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2. Correction: Real‑world data suggest effectiveness of the allogeneic mesenchymal stromal cells preparation MSC‑FFM in ruxolitinib‑refractory acute graft‑versus‑host disease

Author

Bonig, Halvard, Verbeek, Mareike, Herhaus, Peter, Braitsch, Krischan, Beutel, Gernot, Schmid, Christoph, Müller, Nadine, Bug, Gesine, Döring, Michaela, von Stackelberg, Arend, Tischer, Johanna, Ayuk, Francis, Wulf, Gerald, Holtick, Udo, Pfeffermann, Lisa‑Marie, Jahrsdörfer, Bernd, Schrezenmeier, Hubert, Kuci, Selim, Kuci, Zyrafete, Zens, Anke, Tribanek, Michael, Zeiser, Robert, Huenecke, Sabine, and Bader, Peter

Published
2024
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3. Prostaglandin E2 controls the metabolic adaptation of T cells to the intestinal microenvironment

Author

Villa, Matteo, Sanin, David E., Apostolova, Petya, Corrado, Mauro, Kabat, Agnieszka M., Cristinzio, Carmine, Regina, Annamaria, Carrizo, Gustavo E., Rana, Nisha, Stanczak, Michal A., Baixauli, Francesc, Grzes, Katarzyna M., Cupovic, Jovana, Solagna, Francesca, Hackl, Alexandra, Globig, Anna-Maria, Hässler, Fabian, Puleston, Daniel J., Kelly, Beth, Cabezas-Wallscheid, Nina, Hasselblatt, Peter, Bengsch, Bertram, Zeiser, Robert, Sagar, Buescher, Joerg M., Pearce, Edward J., and Pearce, Erika L.

Published
2024
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4. ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease

Author

Maas-Bauer, Kristina, Stell, Anna-Verena, Yan, Kai-Li, de Vega, Enrique, Vinnakota, Janaki Manoja, Unger, Susanne, Núñez, Nicolas, Norona, Johana, Talvard-Balland, Nana, Koßmann, Stefanie, Schwan, Carsten, Miething, Cornelius, Martens, Uta S., Shoumariyeh, Khalid, Nestor, Rosa P., Duquesne, Sandra, Hanke, Kathrin, Rackiewicz, Michal, Hu, Zehan, El Khawanky, Nadia, Taromi, Sanaz, Andrlova, Hana, Faraidun, Hemin, Walter, Stefanie, Pfeifer, Dietmar, Follo, Marie, Waldschmidt, Johannes, Melchinger, Wolfgang, Rassner, Michael, Wehr, Claudia, Schmitt-Graeff, Annette, Halbach, Sebastian, Liao, James, Häcker, Georg, Brummer, Tilman, Dengjel, Joern, Andrieux, Geoffroy, Grosse, Robert, Tugues, Sonia, Blazar, Bruce R., Becher, Burkhard, Boerries, Melanie, and Zeiser, Robert

Published
2024
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5. Multiomic spatial landscape of innate immune cells at human central nervous system borders

Author

Sankowski, Roman, Süß, Patrick, Benkendorff, Alexander, Böttcher, Chotima, Fernandez-Zapata, Camila, Chhatbar, Chintan, Cahueau, Jonathan, Monaco, Gianni, Gasull, Adrià Dalmau, Khavaran, Ashkan, Grauvogel, Jürgen, Scheiwe, Christian, Shah, Mukesch Johannes, Heiland, Dieter Henrik, Schnell, Oliver, Markfeld-Erol, Filiz, Kunze, Mirjam, Zeiser, Robert, Priller, Josef, and Prinz, Marco

Published
2024
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7. The MAGIC algorithm probability predicts treatment response and long-term outcomes to second-line therapy for acute GVHD

Author

DeFilipp, Zachariah, Kim, Haesook T., Spyrou, Nikolaos, Katsivelos, Nikolaos, Kowalyk, Steven, Eng, Gilbert, Kasikis, Stelios, Beheshti, Rahnuma, Baez, Janna, Akahoshi, Yu, Ayuk, Francis, Choe, Hannah, Etra, Aaron, Grupp, Stephan A., Hexner, Elizabeth O., Hogan, William J., Kitko, Carrie L., Qayed, Muna, Reshef, Ran, Vasova, Ingrid, Zeiser, Robert, Young, Rachel, Holler, Ernst, Ferrara, James L. M., Nakamura, Ryotaro, Levine, John E., and Chen, Yi-Bin

Published
2024
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9. Real-world data suggest effectiveness of the allogeneic mesenchymal stromal cells preparation MSC-FFM in ruxolitinib-refractory acute graft-versus-host disease

