10 results on '"Zhenyong Li"'
Search Results
2. Dynamic modelling and optimal control of herd behaviour with time delay and media
- Author
-
Zhenyong Li, Ting Li, Weijun Xu, and Yan Shao
- Subjects
Herd behaviour ,asymptotic stability ,time delay ,media ,optimal control ,Control engineering systems. Automatic machinery (General) ,TJ212-225 ,Systems engineering ,TA168 - Abstract
A dynamic model of herd behaviour with delay time and media is established and analysed to discover the latent mechanism that represents how capital flows in the stock market. We prove that solutions of the model are uniformly bounded, and the contagion threshold [Formula: see text] is obtained. The stability of positive equilibrium points of the model with zero and nonzero delay is discussed. An optimal control problem with media is formulated, and Pontryagin's maximum principle is applied to find an optimal strategy to control herding. Several numerical simulations show the effect of media and delay on herd behaviour. Finally, the practical meaning of the presented model is briefly discussed.
- Published
- 2022
- Full Text
- View/download PDF
3. Bivalirudin Presents a Favorable Safety Profile Regarding Adverse Drug Reactions, Thrombocytopenia, and Bleeding in Chinese Patients With High Bleeding Risk Undergoing Percutaneous Coronary Intervention: A Prospective, Multi-Center, Intensive Monitoring Study
- Author
-
Xiaoping Peng, Zhenyong Li, Dunheng Li, Zhongyin Li, Zhaohua Lu, Caidong Luo, and Zheng Ji
- Subjects
bivalirudin ,percutaneous coronary intervention ,high bleeding risk patients ,adverse events and adverse drug reactions ,thrombocytopenia and bleeding ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
BackgroundThis study aimed to comprehensively explore the occurrence and risk factors for adverse events (AEs) and adverse drug reactions (ADRs) (especially for thrombocytopenia and bleeding) in Chinese patients with high bleeding risk (older adults, or complicated with diabetes mellitus or renal function impairment) undergoing percutaneous coronary intervention (PCI) with bivalirudin as an anticoagulant.MethodsA total of 1,226 patients with high bleeding risk who received PCI with bivalirudin as an anticoagulant from 27 Chinese medical centers were enrolled in this prospective, multi-center, intensive monitoring study. AEs, ADRs, thrombocytopenia, and bleeding were collected from admission to 72 h post-bivalirudin administration; subsequently, patients were followed up on the 30th day with the safety data collected as well.ResultsAdverse events were observed in 198 (16.2) patients, among which severe AEs occurred in 16 (1.3%) patients. Meanwhile, bivalirudin-related ADRs were reported in 66 (5.4%) patients, among which 5 (0.4%) patients experienced bivalirudin-related severe ADRs. Besides, thrombocytopenia and bleeding occurred in 45 (3.7%) and 19 (1.5%) patients, respectively. The subsequent multivariate logistic analysis revealed that age >75 years [p = 0.017, odds ratio (OR) = 1.856] and spontaneous coronary artery dissection (SCAD) (p = 0.030, OR = 2.022) were independently related to higher ADR risk; SCAD (p = 0.017, OR = 2.426) was independently correlated with higher thrombocytopenia risk, while radial artery access (p = 0.015, OR = 0.352) was independently correlated with lower thrombocytopenia risk; and the administration of bivalirudin preoperatively or intraoperatively (p = 0.013, OR = 5.097) was independently associated with higher bleeding risk.ConclusionBivalirudin presents a favorable safety profile regarding ADRs, thrombocytopenia, and bleeding in Chinese patients with high bleeding risk undergoing PCI.
