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3. Long-Term Optimal Delivery Planning for Replacing the Liquefied Petroleum Gas Cylinder

Author

Yoshida, Akihiro, Sato, Haruki, Uchiumi, Shiori, Tateiwa, Nariaki, Kataoka, Daisuke, Tanaka, Akira, Hata, Nozomi, Yatsushiro, Yousuke, Ide, Ayano, Ishikura, Hiroki, Egi, Shingo, Fujii, Miyu, Kai, Hiroki, and Fujisawa, Katsuki

Subjects
Electrical Engineering and Systems Science - Systems and Control, Computer Science - Discrete Mathematics, 90C90 (Primary) 90C27, 90C15 (Secondary), G.1.6, G.2.3
Abstract

In the daily operation of liquefied petroleum gas service, gas providers visit customers and replace cylinders if the gas is about to run out. For a long time, frequent visits to customers were required because they could not determine the amount of remaining gas without a staff visit and observation. To solve this problem, smart meters are started to be employed to acquire gas consumption more frequently without visiting customers. In this study, we construct a system to optimize plans for cylinder replacement, and evaluate it with a large-scale field test. We propose an algorithm to create a replacement plan with three steps: estimating the replacement date, acquiring the customer list for replacement, and determining the delivery route. A more accurate estimation of the replacement date can be acquired with a smart meter, which is used for making a customer list for replacement. The formulation for making a customer list enables the gas provider to replace cylinders some days before the date when the gas would run out. It can suppress the concentration of replacements on certain days. Large-scale verification experiments were performed with more than 1,000 customers in Chiba prefecture in Japan. In the field test, the gas provider incorporated the system into its replacement operations. Moreover, the replacement plans developed by the proposed system were compared with that by the gas provider. Our system reduced the number of gas cylinders with gas shortage, the number of visits without replacement due to plenty of gas remaining, and the working duration per customer, which shows that our system benefits both gas providers and customers., Comment: 25 pages

Published
2021

7. Nested Subspace Arrangement for Representation of Relational Data

Author

Hata, Nozomi, Kaji, Shizuo, Yoshida, Akihiro, and Fujisawa, Katsuki

Subjects
Computer Science - Machine Learning, Statistics - Machine Learning, 68T30, I.2.4
Abstract

Studies on acquiring appropriate continuous representations of discrete objects, such as graphs and knowledge base data, have been conducted by many researchers in the field of machine learning. In this study, we introduce Nested SubSpace (NSS) arrangement, a comprehensive framework for representation learning. We show that existing embedding techniques can be regarded as special cases of the NSS arrangement. Based on the concept of the NSS arrangement, we implement a Disk-ANChor ARrangement (DANCAR), a representation learning method specialized to reproducing general graphs. Numerical experiments have shown that DANCAR has successfully embedded WordNet in ${\mathbb R}^{20}$ with an F1 score of 0.993 in the reconstruction task. DANCAR is also suitable for visualization in understanding the characteristics of graphs., Comment: 11 pages, 13 figures, ICML 2020

Published
2020

8. The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D

Author

Chaikovsky, Andrea C, Li, Chuan, Jeng, Edwin E, Loebell, Samuel, Lee, Myung Chang, Murray, Christopher W, Cheng, Ran, Demeter, Janos, Swaney, Danielle L, Chen, Si-Han, Newton, Billy W, Johnson, Jeffrey R, Drainas, Alexandros P, Shue, Yan Ting, Seoane, Jose A, Srinivasan, Preethi, He, Andy, Yoshida, Akihiro, Hipkins, Susan Q, McCrea, Edel, Poltorack, Carson D, Krogan, Nevan J, Diehl, J Alan, Kong, Christina, Jackson, Peter K, Curtis, Christina, Petrov, Dmitri A, Bassik, Michael C, Winslow, Monte M, and Sage, Julien

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Biological Sciences, Genetics, Cancer, Underpinning research, 1.1 Normal biological development and functioning, Adaptor Proteins, Signal Transducing, Adenocarcinoma of Lung, Animals, Cell Division, Cyclin D, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase 6, Genes, Tumor Suppressor, Humans, Lung Neoplasms, Mice, Piperazines, Pyridines, U937 Cells, Ubiquitination, General Science & Technology
Abstract

