there has been less research into the cellular mechanisms and inflammatory processes involved in the synovial tissue of OA. A barrier to this research has been difficulty in isolating cells from tissues at the site of disease activity. I aimed to identify and compare the cellular phenotype, functional capacity and gene expression of synovial tissue mononuclear cell subsets in OA and IA. After assessing an array of published tissue digestion protocols, I developed a standardised synovial tissue digestion protocol allowing the isolation of multiple cell subsets with high yields, preserved cellular antigens and high cell viability. A multi-colour flow cytometry panel was established to allow the accurate identification and fluorescence-activated cell sorting of cDC2 dendritic cells, CD14+ monocytes, HLA-DR+CD14+ macrophages and CD4+ T cells. Computational analysis of flow cytometry data sets demonstrated greater cellular infiltrate in IA, but an increased proportion of macrophages in OA. However, this proportion was not seen in all OA patients. Owing to their increased but varied proportion, and previously described role in OA pathogenesis, I conducted an in-depth analyses of these cells. OA macrophages had higher expression of surface proteins associated with activation such as CD206, FOLR2 and CD86. Functionality of isolated macrophages was retained, demonstrated by their high phagocytic activity. Next generation RNA-sequencing was performed to better understand their function and heterogeneity in OA synovial tissue. Two distinctive OA endotypes were proposed based on functional gene signatures. One gene signature comprised of cell cycle and proliferation mechanisms, whilst the other consisted of cartilage and tissue development. Despite its central role in arthritic processes, the role of the synovium has remained obscure. This optimised digestion protocol now allows the interrogation of individual cell subsets. Analysis of synovial macrophages using this protocol has demonstrated distinct endotypes within OA patients. Improved investigation into the pathogenesis of OA, especially in the context of OA subtypes, can now be conducted. This could ultimately lead to the modification of treatment strategies for OA patients.
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- 2018
38. Fermipy: An open-source Python package for analysis of Fermi-LAT Data
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Wood, Matthew, Caputo, Regina, Charles, Eric, Di Mauro, Mattia, Magill, Jeffrey, and Perkins, Jeremy
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Fermipy is an open-source python framework that facilitates analysis of data collected by the Fermi Large Area Telescope (LAT). Fermipy is built on the Fermi Science Tools, the publicly available software suite provided by NASA for the LAT mission. Fermipy provides a high-level interface for analyzing LAT data in a simple and reproducible way. The current feature set includes methods for extracting spectral energy distributions and lightcurves, generating test statistic maps, finding new source candidates, and fitting source position and extension. Fermipy leverages functionality from other scientific python packages including NumPy, SciPy, Matplotlib, and Astropy and is organized as a community-developed package following an open-source development model. We review the current functionality of Fermipy and plans for future development., Comment: Proc. 35th ICRC, Busan, South Korea, PoS(ICRC2017)824
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- 2017
39. Reduced capsaicin-induced mechanical allodynia and neuronal responses in the dorsal root ganglion in the presence of protein tyrosine phosphatase non-receptor type 6 overexpression.