Author

Bonig, Halvard, Verbeek, Mareike, Herhaus, Peter, Braitsch, Krischan, Beutel, Gernot, Schmid, Christoph, Müller, Nadine, Bug, Gesine, Döring, Michaela, von Stackelberg, Arend, Tischer, Johanna, Ayuk, Francis, Wulf, Gerald, Holtick, Udo, Pfeffermann, Lisa-Marie, Jahrsdörfer, Bernd, Schrezenmeier, Hubert, Kuci, Selim, Kuci, Zyrafete, Zens, Anke, Tribanek, Michael, Zeiser, Robert, Huenecke, Sabine, and Bader, Peter

Published
2023
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10. Flares of acute graft-versus-host disease: a Mount Sinai Acute GVHD International Consortium analysis

Author

Akahoshi, Yu, Spyrou, Nikolaos, Hoepting, Matthias, Aguayo-Hiraldo, Paibel, Ayuk, Francis, Chanswangphuwana, Chantiya, Choe, Hannah K., Eder, Matthias, Etra, Aaron M., Grupp, Stephan A., Hexner, Elizabeth O., Hogan, William J., Kitko, Carrie L., Kraus, Sabrina, Al Malki, Monzr M., Merli, Pietro, Qayed, Muna, Reshef, Ran, Schechter, Tal, Ullrich, Evelyn, Vasova, Ingrid, Wölfl, Matthias, Zeiser, Robert, Baez, Janna, Beheshti, Rahnuma, Eng, Gilbert, Gleich, Sigrun, Kasikis, Stelios, Katsivelos, Nikolaos, Kowalyk, Steven, Morales, George, Young, Rachel, DeFilipp, Zachariah, Ferrara, James L. M., Levine, John E., and Nakamura, Ryotaro

Published
2024
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12. Outcomes of haploidentical transplants with PT-CY vs 10/10 MUD transplants with ATG in Germany

Author

Kröger, Nicolaus, Schroeder, Thomas, Stelljes, Matthias, Dreger, Peter, Zeiser, Robert, Bethge, Wolfgang, Teschner, Daniel, Edinger, Matthias, Platzbecker, Uwe, Elmaagacli, Ahmet, Hilgendorf, Inken, Burchert, Andreas, Stölzel, Friedrich, Verbeek, Mareike, Sala, Elisa, Tischer, Johanna, Schetelig, Johannes, Brecht, Arne, Kaufmann, Martin, Kimmich, Christoph, Bittenbring, Jörg Thomas, Wulf, Gerald, Blau, Igor Wolfgang, Winkler, Julia, Bug, Gesine, Jost, Edgar, Holderried, Tobias, Dürholt, Mareike, Scheid, Christof, Wagner-Drouet, Eva, Wolleschak, Denise, Ringhoffer, Mark, Kiehl, Michael, Wortmann, Friederike, Kobbe, Guido, Schroers, Roland, Krackhardt, Angela, Klein, Stefan, Müller, Lutz P., Schmid, Christoph, Kaun, Stephan, Wieschermann, Ute, Bartscht, Tobias, Meyer, Ralf Georg, Wölfl, Matthias, Bader, Peter, Niederland, Judith, Maucher, Jakob, Mauz-Körholz, Christine, Burkhardt, Birgit, Kentouche, Karim, Passweg, Jakob, Ehlert, Karoline, Arslan, Aysenur, Labuhn, Svenja, Schröder, Thomas, Franke, Georg-Nikolaus, Eder, Matthias, Amann, Elisa Maria, Neuchel, Christine, Schmid-Möglich, Amelie, Schmeller, Sandra, Beyersmann, Jan, Schrezenmeier, Hubert, Mytilineos, Joannis, and Fürst, Daniel

Published
2024
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13. GPRC5C drives branched-chain amino acid metabolism in leukemogenesis

Author

Zhang, Yu Wei, Velasco-Hernandez, Talia, Mess, Julian, Lalioti, Maria-Eleni, Romero-Mulero, Mari Carmen, Obier, Nadine, Karantzelis, Nikolaos, Rettkowski, Jasmin, Schönberger, Katharina, Karabacz, Noémie, Jäcklein, Karin, Morishima, Tatsuya, Trincado, Juan Luis, Romecin, Paola, Martinez, Alba, Takizawa, Hitoshi, Shoumariyeh, Khalid, Renders, Simon, Zeiser, Robert, Pahl, Heike L., Béliveau, François, Hébert, Josée, Lehnertz, Bernhard, Sauvageau, Guy, Menendez, Pablo, and Cabezas-Wallscheid, Nina

Published
2023
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14. Activated granulocytes and inflammatory cytokine signaling drive T-cell lymphoma progression and disease symptoms

Author

Jaeger, Amelie, Gambheer, Sudheer Madan Mohan, Sun, Xiaoyang, Chernyakov, Dmitry, Skorobohatko, Oleksandra, Mack, Thomas, Kissel, Sandra, Pfeifer, Dietmar, Zeiser, Robert, Fisch, Paul, Andrieux, Geoffroy, Bräuer-Hartmann, Daniela, Bauer, Marcus, Schulze, Susann, Follo, Marie, Boerries, Melanie, von Bubnoff, Nikolas, Miething, Cornelius, Hidalgo, Jose Villacorta, Klein, Claudius, Weber, Thomas, Wickenhauser, Claudia, Binder, Mascha, and Dierks, Christine

