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Nanorod Ag doped hydroxyapatites (Ag-HA) were synthesized by precipitation and hydrothermal method. Crystal structure, morphology and antibacterial property of prepared samples with silver contents prepared by different synthesis methods were investigated. The results show that Ag doped hydroxyapatites synthesized by hydrothermal method possess a higher length to diameter ratio, higher degree of crystallinity, better dispersion,larger grain size and smaller unit cell parameters. The average crystal size of prepared samples by precipitation method at 70℃ and hydrothermal method at 180℃ are (22.7±0.7)nm and (50.7±0.9)nm, respectively. In addition, adding silver into hydroxyapatite may increase grain size and unit cell parameters. When silver content is 1.30%, average grain size and unit cell parameters are (53.7±0.9)nm and a =0.9465nm, c =0.6970nm, respectively. Antibacterial test results indicate that Ag-HA exhibits good bactericidal property against Escherichia coli ( E.coli ) and Staphylococcus aureus ( S.aureus ). The antibacterial rate is 100% when silver content varies after different hours(1, 3, 6, 12, 24h).