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Vroman, Robin, Ishihara, Shingo, Fullam, Spencer, Wood, Matthew J, Adamczyk, Natalie S, Lomeli, Nolan, Malfait, Fransiska, Malfait, Anne-Marie, Miller, Rachel E, and Markovics, Adrienn
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DORSAL root ganglia ,PROTEIN-tyrosine phosphatase ,PHOSPHOPROTEIN phosphatases ,TRPV cation channels ,NUCLEIC acid hybridization ,SPINAL nerve roots - Abstract
Transient Receptor Potential Vanilloid 1 (TRPV1) is a nonselective cation channel expressed by pain-sensing neurons and has been an attractive target for the development of drugs to treat pain. Recently, Src homology region two domain-containing phosphatase-1 (SHP-1, encoded by Ptpn6) was shown to dephosphorylate TRPV1 in dorsal root ganglia (DRG) neurons, which was linked with alleviating different pain phenotypes. These previous studies were performed in male rodents only and did not directly investigate the role of SHP-1 in TRPV-1 mediated sensitization. Therefore, our goal was to determine the impact of Ptpn6 overexpression on TRPV1-mediated neuronal responses and capsaicin-induced pain behavior in mice of both sexes. Twelve-week-old male and female mice overexpressing Ptpn6 (Shp1-Tg) and their wild type (WT) littermates were used. Ptpn6 overexpression was confirmed in the DRG of Shp1-Tg mice by RNA in situ hybridization and RT-qPCR. Trpv1 and Ptpn6 were found to be co-expressed in DRG sensory neurons in both genotypes. Functionally, this overexpression resulted in lower magnitude intracellular calcium responses to 200 nM capsaicin stimulation in DRG cultures from Shp1-Tg mice compared to WTs. In vivo, we tested the effects of Ptpn6 overexpression on capsaicin-induced pain through a model of capsaicin footpad injection. While capsaicin injection evoked nocifensive behavior (paw licking) and paw swelling in both genotypes and sexes, only WT mice developed mechanical allodynia after capsaicin injection. We observed similar level of TRPV1 protein expression in the DRG of both genotypes, however, a higher amount of tyrosine phosphorylated TRPV1 was detected in WT DRG. These experiments suggest that, while SHP-1 does not mediate the acute swelling and nocifensive behavior induced by capsaicin, it does mediate a protective effect against capsaicin-induced mechanical allodynia in both sexes. The protective effect of SHP-1 might be mediated by TRPV1 dephosphorylation in capsaicin-sensitive sensory neurons of the DRG. [ABSTRACT FROM AUTHOR]
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- 2024
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40. Open high-level data formats and software for gamma-ray astronomy
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Deil, Christoph, Boisson, Catherine, Kosack, Karl, Perkins, Jeremy, King, Johannes, Eger, Peter, Mayer, Michael, Wood, Matthew, Zabalza, Victor, Knödlseder, Jürgen, Hassan, Tarek, Mohrmann, Lars, Ziegler, Alexander, Khelifi, Bruno, Dorner, Daniela, Maier, Gernot, Pedaletti, Giovanna, Rosado, Jaime, Contreras, José Luis, Lefaucheur, Julien, Brügge, Kai, Servillat, Mathieu, Terrier, Régis, Walter, Roland, and Lombardi, Saverio
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
In gamma-ray astronomy, a variety of data formats and proprietary software have been traditionally used, often developed for one specific mission or experiment. Especially for ground-based imaging atmospheric Cherenkov telescopes (IACTs), data and software are mostly private to the collaborations operating the telescopes. However, there is a general movement in science towards the use of open data and software. In addition, the next-generation IACT instrument, the Cherenkov Telescope Array (CTA), will be operated as an open observatory. We have created a Github organisation at https://github.com/open-gamma-ray-astro where we are developing high-level data format specifications. A public mailing list was set up at https://lists.nasa.gov/mailman/listinfo/open-gamma-ray-astro and a first face-to-face meeting on the IACT high-level data model and formats took place in April 2016 in Meudon (France). This open multi-mission effort will help to accelerate the development of open data formats and open-source software for gamma-ray astronomy, leading to synergies in the development of analysis codes and eventually better scientific results (reproducible, multi-mission). This write-up presents this effort for the first time, explaining the motivation and context, the available resources and process we use, as well as the status and planned next steps for the data format specifications. We hope that it will stimulate feedback and future contributions from the gamma-ray astronomy community., Comment: 6 pages, 4 figures, Gamma 2016 conference poster contribution
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- 2016
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41. Neurofibromin knockdown in glioma cell lines is associated with changes in cytokine and chemokine secretion in vitro.
