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3. Hydroxyl‐α‐Sanshool Maintains Intestinal Health in Obese Mice Fed a High‐Fat Diet by Activating AMPK Signaling.

Author

Zhu, Yuping, Xu, Fangyan, Li, Bei, Ren, Tingyuan, and Zhou, Xuelin

Subjects
*AMINO acid metabolism, *AMP-activated protein kinases, *GUT microbiome, *METABOLOMICS, *METABOLISM
Abstract

To explore the effects of hydroxyl‐α‐sanshool (HAS) administration on the intestinal health of high‐fat diet‐fed mice, mice were separated into a control (CN) group, a model (MC) group, a HAS (8 mg/kg bw) (HD) group, and a HAS (8 mg/kg bw) + Compound C (10 mg/kg·4 d) (HA) group. After 4 weeks of treatment, the mice were fasted for 12 h prior to sacrifice, and autopsy samples were taken for analysis. HAS improved inflammatory and metabolic imbalances by activating AMPK, as shown by biochemical, microbiota composition, and metabolomics analyses. These findings suggest that HAS can maintain intestinal health through AMPK‐mediated amino acid metabolism. [ABSTRACT FROM AUTHOR]

Published
2024
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4. WCN24-2261 SYSTEMIC HISTOPATHOLOGY AND CALCIUM CHEMICAL COMPOSITION ANALYSIS IN EXTRACUTANEOUS TISSUES FROM A UREMIC CALCIPHYLAXIS PATIENT WHO UNDERWENT TREATMENT WITH HUMAN AMNION-DERIVED MESENCHYMAL STEM CELL

Author

Wang, Ningning, primary, Li, Cui, additional, Yu, Youjia, additional, Yang, Guang, additional, Cao, Yue, additional, Xu, Fangyan, additional, Ren, Wenkai, additional, Yuan, Yanggang, additional, Ji, Qiang, additional, Zhang, Zhiwei, additional, Gu, Mufeng, additional, Ding, Yan, additional, Liang, Ningxia, additional, Liu, Jiayin, additional, Qin, Lianju, additional, and Chen, Feng, additional

Published
2024
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6. The protective role of glucocerebrosidase/ceramide in rheumatoid arthritis

Author

Yang, Mingfeng, Gu, Juanfang, Xu, Fangyan, Wang, Yiwen, Wang, Hongzhi, and Zhang, Bin

Subjects
musculoskeletal diseases, Interleukin-6, Synovial Membrane, Interleukin-18, Cell Biology, Fibroblasts, musculoskeletal system, Ceramides, Arthritis, Experimental, Biochemistry, Arthritis, Rheumatoid, Mice, Rheumatology, Animals, Cytokines, Glucosylceramidase, Proteoglycans, Orthopedics and Sports Medicine, Inflammation Mediators, skin and connective tissue diseases, Molecular Biology, Cells, Cultured
Abstract

To clarify the role of glucocerebrosidase (GBA) and Ceramide (Cer) in rheumatoid arthritis (RA). GBA-expressing lentivirus were constructed and injected into collagen-induced arthritis (CIA) mice, and compared with CIA mice injected with empty vector. The severity of arthritis and inflammatory mediators were evaluated. Fibroblast-like synoviocytes (FLS) from RA patients were transfected with GBA-expressing lentivirus, or pretreated with C6-Cer. The migration and invasion of FLS, the production of inflammatory cytokines, and the relevant signaling pathways were assessed. In CIA mice, GBA markedly improved arthritis compared to that in the CIA mice, with increased content of proteoglycan and integral cartilage surfaces and tidemarks. The circulating inflammatory mediators, including interleukin (IL)-1β, IL-6, IL-18, and matrix metalloproteinase (MMP)-1, were significantly reduced in CIA mice with GBA overexpression compared to those in CIA mice. GBA and C6-Cer treatment inhibited migration and invasion of FLS, and suppressed production of inflammatory cytokines and activation of the MAPK pathways. GBA/Cer exhibited a protective role in CIA mice and RA FLS. These results highlight the potential of targeting GBA/Cer as a therapeutic strategy in RA and warrant further investigation.

Published
2022
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8. Nomogram Model Based on Clinical Risk Factors and Heart Rate Variability for Predicting All-Cause Mortality in Stage 5 CKD Patients

Author

Gao, Xueyan, primary, Wang, Jing, additional, Huang, Hui, additional, Ye, Xiaoxue, additional, Cui, Ying, additional, Ren, Wenkai, additional, Xu, Fangyan, additional, Qian, Hanyang, additional, Gao, Zhanhui, additional, Zeng, Ming, additional, Yang, Guang, additional, Huang, Yaoyu, additional, Tang, Shaowen, additional, Xing, Changying, additional, Wan, Huiting, additional, Zhang, Lina, additional, Chen, Huimin, additional, Jiang, Yao, additional, Zhang, Jing, additional, Xiao, Yujie, additional, Bian, Anning, additional, Li, Fan, additional, Wei, Yongyue, additional, and Wang, Ningning, additional

Published
2022
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9. A novel long-term intravenous combined with local treatment with human amnion-derived mesenchymal stem cells for a multidisciplinary rescued uremic calciphylaxis patient and the underlying mechanism

