1. Decreased grip strength, muscle pain, and atrophy occur in rats following long-term exposure to excessive repetitive motion
- Author
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Takayuki Inoue, Kazuhiro Hayashi, Natsumi Yoshito, Yosuke Aizawa, Mitsuhiro Fujiwara, Shigeyuki Suzuki, and Masahiro Iwata
- Subjects
muscle atrophy ,0301 basic medicine ,medicine.medical_specialty ,Protein degradation ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,Grip strength ,0302 clinical medicine ,Atrophy ,Forearm ,Neurotrophic factors ,Internal medicine ,muscle pain ,work‐related musculoskeletal disorders ,medicine ,Research Articles ,autophagy‐lysosome system ,business.industry ,Work-related musculoskeletal disorders ,ubiquitin‐proteasome system ,medicine.disease ,Muscle atrophy ,Surgery ,030104 developmental biology ,Nerve growth factor ,Endocrinology ,medicine.anatomical_structure ,grip strength ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Research Article - Abstract
Work‐related musculoskeletal disorders (WMSD) are caused by the overuse of muscles in the workplace. Performing repetitive tasks is a primary risk factor for the development of WMSD. Many workers in highly repetitive jobs exhibit muscle pain and decline in handgrip strength, yet the mechanisms underlying these dysfunctions are poorly understood. In our study, rats performed voluntary repetitive reaching and grasping tasks (Task group), while Control group rats did not perform these activities. In the Task group, grip strength and forearm flexor withdrawal threshold declined significantly from week 2 to week 6, compared with these values at week 0 (P
- Published
- 2017
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