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BACKGROUND: The incidence of breast and colorectal cancer (CRC) in younger-than-average-age patients is rising and poorly understood. This is the largest study on patients with both cancers who are less than 60 years old and aims to characterize demographic, clinicopathologic, and genetic features and describe therapeutic dilemmas and management strategies. MATERIALS AND METHODS: This is a retrospective medical records review of patients at the University of California San Francisco with both primary breast and CRC before age 60. RESULTS: Fifty-one patients were identified; 41 had detailed medical records. Median age of diagnosis with breast cancer was 43 (range 27-59) and CRC was 50 (28-59). Most were Caucasian (38, 74.5%) and never smokers (23, 56.1%); about half were current alcohol consumers (20, 48.8%) and about one-third had sedentary jobs (14, 34.1%). Average BMI was 25.8 (range: 14-49), and 30% were overweight or obese. Breast was the first cancer diagnosed in 36 patients (70.6%) and 44 (86.3%) had a metachronous CRC diagnosis. Breast cancer was early stage (0-2) in 32 (78.0%) patients whereas CRC was split between early stage (1-2) in 14 (34.1%) and later stage (3-4) in 19 (46.2%). Ten patients (24.3%) had a known germline mutation, although 23 (56.1%) had a family history of cancer in a first-degree relative. CONCLUSION: Younger patients with both breast and CRC are a unique cohort, often without known risk factors. Alcohol consumption and sedentary jobs were the most common risk factors, and about one-quarter had a known genetic predisposition. Comanagement of both cancers requires individualized, multidisciplinary care.

Background: Archetypal ideas originate from the collective unconscious of humans and because they are embedded in the nature and institution of humans, and in everything that is the product of human thought, taste and feeling, they appear. From the point of view of the schema, excesses in the formation of psychological needs cause the formation of schemas. Literary works, including poetry, due to the fact that it comes from the human soul, are connected with archetypal ideas and poetry is considered as a collective unconscious medium of humans. Aims: The purpose of the current research is the psychological reflection of archetypal ideas (Yang) in the poems of modernist Kurdish poets (not selected poets). Methods: In this regard, in this article written in a library method, archetypal ideas in the poems of several modernist Kurdish poets have been investigated. Results: The results of the research show that these poets have used archetypal images and images abundantly in their poetry. Of course, this has several reasons; One is that most of these poets are in conflict with the manifestations of civilization and urbanization, and they present the elements of nature and countryside as an unattainable dream in their poetry, and this directly causes the elements of nature and archetypal images to enter their poetry. The second reason is that most of these poets have a political and social orientation and themes such as freedom and homeland are considered central themes of their poems, but due to the limitations, they are forced to turn to symbolic and ambiguous language. Conclusion: These poets turn to similes and metaphors to express the themes of freedom and homeland, and this causes natural and archetypal elements to enter their poems. [ABSTRACT FROM AUTHOR]

Early, mild and young COPD concepts are not clearly defined and are often used interchangeably to refer to the onset of the disease. Objective: To describe and compare the characteristics of mild, young and early COPD in a large sample of COPD from primary and secondary care. Methods: Pooled analysis of individual data from four multicenter observational studies of patients with stable COPD (≥40 years, FEV1/FVC < 0.7, smoking ≥ 10 pack-years). Mild COPD was defined as FEV1% ≥ 65%; young COPD as <55 years; and early COPD as <55 years and smoking ≤ 20 pack-years. The relationship between FEV1(%), age and pack-years was analyzed with linear regression equations. Results: We included 5468 patients. Their mean age was 67 (SD: 9.6) years, and 85% were male. A total of 1158 (21.2%) patients had mild COPD; 636 (11.6%) had young COPD and 191 (3.5%) early COPD. The three groups shared common characteristics: they were more frequently female, younger and with less tobacco exposure compared with the remaining patients. Early COPD had fewer comorbidities and fewer COPD admissions, but no significant differences were found in ambulatory exacerbations. In linear regression analysis, the decline in FEV1(%) was more pronounced for the first 20 pack-years for all age groups and was even more important in younger patients. Conclusions: Mild, young and early COPD patients were more frequently women. The steepest decline in FEV1(%) was observed in individuals <55 years and smoking between 10 and 20 pack-years (early COPD), which highlights the importance of an early detection and implementation of preventive and therapeutic measures. [ABSTRACT FROM AUTHOR]

Objective: Young Australian males 15-to-24-years-old have a high prevalence of mental health disorders and suicide but are least likely to seek professional mental health support. Most help-seeking studies fail to consider young males who are disengaged from mainstream education. This research aims to gain an enriched understanding about mental health literacy and help-seeking from the perspective of young rural males disengaged from mainstream education. Method: Participants included sixteen males aged 15-to-24-years. All participants had disengaged from mainstream education and had experienced disadvantage. Qualitative methodology was employed using reflexive thematic analysis to analyse interview transcripts and develop themes. Results: There were four major themes and three subthemes: 1) contextual influence, with subtheme of cultural influence; 2) a spectrum of knowledge with subtheme of subjective threshold; 3) battling stigma; and 4) genuine connection, with subtheme of redefining service models. Conclusions: This research provides the first known insight into the help-seeking perspectives of young rural males disengaged from education. Their narratives, highlight that help-seeking is valued yet action remains ambivalent and hindered by understandings of mental health literacy, stigma, and service models. For these young men, genuine connection that honours their context and experiences is more important than demonstrating clinical expertise. This research offers practical suggestions for tailoring mental health services to meet the needs of young rural men disengaged from education. Keypoints: What is already known about this topic: Young Australian, rural males aged 15–24 years old are at heightened risk of ill mental health and suicide. Young males who disengage from mainstream education face considerable challenges which require support, yet they are amongst the least likely to seek mental health support. Barriers and facilitators to mental health help-seeking for young people are well documented within the literature and youth participation contributes valuable information towards service design and policies for youth mental health services. What this topic adds: This qualitative research provides the first known insight into mental health help-seeking from the perspective of young rural males disengaged from education. Through participant voice, this research captures in depth understanding regarding mental health literacy and stigma for young rural males disengaged from education. This research contributes vital knowledge about how services and policies can improve equity of service provision and help-seeking for young rural males disengaged from education. [ABSTRACT FROM AUTHOR]

Background: The aim of this study is to investigate the effects of a school-based high-intensity interval training (HIIT) program on quality of life and physical fitness in adolescents. Methods: The study included 60 male adolescents (16.2 ± 0.6 years), randomly assigned to one of two groups: the HIIT group (n = 30) and the control group (CG, n = 30). Participants completed the KIDSCREEN-27 questionnaire to evaluate quality of life and physical fitness tests, including vertical jump, repetitive strength, agility, and flexibility. The experimental program consisted of a 12-week intervention integrated into the warm-up phase of regular physical education (PE) classes. Each PE class lasted 45 min, with the HIIT regimen occupying 10 min of the warm-up phase. The HIIT sessions followed a Tabata-style structure, performed twice weekly. A two-way ANOVA with repeated measures assessed group and time interaction effects. Results: The results revealed changes in physical well-being following the HIIT intervention (p = 0.01) compared to the control group (p = 0.42). The results of the two-way ANOVA with repeated measures revealed interaction effects between group and time for the various fitness tests, countermovement jump (p = 0.04), 4 × 10 m agility test (p = 0.02), medicine ball throw test (p = 0.04), and sit-ups (30 s) (p = 0.01). Conclusions: This study highlights the effectiveness of school-based HIIT in significantly enhancing physical well-being and physical fitness among adolescents. [ABSTRACT FROM AUTHOR]

