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In this chapter, the optical fiber sensors based on antiresonant reflecting optical waveguide have been introduced, including the single layer, double layers, double resonators, and hybrid mechanism. Various optical fiber sensors based on antiresonant reflecting optical waveguide have been introduced in this chapter with different working principles, including the fiber optic vibration sensor, humidity sensor, strain sensor, temperature sensor, magnetic field sensor, biosensor, etc. Especially, many long-standing challenges in the fiber optic sensor can be solved through the working principle of the antiresonant reflecting optical waveguide, including the temperature cross-talk compensation, distribution localization, optofluidic biosensing, etc. In general, the optical fiber sensors based on antiresonant reflecting optical waveguide have advantages, such as compact structure, high sensitivity, large dynamic range, and high stability, which appear to have potential applications in researches of structure health monitoring, oil exploiting, and biology detection.