The initiation of cell division integrates a large number of intra- and extracellular inputs. D-type cyclins (hereafter, cyclin D) couple these inputs to the initiation of DNA replication1. Increased levels of cyclin D promote cell division by activating cyclin-dependent kinases 4 and 6 (hereafter, CDK4/6), which in turn phosphorylate and inactivate the retinoblastoma tumour suppressor. Accordingly, increased levels and activity of cyclin D-CDK4/6 complexes are strongly linked to unchecked cell proliferation and cancer2,3. However, the mechanisms that regulate levels of cyclin D are incompletely understood4,5. Here we show that autophagy and beclin 1 regulator 1 (AMBRA1) is the main regulator of the degradation of cyclin D. We identified AMBRA1 in a genome-wide screen to investigate the genetic basis of  the response to CDK4/6 inhibition. Loss of AMBRA1 results in high levels of cyclin D in cells and in mice, which promotes proliferation and decreases sensitivity to CDK4/6 inhibition. Mechanistically, AMBRA1 mediates ubiquitylation and proteasomal degradation of cyclin D as a substrate receptor for the cullin 4 E3 ligase complex. Loss of AMBRA1 enhances the growth of lung adenocarcinoma in a mouse model, and low levels of AMBRA1 correlate with worse survival in patients with lung adenocarcinoma. Thus, AMBRA1 regulates cellular levels of cyclin D, and contributes to cancer development and the response of cancer cells to CDK4/6 inhibitors.

Published
2021

12. Impact of Autophagy on Prognosis of Patients With Dilated Cardiomyopathy

Author

Kanamori, Hiromitsu, Yoshida, Akihiro, Naruse, Genki, Endo, Susumu, Minatoguchi, Shingo, Watanabe, Takatomo, Kawaguchi, Tomonori, Tanaka, Toshiki, Yamada, Yoshihisa, Takasugi, Nobuhiro, Ishihara, Takuma, Mikami, Atsushi, Miyazaki, Nagisa, Nishigaki, Kazuhiko, Minatoguchi, Shinya, Miyazaki, Tatsuhiko, and Okura, Hiroyuki

Published
2022
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14. Effective degradation of various bacterial toxins using ozone ultrafine bubble water.

Author

Takizawa, Fumio, Domon, Hisanori, Hirayama, Satoru, Isono, Toshihito, Sasagawa, Karin, Yonezawa, Daisuke, Ushida, Akiomi, Tsutsuura, Satomi, Miyoshi, Tomohiro, Mimuro, Hitomi, Yoshida, Akihiro, Tabeta, Koichi, and Terao, Yutaka

Subjects
MYCOTOXINS, OZONE, FOODBORNE diseases, ATMOSPHERIC oxygen, STAINS & staining (Microscopy), BACTERIAL toxins, TOXINS
Abstract

Infectious and foodborne diseases pose significant global threats, with devastating consequences in low- and middle-income countries. Ozone, derived from atmospheric oxygen, exerts antimicrobial effects against various microorganisms, and degrades fungal toxins, which were initially recognized in the healthcare and food industries. However, highly concentrated ozone gas can be detrimental to human health. In addition, ozonated water is unstable and has a short half-life. Therefore, ultrafine-bubble technology is expected to overcome these issues. Ultrafine bubbles, which are nanoscale entitles that exist in water for considerable durations, have previously demonstrated bactericidal effects against various bacterial species, including antibiotic-resistant strains. This present study investigated the effects of ozone ultrafine bubble water (OUFBW) on various bacterial toxins. This study revealed that OUFBW treatment abolished the toxicity of pneumolysin, a pneumococcal pore-forming toxin, and leukotoxin, a toxin that causes leukocyte injury. Silver staining confirmed the degradation of pneumolysin, leukotoxin, and staphylococcal enterotoxin A, which are potent gastrointestinal toxins, following OUFB treatment. In addition, OUFBW treatment significantly inhibited NF-κB activation by Pam3CSK4, a synthetic triacylated lipopeptide that activates Toll-like receptor 2. Additionally, OUFBW exerted bactericidal activity against Staphylococcus aureus, including an antibiotic-resistant strain, without displaying significant toxicity toward human neutrophils or erythrocytes. These results suggest that OUFBW not only sterilizes bacteria but also degrades bacterial toxins. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Accessory pathway analysis using a multimodal deep learning model

Author

Nishimori, Makoto, Kiuchi, Kunihiko, Nishimura, Kunihiro, Kusano, Kengo, Yoshida, Akihiro, Adachi, Kazumasa, Hirayama, Yasutaka, Miyazaki, Yuichiro, Fujiwara, Ryudo, Sommer, Philipp, El Hamriti, Mustapha, Imada, Hiroshi, Takemoto, Makoto, Takami, Mitsuru, Shinohara, Masakazu, Toh, Ryuji, Fukuzawa, Koji, and Hirata, Ken-ichi

Published
2021
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34. TCT-254 Coronary Artery Segmentation and Tissue Characterization Using Deep Learning: “Virtual” IB-IVUS

Author

Masuda, Yuto, primary, Takeshita, Ryo, additional, Wakasa, Shiho, additional, Tochibora, Ryota, additional, Ichiryu, Hajime, additional, Takai, Mizuki, additional, Ishihara, Takeshi, additional, Endo, Susumu, additional, Sahashi, Yuki, additional, Hayashi, MIsayo, additional, Yoshida, Tamami, additional, Yamamoto, Saori, additional, Ishiguro, Maya, additional, Naruse, Genki, additional, Miwa, Hirotaka, additional, Yoshida, Akihiro, additional, Minatoguchi, Shingo, additional, Nakabo, Ayumi, additional, Watanabe, Takatomo, additional, Takasugi, Nobuhiro, additional, Yamada, Yoshihisa, additional, Kanamori, Hiromitsu, additional, Fukuoka, Daisuke, additional, Hara, Takeshi, additional, and Okura, Hiroyuki, additional

Published
2023
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38. Reductions in liver enzymes are associated with anti‐hyperglycaemic and anti‐obesity effects of tofogliflozin in people with type 2 diabetes: Post‐hoc analyses.