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Wood, Matthew D, Mukherjee, Joydeep, and Pieper, Russell O
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Neuroglia ,Cell Line ,Tumor ,Humans ,Neurofibromin 1 ,RNA ,Messenger ,Gene Expression Profiling ,Gene Expression Regulation ,Gene Knockdown Techniques ,Endoglin ,Chitinase-3-Like Protein 1 ,Cell Line ,Tumor ,RNA ,Messenger - Abstract
The neurofibromin-1 tumor suppressor gene (NF1) is altered in approximately 20% of sporadic glioblastoma (GBM) cases. NF1 deficient GBM frequently shows a mesenchymal gene expression signature, suggesting a relationship between NF1 status and the tumor microenvironment. To identify changes in the production of secreted cytokines/chemokines in NF1 deficient glioma, we applied cytokine arrays to conditioned media from a panel of three GBM cell lines after siRNA-mediated NF1 knockdown. We identified increased secretion of platelet-derived growth factor AA (PDGF-AA), chitinase-3-like protein 1 (CHI3L1), interleukin-8 (IL-8), and endoglin (ENG) in different subsets of these cell lines. Secretion was associated with induction of the corresponding messenger RNA, suggesting a mechanism involving transcriptional upregulation. By contrast, in non-transformed immortalized normal human astrocytes, PDGF-AA secretion was increased upon NF1 knockdown, while secreted CHI3L1, ENG, and IL-8 were reduced or unchanged. Analysis of The Cancer Genome Atlas confirmed a relationship between glioma NF1 status and ENG and CHI3L1 in tumor samples. Overall, this study identifies candidate changes in secreted proteins from NF1 deficient glioma cells that could influence the tumor microenvironment, and suggests a direct link between NF1 loss and increased tumor cell production of CHI3L1 and endoglin, two factors implicated in mesenchymal identity in glioblastoma.
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- 2018
42. Genomic analysis of the origins and evolution of multicentric diffuse lower-grade gliomas
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Hayes, Josie, Yu, Yao, Jalbert, Llewellyn E, Mazor, Tali, Jones, Lindsey E, Wood, Matthew D, Walsh, Kyle M, Bengtsson, Henrik, Hong, Chibo, Oberndorfer, Stefan, Roetzer, Thomas, Smirnov, Ivan V, Clarke, Jennifer L, Aghi, Manish K, Chang, Susan M, Nelson, Sarah J, Woehrer, Adelheid, Phillips, Joanna J, Solomon, David A, and Costello, Joseph F
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Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Brain Disorders ,Orphan Drug ,Brain Cancer ,Genetics ,Biotechnology ,Cancer Genomics ,Cancer ,Neurosciences ,Human Genome ,Rare Diseases ,Clinical Research ,Adult ,Biomarkers ,Tumor ,Brain Neoplasms ,Clonal Evolution ,Female ,Genomics ,Glioma ,Humans ,Male ,Middle Aged ,Mutation ,Neoplasm Grading ,Phylogeny ,Young Adult ,astrocytoma ,bilateral ,IDH1 ,multicentric ,oligodendroglioma ,Oncology & Carcinogenesis ,Oncology and carcinogenesis - Abstract
BackgroundRare multicentric lower-grade gliomas (LGGs) represent a unique opportunity to study the heterogeneity among distinct tumor foci in a single patient and to infer their origins and parallel patterns of evolution.MethodsIn this study, we integrate clinical features, histology, and immunohistochemistry for 4 patients with multicentric LGG, arising both synchronously and metachronously. For 3 patients we analyze the phylogeny of the lesions using exome sequencing, including one case with a total of 8 samples from the 2 lesions.ResultsOne patient was diagnosed with multicentric isocitrate dehydrogenase 1 (IDH1) mutated diffuse astrocytomas harboring distinct IDH1 mutations, R132H and R132C; the latter mutation has been associated with Li-Fraumeni syndrome, which was subsequently confirmed in the patient's germline DNA and shown in additional cases with The Cancer Genome Atlas data. In another patient, phylogenetic analysis of synchronously arising grade II and grade III diffuse astrocytomas demonstrated a single shared mutation, IDH1 R132H, and revealed convergent evolution via non-overlapping mutations in ATRX and TP53. In 2 cases, there was divergent evolution of IDH1-mutated and 1p/19q-codeleted oligodendroglioma and IDH1-mutated and 1p/19q-intact diffuse astrocytoma, occurring synchronously in one case and metachronously in a second.ConclusionsEach tumor in multicentric LGG cases may arise independently or may diverge very early in their development, presenting as genetically and histologically distinct tumors. Comprehensive sampling of these lesions can therefore significantly alter diagnosis and management. Additionally, somatic IDH1 R132C mutation in either multicentric or solitary LGG identifies unsuspected germline TP53 mutation, validating the limited number of published cases.