Background and purpose Methods Results Conclusions Knowledge about the prevalence of atrial fibrillation (AF) in young stroke patients, as well as its associated factors and outcomes, is scarce. Our objective was to analyse it.A retrospective analysis of the Spain Nationwide Minimum Basic Data Set (MBDS) (2016–2020), including ischaemic stroke (IS) patients aged 18 and 50 years, was conducted. Multivariate analyses were conducted to identify factors related to AF diagnosis.Amongst 11,615 young IS patients, 426 (3.7%) had AF. Patients with AF were older (median age 45, interquartile range 42–48 vs. 44, interquartile range 40–47 years, p < 0.001) and displayed more incapacitating symptoms, higher in‐hospital complications and were less often discharged home (p < 0.001). Multivariate analyses showed that older age (odds ratio [OR] 1.053, 95% confidence interval [CI] 1.032–1.074), obstructive sleep apnoea (OR 1.508, 95% CI 1.018–2.233), hyperthyroidism (OR 3.741, 95% CI 1.798–7.783), valvular heart disease (OR 6.094, 95% CI 4.261–8.716), congenital (OR 2.386, 95% CI 1.146–4.969) and non‐congenital (OR 4.446, 95% CI 3.149–6.278) cardiopathies and heart failure (OR 3.098, 95% CI 1.905–5.037) were independently associated with higher probability of AF, whereas female gender (OR 0.647, 95% CI 0.516–0.812), diabetes mellitus (0.487, 95% CI 0.339–0.699), smoking (OR 0.617, 95% CI 0.501–0.759), patent foramen ovale (OR 0.210, 95% CI 0.111–0.396) and arterial dissection (OR 0.294, 95% CI 0.130–0.668) were associated with a lower probability.In young IS patients, AF is associated with more in‐hospital complications and disabling strokes. These findings emphasize the need to recognize AF in this demographic group, especially in patients with risk factors like hyperthyroidism and cardiomyopathies. Clinicians should assess these risk factors to ensure timely diagnosis and management of AF. [ABSTRACT FROM AUTHOR]

Background: The diagnosis of colorectal cancer (CRC) at early ages has become a challenging trend for oncology due to high rates of mortality worldwide. The correlation of clinical features with young-age prognosis in CRC remains unclear. Therefore, we aimed to describe the clinicopathological features and their impact on the overall survival of young Mexican adults diagnosed with CRC treated in the National Cancer Institute. Methods: This was a retrospective, observational study. The included patients were treated at the National Cancer Institute between 2004 and 2020. The statistical analyses comprised the X2 and t tests, Kaplan–Meier, log rank, and Cox regression. Statistical significances were assessed when p was bilaterally < 0.05. Results: A total of 3652 patients diagnosed with CRC attended the National Cancer Institute. Cases of early onset of CRC increased over the 16 years under study, with significant differences between the median age, from 57 in 2004 to 55 years old in 2020 (F = 5.49; gl: 12 p = 0.019). For this analysis, the population was divided in three groups: young (≤30 years), adults (31–70), and elderly (>70). The young population was mostly composed of men (62%; (n = 63), (p = 0.020), with high rates of metastatic disease (44%) (p = 0.001) and right-side tumors (57%), (p = 0.046), and with 44% with a moderate grade (p = 0.750). According to the overall survival (OS) analysis, the median OS was 29 months for young, versus 170 months for adult and 56 months for elderly patients (p <0.001, HR 1.53, 95% CI 1.11–2.10). A sub-analysis was performed considering only patients with metastatic disease. The median OS was 12 months for young, versus 17 and 9 months for adults and elderly (p = 0.08, HR 1.27, 95% CI 1.02–1.46). Conclusions: CRC diagnosis in the young population is increasing due unhealthy lifestyle habits and lack of screening. This population have clinical features of bad prognosis, such as left side, poor grade differentiation, and metastatic disease, precluding prognosis and OS. [ABSTRACT FROM AUTHOR]

Hereditary aortopathies are a group of rare genetic diseases affecting the aorta and its major branches, and they represent a cause of sudden cardiac death. These pathologies are classified into syndromic hereditary aortopathies and non-syndromic hereditary aortopathies. The epidemiology of hereditary aortopathies varies according to the specific genetic condition involved; however, these disorders are believed to account for a significant proportion of sudden cardiac death in young individuals with a family history of inherited cardiovascular conditions. The causes of hereditary aortopathies are primarily genetic, with pathogenic variants in various genes encoding structural proteins of the vascular wall, leading to dissection, aneurysms, rupture, and ultimately sudden cardiac death. When the cause of death remains unknown after an autopsy, it is referred to as sudden unexplained death, and post-mortem genetic testing, known as a molecular autopsy, is crucial to confirm hereditary aortopathies and assess the genetic risk in the patient's relatives. This helps to facilitate diagnostic and therapeutic pathways and/or implement monitoring strategies to prevent sudden cardiac death. In this state-of-the-art review, we focus on syndromic and non-syndromic hereditary aortopathies causing sudden cardiac death in the young and explore preventive strategies for affected family members. [ABSTRACT FROM AUTHOR]

BackgroundSmartphone apps may provide an opportunity to deliver mental health resources and interventions in a scalable and cost-effective manner. However, young people from marginalized and underserved groups face numerous and unique challenges to accessing, engaging with, and benefiting from these apps.ObjectiveThis study aims to better understand the acceptability (ie, perceived usefulness and satisfaction with an app) and feasibility (ie, the extent to which an app was successfully used) of mental health apps for underserved young people. A secondary aim was to establish whether adaptations can be made to increase the accessibility and inclusivity of apps for these groups.MethodsWe conducted 2 sequential studies, consisting of a systematic literature review of mental health apps for underserved populations followed by a qualitative study with underserved young male participants (n=20; age: mean 19). Following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, an electronic search of 5 databases was conducted in 2021. The search yielded 18,687 results, of which 14 articles met the eligibility criteria.ResultsThe included studies comprised a range of groups, including those affected by homelessness, having physical health conditions, living in low- and middle-income countries, and those with sexual and gender minority identities. Establishing and maintaining user engagement was a pervasive challenge across mental health apps and populations, and dropout was a reported problem among nearly all the included studies. Positive subjective reports of usability, satisfaction, and acceptability were insufficient to determine users' objective engagement.ConclusionsDespite the significant amount of funding directed to the development of mental health apps, juxtaposed with only limited empirical evidence to support their effectiveness, few apps have been deliberately developed or adapted to meet the heterogeneous needs of marginalized and underserved young people. Before mental health apps are scaled up, a greater understanding is needed of the types of services that more at-risk young people and those in limited-resource settings prefer (eg, standard vs digital) followed by more rigorous and consistent demonstrations of acceptability, effectiveness, and cost-effectiveness. Adopting an iterative participatory approach by involving young people in the development and evaluation process is an essential step in enhancing the adoption of any intervention, including apps, in "real-world" settings and will support future implementation and sustainability efforts to ensure that marginalized and underserved groups are reached.Trial registrationPROSPERO CRD42021254241; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=254241.

