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2. A cross sectional study of role of technology in health for middle-aged and older adults in Singapore

Author

Jia Yang Tan, Jeremie Shun Hong Choo, Shruthi C. Iyer, Beth Shi Yu Lim, Jarell Jie-Rae Tan, Joanna Min Yu Ng, Terence Teng Yang Lian, and Saima Hilal

Subjects
Medicine, Science
Abstract

Abstract Telemedicine has gained popularity due to the increasing use of technology in our lives. However, no studies have explored the demographic factors affecting acceptability, desirability and adherence (ADA) to telemedicine in Singapore. Our study aims to evaluate the level of ADA of telemedicine services within demographic factors and to explore the association of potential demographic factors with the degree of acceptability, desirability and adherence of telemedicine among older adults in Singapore. A cross-sectional study was conducted with Singapore citizens or permanent residents aged 40–99 years, who were able to provide informed consent. Interviewers conducted door-to-door surveys in 67 Blocks of Housing & Development Board flats in Singapore, offering a self-administered electronic questionnaire available in four languages. Random sampling without replacement determined the order of blocks, floors and units visited. The questionnaire utilised Qtelemediab scoring and covered sociodemographic data, usage of telemedicine, as well as ADA towards telemedicine. A total of 324 valid responses were analysed. Increased age was associated with a significant decrease across all three domains of ADA namely acceptability (β = − 0.02, 95%CI − 0.03; − 0.02, p-value = 0.002), desirability (β = − 0.02, 95%CI − 0.02; − 0.02, p-value

Published
2024
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14. Clinicopathological correlation of p40/TTF1 co-expression in NSCLC and review of related literature

Author

Yang, Lian, Xiao, Ming, Li, Xian, and Wang, Ya-lan

Subjects
Quantitative Biology - Tissues and Organs
Abstract

TTF1 and {\Delta}Np63/p40 have been used to differentiate ADC and SQC in hypofractionated NSCLC because of their sensitivity and specificity. There are few cases where TTF1 and {\Delta}Np63/p40 are expressed together in the same tumour cells, and little is known about the clinicopathological features, treatment and prognosis of such cases. We investigated the electron microscopic features, immunohistochemical expression and molecular variation of a case of TTF1/p40 co-expressing NSCLC and reviewed and summarised the relevant literature. Our patient was a 58-year-old male with a CT showing a left-sided lung occupancy. As in all other cases reported in the literature, the tumour showed a solid growth pattern with polygonal cells, eosinophilic cytoplasm and clearly visible nuclear fission. Immunohistochemistry showed positive for TTF-1, p40, CK5/6, CK7, P63 and p53, and negative for NapsinA and ALK. Electron microscopy showed tumour cells characterised by bidirectional differentiation of adenocytes and squamous cells, consistent with previous reports. Second-generation sequencing suggested co-mutation of STK11/LKB1 and NF1 genes in this case. Mutations in STK11/LKB1 and NF1 genes have been found in ADC and SQC and are often associated with drug resistance and poor prognosis, but STK11/NF1 co-mutation has not been reported and more cases are needed to reveal the association. p40/TTF1 co-expression in NSCLC may be an under-recognised variant of NSCLC The origin may be a double positive stem cell-like basal cell located in the distal airway, with rapid clinical progression and poor prognosis.

Published
2022

16. Research on work zone vehicle queuing behavior based on cellular automata

Author

Chen, Shao-Yuan, Zhong, Li-Xian, Zhu, Rui-Xi, Yang, Lian-Sheng, Aikebaier, Mirizhati, and Lin, Ci-Yun

Subjects
Nonlinear Sciences - Cellular Automata and Lattice Gases
Abstract

A model is proposed to estimate the work zone queue length, and the cellular automata based on empirical data is used for model validation. This estimation model can be applied to work zone organization and management to improve work zone capacity and security. Relationship between the average queue length and the warning zone length can be found, and the appropriate warning zone length can be determined according to design flow. Moreover, the appropriate work zone lane-changing strategies under different design flows are found through the estimation model.

