13 results on '"Yin ZC"'
Search Results
2. Unexpected and divergent mechanosynthesis of furanoid-bridged fullerene dimers C 120 O and C 120 O 2 .
- Author
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Shao G, Liu YY, Niu C, Yin ZC, Ye SQ, Yao YR, Chen M, Chen JS, Xia XL, Yang S, and Wang GW
- Abstract
An unexpected, divergent and efficient approach toward furanoid-bridged fullerene dimers C
120 O and C120 O2 was established under different solvent-free ball-milling conditions by simply using pristine C60 as the starting material, water as the oxygen source and FeCl3 as the mediator. The structures of C120 O and C120 O2 were unambiguously established by single-crystal X-ray crystallography. A plausible reaction mechanism is proposed on the basis of control experiments. Furthermore, C120 O2 has been applied in organic solar cells as the third component and exhibits good performance., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)- Published
- 2024
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3. Black rice diet alleviates colorectal cancer development through modulating tryptophan metabolism and activating AHR pathway.
- Author
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Wang L, Tu YX, Chen L, Yu KC, Wang HK, Yang SQ, Zhang Y, Zhang SJ, Song S, Xu HL, Yin ZC, Feng MQ, Yue JQ, Huang XH, Tang T, Wei SZ, Liang XJ, and Chen ZX
- Abstract
Consumption of dietary fiber and anthocyanin has been linked to a lower incidence of colorectal cancer (CRC). This study scrutinizes the potential antitumorigenic attributes of a black rice diet (BRD), abundantly rich in dietary fiber and anthocyanin. Our results demonstrate notable antitumorigenic effects in mice on BRD, indicated by a reduction in both the size and number of intestinal tumors and a consequent extension in life span, compared to control diet-fed counterparts. Furthermore, fecal transplants from BRD-fed mice to germ-free mice led to a decrease in colonic cell proliferation, coupled with maintained integrity of the intestinal barrier. The BRD was associated with significant shifts in gut microbiota composition, specifically an augmentation in probiotic strains Bacteroides uniformis and Lactobacillus . Noteworthy changes in gut metabolites were also documented, including the upregulation of indole-3-lactic acid and indole. These metabolites have been identified to stimulate the intestinal aryl hydrocarbon receptor pathway, inhibiting CRC cell proliferation and colorectal tumorigenesis. In summary, these findings propose that a BRD may modulate the progression of intestinal tumors by fostering protective gut microbiota and metabolite profiles. The study accentuates the potential health advantages of whole-grain foods, emphasizing the potential utility of black rice in promoting health., Competing Interests: The authors have declared no competing interests., (© 2024 The Authors. iMeta published by John Wiley & Sons Australia, Ltd on behalf of iMeta Science.)
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- 2024
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4. Electrosynthesis of buckyballs with fused-ring systems from PCBM and its analogue.
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Wang WF, Liu KQ, Niu C, Wang YS, Yao YR, Yin ZC, Chen M, Ye SQ, Yang S, and Wang GW
- Abstract
[6,6]-Phenyl-C
61 -butyric acid methyl ester (PCBM), a star molecule in the fullerene field, has found wide applications in materials science. Herein, electrosynthesis of buckyballs with fused-ring systems has been achieved through radical α-C-H functionalization of the side-chain ester for both PCBM and its analogue, [6,6]-phenyl-C61 -propionic acid methyl ester (PCPM), in the presence of a trace amount of oxygen. Two classes of buckyballs with fused bi- and tricyclic carbocycles have been electrochemically synthesized. Furthermore, an unknown type of a bisfulleroid with two tethered [6,6]-open orifices can also be efficiently generated from PCPM. All three types of products have been confirmed by single-crystal X-ray crystallography. A representative intramolecularly annulated isomer of PCBM has been applied as an additive to inverted planar perovskite solar cells and boosted a significant enhancement of power conversion efficiency from 15.83% to 17.67%., (© 2023. The Author(s).)- Published
- 2023
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5. Male-Biased Gut Microbiome and Metabolites Aggravate Colorectal Cancer Development.