Published
2023
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15. Reg3α concentrations at day of allogeneic stem cell transplantation predict outcome and correlate with early antibiotic use

Author

Weber, Daniela, Weber, Markus, Meedt, Elisabeth, Ghimire, Sakhila, Wolff, Daniel, Edinger, Matthias, Poeck, Hendrik, Hiergeist, Andreas, Gessner, André, Ayuk, Francis, Roesler, Wolf, Wölfl, Matthias, Kraus, Sabrina, Zeiser, Robert, Bertrand, Hannah, Bader, Peter, Ullrich, Evelyn, Eder, Matthias, Gleich, Sigrun, Young, Rachel, Herr, Wolfgang, Levine, John E., Ferrara, James L. M., and Holler, Ernst

Published
2023
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17. Retinoic acid signaling acts as a rheostat to balance Treg function

Author

Thangavelu, Govindarajan, Andrejeva, Gabriela, Bolivar-Wagers, Sara, Jin, Sujeong, Zaiken, Michael C., Loschi, Michael, Aguilar, Ethan G., Furlan, Scott N., Brown, Chrysothemis C., Lee, Yu-Chi, Hyman, Cameron McDonald, Feser, Colby J., Panoskaltsis-Mortari, Angela, Hippen, Keli L., MacDonald, Kelli P., Murphy, William J., Maillard, Ivan, Hill, Geoffrey R., Munn, David H., Zeiser, Robert, Kean, Leslie S., Rathmell, Jeffrey C., Chi, Hongbo, Noelle, Randolph J., and Blazar, Bruce R.

Published
2022
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18. Donor and host B7-H4 expression negatively regulates acute graft-versus-host disease lethality

Author

Saha, Asim, Taylor, Patricia A, Lees, Christopher J, Panoskaltsis-Mortari, Angela, Osborn, Mark J, Feser, Colby J, Thangavelu, Govindarajan, Melchinger, Wolfgang, Refaeli, Yosef, Hill, Geoffrey R, Munn, David H, Murphy, William J, Serody, Jonathan S, Maillard, Ivan, Kreymborg, Katharina, van den Brink, Marcel, Dong, Chen, Huang, Shuyu, Zang, Xingxing, Allison, James P, Zeiser, Robert, and Blazar, Bruce R

Subjects
Transplantation, Stem Cell Research, Rare Diseases, Hematology, Animals, Bone Marrow Transplantation, Cell Line, Tumor, Cell Proliferation, Cytokines, Disease Models, Animal, Female, Gastrointestinal Tract, Graft vs Host Disease, Lung, Lymphoma, Metabolic Networks and Pathways, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Oxygen Consumption, T-Lymphocytes, Tissue Donors, Transcriptome, V-Set Domain-Containing T-Cell Activation Inhibitor 1, Bone marrow transplantation, Immunology, T cells
Abstract

B7-H4 is a negative regulatory B7 family member. We investigated the role of host and donor B7-H4 in regulating acute graft-versus-host disease (GVHD). Allogeneic donor T cells infused into B7-H4-/- versus WT recipients markedly accelerated GVHD-induced lethality. Chimera studies pointed toward B7-H4 expression on host hematopoietic cells as more critical than parenchymal cells in controlling GVHD. Rapid mortality in B7-H4-/- recipients was associated with increased donor T cell expansion, gut T cell homing and loss of intestinal epithelial integrity, increased T effector function (proliferation, proinflammatory cytokines, cytolytic molecules), and reduced apoptosis. Higher metabolic demands of rapidly proliferating donor T cells in B7-H4-/- versus WT recipients required multiple metabolic pathways, increased extracellular acidification rates (ECARs) and oxygen consumption rates (OCRs), and increased expression of fuel substrate transporters. During GVHD, B7-H4 expression was upregulated on allogeneic WT donor T cells. B7-H4-/- donor T cells given to WT recipients increased GVHD mortality and had function and biological properties similar to WT T cells from allogeneic B7-H4-/- recipients. Graft-versus-leukemia responses were intact regardless as to whether B7-H4-/- mice were used as hosts or donors. Taken together, these data provide new insights into the negative regulatory processes that control GVHD and provide support for developing therapeutic strategies directed toward the B7-H4 pathway.