The proportion of young individuals that present with acute myocardial infarction is a major problem that keeps increasing. The specific characteristics of premature coronary artery disease and its differences between young and older individuals need to be elucidated. Although risk factors are similar in different age categories, there is a great difference in their prevalence. The vast majority of young patients are males and there is a higher prevalence of cigarette smoking, family history of premature coronary artery disease, lipid disorders, and illicit drug use, while the prevalence of hypertension and diabetes mellitus is lower. Young individuals with acute coronary syndrome usually present either with ST-segment elevation or non-ST-segment elevation myocardial infarction. It is not unusual for young patients to present with atypical symptoms to the office of primary care physicians, leading occasionally to incorrect or delayed diagnosis. Therefore, prompt and correct diagnosis is necessary to implement the specific management as quickly as possible. A literature research of studies was conducted for the last 10 years, regarding the risk factors and prevention of premature myocardial infarction. As databases, we used PubMed and peer reviewed journals. The aim of this review is to raise awareness among family medicine and primary care physicians, regarding the clinical presentation of young patients with acute myocardial infarction, to provide optimal medical attention.

Introduction: Chemonucleolysis with condoliase is a minimally invasive treatment option for lumbar disk herniation (LDH). However, studies reporting the efficacy of condoliase in patients aged

It has been observed that married women refrain from utilizing contraceptive methods owing to a variety of reasons, including postpartum-amenorrhea, side-effects-worries, rarely or never having sex, no contraception while breastfeeding, or frustration with a particular method. The current study sought to investigate the sociodemographic disparities and contributing factors related to married women who are young (15–24 years old) and non-young (25–49 years old) and who do not utilize contemporary contraceptive methods. The research utilized cross-sectional data obtained from the fifth round of the National Family Health Survey (NFHS-5) to explore the determinants of contraceptive non-utilization among 175,652 married women in India. Multiple logistic regression analysis was utilized for the examination. The study found that non-young married females (25-49) had a higher prevalence of not using contemporary contraceptives (72%) compared to young married females (45.8%). The majority of non-users were from the central region (24.4%), followed by the east (17.4%), north-east (17.2%), north (15.9%), south (15.2%), and west region (9.9%). The majority of non-users were non-working and had male and female household heads. Most non-users knew about modern contraceptives but were unaware of family planning on radio and TV. Higher odds ratios in the non-use among married females were found significant among central-region females (OR=2.189, CI: 1.815-2.641), East-region (OR=1.324, CI: 1.148-1.527), South-region (OR=1.262, CI: 1.063-1.497), females who don’t know caste (OR=1.898, CI: 1.176-3.062), females having primary (OR=3.466, CI: 2.889-4.157) and secondary education (OR=2.281, CI: 1.890-2.753), females who used since last birth (OR=1.851, CI: 1.658-2.068) and never used (OR=1.632, CI: 1.474-1.806). The study found that economically disadvantaged females, household heads, and those with multiple children are less likely to avoid birth control methods, while marital status, religion, caste, education, and birth order did not have a significant impact on non-usage. The study highlights sociodemographic disparities in contraceptive use, emphasizing the need to address issues like low education, media exposure, and ignorance towards birth-control practices, and recommends immediate actions to reduce non-use among married females.

Background and objectives: COVID-19 vaccination program has become a global priority to combat the worldwide pandemic. Studies claimed that severity and case fatality could be minimized by vaccination. The durability of antibodies developed after vaccination is crucial for preventing COVID-19. The purpose of this study was to investigate the dynamics of antibody responses to an inactivated SARS-CoV-2 virus vaccine over time. Materials and method: The study was conducted from November 2021 to November 2022 among young adults. A pre-tested structured questionnaire was used to record the socio-demographic and clinical data of all the participants. All the participants were vaccinated with two doses of Sinopharm COVID-19 vaccine. Blood samples were collected for estimation of IgG antibodies to SARS-CoV-2 spike S1 protein by indirect ELISA. Biochemical parameters namely random blood sugar (RBS), lipid profile, total protein, thyroid stimulating hormone (TSH), FT4 (free thyroxin) and vitamin D levels were determined in baseline samples by standard methods. Result: Total 348 adults, aged 18-28 years, were enrolled and of which 35.3% and 64.7% were male and female respectively. Out of 348 participants, 51.7% was seropositive for anti- SARS-CoV-2 antibodies before receiving vaccination. Seropositivity was not significantly (p >0.05) different in male and female participants before and after vaccination. Seropositivity at 1 month after 1st dose and 4 and 7 months after 2nd dose of vaccination increased significantly (p 0.05) different before and after vaccination in participants having adequate and insufficient/deficient vitamin D levels. Conclusion: The study revealed that a good proportion of young adults possessed anti- SARS-CoV-2 antibody before vaccination and the seropositivity increased to over 90% following vaccination with Sinopharm COVID-19 vaccine. High level of anti- SARS-CoV-2 antibody persisted 7 months after 2nd dose of vaccine. July 2024; Vol. 18(2):012. DOI:https://doi.org/10.55010/imcjms.18.024 *Correspondence: Nehlin Tomalika, Department of Community Medicine & Public Health, Ibrahim Medical College, 1/A, Ibrahim Sarani, Segunbagicha, Dhaka 1000, Bangladesh. Email: nehlintomalika@gmail.com

Background: Breast cancer (BC) in adolescents and young adults (AYAs, aged 15--39 years), remains inadequately understood. The incidence of BC in AYAs has been steadily increasing, making it the second leading cause of cancer-related mortality among females aged 0--39 globally. This study aimed to elucidate the clinical characteristics and long-term outcomes of AYAs and older adults (OAs, aged > 39 years) with BC who underwent surgery. Methods: From January 2011 to June 2017, BC patients who underwent surgery were enrolled in this study and divided into AYA group and OA group. Clinical characteristics, recurrence-free survival (RFS), and overall survival (OS) were compared between these two groups, both before and after propensity score matching (PSM). Univariate and multivariate Cox proportional hazard regression analyses were performed to assess the influence of age on OS and RFS. Results: Compared to the OA group, the AYA group exhibited a younger age at menarche (p < 0.001), a lower prevalence of menopausal status (p < 0.001), a reduced occurrence of comorbid conditions (p < 0.001), fewer instances of undergoing mastectomy (p = 0.031), a higher incidence of Triple-Negative Breast Cancer (TNBC) (p = 0.046), and elevated Ki-67 levels (p = 0.036). In terms of prognostic outcomes, within the study cohort, AYAs had a higher mortality rate and poorer long-term survival compared to OAs, both before and after PSM. In the PSM cohort, AYAs experienced a significantly shorter mean OS (p < 0.001) and RFS (p < 0.001). Young age (15--39 years) emerged as an independent risk factor for OS (HR 2.659, 95% CI 1.385--5.106, p = 0.003) and RFS (HR 3.235, 95% CI 2.085--5.022, p < 0.001) in BC patients following surgery. Conclusion: Significant differences were identified in the clinicopathological characteristics between AYA and OA patients with BC. In comparison to OA patients, AYA patients exhibited a less favorable long-term prognosis, with young age emerging as an independent prognostic risk factor for both OS and RFS in BC patients following surgery. Further investigations are warranted to develop agespecific therapeutic approaches for AYA BC patients. [ABSTRACT FROM AUTHOR]