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- 2018
43. MRI Features and IDH Mutational Status of Grade II Diffuse Gliomas: Impact on Diagnosis and Prognosis.
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Villanueva-Meyer, Javier E, Wood, Matthew D, Choi, Byung Se, Mabray, Marc C, Butowski, Nicholas A, Tihan, Tarik, and Cha, Soonmee
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Biomedical and Clinical Sciences ,Clinical Sciences ,Brain Disorders ,Cancer ,Brain Cancer ,Biomedical Imaging ,Clinical Research ,Rare Diseases ,Adult ,Age Factors ,Brain Neoplasms ,Contrast Media ,Female ,Glioma ,Humans ,Isocitrate Dehydrogenase ,Magnetic Resonance Imaging ,Male ,Middle Aged ,Neoplasm Grading ,Organometallic Compounds ,Prognosis ,Risk Factors ,grade II diffuse gliomas ,IDH ,isocitrate dehydrogenase ,low-grade glioma ,MRI ,Nuclear Medicine & Medical Imaging ,Clinical sciences - Abstract
ObjectiveGrade II diffuse gliomas (DGs) with isocitrate dehydrogenase (IDH) mutations are associated with better prognosis than their IDH wild-type counterparts. We sought to determine the MRI characteristics associated with IDH mutational status and ascertain whether MRI considered in combination with IDH mutational status can better predict the clinical outcomes of grade II DGs.Materials and methodsPreoperative MRI examinations were retrospectively studied for qualitative tumor characteristics, including location, extent, cortical involvement, margin sharpness, cystic component, mineralization or hemorrhage, and contrast enhancement. Quantitative diffusion and perfusion metrics were also assessed. Logistic regression and ROC analyses were used to evaluate the relationship between MRI features and IDH mutational status. The association between IDH mutational status, 1p19q codeletion, MRI features, extent of resection, and clinical outcomes was assessed by Kaplan-Meier and Cox proportional hazards models.ResultsOf 100 grade II DGs, 78 were IDH mutant and 22 were IDH wild type. IDH wild-type tumors were associated with older age, multifocality, brainstem involvement, lack of cystic change, and a lower apparent diffusion coefficient (ADC). Multivariable regression showed that age older than 45 years as well as low minimum ADC (ADCmin), mean ADC, and maximum ADC values were independently associated with IDH mutational status. Of these, an ADCmin threshold of 0.9 × 10-3 mm2/s or less provided the greatest sensitivity and specificity (91% and 76%, respectively) in defining IDH wild-type grade II DGs. Combining low ADCmin with IDH wild-type status conferred worse outcomes than did IDH wild-type status alone.ConclusionIDH wild-type grade II DGs are associated with a lower ADC and poor clinical outcomes. Combining IDH mutational status and ADC may allow more accurate prediction of clinical outcomes for patients with grade II DGs.
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- 2018
44. Multimodal molecular analysis of astroblastoma enables reclassification of most cases into more specific molecular entities.