Author

Takamura, Toshinari, Kaku, Kohei, Yoshida, Akihiro, Kusakabe, Hiromi, Nakamura, Hiroyuki, and Suganami, Hideki

Subjects
LIVER enzymes, GAMMA-glutamyltransferase, TYPE 2 diabetes, ALANINE aminotransferase, BLOOD sugar, BIOMARKERS
Abstract

Aims: How the pathology of type 2 diabetes (T2D), including hyperglycaemia and obesity, affects liver enzymes has not been clinically demonstrated. Thus, we compared time courses of gamma‐glutamyltransferase (GGT) and alanine aminotransferase (ALT) with those of fasting plasma glucose (FPG) and body weight (BW) during treatment with the SGLT2 inhibitor tofogliflozin for T2D. Materials and Methods: We post‐hoc analysed preexisting data on 1046 people with T2D administered tofogliflozin or placebo for 24 weeks in four tofogliflozin studies. First, time courses of percent changes in variables during the intervention were analysed using a mixed effect model to explore the similarity of the time courses and to evaluate time‐treatment interactions. Second, clinical factors related to the percent changes in GGT and ALT were clarified using multivariate analyses. Results: GGT levels and FPG values rapidly and significantly decreased via tofogliflozin as early as week 4, with decreases maintained until week 24. Conversely, BW and ALT decreased progressively until week 24. Time courses of FPG (p =.365, time‐treatment interaction) and GGT (p =.510) reductions were parallel between tofogliflozin and placebo from weeks 4 to 24, while BW and ALT reductions (p <.001, respectively) were not. Reductions in GGT at week 24 were associated with reductions in FPG and BW at week 24, whereas ALT reductions were only associated with reductions in BW. Conclusions: Reductions in GGT and ALT were associated with the anti‐hyperglycaemic and anti‐obesity effects of tofogliflozin, respectively, in people with T2D. Therefore, GGT and ALT may be surrogate markers for hyperglycaemia and obesity in T2D. [ABSTRACT FROM AUTHOR]

Published
2024
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39. The effects of exposure to O2- and HOCl-nanobubble water on human salivary microbiota.

Author

Sagara, Ken, Kataoka, Shota, Yoshida, Akihiro, and Ansai, Toshihiro

Subjects
HUMAN microbiota, NUCLEOTIDE sequencing, WATER purification, DISSOLVED air flotation (Water purification), SEQUENCE analysis, DENTISTRY, BUBBLES
Abstract

Nanobubbles of gas remain dissolved in water for longer periods than ordinary bubbles, and exhibit unique physicochemical and biological properties. As a result, nanobubble water (NBW) is finding widespread use many applications, such as cleaning in the industry and purification of lake water. The ozone NBW (O3-NBW), in particular, has been used in clinical dentistry; however, it has several disadvantages, including the instability of ozone, which is spontaneously converted to molecular oxygen (O3 to O2), and its broad range of antibacterial activity, which can disrupt the oral microbiota. Therefore, the use of NBW in dental medicine requires greater evaluation. Here, we examined the effects of oxygen and hypochlorite NBW (O2-NBW and HOCl-NBW, respectively) on the microbiota in human saliva in 16 male patients (35–75 years old; median: 53.5 years) using multiple assays, including next generation sequencing analysis. 16S rRNA gene sequencing revealed no significant changes in both alpha-diversity and beta-diversity. Principal Coordinate Analysis (PCoA) revealed two subclusters in both unweighted and weighted UniFrac distances. Overall, the results revealed that HOCl-NBW exposure of saliva may lead to inhibition or delay in oral biofilm formation while maintaining the balance of the oral microbiome. These results can lead to the development of a novel type of mouthrinse for prevention of oral infectious diseases. [ABSTRACT FROM AUTHOR]

Published
2023
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46. Structural basis for the toxin-coregulated pilus–dependent secretion of Vibrio cholerae colonization factor

Author

Oki, Hiroya, primary, Kawahara, Kazuki, additional, Iimori, Minato, additional, Imoto, Yuka, additional, Nishiumi, Haruka, additional, Maruno, Takahiro, additional, Uchiyama, Susumu, additional, Muroga, Yuki, additional, Yoshida, Akihiro, additional, Yoshida, Takuya, additional, Ohkubo, Tadayasu, additional, Matsuda, Shigeaki, additional, Iida, Tetsuya, additional, and Nakamura, Shota, additional

Published
2022
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