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Background: Type 1 diabetes is a chronic disease especially affecting young people. Mindfulness-based psychological interventions might reduce emotional symptoms post-diagnosis, but the evidence is limited. Objectives: This systematic review aimed to evaluate the effectiveness of mindfulness interventions on psychological well-being and biomedical variables in young people with type 1 diabetes. Methods: A systematic review of trials was conducted that involved a bibliographic search in electronic databases (Web of Science, MEDLINE, SciELO, Scopus, PsycINFO, and Cochrane Library) considering studies published between 2013 and 2024. Results: A total of 434 records were identified, of which 252 underwent selection according to title and abstract, leaving 32 that were evaluated for eligibility and 7 included in this review. From Google Scholar, six more studies were identified and evaluated, and two were selected. Finally, nine studies were subjected to full reading and a detailed analysis of the inclusion criteria. A total of 66.6% of the studies were evaluated as having a methodological quality of moderate or optimal, but the samples analysed tended to be small, and only two articles carried out short-term follow-up evaluations. Conclusions: Mindfulness-based interventions, upon reviewing the preliminary results, may be posited as a viable strategy to enhance psychological (anxiety, diabetes distress, perceived stress, depression, self-efficacy, psychological well-being, and quality of life) and biomedical outcomes (glycaemic control, blood glucose levels, and diastolic blood pressure) for type 1 diabetes in young people. Although promising, further research is required to improve the quality, methodology, and design of studies. [ABSTRACT FROM AUTHOR]

ABSTRACT: The proportion of young individuals that present with acute myocardial infarction is a major problem that keeps increasing. The specific characteristics of premature coronary artery disease and its differences between young and older individuals need to be elucidated. Although risk factors are similar in different age categories, there is a great difference in their prevalence. The vast majority of young patients are males and there is a higher prevalence of cigarette smoking, family history of premature coronary artery disease, lipid disorders, and illicit drug use, while the prevalence of hypertension and diabetes mellitus is lower. Young individuals with acute coronary syndrome usually present either with ST-segment elevation or non-ST-segment elevation myocardial infarction. It is not unusual for young patients to present with atypical symptoms to the office of primary care physicians, leading occasionally to incorrect or delayed diagnosis. Therefore, prompt and correct diagnosis is necessary to implement the specific management as quickly as possible. A literature research of studies was conducted for the last 10 years, regarding the risk factors and prevention of premature myocardial infarction. As databases, we used PubMed and peer reviewed journals. The aim of this review is to raise awareness among family medicine and primary care physicians, regarding the clinical presentation of young patients with acute myocardial infarction, to provide optimal medical attention. [ABSTRACT FROM AUTHOR]

In the quotidian, people perform voluntary whole-body movements requiring dynamic body balance. However, the literature is scarce of dynamic balance evaluations employing standardized voluntary movements. In this investigation, we aimed to analyze the sensitivity of balance evaluation between gymnasts and athletes from other sports in the performance of balance tasks. Participants were evaluated in upright quiet standing and the performance of cyclic dynamic tasks of hip flexion-extension and squat-lift movements. Movements were individually standardized in amplitude, while the rhythm was externally paced at the frequency of 0.5 Hz. Tasks were performed on a force plate, with dynamic balance measured through the center of pressure displacement. Results showed that in quiet standing and the dynamic hip flexion-extension task, no significant differences were found between the groups. Conversely, results for the squat-lift task revealed a better balance of the gymnasts over controls, as indicated by the reduced amplitude and velocity of the center of pressure displacement during the task execution. The superior balance performance of gymnasts in the squat-lift task was also observed when vision was suppressed. These findings suggest the employed squat-lift task protocol is a potentially sensitive procedure for the evaluation of voluntary dynamic balance. [ABSTRACT FROM AUTHOR]

The Philadelphia-negative chronic myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders predominantly occurring in elderly, whereas in children and young adults are quite infrequent. Therefore, less is known about clinical presentation, genetic abnormalities, prognosis and best management strategies for this groups of patients. Currently, more cases of younger MPN patients are diagnosed. Nevertheless, diagnosis of MPNs, especially in childhood, may be difficult due to lower incidence of JAK2V617F and CALR mutations and differences in peripheral blood counts between adults and children. Challenges for younger MPN patients are longer life expectances, specific psychosocial need, fertility and pregnancy need and a long term therapy side effect (including second cancers). The most severe MPNs complication is transformation to secondary myelofibrosis (MF) or acute myeloid leukemia (AML). Optimal management of young MPNs remains a challenge as the classical risk scores fail in young MPNs. Moreover, the main objective of young MPNs therapy should be the disease outcome modification. Therefore, international collaborative work between pediatricians and "adult hematologists" is required to measure outcomes and generate protocol of management of young MPNs. [ABSTRACT FROM AUTHOR]

Background: Suicide attempts and anxiety are common commodities in patients with major depressive disorder (MDD), and suicide attempts are often associated with anxiety symptoms. Studies have found gender differences in several aspects of MDD; however, gender differences in suicide attempts in young first-episode and drug-naive (FEDN) MDD patients with anxiety remain unknown. This study aimed to investigate potential gender differences in the prevalence of suicide attempts and associated risk factors among young FEDN MDD patients with anxiety in a Chinese Han population. Methods: A cross-sectional study was conducted on 1289 young patients with FEDN MDD. Demographics, clinical characteristics, and biochemical parameters of patients were collected. Results: Suicide attempters accounted for 23.80% and 26.12% of male and female FEDN MDD patients with anxiety, respectively, with no significant gender differences. Binary logistic regression analyses showed that anxiety, clinical global impression severity, and thyroid peroxidase antibody significantly predicted suicide attempts in both male and female FEDN MDD patients with anxiety, while body mass index significantly predicted suicide attempts only in males, and psychotic symptoms predicted suicide attempts only in females. Conclusion: The present study represents the first large-scale investigation of gender differences in the prevalence of suicide attempts and related risk factors among young FEND MDD patients with anxiety in the Chinese Han population. The results indicate that risk factors associated with suicide attempts vary by gender among young FEND MDD patients with anxiety, although a comparable rate of suicide attempts was observed in both female and male patients. [ABSTRACT FROM AUTHOR]