Published
2019

19. Dendritic Cell Expression of Retinal Aldehyde Dehydrogenase-2 Controls Graft-versus-Host Disease Lethality

Author

Thangavelu, Govindarajan, Lee, Yu-Chi, Loschi, Michael, Schaechter, K Melanie, Feser, Colby J, Koehn, Brent H, Nowak, Elizabeth C, Zeiser, Robert, Serody, Jonathan S, Murphy, William J, Munn, David H, Chambon, Pierre, Noelle, Randolph J, and Blazar, Bruce R

Subjects
Prevention, Transplantation, Rare Diseases, 2.1 Biological and endogenous factors, Aetiology, Inflammatory and immune system, Aldehyde Oxidoreductases, Animals, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Dendritic Cells, Female, Gene Expression Regulation, Enzymologic, Graft vs Host Disease, Mice, Mice, Inbred BALB C, Mice, Transgenic, Retinoic Acid 4-Hydroxylase, Tretinoin, Immunology
Abstract

Recent studies have underscored the critical role of retinoic acid (RA) in the development of lineage-committed CD4 and CD8 T cells in vivo. We have shown that under acute graft-versus-host disease (GVHD) inflammatory conditions, RA is upregulated in the intestine and is proinflammatory, as GVHD lethality was attenuated when donor allogeneic T cells selectively expressed a dominant negative RA receptor α that blunted RA signaling. RA can function in an autocrine and paracrine fashion, and as such, the host cell lineage responsible for the production of RA metabolism and the specific RA-metabolizing enzymes that potentiate GVHD severity are unknown. In this study, we demonstrate that enhancing RA degradation in the host and to a lesser extent donor hematopoietic cells by overexpressing the RA-catabolizing enzyme CYP26A1 reduced GVHD. RA production is facilitated by retinaldehyde isoform-2 (RALDH2) preferentially expressed in dendritic cells (DCs). Conditionally deleted RA-synthesizing enzyme RALDH2 in host or to a lesser extent donor DCs reduced GVHD lethality. Improved survival in recipients with RALDH2-deleted DCs was associated with increased T cell death, impaired T effector function, increased regulatory T cell frequency, and augmented coinhibitory molecule expression on donor CD4+ T cells. In contrast, retinaldehydrogenase isoform-1 (RALDH1) is dominantly expressed in intestinal epithelial cells. Unexpectedly, conditional host intestinal epithelial cells RALDH1 deletion failed to reduce GVHD. These data demonstrate the critical role of both donor and especially host RALDH2+ DCs in driving murine GVHD and suggest RALDH2 inhibition or CYP26A1 induction as novel therapeutic strategies to prevent GVHD.

Published
2019

20. Fever supports CD8⁺ effector T cell responses by promoting mitochondrial translation

Author

O’Sullivan, David, Stanczak, Michal A., Villa, Matteo, Uhl, Franziska M., Corrado, Mauro, Geltink, Ramon I. Klein, Sanin, David E., Apostolova, Petya, Rana, Nisha, Edwards-Hicks, Joy, Grzes, Katarzyna M., Kabat, Agnieszka M., Kyle, Ryan L., Fabri, Mario, Curtis, Jonathan D., Buck, Michael D., Patterson, Annette E., Regina, Annamaria, Field, Cameron S., Baixauli, Francesc, Puleston, Daniel J., Pearce, Edward J., Zeiser, Robert, and Pearce, Erika L.

Published
2021

21. Targeting MDM2 enhances antileukemia immunity after allogeneic transplantation via MHC-II and TRAIL-R1/2 upregulation

Author

Ho, Jenny N.H.G., Schmidt, Dominik, Lowinus, Theresa, Ryoo, Jeongmin, Dopfer, Elaine-Pashupati, Gonzalo Núñez, Nicolás, Costa-Pereira, Sara, Toffalori, Cristina, Punta, Marco, Fetsch, Viktor, Wertheimer, Tobias, Rittmann, Marie-Claire, Braun, Lukas M., Follo, Marie, Briere, Christelle, Vinnakota, Janaki Manoja, Langenbach, Marlene, Koppers, Felicitas, Shoumariyeh, Khalid, Engel, Helena, Rückert, Tamina, Märklin, Melanie, Holzmayer, Samuel, Illert, Anna L., Magon, Federica, Andrieux, Geoffroy, Duquesne, Sandra, Pfeifer, Dietmar, Staniek, Julian, Rizzi, Marta, Miething, Cornelius, Köhler, Natalie, Duyster, Justus, Menssen, Hans D., Boerries, Melanie, Buescher, Joerg M., Cabezas-Wallscheid, Nina, Blazar, Bruce R., Apostolova, Petya, Vago, Luca, Pearce, Erika L., Becher, Burkhard, and Zeiser, Robert

Published
2022
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22. Toward a Better Understanding of the Atypical Features of Chronic Graft-Versus-Host Disease: A Report from the 2020 National Institutes of Health Consensus Project Task Force

Author

Cuvelier, Geoffrey D.E., Schoettler, Michelle, Buxbaum, Nataliya P., Pinal-Fernandez, Iago, Schmalzing, Marc, Distler, Jörg H.W., Penack, Olaf, Santomasso, Bianca D., Zeiser, Robert, Angstwurm, Klemens, MacDonald, Kelli P.A., Kimberly, W. Taylor, Taylor, Naomi, Bilic, Ervina, Banas, Bernhard, Buettner-Herold, Maike, Sinha, Namita, Greinix, Hildegard T., Pidala, Joseph, Schultz, Kirk R., Williams, Kirsten M., Inamoto, Yoshihiro, Cutler, Corey, Griffith, Linda M., Lee, Stephanie J., Sarantopoulos, Stefanie, Pavletic, Steven Z., and Wolff, Daniel