- Published
- 2022
- Full Text
- View/download PDF
4. Occurrence and Risk Factors of Adverse Drug Reactions in Patients Receiving Bivalirudin as Anticoagulant During Percutaneous Coronary Intervention: A Prospective, Multi-Center, Intensive Monitoring Study
- Author
-
Ping Li, Hongyan Zhang, Caidong Luo, Zheng Ji, Zeqi Zheng, Zhenyong Li, Fan Wu, Jinlong Li, and Lang Hong
- Subjects
bivalirudin ,percutaneous coronary intervention ,adverse events ,adverse drug reactions ,bleeding and thrombocytopenia ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
BackgroundBivalirudin is a common anticoagulant during percutaneous coronary intervention (PCI); however, since its application in China, it still lacks comprehensive evaluation of adverse events (AEs) or adverse drug reactions (ADRs) under the real-clinical setting conditions with a large-sample-size population. Therefore, this prospective, multi-center, intensive monitoring study aimed to comprehensively investigate the occurrence and risk factors of AEs and ADRs during PCI with bivalirudin as an anticoagulant.MethodsA total of 3,049 patients who underwent PCI with bivalirudin as anticoagulant from 27 Chinese medical centers were enrolled. Safety data (AEs/ADRs) were collected from hospital admission to 72 h after bivalirudin administration; then, patients were followed up at the 30th day with the safety data collected as well.ResultsA total of 414 (13.58%) patients occurred AEs, among which 31 (1.02%) cases suffered from severe AEs and 8 (0.26%) cases died due to AEs. Importantly, 118 (3.87%) patients occurred bivalirudin related ADRs, among which 7 (0.23%) cases suffered from severe ADRs while no case (0%) died due to ADRs. Of note, 7 (0.23%) patients showed new ADRs, 34 (1.12%) patients experienced bleeding, and 79 (2.59%) patients had thrombocytopenia. Furthermore, age, renal function impairment, CRUSADE high risk stratification independently correlated with total ADRs risk; CRUSADE high risk stratification, emergency operation, full dose bivalirudin independently associated with bleeding risk; age, renal function impairment independently related to thrombocytopenia risk.ConclusionBivalirudin is well-tolerated as an anticoagulant for PCI procedure; meanwhile, older age, renal function impairment, and CRUSADE high risk stratification serve as independent risk factors of bivalirudin related ADRs.
- Published
- 2022
- Full Text
- View/download PDF
5. Comparison of percutaneous balloon compression and microvascular decompression in the treatment of trigeminal neuralgia.
- Author
-
Zhenyong Li, Zhuqing Xie, Guoqiang Tang, and Shihui Jin
- Subjects
- *
TRIGEMINAL neuralgia , *ANALGESIA , *MASTICATORY muscles , *MUSCLE strength , *MUSCLE weakness , *SURGICAL complications - Abstract
Objective: To compare the effect of percutaneous balloon compression (PBC) and microvascular decompression (MVD) in the treatment of trigeminal neuralgia (TN). Methods: Data of 98 patients with TN, admitted to Chenzhou First People’s Hospital from May 2020 to May 2022, were retrospectively collected. Patients were divided into two groups based on the surgical method. A total of 53 patients treated with PBC comprised the PBC-group and 45 patients treated with MVD comprised the MVD-group. The immediate pain relief, long-term efficacy, surgical complications, and masticatory muscle strength of the two groups were compared and analyzed. Results: There was no significant difference in the immediate pain relief and long-term e efficacy, between the two groups (P>0.05). Complication rate in the PBC-group was significantly lower than that in the MVD-group (3.77% vs 17.78%, P<0.05). Medical records within 14 days after the operation showed that the incidence of facial numbness and masticatory muscle weakness in the PBC-group were 37.74% and 28.30% respectively, significantly higher than those in MVD-group (4.44% and 2.22%) (P<0.05). These symptoms gradually improved three months after the surgery, and were almost completely resolved after six months. Conclusions: Compared with MVD, PBC has the same effect in the treatment of TN. PBC is a minimally invasive, safe, and effective method with a low complication rate. Although masticatory muscle strength is slightly impacted by PBC, it gradually recovers within six months after the operation. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
6. OsPEX1, an extensin-like protein, negatively regulates root growth in a gibberellin-mediated manner in rice