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Wang L, Tu YX, Chen L, Zhang Y, Pan XL, Yang SQ, Zhang SJ, Li SH, Yu KC, Song S, Xu HL, Yin ZC, Yue JQ, Ni QL, Tang T, Zhang JL, Guo M, Zhang S, Yao F, Liang XJ, and Chen ZX
- Subjects
- Male, Female, Animals, Mice, Dextran Sulfate, Carcinogenesis, Cell Transformation, Neoplastic, Colorectal Neoplasms pathology, Gastrointestinal Microbiome
- Abstract
Men demonstrate higher incidence and mortality rates of colorectal cancer (CRC) than women. This study aims to explain the potential causes of such sexual dimorphism in CRC from the perspective of sex-biased gut microbiota and metabolites. The results show that sexual dimorphism in colorectal tumorigenesis is observed in both Apc
Min/ + mice and azoxymethane (AOM)/dextran sulfate sodium (DSS)-treated mice with male mice have significantly larger and more tumors, accompanied by more impaired gut barrier function. Moreover, pseudo-germ mice receiving fecal samples from male mice or patients show more severe intestinal barrier damage and higher level of inflammation. A significant change in gut microbiota composition is found with increased pathogenic bacteria Akkermansia muciniphila and deplets probiotic Parabacteroides goldsteinii in both male mice and pseudo-germ mice receiving fecal sample from male mice. Sex-biased gut metabolites in pseudo-germ mice receiving fecal sample from CRC patients or CRC mice contribute to sex dimorphism in CRC tumorigenesis through glycerophospholipids metabolism pathway. Sexual dimorphism in tumorigenesis of CRC mouse models. In conclusion, the sex-biased gut microbiome and metabolites contribute to sexual dimorphism in CRC. Modulating sex-biased gut microbiota and metabolites could be a potential sex-targeting therapeutic strategy of CRC., (© 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.)- Published
- 2023
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6. Palladium-Catalyzed Three-Component 1,4-Alkoxyarylation Reaction of [60]Fullerene.
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Su YT, Yin ZC, and Wang GW
- Abstract
The palladium-catalyzed three-component alkoxyarylation reaction of [60]fullerene with primary/secondary alcohols and aryl iodides generates a series of 1,4-(alkoxy)(aryl)[60]fullerene derivatives. Plausible reaction pathways for the formation of 1,4-(alkoxy)(aryl)[60]fullerenes are proposed. In addition, the electrochemical properties of the synthesized 1,4-alkoxyarylation adducts are investigated.
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- 2022
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7. Alternative Access to Cyclopentafullerenes through the Reaction of [60]Fullerene with Aldehydes and Secondary Amines.
- Author
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Niu C, Chen XP, Yin ZC, Wang WF, and Wang GW
- Abstract
A series of cyclopentafullerenes have been synthesized in high stereoselectivity by the thermal reaction of [60]fullerene with aldehydes and secondary amines. Both α,β-unsaturated aldehydes and saturated aldehydes can be utilized to synthesize cyclopentafullerenes as the cis isomers. The possible reaction mechanisms for the formation of cyclopentafullerenes are proposed on the basis of the experimental results.
- Published
- 2020
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8. Effects of multiple N, P, and K fertilizer combinations on adzuki bean (Vigna angularis) yield in a semi-arid region of northeastern China.