Background The rising prevalence of acute ischemic stroke (AIS) in young adults, particularly with undetermined pathogenesis, is a growing concern. This study assessed risk factors, treatments, and outcomes between young AIS patients with undetermined and determined pathogeneses. Methods and Results This was a retrospective cohort study including AIS patients aged 18 to 55 years in Switzerland, treated between 2014 and 2022. Stroke pathogeneses were classified using a modified TOAST (Trial of ORG 10172 in Acute Stroke Treatment) classification, with undetermined pathogenesis defined as no identified cause (including patent foramen ovale and cervical artery dissection). We examined vascular risk factors, acute treatments, 3‐month functional outcomes, and AIS recurrence within 3 months using logistic regression and Fine–Gray proportional hazards models. Of 3995 patients, 863 (22%) had undetermined pathogenesis. Compared with patients with determined pathogenesis, those with undetermined pathogenesis had a higher prevalence of dyslipidemia (54% versus 59%, P=0.007) and smoking (37% versus 43%, P=0.001), and were more likely to receive intravenous thrombolysis (27% versus 31%, P=0.046). Despite higher 3‐month AIS recurrence risk for the undetermined group (adjusted hazard ratio, 1.72 [95% CI, 1.01–2.94]), favorable functional outcomes at 3 months were more frequent (modified Rankin Scale score, 0–2: 90% versus 87%, P=0.033). Patients aged 46 to 55 years with undetermined pathogenesis had better outcomes than those with determined pathogenesis (modified Rankin Scale score, 0–1: 70% versus 64%, P=0.013; modified Rankin Scale score, 0–2: 89% versus 85%, P=0.023), while those aged 18 to 45 years showed higher recurrence rates (4.5% versus 1.8%, P

Objective Young Australian males 15-to-24-years-old have a high prevalence of mental health disorders and suicide but are least likely to seek professional mental health support. Most help-seeking studies fail to consider young males who are disengaged from mainstream education. This research aims to gain an enriched understanding about mental health literacy and help-seeking from the perspective of young rural males disengaged from mainstream education.Method Participants included sixteen males aged 15-to-24-years. All participants had disengaged from mainstream education and had experienced disadvantage. Qualitative methodology was employed using reflexive thematic analysis to analyse interview transcripts and develop themes.Results There were four major themes and three subthemes: 1) contextual influence, with subtheme of cultural influence; 2) a spectrum of knowledge with subtheme of subjective threshold; 3) battling stigma; and 4) genuine connection, with subtheme of redefining service models.Conclusions This research provides the first known insight into the help-seeking perspectives of young rural males disengaged from education. Their narratives, highlight that help-seeking is valued yet action remains ambivalent and hindered by understandings of mental health literacy, stigma, and service models. For these young men, genuine connection that honours their context and experiences is more important than demonstrating clinical expertise. This research offers practical suggestions for tailoring mental health services to meet the needs of young rural men disengaged from education.

Time-restricted eating (TRE) has been shown to extent lifespans in drosophila and mouse models by affecting metabolic and anti-inflammatory activities. However, the effect of TRE on the human immune system, especially on immunosenescence, intestinal microbiome, and metabolism remains unclear. We conducted a 30-day 16:8 TRE single-arm clinical trial with 49 participants. Participants consumed daily meals from 9 a.m. to 5 p.m., provided by a nutrition canteen with a balanced, calorie-appropriate nutrition, which is designed by clinical nutritionists (ChiCTR2200058137). We monitored weight changes and weight-related parameters and focused on changes in the frequency of CD4+ senescent T cells, immune repertoire from peripheral blood, as well as serum metabolites and gut microbiota. We found that up to 95.9 % of subjects experienced sustained weight loss after TRE. The frequency of circulating senescent CD4+ T cells was decreased, while the frequency of Th1, Treg, Tfh-like, and B cells was increased. Regarding the immune repertoire, the proportions of T cell receptor alpha and beta chains were increased, whereas B cell receptor kappa and lambda chains were reduced. In addition, a reduced class switch recombination from immunoglobulin M (IgM) to immunoglobulin A (IgA) was observed. TRE upregulated the levels of anti-inflammatory and anti-aging serum metabolites named sphingosine-1-phosphate and prostaglandin-1. Additionally, several anti-inflammatory bacteria and probiotics were increased, such as Akkermansia and Rikenellaceae, and the composition of the gut microbiota tended to be “younger”. Overall, TRE showed multiple anti-aging effects, which may help humans maintain a healthy lifestyle to stay “young”. Clinical Trial Registration URL: https://www.chictr.org.cn/showproj.html?proj=159876.

Aims: This research's objective was to explore the correlation of overweight/obesity and suicide attempts in young patients with major depressive disorder (MDD) and the related factors of suicide attempts in patients with/without overweight/obesity. Methods: This study included 520 young patients with MDD who were first-episode and drug-naïve (FEDN), with an average age of 20.50 ± 2.36 years. Height and weight of each subject were measured, and overweight was classified as 24≤BMI

Aim: To identify incidence, type of drug abuse study clinical and angiographic profile in very young population presenting with acute coronary syndrome (ACS). Materials and methods: All consecutive patients less than 30 years with ACS included and segregated into Group 1 and 2 (with and without drug abuse respectively) Result: n = 153; n = 17 in group 1 of whom 35.29 % consumed opium, 17.64 % energy drinks, 17.64 % whey protein supplements, 17.64 % inhaled marijuana, 5.88 % heroin and spasmoproxyvon and 23.52 % multi-substance abusers. STEMI, Single vessel disease and urban domicile were predominant. Rising trends of drug abuse were identified in prospective (28.20 %) versus retrospective (5.30 %) timeframe (p = 0.011). Conclusion: Rising trends of drug abuse, a potentially modifiable risk factor of ACS in the young are alarming. Strict regulations are needed to curb this menace.

Isolated stenosis of the left coronary artery is extremely rare. Studies have shown a 2%–10% incidence of acute myocardial infarction in patients aged 45 years or younger. Stable angina and multivessel disease are uncommon in the young. It is more commonly reported in postmenopausal women. Here, we describe a 30-year-old female who presented to the emergency department with angina. Coronary angiography (CAG) was suggestive of isolated left main coronary artery (LMCA) ostial disease with rest of the coronaries normal. Computed tomography CAG performed with a calcium score of 0 revealed isolated osteoproximal stenosis of the LMCA. The patient was extensively evaluated for all risk factors but was devoid of any. Coronary artery bypass grafting was performed without complications.

Chronic hand eczema (CHE) is persistent inflammatory dermatitis that may significantly affect the quality of life, with psychosocial effects, impact on school, work, and leisure activities, influence on socioeconomic status, and high health care costs. Pediatric-CHE (P-CHE) has a high prevalence yet has not been extensively studied in children and adolescents. There is minimal published data on P-CHE in North America, and no specific management guidelines. Limited prevalence data show broad ranges (0.9%-4.4%) in preschool and school children, with 1 study stating up to 10.0% 1-year prevalence for ages 16 to 19 years. Atopic dermatitis and allergic contact dermatitis appear important in the pathogenesis of this disease process, although there is limited pediatric data assessing disease associations and no standardized methodology for evaluating this disorder. Given the potential life-changing consequences of P-CHE, further research into this disease process is warranted to help generate best therapeutic practices and minimize this disease process' morbidity in adulthood.