Published
2022

17. Dynamic Clustering and Power Control for Two-Tier Wireless Federated Learning

Author

Guo, Wei, Huang, Chuan, Qin, Xiaoqi, Yang, Lian, and Zhang, Wei

Subjects
Computer Science - Information Theory, Electrical Engineering and Systems Science - Signal Processing
Abstract

Federated learning (FL) has been recognized as a promising distributed learning paradigm to support intelligent applications at the wireless edge, where a global model is trained iteratively through the collaboration of the edge devices without sharing their data. However, due to the relatively large communication cost between the devices and parameter server (PS), direct computing based on the information from the devices may not be resource efficient. This paper studies the joint communication and learning design for the over-the-air computation (AirComp)-based two-tier wireless FL scheme, where the lead devices first collect the local gradients from their nearby subordinate devices, and then send the merged results to the PS for the second round of aggregation. We establish a convergence result for the proposed scheme and derive the upper bound on the optimality gap between the expected and optimal global loss values. Next, based on the device distance and data importance, we propose a hierarchical clustering method to build the two-tier structure. Then, with only the instantaneous channel state information (CSI), we formulate the optimality gap minimization problem and solve it by using an efficient alternating minimization method. Numerical results show that the proposed scheme outperforms the baseline ones.

Published
2022

43. Enhanced acupuncture therapy for radiotherapy-related neuropathic pain in patients with gynecologic cancer: a report of two cases and brief review

Author

Zhou Dan-feng, Rong Jian-cheng, Zheng Shu-zhen, Zhang Kun, Yang Hong-zhi, Yang Lian-sheng, and Tang Chun-zhi

Subjects
neuropathic pain, radiotherapy, acupuncture, cancer, case report, Neurology. Diseases of the nervous system, RC346-429
Abstract

As radiation therapy is increasingly utilized in the treatment of cancer, neuropathic pain (NP) is a common radiotherapy-related adverse effect and has a significant impact on clinical outcomes negatively. However, despite an improved understanding of neuropathic pain management, pain is often undertreated in patients with cancer. Herein, we reported two cases with radiotherapy-related neuropathic pain (RRNP) who presented a positive reaction to acupuncture. Patient 1 (a 73-year-old woman) with gynecologic cancer complained of burning and electric shock-like pain in the lower limb after radiotherapy. With the accepted combination of acupuncture and drugs, the pain was alleviated completely in 8 weeks. Patient 2 (a 64-year-old woman) accepted acupuncture in the absence of medication because of her inability to tolerate the adverse events of anticonvulsant drugs. She achieved remission of pain 4 weeks later. The results of this study showed that acupuncture might be promising for controlling the RRNP in patients with cancer, especially who were intolerant or unresponsive to medications.

Published
2023
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49. Molecular detection and genetic characterization of bovine hepacivirus identified in ticks collected from cattle in Harbin, northeastern China

Author

Sheng Yuan, Xin-Yan Yao, Chun-Yang Lian, Sa Kong, Jian-Wei Shao, and Xue-Lian Zhang

Subjects
bovine hepacivirus, subtype G, genetic diversity, tick, Northeastern China, Veterinary medicine, SF600-1100
Abstract

Bovine hepacivirus (BovHepV) is a member of the genus Hepacivirus of the family Flaviviridae, which can cause acute or persistent infections in cattle. Currently, BovHepV strains identified in cattle populations worldwide can be classified into two genotypes with eight subtypes in genotype 1. BovHepV has been identified in a wide geographic area in China. Interestingly, the viral RNA of BovHepV has also been detected in ticks in Guangdong province, China. In this study, Rhipicephalus microplus tick samples were collected in Heilongjiang province, northeastern China, and BovHepV was screened with an overall positive rate of 10.9%. Sequence comparison and phylogenetic analysis showed that the BovHepV strains detected in this study belong to the subtype G. This is the first report about the detection of BovHepV in ticks in Heilongjiang province, China, which expands our knowledge that ticks may be a transmission vector of BovHepV.

Published
2023
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50. Look for the meaning of rural school work: Qualitative study on identity of comprehensive teachers in rural primary schools in China

Author

Yang Lian, He Xiaojun, and Wu Cuiling

Subjects
rural schools, comprehensive teachers, identity, caring teachers, re-recognition, Psychology, BF1-990
Abstract

In the working environment of rural schools, whether and how does the identity of new comprehensive teachers change before and after service? Research on this problem is beneficial to optimize pre-service training and provide effective support for in-service training. In this study, phenomenological interviews were conducted to understand the formation and change of their identities in the three stages of pre-service, working and current teaching of four new teachers with 3-year teaching experience in the minority areas of western China. The results show that in the working environment of rural schools, three comprehensive teachers in primary schools have gradually changed from being excellent subject teachers to caring teachers. Another determined to become a caring teacher before her career, she retained her own identity in her work and focused more on the healthy growth of her students. The results show that the working environment of rural schools has a significant impact on the identity of first-term teachers of primary schools. Pre-service training should be integrated into local culture to promote the integration of pre-service and in-service and realize its sustainable development.

Published
2023
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