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Wood, Matthew D, Tihan, Tarik, Perry, Arie, Chacko, Geeta, Turner, Clinton, Pu, Cunfeng, Payne, Christopher, Yu, Alexander, Bannykh, Serguei I, and Solomon, David A
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Brain ,Humans ,Neoplasms ,Neuroepithelial ,Brain Neoplasms ,Tumor Suppressor Proteins ,Diagnosis ,Differential ,Immunohistochemistry ,Retrospective Studies ,Phenotype ,Adult ,Aged ,Child ,Female ,Male ,Neoplasm Grading ,Genotyping Techniques ,CNS-HGNET-MN1 ,DNA methylation profiling ,astroblastoma ,next-generation sequencing ,Trans-Activators ,Neoplasms ,Neuroepithelial ,Diagnosis ,Differential ,Brain Disorders ,Biotechnology ,Cancer ,Brain Cancer ,Genetics ,Human Genome ,Genetic Testing ,Rare Diseases ,Neurosciences ,2.1 Biological and endogenous factors ,Clinical Sciences ,Neurology & Neurosurgery - Abstract
Astroblastoma is a rare and controversial glioma with variable clinical behavior. The diagnosis currently rests on histologic findings of a circumscribed glioma with astroblastomatous pseudorosettes and vascular hyalinization. Immunohistochemical studies have suggested different oncogenic drivers, such as BRAF p.V600E, but very few cases have been studied using genome-wide methodologies. Recent genomic profiling identified a subset of CNS embryonal tumors with astroblastoma-like morphology that harbored MN1 gene fusions, termed "CNS high-grade neuroepithelial tumors with MN1 alteration" (CNS-HGNET-MN1). To further characterize the genetic alterations that drive astroblastomas, we performed targeted next-generation sequencing (NGS) of 500 cancer-associated genes in a series of eight cases. We correlated these findings with break-apart fluorescence in situ hybridization (FISH) analysis of the MN1 locus and genome-wide DNA methylation profiling. Four cases showed MN1 alteration by FISH, including two pediatric cases that lacked other pathogenic alterations, and two adult cases that harbored other cancer-associated gene mutations or copy number alterations (eg, CDKN2A/B homozygous deletion, TP53, ATM and TERT promoter mutations). Three of these cases grouped with the CNS-HGNET-MN1 entity by methylation profiling. Two of four MN1 intact cases by FISH showed genetic features of either anaplastic pleomorphic xanthoastrocytoma (BRAF p.V600E mutation, CDKN2A/B homozygous deletion and TERT promoter mutation) or IDH-wildtype glioblastoma (trisomy 7, monosomy 10, CDK4 amplification and TP53, NRAS and TERT promoter mutations) and these cases had an aggressive clinical course. Two clinically indolent cases remained unclassifiable despite multimodal molecular analysis. We conclude that astroblastoma histology is not specific for any entity including CNS-HGNET-MN1, and that additional genetic characterization should be considered for astroblastomas, as a number of these tumors likely contain a methylation profile or genetic alterations that suggest classification as other tumor entities. Our heterogeneous molecular findings help to explain the clinical unpredictability of astroblastoma.
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- 2018
45. Scalable purification of extracellular vesicles with high yield and purity using multimodal flowthrough chromatography
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Bonner, Scott E., primary, van de Wakker, Simonides I., additional, Phillips, William, additional, Willms, Eduard, additional, Sluijter, Joost P. G., additional, Hill, Andrew F., additional, Wood, Matthew J. A., additional, and Vader, Pieter, additional
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- 2024
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46. Why is early-onset atrial fibrillation uncommon in patients with Duchenne muscular dystrophy? Insights from the mdx mouse
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Nguyen, My-Nhan, primary, Hooper, Charlotte, additional, Stefanini, Matilde, additional, Vrellaku, Besarte, additional, Carnicer, Ricardo, additional, Wood, Matthew J, additional, Simon, Jillian N, additional, and Casadei, Barbara, additional
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- 2024
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47. Crystal structure and analytical profile of 1,2-diphenyl-2-pyrrolidin-1-ylethanone hydrochloride or `α-D2PV': a synthetic cathinone seized by law enforcement, along with its diluent sugar, myo-inositol
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Wood, Matthew R., primary, Bernal, Ivan, additional, and Lalancette, Roger A., additional
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- 2024
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48. Science communication as interdisciplinary training
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Wood, Matthew, primary
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- 2023
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49. The development of a new conceptual and theoretical approach to social marketing
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Wood, Matthew
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658.8 ,N000 Business and Management - Abstract