In the quotidian, people perform voluntary whole-body movements requiring dynamic body balance. However, the literature is scarce of dynamic balance evaluations employing standardized voluntary movements. In this investigation, we aimed to analyze the sensitivity of balance evaluation between gymnasts and athletes from other sports in the performance of balance tasks. Participants were evaluated in upright quiet standing and the performance of cyclic dynamic tasks of hip flexion-extension and squat-lift movements. Movements were individually standardized in amplitude, while the rhythm was externally paced at the frequency of 0.5 Hz. Tasks were performed on a force plate, with dynamic balance measured through the center of pressure displacement. Results showed that in quiet standing and the dynamic hip flexion-extension task, no significant differences were found between the groups. Conversely, results for the squat-lift task revealed a better balance of the gymnasts over controls, as indicated by the reduced amplitude and velocity of the center of pressure displacement during the task execution. The superior balance performance of gymnasts in the squat-lift task was also observed when vision was suppressed. These findings suggest the employed squat-lift task protocol is a potentially sensitive procedure for the evaluation of voluntary dynamic balance.

Highlight: • Unhealthy lifestyles are believed to be cause of hypertension at a young age. • Untreated hypertension increases cardiovascular disease morbidity and mortality. • The incidence of intracranial hemorrhage associated with hypertension is approximately 60%. It commonly occurs in the deep brain structure, which is considered to have a poor clinical outcome. ABSTRACT Introduction: The incidence of hypertension is currently moving toward younger ages. It’s thought that an unhealthy lifestyle serves as a trigger. Hypertension can increase morbidity and mortality related to cardiovascular disease, even at a young age. This case report is intended to report the incidence of spontaneous intracranial hemorrhage in a 34-year-old male patient during a hypertensive emergency. Case: A 34-year-old male patient was rushed to the emergency unit at midnight due to a sudden decrease in consciousness. Headaches and seizures occurred before admission. The patient denied having any history of head trauma. The patient’s habits included excessive caffeine consumption, frequent late-night sleeping, and extensive smoking. At the time of admission, the patient’s vital signs indicated a poor clinical condition: GCS E1V1M1, BP 212/118 mm/Hg, deep irregular rapid breathing, sometimes followed by periodic apnea, RR 28 breath/minute, HR 111 beat/minute, SpO2 50%, T 36.8°C, which gradually developed hyperthermia. Both eyes had constricted and fixed pupils; the light reflexes were negative. A neurological examination revealed the body’s left lateralization. The head CT scan without contrast indicated hemorrhage in the right intracerebral, midbrain, pons, intraventricular, and subarachnoid areas, with estimated total volume of about 31 ml. Conservative treatment was chosen due to the bleeding location in the deep brain structure of GCS 3, which was considered to have a poor outcome. Conclusion: Hypertension in the younger age group is commonly associated with unhealthy lifestyles, which increase morbidity and mortality related to cardiovascular disease.

This research paper sheds the light on the meaning of the term 'Hybridity' according to Young as shown in the OED and during the nineteenth century which is dominated by colonialism. The spread of the British imperial powers across the different countries lead to the mixing of the various races together. So, Young discusses the prominent ideas that lead to the emergence of racial hybridity such as immigration, diaspora, displacement and others. He also focuses on the debates of the nineteenth century that highlight the theme of racial hybridity in order to determine the specific race of the English nation as it consists of hybrid races. A close reading to Young's analysis to these arguments reveals themes grounded in racism and class distinction. Young in this study resists against the racist theories that are set against the colonized countries during the nineteenth century.This research paper sheds the light on the meaning of the term 'Hybridity' according to Young as shown in the OED and during the nineteenth century which is dominated by colonialism. The spread of the British imperial powers across the different countries lead to the mixing of the various races together.

Abstract Background There is dearth of literature addressing early outcomes of acute coronary syndrome (ACS) among young patients, particularly South Asians descent who are predisposed to premature coronary artery disease (CAD). Therefore, we compared presentation, management, and early outcomes of young vs. old ACS patients and explored predictors of in-hospital mortality. Methods We extracted data of 23,560 ACS patients who presented at Tabba Heart Institute, Karachi, Pakistan, from July 2012-June 2020, from the Chest pain-MI-Registry™. We categorized data into young ≤ 45 and old ACS patients > 45 years. Chi-sq/Fischer exact tests were used to assess the difference between presentation, disease management, and in-hospital mortality between both groups. Logistic regression was used to determine odds ratio along with 95% confidence interval of factors associated with early mortality. Results The younger patients were 12.2% and women 23.5%. The prevalence of dyslipidemia (34.5% vs. 22.4%), diabetes (52.1% vs. 27.4%), and hypertension (68.3% vs. 42.9%) was higher in older patients. Family history of premature CAD (18.1% vs. 32.7%), smoking (40.0% vs. 22.9%), and smokeless tobacco use (6.5% vs. 8.4%) were lower in older patients compared to younger ones. Younger patients were more likely to present with STEMI (33.2% vs. 45%). The median symptom-to-door time was 125 min longer (p-value

Background: Although studies often report the prevalence of obesity, community-based studies reporting the incidence of overweight or obesity in India are scarce. Such incidence data are crucial for improving projections about the future burden of obesity. Methods: A non-concurrent follow-up study was done in 2015 in urban Vellore, Tamil Nadu, among two groups of women aged 30-40 years, with body mass index (BMI) 25 kg/m2. The incidence of overweight (BMI ≥25 kg/m2) in three years, was 29.2% (24/82), among women with a normal BMI (

Abstract Background Motor alterations and lowered physical activity are common in affective disorders. Previous research has indicated a link between depressive symptoms and declining muscle strength primarily focusing on the elderly but not younger individuals. Thus, we aimed to evaluate the relationship between mood and muscle strength in a sample of N = 73 young to middle-aged hospitalized patients (18–49 years, mean age 30.7 years) diagnosed with major depressive, bipolar and schizoaffective disorder, with a focus on moderating effects of psychopharmacotherapy. The study was carried out as a prospective observational study at a German psychiatric university hospital between September 2021 and March 2022. Methods Employing a standardized strength circuit consisting of computerized strength training devices, we measured the maximal muscle strength (Fmax) using three repetitions maximum across four muscle regions (abdomen, arm, back, leg) at three time points (t1-t3) over four weeks accompanied by psychometric testing (MADRS, BPRS, YRMS) and blood lipid profiling in a clinical setting. For analysis of psychopharmacotherapy, medication was split into activating (AM) and inhibiting (IM) medication and dosages were normalized by the respective WHO defined daily dose. Results While we observed a significant decrease of the MADRS score and increase of the relative total Fmax (rTFmax) in the first two weeks (t1-t2) but not later (both p

Introduction: Merkel cell carcinoma (MCC) is a rare neuroendocrine skin tumor associated with Merkel cell polyomavirus and ultraviolet light exposure. MCC typically affects older individuals, and it also influences young patients with immunosuppressive conditions. We report a case of lower eyelid MCC in a non-immunocompromised 37-year-old woman. Case Presentation: A 37-year-old woman presenting with suspected MCC on her right lower eyelid was referred to our hospital for further resection. The patient underwent wide excision with clear margins followed by reconstruction and radiation therapy. The patient has shown no signs of recurrence after 5 months of follow-up. Conclusion: MCC needs to be considered as a possible diagnosis when examining an eyelid tumor in a young patient.

