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4 results on '"Yoshida, Moemi"'

1. Staining of stratum corneum with fluorescent ε‐poly‐L‐lysine and its application to evaluation of skin conditions

Author

Yoshida, Moemi, primary, Numajiri, Sana, additional, Notani, Nao, additional, Sato, Nao, additional, Nomoto, Koji, additional, Arikawa, Hitomi, additional, Urabe, Hiroya, additional, Ichikawa, Hideyuki, additional, Akimoto, Ryuji, additional, Sato, Jun‐ichi, additional, Yamashita, Yuji, additional, and Hirao, Tetsuji, additional

Published
2022
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2. Staining of stratum corneum with fluorescent ε‐poly‐L‐lysine and its application to evaluation of skin conditions.

Author

Yoshida, Moemi, Numajiri, Sana, Notani, Nao, Sato, Nao, Nomoto, Koji, Arikawa, Hitomi, Urabe, Hiroya, Ichikawa, Hideyuki, Akimoto, Ryuji, Sato, Jun‐ichi, Yamashita, Yuji, and Hirao, Tetsuji

Subjects
*SOLUTION (Chemistry), *IONIC interactions, *FLUORESCENCE microscopy, *CATIONIC polymers, *FLUORITE
Abstract

Background: ε‐Poly‐L‐lysine (PLL) is a cationic polymer consisting of 25 to 35 L‐lysine residues that adheres to the surface of skin as well as hair. However, the properties of PLL regarding its adhesion to the skin remain to be elucidated. In this study, we examined the staining of stratum corneum (SC) with fluorescence‐labeled PLL and explored its relationship with skin condition. Materials and methods: Alexa Fluor 488‐labeled PLL (AF‐PLL) was reacted with tape‐stripped stratum corneum (SC), and the staining properties were monitored by fluorescence microscopy. Clinical study was performed by measuring the water content of the cheek SC and transepidermal water loss (TEWL), and the tape‐stripped SC was subjected to staining with AF‐PLL. Results: AF‐PLL staining of the SC was inhibited at acidic pH or by the addition of high concentration of salt solution, suggesting the involvement of ionic interaction between PLL and the SC, at least in part. The AF‐PLL staining was inhibited by unlabeled PLL or various alkyl amines, but not by L‐lysine monomer. AF‐PLL staining was observed inside the corneocytes as well as surrounding cornified envelope. Clinical study revealed that AF‐PLL staining intensity of the SC was negatively correlated with its water content and positively correlated with its TEWL. Conclusion: PLL can efficiently adhere to SC and AF‐PLL staining of SC can be applied to evaluate skin conditions. [ABSTRACT FROM AUTHOR]

Published
2023
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3. Dermal Fibroblasts Internalize Phosphatidylserine-Exposed Secretory Melanosome Clusters and Apoptotic Melanocytes

Author

Ando, Hideya, primary, Yoshimoto, Satoshi, additional, Yoshida, Moemi, additional, Shimoda, Nene, additional, Tadokoro, Ryosuke, additional, Kohda, Haruka, additional, Ishikawa, Mami, additional, Nishikata, Takahito, additional, Katayama, Bunpei, additional, Ozawa, Toshiyuki, additional, Tsuruta, Daisuke, additional, Mizutani, Ken-ichi, additional, Yagi, Masayuki, additional, and Ichihashi, Masamitsu, additional

Published
2020
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4. Photocatalysis in the Skin Related to UVA Photoaging

Author

Yoshimoto, Satoshi, Ichihashi, Masamitsu, and Yoshida, Moemi

Subjects
Science / Chemistry
Abstract

Skin aging is classified into chronological aging and photoaging, involving ultraviolet radiation (UV), visible light, and others. UVA and UVA-photosensitizers (involving photocatalysis) contribute to the production of chronically induced skin damage that results in photoaging, especially wrinkles that are associated with histopathological actinic elastosis in the dermis. Hydrogen peroxide produced by the photosensitization involving photocatalysis, such as flavin, has been proposed as a risk factor for photoaging. It was also revealed that hydrogen peroxide production by UVA is amplified through the following reactions. The photosensitization of type I and type II by riboflavin as an initiator oxidizes coexisted amino acids and vitamins. The oxidized amino acids and vitamins produce reactive oxygen species (ROS), including hydrogen peroxide, through secondary UVA-photosensitization. Finally, we proposed a screening method for detecting the effects of antioxidants on UVA-photosensitization. In our previous study, histidine and other antioxidants did not inhibit UVA-photosensitized by riboflavin, even though they have been reported to scavenge singlet oxygen and superoxide. In contrast, we demonstrated that ergothioneine suppressed the production of hydrogen peroxide by UVA-photosensitization. The purpose of this report is to provide new findings for the prevention of photoaging by discussing the characteristics of UVA-photocatalysts in the skin.

Published
2020

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