Author

Qin, Lianju, primary, Zhang, Jing, additional, Xiao, Yujie, additional, Liu, Kang, additional, Cui, Yugui, additional, Xu, Fangyan, additional, Ren, Wenkai, additional, Yuan, Yanggang, additional, Jiang, Chunyan, additional, Ning, Song, additional, Ye, Xiaoxue, additional, Zeng, Ming, additional, Qian, Hanyang, additional, Bian, Anning, additional, Li, Fan, additional, Yang, Guang, additional, Tang, Shaowen, additional, Zhang, Zhihong, additional, Dai, Juncheng, additional, Guo, Jing, additional, Wang, Qiang, additional, Sun, Bin, additional, Ge, Yifei, additional, Ouyang, Chun, additional, Xu, Xueqiang, additional, Wang, Jing, additional, Huang, Yaoyu, additional, Cui, Hongqing, additional, Zhou, Jing, additional, Wang, Meilian, additional, Su, Zhonglan, additional, Lu, Yan, additional, Wu, Di, additional, Shi, Jingping, additional, Liu, Wei, additional, Dong, Li, additional, Pan, Yinbing, additional, Zhao, Baiqiao, additional, Cui, Ying, additional, Gao, Xueyan, additional, Gao, Zhanhui, additional, Ma, Xiang, additional, Chen, Aiqin, additional, Wang, Jie, additional, Cao, Meng, additional, Cui, Qian, additional, Chen, Li, additional, Chen, Feng, additional, Yu, Youjia, additional, Ji, Qiang, additional, Zhang, Zhiwei, additional, Gu, Mufeng, additional, Zhuang, Xiaojun, additional, Lv, Xiaolin, additional, Wang, Hui, additional, Pan, Yanyan, additional, Wang, Ling, additional, Xu, Xianrong, additional, Zhao, Jing, additional, Wang, Xiuqin, additional, Liu, Cuiping, additional, Liang, Ningxia, additional, Xing, Changying, additional, Liu, Jiayin, additional, and Wang, Ningning, additional

Published
2022
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10. Effects of parathyroidectomy on plasma PTH fragments and heart rate variability in stage 5 chronic kidney disease patients

Author

Chen, Huimin, primary, Ren, Wenkai, additional, Gao, Zhanhui, additional, Zeng, Ming, additional, Tang, Shaowen, additional, Xu, Fangyan, additional, Huang, Yaoyu, additional, Zhang, Lina, additional, Cui, Ying, additional, Yang, Guang, additional, Qian, Hanyang, additional, Zhou, Wenbin, additional, Ouyang, Chun, additional, Gao, Xueyan, additional, Zhang, Jing, additional, Xiao, Yujie, additional, Zhao, Baiqiao, additional, Wang, Jing, additional, Bian, Anning, additional, Li, Fan, additional, Wan, Huiting, additional, Gao, Wei, additional, Wang, Xiaoyun, additional, Xing, Changying, additional, Zha, Xiaoming, additional, and Wang, Ningning, additional

Published
2021
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11. novel long-term intravenous combined with local treatment with human amnion-derived mesenchymal stem cells for a multidisciplinary rescued uremic calciphylaxis patient and the underlying mechanism.

Author

Qin, Lianju, Zhang, Jing, Xiao, Yujie, Liu, Kang, Cui, Yugui, Xu, Fangyan, Ren, Wenkai, Yuan, Yanggang, Jiang, Chunyan, Ning, Song, Ye, Xiaoxue, Zeng, Ming, Qian, Hanyang, Bian, Anning, Li, Fan, Yang, Guang, Tang, Shaowen, Zhang, Zhihong, Dai, Juncheng, and Guo, Jing

Abstract

Calciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis, with high mortality and no proven therapy. Here, we reported a severe uremic calciphylaxis patient with progressive skin ischemia, large areas of painful malodorous ulcers, and mummified legs. Because of the worsening symptoms and signs refractory to conventional therapies, treatment with human amnion-derived mesenchymal stem cells (hAMSCs) was approved. Preclinical release inspections of hAMSCs, efficacy, and safety assessment, including cytokine secretory ability, immunocompetence, tumorigenicity, and genetics analysis in vitro , were introduced. We further performed acute and long-term hAMSC toxicity evaluations in C57BL/6 mice and rats, abnormal immune response tests in C57BL/6 mice, and tumorigenicity tests in neonatal Balbc-nu nude mice. After the preclinical research, the patient was treated with hAMSCs by intravenous and local intramuscular injection and external supernatant application to the ulcers. When followed up to 15 months, the blood-based markers of bone and mineral metabolism improved, with skin soft tissue regeneration and a more favorable profile of peripheral blood mononuclear cells. Skin biopsy after 1-month treatment showed vascular regeneration with mature noncalcified vessels within the dermis, and 20 months later, the re-epithelialization restored the integrity of the damaged site. No infusion or local treatment-related adverse events occurred. Thus, this novel long-term intravenous combined with local treatment with hAMSCs warrants further investigation as a potential regenerative treatment for uremic calciphylaxis due to effects of inhibiting vascular calcification, stimulating angiogenesis and myogenesis, anti-inflammatory and immune modulation, multidifferentiation, re-epithelialization, and restoration of integrity. [ABSTRACT FROM AUTHOR]

Published
2022
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12. Comparison of microwave ablation treatments in patients with renal secondary and primary hyperparathyroidism

Author

Ma, Haoyang, primary, Ouyang, Chun, additional, Huang, Yaoyu, additional, Xing, Changying, additional, Cheng, Chen, additional, Liu, Wei, additional, Yuan, Donglan, additional, Zeng, Ming, additional, Yu, Xiangbao, additional, Ren, Haibin, additional, Yuan, Yanggang, additional, Zhang, Lina, additional, Xu, Fangyan, additional, Cui, Ying, additional, Ren, Wenkai, additional, Huang, Hui, additional, Qian, Hanyang, additional, Fan, Boqiang, additional, and Wang, Ningning, additional

Published
2020
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