The purpose of this study was to (a) correlate the weekly external training load with the game running performance in season microcycles and (b) specify the optimal training/game ratio of the weekly external load in elite youth soccer players. The total distance (TD), the high-speed running distance (HSRD) (19.8–25.2 km/h), the ZONE6 distance (>25.2 km/h), the acceleration (ACC) (≥+2 m/s2), and the deceleration (DEC) (≥−2 m/s2) were monitored with global positioning system (GPS) technology throughout 18 microcycles and official games. TD had a very high positive correlation average (r = 0.820, p = 0.001), the HSRD had a high positive correlation average (r = 0.658, p = 0.001), the ZONE6 distance and DEC had a moderate positive correlation average ((r = 0.473, p = 0.001) and (r = 0.478, p = 0.001), respectively), and the ACC had a low positive correlation average (r = 0.364, p = 0.001) between microcycles and games. Regarding the training/game ratio, the HSRD showed statistically significant differences between ratios 1.43 and 2.60 (p = 0.012, p ≤ 0.05), the ACC between ratios 2.42 and 4.45 (p = 0.050, p ≤ 0.05) and ratios 3.29 and 4.45 (p = 0.046, p ≤ 0.05), and the DEC between ratios 2.28 and 3.94 (p = 0.034, p ≤ 0.05). Considering the correlation between weekly training and game external load, high weekly training TD values correspond to higher game values, whereas HSRD, ZONE6 distance, ACC, and DEC, which determine training intensity, should be trained in a specific volume. Training/game ratios of 1.43, 2.42 to 3.29, and 2.28 to 3.11 seem to be optimal for HSRD, ACC, and DEC weekly training, respectively. [ABSTRACT FROM AUTHOR]

Background: There is dearth of literature addressing early outcomes of acute coronary syndrome (ACS) among young patients, particularly South Asians descent who are predisposed to premature coronary artery disease (CAD). Therefore, we compared presentation, management, and early outcomes of young vs. old ACS patients and explored predictors of in-hospital mortality. Methods: We extracted data of 23,560 ACS patients who presented at Tabba Heart Institute, Karachi, Pakistan, from July 2012-June 2020, from the Chest pain-MI-Registry™. We categorized data into young ≤ 45 and old ACS patients > 45 years. Chi-sq/Fischer exact tests were used to assess the difference between presentation, disease management, and in-hospital mortality between both groups. Logistic regression was used to determine odds ratio along with 95% confidence interval of factors associated with early mortality. Results: The younger patients were 12.2% and women 23.5%. The prevalence of dyslipidemia (34.5% vs. 22.4%), diabetes (52.1% vs. 27.4%), and hypertension (68.3% vs. 42.9%) was higher in older patients. Family history of premature CAD (18.1% vs. 32.7%), smoking (40.0% vs. 22.9%), and smokeless tobacco use (6.5% vs. 8.4%) were lower in older patients compared to younger ones. Younger patients were more likely to present with STEMI (33.2% vs. 45%). The median symptom-to-door time was 125 min longer (p-value < 0.01) in the young patients compared to the older age group. In-hospital mortality (4.3% vs. 1.7%), cardiac arrest (1.9% vs. 0.7%), cardiogenic shock (1.9% vs. 0.9%), and heart failure (1% vs. 0.6%) were more common in older patients. After adjusting for other factors, younger age (AOR 0.6, 95% CI 1.5–3.7) had significantly lesser odds of in-hospital mortality. Other factors associated with early mortality included women, family history of premature CAD, STEMI, Killip class III and IV, coronary angiography, revascularization, CABG, and use of aspirin and beta blockers within the first 24 h. Conclusion: We found every tenth ACS patient was younger than 45 years of age despite a lesser number of comorbidities such as hypertension and diabetes. Overall, the in-hospital prognosis of young patients was more favorable than that of older patients. The study emphasizes the need for tailored primary prevention programs for ACS, considering the varying risks among different age groups. [ABSTRACT FROM AUTHOR]

Business people are the daring person of the business. A Business visionary needs to get more data from his business. Each business person needs to be familiar with his business information. He acquires information on each circumstance. A business visionary needs to believe the individual who relies upon individuals yet not trust constantly. Each situation wants to be taking better decision-production of his business. Individuals might become too different mentalities and requirements for their fulfillment. So every business visionary needs to be satisfied with his necessities and needs. A youthful business visionary needs to begin a business carefully. The youthful Business person needs to design the business. To execute the young business visionary business is very tuff of dealing with each circumstance. So they complicate all their circumstances. A Business person has to know the delivering situation while business navigation. A worker has been absence of knowledge about his business. The business person needs to give legitimate preparation to them. In this way, an entrepreneur's are exercises not a simple errand. We ought to be examined about the young entrepreneur's difficulties and troubles exhaustively underneath. [ABSTRACT FROM AUTHOR]

Establishing goals for young people in residential care (RC) is a gap in the literature, especially in terms of the relationship between family support and resilience. The literature suggests that RC is associated with the breakdown of family relationships, so the possibility of the family playing a positive role in establishing life goals for young people is reduced. However, family support in the context of organization and stability can be assumed to be a protective factor for the formulation of life goals and contribute to the resilient development of young people. This study aimed to analyze the role of family support in the process of setting goals for young people in RC, as well as to analyze the potential mediating role of resilience in the previous association. The sample included 124 young people aged between 12 and 23 years living in RC. The results point to a positive association between family support (autonomy) and the planning of life goals and verify the total mediating effect of resilience in this association. The results are discussed considering attachment theory and the role of the family in the adaptive development of young people. This study's findings provide important indications for developing future interventions. [ABSTRACT FROM AUTHOR]

Background: The information relating to the outcome specifically for juvenile dogs with meningoencephalitis of unknown etiology (MUE) is lacking. Objectives: To describe the clinical presentation, diagnostic findings, treatment, and outcome in a cohort of dogs with MUE <52 weeks old. Animals: Thirty‐four client‐owned dogs. Methods: Multicenter retrospective case series. Records from 5 referral centers were searched. Data was extracted from the medical records and referring veterinarians were contacted for survival data if this was not available from the record. Results: The mean age was 31 weeks; the youngest dog was 11 weeks and 3 dogs were <16 weeks old. Altered mentation (71%), ataxia (44%), seizures (29%), and circling (26%) were the most common presenting complaints. Neuroanatomical localization was to the forebrain (38%), multifocal (35%), brainstem (18%), and cerebellum (12%). Corticosteroid monotherapy (n = 15) and corticosteroid plus cytosine arabinoside (n = 15) were used in equal proportions. Outcome data was available for 26 dogs, 8 (31%) were alive at the time of data collection with a follow‐up range of 135 to 2944 days. Death or euthanasia was related to MUE in 17/18 dogs that died during the study period. Kaplan‐Meier survival analysis demonstrated a median survival time for all‐cause death of 84 days. Conclusion: The prognosis for MUE in this subset of dogs was considered poor. [ABSTRACT FROM AUTHOR]