Published
2022
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27. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: III. The 2020 Treatment of Chronic GVHD Report

Author

DeFilipp, Zachariah, Couriel, Daniel R., Lazaryan, Aleksandr, Bhatt, Vijaya Raj, Buxbaum, Nataliya P., Alousi, Amin M., Olivieri, Attilio, Pulanic, Drazen, Halter, Joerg P., Henderson, Lori A., Zeiser, Robert, Gooley, Ted A., MacDonald, Kelli P.A., Wolff, Daniel, Schultz, Kirk R., Paczesny, Sophie, Inamoto, Yoshihiro, Cutler, Corey S., Kitko, Carrie L., Pidala, Joseph A., Lee, Stephanie J., Socie, Gerard, Sarantopoulos, Stefanie, Pavletic, Steven Z., Martin, Paul J., Blazar, Bruce R., and Greinix, Hildegard T.

Published
2021
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28. Repurposing a novel anti-cancer RXR agonist to attenuate murine acute GVHD and maintain graft-versus-leukemia responses

Author

Thangavelu, Govindarajan, Wang, Chao, Loschi, Michael, Saha, Asim, Osborn, Mark J., Furlan, Scott N., Aoyama, Kazutoshi, McDonald-Hyman, Cameron, Aguilar, Ethan G., Janesick, Amanda S., Chandraratna, Roshantha A., Refaeli, Yosef, Panoskaltsis-Mortari, Angela, MacDonald, Kelli P., Hill, Geoffrey R., Zeiser, Robert, Maillard, Ivan, Serody, Jonathan S., Murphy, William J., Munn, David H., Blumberg, Bruce, Brown, Chrysothemis, Kuchroo, Vijay, Kean, Leslie S., Hippen, Keli L., Noelle, Randolph J., and Blazar, Bruce R.

Published
2021
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29. Acute Graft-Versus-Host Disease

Author

Holler, Ernst, Greinix, Hildegard, Zeiser, Robert, Carreras, Enric, editor, Dufour, Carlo, editor, Mohty, Mohamad, editor, and Kröger, Nicolaus, editor

Published
2019
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31. Flares of Acute Graft-Versus-Host Disease (GVHD): A Mount Sinai Acute GVHD International Consortium (MAGIC) Analysis

Author

Akahoshi, Yu, primary, Spyrou, Nikolaos, additional, Hoepting, Matthias, additional, Aguayo-Hiraldo, Paibel, additional, Ayuk, Francis Ayuketang, additional, Chanswangphuwana, Chantiya, additional, Choe, Hannah K, additional, Eder, Matthias, additional, Etra, Aaron M., additional, Grupp, Stephan A., additional, Hexner, Elizabeth O., additional, Hogan, William J, additional, Kitko, Carrie L., additional, Kraus, Sabrina, additional, Al Malki, Monzr M, additional, Merli, Pietro, additional, Qayed, Muna, additional, Reshef, Ran, additional, Schechter-Finkelstein, Tal, additional, Ullrich, Evelyn, additional, Vasova, Ingrid, additional, Wölfl, Matthias, additional, Zeiser, Robert, additional, Baez, Janna, additional, Beheshti, Rahnuma, additional, Eng, Gilbert W, additional, Gleich, Sigrun, additional, Kasikis, Stelios, additional, Katsivelos, Nikolaos, additional, Kowalyk, Steven, additional, Morales, George, additional, Young, Rachel, additional, DeFilipp, Zachariah, additional, Ferrara, James L.M., additional, Levine, John E, additional, and Nakamura, Ryotaro, additional

Published
2024
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34. The Mount Sinai Acute Gvhd International Consortium (MAGIC) Model: An Integrated Clinical and Biomarker Grading System for Acute Graft-Versus-Host Disease (GVHD)

Author

Akahoshi, Yu, primary, Spyrou, Nikolaos, additional, Weber, Daniela, additional, Aguayo-Hiraldo, Paibel Ixia, additional, Ayuk, Francis, additional, Bunworasate, Udomsak, additional, Choe, Hannah, additional, Eder, Matthias, additional, Etra, Aaron, additional, Grupp, Stephan A., additional, Hexner, Elizabeth O, additional, Hogan, William J., additional, Kitko, Carrie L., additional, Kraus, Sabrina, additional, Merli, Pietro, additional, Qayed, Muna, additional, Reshef, Ran, additional, Schechter, Tal, additional, Ullrich, Evelyn, additional, Vasova, Ingrid, additional, Wölfl, Matthias, additional, Zeiser, Robert, additional, Baez, Janna, additional, Beheshti, Rahnuma, additional, Gleich, Sigrun, additional, Katsivelos, Nikolaos, additional, Kowalyk, Steven, additional, Morales, George, additional, Young, Ms. Rachel, additional, Chen, Dr. Yi-Bin, additional, Nakamura, Ryotaro, additional, Ferrara, James, additional, and Levine, John E, additional