- Author
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Yin ZC, Guo WY, Liang J, Xiao HY, Hao XY, Hou AF, Zong XX, Leng TR, Wang YJ, Wang QY, and Yin FX
- Subjects
- China, Models, Theoretical, Regression Analysis, Vigna drug effects, Desert Climate, Fertilizers economics, Nitrogen pharmacology, Phosphorus pharmacology, Potassium pharmacology, Vigna growth & development
- Abstract
Nitrogen (N), phosphorus (P), and potassium (K) exert various effects on adzuki bean yields. Our research was conducted in a semi-arid area, and four test sites were established in environments that have chernozem or sandy loam soils. During a five-year period, the effects of N, P, and K fertilizers on yield were comprehensively investigated in field trials (2014-2016) and for model-implementation trials (2017-2018), with models established prior to the latter. In the field trials, 23 treatments comprising different N, P, and K combinations significantly affected both yield and yield components, and regression analysis indicated that the experimental results were suitable for model establishment. The model subsequently demonstrated that the yield and the yield components were more sensitive to N and K fertilizer than to P fertilizer. Moreover, the yield and yield components increased. These yield increases were intense in response to the 0.5 to 1.34 levels in terms of the single effects; interaction effects; and the effects of combinations of N, P, and K fertilizers. Moreover, the effects of combinations of N, P, and K fertilizers were more significant on yield than were the single or interaction effects of N, P, and K fertilizers. The optimal fertilizer combination that resulted in high yields (≥1941.53 kg ha
-1 ) comprised 57.23-68.43 kg ha-1 N, 36.04-47.32 kg ha-1 P2 O5 and 50.29-61.27 kg ha-1 K2 O. The fertilizer combination that resulted in the maximum yield was 62.98 kg ha-1 N, 47.04 kg ha-1 P2 O5 and 59.95 kg ha-1 K2 O (N:P2 O5 :K2 O = 1:0.75:0.95), which produced the model-expected yield in trials at multiple sites. An economical fertilizer combination was determined on the basis of the best fertilizer measures in consideration of the cost of fertilizer and seed; this combination achieved yields of 2236.17 kg ha-1 , the profit was 15,653.16 Yuan ha-1 , and the corresponding rates were 57.60 kg ha-1 N, 47.03 kg ha-1 P2 O5 , and 31.64 kg ha-1 K2 O (N:P2 O5 :K2 O = 1:0.82:0.55).- Published
- 2019
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9. A retro Baeyer-Villiger reaction: electrochemical reduction of [60]fullerene-fused lactones to [60]fullerene-fused ketones.
- Author
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Niu C, Zhou DB, Yang Y, Yin ZC, and Wang GW
- Abstract
A highly efficient electrochemical reduction of [60]fullerene-fused lactones to [60]fullerene-fused ketones, a formal process of retro Baeyer-Villiger reaction, has been achieved for the first time. The electrochemically generated dianionic [60]fullerene-fused lactones can be transformed into [60]fullerene-fused ketones in the presence of acetic acid in 85-91% yields. Control experiments have been performed to elucidate the reaction mechanism. The products have been characterized with spectroscopic data and single-crystal X-ray analysis. Moreover, the electrochemical properties have also been investigated.
- Published
- 2019
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10. Therapeutic role of glutamine in management of radiation enteritis: a meta-analysis of 13 randomized controlled trials.
- Author
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Cao DD, Xu HL, Xu M, Qian XY, Yin ZC, and Ge W
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- Case-Control Studies, Enteritis diagnosis, Glutamine administration & dosage, Humans, Neoplasms complications, Neoplasms radiotherapy, Odds Ratio, Publication Bias, Radiation Injuries diagnosis, Radiotherapy adverse effects, Randomized Controlled Trials as Topic, Severity of Illness Index, Treatment Outcome, Enteritis drug therapy, Enteritis etiology, Glutamine therapeutic use, Radiation Injuries drug therapy
- Abstract
Objective: To systematically evaluate the clinical efficacy of glutamine in treating radiation enteritis in cancer patients treated with radiotherapy., Methods: Electronic databases including Pubmed, Embase, the Cochrane library, and CNKI were systematically searched, until April 2016. Randomized controlled trials (RCT) of glutamine in the treatment of radiation enteritis in cancer patients were searched, and RevMan 5.3 software was used for Meta-analysis., Results: A total of 13 RCTs were included, involving 979 patients. The results of meta-analysis showed that the total efficacy of glutamine was higher for patients with radiation enteritis compared with that in control group, however, there was no statistically significant difference(OR = 3.07, 95%CI: 0.79-11.96; P > 0.05). The combined ORs for all 5 grades(from grade 0 to grade 4) of radiation enteritis in patients receiving glutamine were 2.06, 1.35, 0.55, 0.62 and 0.59, respectively(P > 0.05 for all). Glutamine also failed to significantly improve the symptoms of radiation enteritis in terms of tenesmus, abdominal cramping and blood in bowel movement(P > 0.05)., Conclusions: Implementation of glutamine fails to improve the severity and symptoms in patients with radiation enteritis.
- Published
- 2017
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11. Development and significance of SCAR marker QG12-5 for Canarium album (Lour.) Raeusch by molecular cloning from improved RAPD amplification.