- Author
-
Jieni Li, Yuexiong Zhang, Zhenyong Li, Hang Dai, Xin Luan, Tianxiu Zhong, Shu Chen, Xin-Ming Xie, Gang Qin, Xiang-Qian Zhang, and Haifeng Peng
- Subjects
Genetics ,Plant Science ,General Medicine ,Agronomy and Crop Science - Abstract
Leucine-rich repeat extensins (LRXs) are required for plant growth and development through affecting cell growth and cell wall formation. LRX gene family can be classified into two categories: predominantly vegetative-expressed LRX and reproductive-expressed PEX. In contrast to the tissue specificity of Arabidopsis PEX genes in reproductive organs, rice OsPEX1 are also highly expressed in roots in addition to reproductive tissue. However, whether and how OsPEX1 affects root growth is unclear. Here, we found that overexpression of OsPEX1 in the pex1 mutant retarded root growth by reducing cell elongation resulting from an increase of lignin deposition, whereas knockdown of OsPEX1 had an opposite effect on root growth, indicating that OsPEX1 negatively regulated root growth in rice seedling. Upon further investigation, we uncovered the existence of a feedback loop between OsPEX1 transcription and GA biosynthesis for proper root growth. This was supported by the facts that exogenous GA3 application downregulated the transcription levels of OsPEX1 and lignin-related genes, rescuing the development defects of the root in the pex1 mutant, whereas OsPEX1 negatively regulated GA level by altering the expression of GA biosynthesis genes. Moreover, OsPEX1 and GA showed antagonistic action on the lignin biosynthesis in root. OsPEX1 overexpression upregulated the transcription levels of lignin-related genes, whereas exogenous GA application downregulated their expression, accompanied by altered root growth phenotypes. Taken together, our studies reveal a possible molecular pathway of OsPEX1-mediated root growth through coordinate modulation of lignin deposition via a negative feedback regulation between OsPEX1 transcription and GA biosynthesis.
- Published
- 2022
7. the Dynamic Portfolio Strategy employing the Investor Sentiment under Stochastic Environment
- Author
-
Qian Feng, Ting Li, and Zhenyong Li
- Published
- 2020
8. TFE3–SLC36A1 axis promotes resistance to glucose starvation in kidney cancer cells.
- Author
-
Suli Lv, Zongbiao Zhang, Zhenyong Li, Qian Ke, Xianyun Ma, Neng Li, Xuefeng Zhao, Qingli Zou, Lidong Sun, and Tanjing Song
- Subjects
- *
RENAL cancer , *TRANSCRIPTION factors , *GLUCOSE , *CANCER cell proliferation , *STARVATION , *CANCER cells - Abstract
Higher demand for nutrients including glucose is characteristic of cancer. "Starving cancer" has been pursued to curb tumor progression. An intriguing regime is to inhibit glucose transporter GLUT1 in cancer cells. In addition, during cancer progression, cancer cells may suffer from insufficient glucose supply. Yet, cancer cells can somehow tolerate glucose starvation. Uncovering the underlying mechanisms shall shed insight into cancer progression and benefit cancer therapy. TFE3 is a transcription factor known to activate autophagic genes. Physiological TFE3 activity is regulated by phosphorylationtriggered translocation responsive to nutrient status. We recently reported TFE3 constitutively localizes to the cell nucleus and promotes cell proliferation in kidney cancer even under nutrient replete condition. It remains unclear whether and how TFE3 responds to glucose starvation. In this study, we show TFE3 promotes kidney cancer cell resistance to glucose starvation by exposing cells to physiologically relevant glucose concentration. We find glucose starvation triggers TFE3 protein stabilization through increasing its O-GlcNAcylation. Furthermore, through an unbiased functional genomic study, we identify SLC36A1, a lysosomal amino acid transporter, as a TFE3 target gene sensitive to TFE3 protein level. We find SLC36A1 is overexpressed in kidney cancer, which promotes mTOR activity and kidney cancer cell proliferation. Importantly, SLC36A1 level is induced by glucose starvation through TFE3, which enhances cellular resistance to glucose starvation. Suppressing TFE3 or SLC36A1 significantly increases cellular sensitivity to GLUT1 inhibitor in kidney cancer cells. Collectively, we uncover a functional TFE3–SLC36A1 axis that responds to glucose starvation and enhances starvation tolerance in kidney cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