Published
2024
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35. The MAGIC Algorithm Probability Predicts Treatment Response and Long-Term Outcomes to Second-Line Therapy for Acute Gvhd

Author

DeFilipp, Zachariah, primary, Kim, Haesook T, additional, Spyrou, Nikolaos, additional, Kasikis, Stelios, additional, Kowalyk, Steven, additional, Eng, Gilbert, additional, Beheshti, Rahnuma, additional, Baez, Janna, additional, Ayuk, Francis, additional, Bunworasate, Udomsak, additional, Choe, Hannah, additional, Etra, Aaron, additional, Grupp, Stephan A., additional, Hexner, Elizabeth O, additional, Hogan, William J., additional, Kitko, Carrie L., additional, Qayed, Muna, additional, Reshef, Ran, additional, Vasova, Ingrid, additional, Zeiser, Robert, additional, Young, Ms. Rachel, additional, Holler, Ernst, additional, Ferrara, James, additional, Nakamura, Ryotaro, additional, Levine, John E, additional, and Chen, Dr. Yi-Bin, additional

Published
2024
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36. Interferon regulatory factor 4 plays a pivotal role in the development of aGVHD-associated colitis

Author

Frueh, Jochen T., primary, Campe, Julia, additional, Sunaga-Franze, Daniele Yumi, additional, Verheyden, Nikita A., additional, Ghimire, Sakhila, additional, Meedt, Elisabeth, additional, Haslinger, Denise, additional, Harenkamp, Sabine, additional, Staudenraus, Daniel, additional, Sauer, Sascha, additional, Kreft, Andreas, additional, Schubert, Ralf, additional, Lohoff, Michael, additional, Krueger, Andreas, additional, Bonig, Halvard, additional, Chiocchetti, Andreas G., additional, Zeiser, Robert, additional, Holler, Ernst, additional, and Ullrich, Evelyn, additional

Published
2023
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37. Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms

Author

Jayavelu, Ashok Kumar, Schnöder, Tina M., Perner, Florian, Herzog, Carolin, Meiler, Arno, Krishnamoorthy, Gurumoorthy, Huber, Nicolas, Mohr, Juliane, Edelmann-Stephan, Bärbel, Austin, Rebecca, Brandt, Sabine, Palandri, Francesca, Schröder, Nicolas, Isermann, Berend, Edlich, Frank, Sinha, Amit U., Ungelenk, Martin, Hübner, Christian A., Zeiser, Robert, Rahmig, Susann, Waskow, Claudia, Coldham, Iain, Ernst, Thomas, Hochhaus, Andreas, Jilg, Stefanie, Jost, Philipp J., Mullally, Ann, Bullinger, Lars, Mertens, Peter R., Lane, Steven W., Mann, Matthias, and Heidel, Florian H.

Published
2020
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38. Immunization against poly- N -acetylglucosamine reduces neutrophil activation and GVHD while sparing microbial diversity

Author

Hülsdünker, Jan, Thomas, Oliver S., Haring, Eileen, Unger, Susanne, Núñez, Nicolás Gonzalo, Tugues, Sonia, Gao, Zhan, Duquesne, Sandra, Cywes-Bentley, Colette, Oyardi, Ozlem, Kirschnek, Susanne, Schmitt-Graeff, Annette, Pabst, Oliver, Koenecke, Christian, Duyster, Justus, Apostolova, Petya, Blaser, Martin J., Becher, Burkhard, Pier, Gerald B., Häcker, Georg, and Zeiser, Robert

Published
2019

39. Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia

Author

El Khawanky, Nadia, Hughes, Amy, Yu, Wenbo, Myburgh, Renier, Matschulla, Tony, Taromi, Sanaz, Aumann, Konrad, Clarson, Jade, Vinnakota, Janaki Manoja, Shoumariyeh, Khalid, Miething, Cornelius, Lopez, Angel F., Brown, Michael P., Duyster, Justus, Hein, Lutz, Manz, Markus G., Hughes, Timothy P., White, Deborah L., Yong, Agnes S. M., and Zeiser, Robert

Published
2021
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40. Loss of the Fanconi anemia-associated protein NIPA causes bone marrow failure

Author

Kreutmair, Stefanie, Erlacher, Miriam, Andrieux, Geoffroy, Istvanffy, Rouzanna, Mueller-Rudorf, Alina, Zwick, Melissa, Ruckert, Tamina, Pantic, Milena, Poggio, Teresa, Shoumariyeh, Khalid, Mueller, Tony A., Kawaguchi, Hiroyuki, Follo, Marie, Klingeberg, Cathrin, Wlodarski, Marcin, Baumann, Irith, Pfeifer, Dietmar, Kulinski, Michal, Rudelius, Martina, Lemeer, Simone, Kuster, Bernhard, Dierks, Christine, Peschel, Christian, Cabezas-Wallscheid, Nina, Duque-Afonso, Jesus, Zeiser, Robert, Cleary, Michael L., Schindler, Detlev, Schmitt-Graeff, Annette, Boerries, Melanie, Niemeyer, Charlotte M., Oostendorp, Robert A.J., Duyster, Justus, and Illert, Anna Lena