Social marketing is the adaptation of commercial marketing principles, tools and approaches to programmes designed to influence the voluntary behaviour of target audiences to improve their personal welfare and that of society of which they are a part. The idea that marketing tools and techniques could be used to promote social good and help address social problems was developed in the late 1960s and early 1970s, when it was argued that marketing is relevant to all organisations with "customers". According to this early view of social marketing, commercial approaches, such as the 4Ps (product, price, place, promotion) framework, could be used to influence individuals. This view places responsibility for change on individuals and largely ignores the systematic and environmental influences on behaviours. This critical review is underpinned by the need for a new perspective on social marketing, recognising the complexities of behaviour change and focusing on human beings within a systems/socio-ecological context. It starts by challenging the traditional view of social marketing and the applicability of models such as the 4Ps. Subsequent papers build upon this by demonstrating behaviour change is dependent on relationships, emotional connections, community cohesion and communications between human beings. A new behavioural change framework was developed and tested to demonstrate how this approach could be applied in practice. This model was developed further to include a unique view of 'midstream social marketing', which proposes service staff, and the interactions they have with clients and other stakeholders, is of critical importance for behaviour change. Since the relevant paper was published, midstream social marketing features regularly in journal papers and conferences. This critical review also adds to social marketing knowledge tlu·ough the adaptation and application of the socio-ecological model to the discipline. The author's research shows how the resilience construct -the ability of individuals and communities to cope with adversity -can be used to integrate upstream (policy level), midstrean1 (organisational and community level) and downstream (individual level) social marketing approaches, underpinned by socio-ecological models of behaviour. This extends the more common use of resilience in the context of ecological sustainability or response to disasters. For the first time, this thesis demonstrates how social marketers can use developmental psychology and social work theory to shift their thinking away from targeting individual behaviour problems (smoking, dangerous drinking and unhealthy eating etc.) towards working with young people, families and communities to build long-term resilience to a range of risk factors.
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- 2017
50. Sensitivity Projections for Dark Matter Searches with the Fermi Large Area Telescope
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Charles, Eric, Sanchez-Conde, Miguel, Anderson, Brandon, Caputo, Regina, Cuoco, Alessandro, Di Mauro, Mattia, Drlica-Wagner, Alex, Gomez-Vargas, German, Meyer, Manuel, Tibaldo, Luigi, Wood, Matthew, Zaharijas, Gabrijela, Zimmer, Stephan, Ajello, Marco, Albert, Andrea, Baldini, Luca, Bechtol, Keith, Bloom, Elliott, Ceraudo, Francesco, Cohen-Tanugi, Johann, Digel, Seth, Gaskins, Jennifer, Gustafsson, Michael, Mirabal, Nestor, and Razzano, Massimiliano
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
The nature of dark matter is a longstanding enigma of physics; it may consist of particles beyond the Standard Model that are still elusive to experiments. Among indirect search techniques, which look for stable products from the annihilation or decay of dark matter particles, or from axions coupling to high-energy photons, observations of the $\gamma$-ray sky have come to prominence over the last few years, because of the excellent sensitivity of the Large Area Telescope (LAT) on the Fermi Gamma-ray Space Telescope mission. The LAT energy range from 20 MeV to above 300 GeV is particularly well suited for searching for products of the interactions of dark matter particles. In this report we describe methods used to search for evidence of dark matter with the LAT, and review the status of searches performed with up to six years of LAT data. We also discuss the factors that determine the sensitivities of these searches, including the magnitudes of the signals and the relevant backgrounds, considering both statistical and systematic uncertainties. We project the expected sensitivities of each search method for 10 and 15 years of LAT data taking. In particular, we find that the sensitivity of searches targeting dwarf galaxies, which provide the best limits currently, will improve faster than the square root of observing time. Current LAT limits for dwarf galaxies using six years of data reach the thermal relic level for masses up to 120 GeV for the $b\bar{b}$ annihilation channel for reasonable dark matter density profiles. With projected discoveries of additional dwarfs, these limits could extend to about 250 GeV. With as much as 15 years of LAT data these searches would be sensitive to dark matter annihilations at the thermal relic cross section for masses to greater than 400 GeV (200 GeV) in the $b\bar{b}$ ($\tau^+ \tau^-$) annihilation channels., Comment: Updated with a few additional and corrected references; otherwise, text is identical to previous version. Submitted on behalf of the Fermi-LAT collaboration. Accepted for publication in Physics Reports, 59 pages, 34 figures; corresponding author: Eric Charles (echarles@slac.stanford.edu)
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- 2016
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