- Author
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Cheng JL, Yin ZC, Mei ZQ, Wei CL, Chen HC, Wu XS, and Fu JJ
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- Base Sequence, Cloning, Molecular, DNA Primers chemical synthesis, Minisatellite Repeats, Plants, Medicinal, Polymerase Chain Reaction, Sequence Analysis, DNA, Burseraceae genetics, DNA, Plant genetics, Genetic Markers, Genome, Plant, Random Amplified Polymorphic DNA Technique
- Abstract
Sequence-characterized amplified region (SCAR) is a valuable molecular marker for the genetic identification of any species. This marker is mainly derived from molecular cloning of random amplified polymorphic DNA (RAPD). We have previously reported the use of an improved RAPD technique for the genetic characterization of different samples of Canarium album (Lour.) Raeusch (C. album). In this study, DNA fragments were amplified using improved RAPD amplified from different samples of C. album. The amplified DNA fragment was excised, purified from an agarose gel and cloned into a pGM-T vector; subsequently, a positive clone, called QG12-5 was identified by PCR amplification and enzymatic digestion and sequenced by Sanger di-deoxy sequencing method. This clone was revealed consisting of 510 nucleotides of C. album. The SCAR marker QG12-5 was developed using specifically designed PCR primers and optimized PCR conditions. This SCAR marker expressed seven continuous "TATG" [(TATG)n] tandem repeats, which was found to characterize C. album. Subsequently, this novel SCAR marker was deposited in GenBank with accession No. KT359568. Therefore, we successfully developed a C. album-specific SCAR marker for the identification and authentication of different C. album species in this study., Competing Interests: The authors declare no conflict of interest.
- Published
- 2016
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12. Genetic affinities of central China populations.
- Author
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Zhou HY, Wang HW, Tan SN, Chen Y, Wang WL, Tao HX, Yin ZC, Zou YH, Ouyang SM, and Ni B
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- China, Haplotypes, Humans, Phylogeny, Polymorphism, Genetic, Asian People genetics, Chromosomes, Human, Y genetics, DNA, Mitochondrial genetics, Genetics, Population
- Abstract
Hunan locates in the south-central part of China, to the south of the middle reaches of the Yangtze River and south of Lake Dongting. According to the historical records, the peopling of Hunan by modern human ancestors can ascend to 40 thousand years ago. Thus, to trace the ancient maternal components can offer further insight into the origin of south-central China. In this study, we investigated the mitochondrial DNA of 114 individuals from Hunan Province (including 34 Han, 40 Tujia and 40 Miao). Hypervariable regions I and II of the mtDNA control region were sequenced, and the relative diagnostic variations in coding region according to the updated worldwide phylogeny tree were selected and typed by restriction fragment length polymorphism analysis or direct sequencing. All individuals were classified into specific (sub)haplogroups. By comparison with the surrounding populations, southern China-prevalent haplogroups were detected with relative higher frequency in the Tujia and Miao ethnic populations, such as haplogroup B, with more than 20%, lacking in the Han population, which illustrated its southern origin characters. In addition, we also detected northern of East Asia prevalent haplogroups with a relative higher frequency in Tujia populations than in the Miao and Yao ethnic groups, implying a gene flow from Han populations. However, the language-clustering tendency was supported by our principal component analysis and further genetic estimation results. Han and ethnic groups in central China exhibited specific ancestors related to their closer language affinity, although there was extensively genetic admixture between Han and ethnic groups.
- Published
- 2014
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13. The management of acetabular malunion with traumatic arthritis by total hip arthroplasty.
- Author
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Pang QJ, Yu X, Chen XJ, Yin ZC, and He GZ
- Abstract
Objective: To explore the treatment strategies and clinical effect of the acetabular malunion with traumatic arthritis by total hip arthroplasty., Methodology: A retrospective analysis was conducted on 47 cases of acetabular malunion with traumatic arthritis from June 2000 to December 2009. All the patients underwent total hip arthroplasty with bone grafting or titanium cage for bone defect of the acetabulum. Harris hip scoring system was used for evaluating the functional recovery of the hip joint., Results: Thirty three cases had an average of 47 months follow-up. No prosthesis was loosened and the function of hip joint was improved obviously with the Harris hip scores improving from 43.5 to 87.6. However, there were one case of sciatic nerve injury and four cases of heterotopic ossification postoperatively., Conclusion: Total hip arthroplasty might be an effective treatment of acetabular malunion with traumatic arthritis. Proper evaluation and reasonable reconstruction of acetabular defect as well as reasonable selection of prosthesis are essential to obtain an excellent outcome.
- Published
- 2013
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