Search

Your search keyword '"Zheng, Nanxin"' showing total 21 results
Start Over Author "Zheng, Nanxin" Search Limiters Available in Library Collection
21 results on '"Zheng, Nanxin"'

10. Changing trends, clinicopathological characteristics, surgical treatment patterns, and prognosis of schistosomiasis-associated versus non-schistosomiasis-associated colorectal cancer: a large retrospective cohort study of 31 153 cases in Shanghai, China (2001–2021)

Author

Zheng, Nanxin, primary, Wang, Hao, additional, Yu, Qing, additional, Wang, Chen, additional, Bai, Chen Guang, additional, Pan, An Fu, additional, Jiang, Jianjun, additional, Lu, Jian, additional, Dai, Si Min, additional, Mei, Zubing, additional, Zhang, Wei, additional, and Gao, Xian Hua, additional

Published
2023
Full Text
View/download PDF

21. Alsterpaullone induces apoptosis of HepG2 cells via a p38 mitogen-activated protein kinase signaling pathway.

Author

Yin, Peng, Zheng, Nanxin, Dong, Junfeng, Xu, Chunyang, Zhang, Xiaomei, and Ding, Guoshan

Subjects
*MITOGEN-activated protein kinases, *CYCLIN-dependent kinases, *CELL tumors
Abstract

Alsterpaullone (Alp) is a small-molecule inhibitor that targets cyclin-dependent kinases to inhibit tumor cell activity. However, to the best of our knowledge, the effect of Alp on hepatoblastoma has not been investigated. Therefore, the function of Alp in apoptotic induction of hepatoblastoma cells and a potential mechanism of action were investigated. Results indicated that low doses of Alp (1 µM) significantly induced apoptosis in the HepG2 hepatoblastoma cell line. In vivo experiments of tumor suppression further indicated that Alp (3 mg/kg) exerted an inhibitory effect on HepG2 ×enograft tumor growth. Following Alp treatment, the expression level of B-cell lymphoma 2 (Bcl-2)-associated X protein, and cleaved caspase-3 and −9 in HepG2 cells was significantly increased; however, the expression of Bcl-2 was significantly decreased. In addition, phosphorylation of p38 mitogen-activated protein kinase (MAPK) significantly decreased Alp-induced caspase-3 and −9 activation. These results suggested that Alp induces apoptosis and inhibited proliferation via the p38MAPK signaling pathway. Therefore, Alp may be a therapeutic agent for treating hepatoblastoma. [ABSTRACT FROM AUTHOR]

Published
2019

Catalog

Books, media, physical & digital resources
See catalog results