Subjects
DNA damage -- Genetic aspects, Fanconi's anemia -- Genetic aspects, Genes -- Genetic aspects, Disease susceptibility -- Genetic aspects, Hematopoietic stem cells, Proteins -- Genetic aspects, Health care industry
Abstract

Inherited bone marrow failure syndromes (IBMFSs) are a heterogeneous group of disorders characterized by defective hematopoiesis, impaired stem cell function, and cancer susceptibility. Diagnosis of IBMFS presents a major challenge due to the large variety of associated phenotypes, and novel, clinically relevant biomarkers are urgently needed. Our study identified nuclear interaction partner of ALK (NIPA) as an IBMFS gene, as it is significantly downregulated in a distinct subset of myelodysplastic syndrome-type (MDS-type) refractory cytopenia in children. Mechanistically, we showed that NIPA is major player in the Fanconi anemia (FA) pathway, which binds FANCD2 and regulates its nuclear abundance, making it essential for a functional DNA repair/FA/BRCA pathway. In a knockout mouse model, Nipa deficiency led to major cell-intrinsic defects, including a premature aging phenotype, with accumulation of DNA damage in hematopoietic stem cells (HSCs). Induction of replication stress triggered a reduction in and functional decline of murine HSCs, resulting in complete bone marrow failure and death of the knockout mice with 100% penetrance. Taken together, the results of our study add NIPA to the short list of FA-associated proteins, thereby highlighting its potential as a diagnostic marker and/or possible target in diseases characterized by hematopoietic failure., Introduction Inherited BM failure syndromes (IBMFSs) include a wide spectrum of hematological disorders characterized by hypocellular BM and peripheral blood (PB) cytopenia (1, 2). The best-characterized IBMFSs are Fanconi anemia [...]

Published
2020
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41. Graft-versus-host disease of the CNS is mediated by TNF upregulation in microglia

Author

Mathew, Nimitha R., Vinnakota, Janaki M., Apostolova, Petya, Erny, Daniel, Hamarsheh, Shaimaa, Andrieux, Geoffroy, Kim, Jung-Seok, Hanke, Kathrin, Goldmann, Tobias, Chappell-Maor, Louise, Khawanky, Nadia El-, Ihors, Gabriele, Schmid, Dominik, Duyster, Justus, Finke, Jurgen, Blank, Thomas, Boerries, Melanie, Blazar, Bruce R., Jung, Steffen, Prinz, Marco, and Zeiser, Robert

Subjects
Tumor necrosis factor -- Analysis, Transforming growth factors -- Analysis, Bone morphogenetic proteins -- Analysis, RNA sequencing -- Analysis, T cells -- Analysis, Genes, Endothelium, Leukemia, RNA, Central nervous system, Diseases, Health care industry
Abstract

Acute graft-versus-host disease (GVHD) can affect the central nervous system (CNS). The role of microglia in CNS-GVHD remains undefined. In agreement with microglia activation, we found that profound morphological changes and MHC-II and CD80 upregulation occurred upon GVHD induction. RNA sequencing-based analysis of purified microglia obtained from mice with CNS-GVHD revealed TNF upregulation. Selective TNF gene deletion in microglia of [Cx3cr1.sup.creER] [Tnf.sup.fl-] mice reduced MHC-II expression and decreased CNS T cell infiltrates and [VCAM-1.sup.+] endothelial cells. GVHD increased microglia TGF-[beta]-activated kinase-1 (TAK1) activation and NF-[kappa]B/p38 MAPK signaling. Selective Tak1 deletion in microglia using [Cx3cr1.sup.creER] [Tak1.sup.fl/fl] mice resulted in reduced TNF production and microglial MHC-II and improved neurocognitive activity. Pharmacological TAK1 inhibition reduced TNF production and MHC-II expression by microglia, Th1 and Th17 T cell infiltrates, and [VCAM-1.sup.+] endothelial cells and improved neurocognitive activity, without blocking graft- versus-leukemia effects. Consistent with these findings in mice, we observed increased activation and TNF production of microglia in the CNS of GVHD patients. In summary, we prove a role for microglia in CNS-GVHD, identify the TAK1/TNF/MHC-II axis as a mediator of CNS-GVHD, and provide a TAK1 inhibitor-based approach against GVHD-induced neurotoxicity., Introduction Acute graft-versus-host disease (GVHD) is a life-threatening complication after allogeneic hematopoietic cell transplantation (allo-HCT). About 50% of patients with severe acute GVHD fail to respond to corticosteroids, and steroid-refractory [...]