Background: Although studies often report the prevalence of obesity, community-based studies reporting the incidence of overweight or obesity in India are scarce. Such incidence data are crucial for improving projections about the future burden of obesity. Methods: A non-concurrent follow-up study was done in 2015 in urban Vellore, Tamil Nadu, among two groups of women aged 30-40 years, with body mass index (BMI) <25 kg/m² (normal) and BMI ≥25 kg/m² (overweight/obese) in 2012, to assess changes in BMI. The sampling frame consisted of 473 women: 209 women with BMI <25 kg/m², and 264 women with BMI ≥25 kg/m², who were part of a cross-sectional survey in 2012. A randomly selected list of 370 women (80% of the original cohort) was used to trace the women. Measurements at follow-up included weight, height, dietary and other risk factors. Results: Of 370 women, 170 (45.9%) were followed up at the end of three years, which included 82 with BMI <25 kg/m² and 88 with BMI >25 kg/m². The incidence of overweight (BMI ≥25 kg/m²) in three years, was 29.2% (24/82), among women with a normal BMI (<25 kg/m²) in 2012. Among the 88 women who were overweight/obese in 2012, there was no regression to normal BMI within the three years of follow-up. There was an association between the incidence of overweight and the intake of carbohydrates (adjusted odds ratios (AORs): 3, 95% confidence interval (CI): 1.04 to 8.63) and protein intake (AOR: 20.0, 95% CI: 2.5 to 158.3). Conclusions: This study found an incidence of nearly one-third (29.2%) of developing high BMI (≥25.0 kg/m²) in 30-40-year-old urban women from Vellore, implying a rapid increase in overweight and obesity among young women. [ABSTRACT FROM AUTHOR]

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Background: The development of autism spectrum disorder (ASD) may stem from exposure to environmental pollutants such as heavy metals. The primary objective of this study is to determine the role of heavy metals of concern such as manganese (Mn), cadmium (Cd), lead (Pb), arsenic (As), and essential trace element selenium (Se) among ASD children in Kuala Lumpur, Malaysia. Method: A total of 155 preschoolers in Kuala Lumpur between the ages 3 to 6 participated in an unmatched case-control study, comprising ASD children (n = 81) recruited from an early intervention program for autism, and 74 children without autism who were recruited from public preschools. Urine samples were collected at home, delivered to the study site, and transported to the environmental lab within 24 hours. Inductively coupled plasma mass spectrometry (ICP-MS) was applied to measure the concentration of heavy metals in the samples. Data were analysed using bivariate statistical tests (Chi-square and T-test) and logistic regression models. Result: This study demonstrated that Cd, Pb, and As urine levels were significantly greater in children without autism relative to those affected with ASD (p < 0.05). No significant difference was in the levels of Se (p = 0.659) and Mn (p = 0.875) between children with ASD and the control group. The majority of children in both groups have urine As, Pb, and Cd values lower than 15.1 µg/dL, 1.0 µg/dL, and 1.0 µg/dL, respectively which are the minimal risk values for noncarcinogenic detrimental human health effect due to the heavy metal's exposure. Factors associated with having an ASD child included being a firstborn, male, and higher parental education levels (adjusted odds ratios (aOR) > 1, p < 0.05). Conclusion: Preschoolers in this study demonstrated low levels of heavy metals in their urine samples, which was relatively lower in ASD children compared to the healthy matched controls. These findings may arise from the diminished capacity to excrete heavy metals, especially among ASD children, thereby causing further accumulation of heavy metals in the body. These findings, including the factors associated with having an ASD child, may be considered by healthcare professionals involved in child development care, for early ASD detection. Further assessment of heavy metals among ASD children in the country and interventional studies to develop effective methods of addressing exposure to heavy metals will be beneficial for future reference. [ABSTRACT FROM AUTHOR]

Background: To investigate the perception of young European otolaryngologists (OTOs), i.e., head and neck surgeons, toward transoral robotic surgery (TORS). Methods: Members of the Young Confederation of European Otorhinolaryngology-Head and Neck Surgery and Young Otolaryngologists of International Federation of Otorhinolaryngological Societies were surveyed about TORS perception and practice. Results: The survey was completed by 120 young OTOS (26%). The most important barriers to TORS were robot availability (73%), cost (69%), and lack of training (37%). The participants believed that the main benefits include better surgical filed view (64%), shorter hospital stay (62%), and better postoperative outcomes (61%) than the conventional approach. Head and neck surgeons considered cT1-T2 oropharyngeal cancers (94%), resection of base of tongue for sleep apnea (86%), or primary unknown cancer (76%) as the most appropriate indications. A total of 67% of TORS surgeons assessed themselves as adequately trained in TORS. Conclusions: Young European OTOs report positive perception, adoption, and knowledge of TORS. The cost-related unavailability and the lack of training or access are reported to be the most important barriers for the spread of TORS. [ABSTRACT FROM AUTHOR]

The changes brought about by globalization mean that young people are increasingly prepared not only intellectually, but also financially. From the point of view of financial education, its importance for the development of the quality of life of young people in higher education is described. The main objective of the research is to describe the results of researches that were conducted on financial education in young people of higher education taking into consideration researches published between the period of 2017-2022. The research corresponds to a documentary design. Scielo, Scopus, Dialnet, Redalyc, Alicia and Google Scholar were searched. Some research has related the type of university career, the level of indebtedness, technological gap or use of ICT, materialism and gender inequality. The study leads to the conclusion that the development of financial education is fundamental in the training of higher education students because it will allow them to have knowledge that can be related between theory and practice. [ABSTRACT FROM AUTHOR]

This research paper sheds the light on the meaning of the term 'Hybridity' according to Young as shown in the OED and during the nineteenth century which is dominated by colonialism. The spread of the British imperial powers across the different countries lead to the mixing of the various races together. So, Young discusses the prominent ideas that lead to the emergence of racial hybridity such as immigration, diaspora, displacement and others. He also focuses on the debates of the nineteenth century that highlight the theme of racial hybridity in order to determine the specific race of the English nation as it consists of hybrid races. A close reading to Young's analysis to these arguments reveals themes grounded in racism and class distinction. Young in this study resists against the racist theories that are set against the colonized countries during the nineteenth century. [ABSTRACT FROM AUTHOR]

Background:To assess the risk factors of Myocardial infarction among young people in central India. Materials & methods: A total of 100 subjects with age between 20-30 years were enrolled. Informed consent was taken. Only those patients were enrolled which had MI. Detailed clinical history was taken. Information on age, sex, history of type-2 diabetes mellitus, hypertension, substance abuse, and family history of premature coronary artery disease (CAD) and angiographic profile were obtained. The results were analysed using SPSS software. Results: Apart from the male gender, the most common risk factor was dyslipidemia, followed by smokeless tobacco consumption, obesity, and smoking. Conclusion: Dyslipidemia is the most prevalent risk factor. Smoking was identified as the most common avoidable risk factor. [ABSTRACT FROM AUTHOR]