9. The P53-P21-RB1 pathway promotes BRD4 degradation in liver cancer through USP1.
- Author
-
Neng Li, Erlei Zhang, Zhenyong Li, Suli Lv, Xuefeng Zhao, Qian Ke, Qingli Zou, Wensheng Li, Yifei Wang, Haocheng Guo, Tanjing Song, and Lidong Sun
- Subjects
- *
LIVER cancer , *TUMOR suppressor genes , *P53 protein , *GENE regulatory networks , *GENETIC regulation , *P53 antioncogene - Abstract
Liver cancer is notoriously refractory to conventional therapeutics. Tumor progression is governed by the interplay between tumor-promoting genes and tumor-suppressor genes. BRD4, an acetyl lysine-binding protein, is overexpressed in many cancer types, which promotes activation of a pro-tumor gene network. But the underlying mechanism for BRD4 overexpression remains incompletely understood. In addition, understanding the regulatory mechanism of BRD4 protein level will shed insight into BRD4-targeting therapeutics. In this study, we investigated the potential relation between BRD4 protein level and P53, the most frequently dysregulated tumor suppressor. By analyzing the TCGA datasets, we first identify a strong negative correlation between protein levels of P53 and BRD4 in liver cancer. Further investigation shows that P53 promotes BRD4 protein degradation. Mechanistically, P53 indirectly represses the transcription of USP1, a deubiquitinase, through the P21-RB1 axis. USP1 itself is also overexpressed in liver cancer and we show USP1 deubiquitinates BRD4 in vivo and in vitro, which increases BRD4 stability. With cell proliferation assays and xenograft model, we show the protumor role of USP1 is partially mediated by BRD4. With functional transcriptomic analysis, we find the USP1-BRD4 axis upholds expression of a group of cancer-related genes. In summary, we identify a functional P53-P21-RB1-USP1-BRD4 axis in liver cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
10. Comparison of percutaneous balloon compression and microvascular decompression in the treatment of trigeminal neuralgia.
- Author
-
Li Z, Xie Z, Tang G, and Jin S
- Abstract
Objective: To compare the effect of percutaneous balloon compression (PBC) and microvascular decompression (MVD) in the treatment of trigeminal neuralgia (TN)., Methods: Data of 98 patients with TN, admitted to Chenzhou First People's Hospital from May 2020 to May 2022, were retrospectively collected. Patients were divided into two groups based on the surgical method. A total of 53 patients treated with PBC comprised the PBC-group and 45 patients treated with MVD comprised the MVD-group. The immediate pain relief, long-term efficacy, surgical complications, and masticatory muscle strength of the two groups were compared and analyzed., Results: There was no significant difference in the immediate pain relief and long-term e efficacy, between the two groups ( P >0.05). Complication rate in the PBC-group was significantly lower than that in the MVD-group (3.77% vs 17.78%, P <0.05). Medical records within 14 days after the operation showed that the incidence of facial numbness and masticatory muscle weakness in the PBC-group were 37.74% and 28.30% respectively, significantly higher than those in MVD-group (4.44% and 2.22%) ( P <0.05). These symptoms gradually improved three months after the surgery, and were almost completely resolved after six months., Conclusions: Compared with MVD, PBC has the same effect in the treatment of TN. PBC is a minimally invasive, safe, and effective method with a low complication rate. Although masticatory muscle strength is slightly impacted by PBC, it gradually recovers within six months after the operation., (Copyright: © Pakistan Journal of Medical Sciences.)
- Published
- 2023
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.