Published
2020
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42. Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD

Author

Koehn, Brent H., Saha, Asim, McDonald-Hyman, Cameron, Loschi, Michael, Thangavelu, Govindarajan, Ma, Lie, Zaiken, Michael, Dysthe, Josh, Krepps, Walker, Panthera, Jamie, Hippen, Keli, Jameson, Stephen C., Miller, Jeffrey S., Cooper, Matthew A., Farady, Christopher J., Iwawaki, Takao, Ting, Jenny P.-Y., Serody, Jonathan S., Murphy, William J., Hill, Geoffrey R., Murray, Peter J., Bronte, Vincenzo, Munn, David H., Zeiser, Robert, and Blazar, Bruce R.

Published
2019
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43. Changes in Immunosuppressive Treatment of Chronic Graft-versus-Host Disease: Comparison of 2 Surveys within Allogeneic Hematopoietic Stem Cell Transplant Centers in Germany, Austria, and Switzerland

Author

Wolff, Daniel, Hilgendorf, Inken, Wagner-Drouet, Eva, Jedlickova, Zuzana, Ayuk, Francis, Zeiser, Robert, Schäfer-Eckart, Kerstin, Gerbitz, Armin, Stadler, Michael, Klein, Stefan, Middeke, Jan-Moritz, Lawitschka, Anita, Winkler, Julia, Halter, Jörg, Holler, Ernst, Kobbe, Guido, Stelljes, Matthias, Ditschkowski, Markus, and Greinix, Hildegard

Published
2019
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44. Prevention of CMV/EBV reactivation by double-specific T cells in patients after allogeneic stem cell transplantation: results from the randomized phase I/IIa MULTIVIR-01 study

Author

Gerbitz, Armin, primary, Gary, Regina, additional, Aigner, Michael, additional, Moosmann, Andreas, additional, Kremer, Anita, additional, Schmid, Christoph, additional, Hirschbuehl, Klaus, additional, Wagner, Eva, additional, Hauptrock, Beate, additional, Teschner, Daniel, additional, Roesler, Wolf, additional, Spriewald, Bernd, additional, Tischer, Johanna, additional, Moi, Stephanie, additional, Balzer, Heidi, additional, Schaffer, Stefanie, additional, Bausenwein, Judith, additional, Wagner, Anja, additional, Schmidt, Franziska, additional, Brestrich, Jens, additional, Ullrich, Barbara, additional, Maas, Stefanie, additional, Herold, Susanne, additional, Strobel, Julian, additional, Zimmermann, Robert, additional, Weisbach, Volker, additional, Hansmann, Leo, additional, Lammoglia-Cobo, Fernanda, additional, Remberger, Mats, additional, Stelljes, Matthias, additional, Ayuk, Francis, additional, Zeiser, Robert, additional, and Mackensen, Andreas, additional

Published
2023
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47. High Mortality of COVID-19 Early after Allogeneic Stem Cell Transplantation: A Retrospective Multicenter Analysis on Behalf of the German Cooperative Transplant Study Group

Author

Schaffrath, Judith, Brummer, Christina, Wolff, Daniel, Holtick, Udo, Kröger, Nicolaus, Bornhäuser, Martin, Kraus, Sabrina, Hilgendorf, Inken, Blau, Igor-Wolfgang, Penack, Olaf, Wittke, Christoph, Steiner, Normann, Nachbaur, David, Thurner, Lorenz, Hindahl, Heidrun, Zeiser, Robert, Maier, Claus-Philipp, Bethge, Wolfgang, and Müller, Lutz P.

Published
2022
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48. Neutrophils provide cellular communication between ileum and mesenteric lymph nodes at graft-versus-host disease onset

Author

Hülsdünker, Jan, Ottmüller, Katja J., Neeff, Hannes P., Koyama, Motoko, Gao, Zhan, Thomas, Oliver S., Follo, Marie, Al-Ahmad, Ali, Prinz, Gabriele, Duquesne, Sandra, Dierbach, Heide, Kirschnek, Susanne, Lämmermann, Tim, Blaser, Martin J., Fife, Brian T., Blazar, Bruce R., Beilhack, Andreas, Hill, Geoffrey R., Häcker, Georg, and Zeiser, Robert

Published
2018
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50. Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion

Author

Paczulla, Anna M., Rothfelder, Kathrin, Raffel, Simon, Konantz, Martina, Steinbacher, Julia, Wang, Hui, Tandler, Claudia, Mbarga, Marcelle, Schaefer, Thorsten, Falcone, Mattia, Nievergall, Eva, Dörfel, Daniela, Hanns, Pauline, Passweg, Jakob R., Lutz, Christoph, Schwaller, Juerg, Zeiser, Robert, Blazar, Bruce R., Caligiuri, Michael A., Dirnhofer, Stephan, Lundberg, Pontus, Kanz, Lothar, Quintanilla-Martinez, Leticia, Steinle, Alexander, Trumpp, Andreas, Salih, Helmut R., and Lengerke, Claudia

Published
2019
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