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10 results on '"Zhong, Manli"'

3. Fungal acetylome comparative analysis identifies an essential role of acetylation in human fungal pathogen virulence

Author

Li, Yanjian, Li, Hailong, Sui, Mingfei, Li, Minghui, Wang, Jiamei, Meng, Yang, Sun, Tianshu, Liang, Qiaojing, Suo, Chenhao, Gao, Xindi, Li, Chao, Li, Zhuoran, Du, Wei, Zhang, Baihua, Sai, Sixiang, Zhang, Zhang, Ye, Jing, Wang, Hongchen, Yue, Shang, Li, Jiayi, Zhong, Manli, Chen, Changbin, Qi, Shouliang, Lu, Ling, Li, Dancheng, and Ding, Chen

Published
2019
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7. Nasal Delivery of D-Penicillamine Hydrogel Upregulates a Disintegrin and Metalloprotease 10 Expression via Melatonin Receptor 1 in Alzheimer’s Disease Models

Author

Zhong, Manli, primary, Kou, Hejia, additional, Zhao, Pu, additional, Zheng, Wei, additional, Xu, He, additional, Zhang, Xiaoyu, additional, Lan, Wang, additional, Guo, Chuang, additional, Wang, Tao, additional, Guo, Feng, additional, Wang, Zhanyou, additional, and Gao, Huiling, additional

Published
2021
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10. A Novel Cu(II)-Binding Peptide Identified by Phage Display Inhibits Cu 2+ -Mediated Aβ Aggregation.

Author

Zhang, Xiaoyu, Zhang, Xiancheng, Zhong, Manli, Zhao, Pu, Guo, Chuang, Li, You, Xu, He, Wang, Tao, and Gao, Huiling

Subjects
ALZHEIMER'S disease, THERAPEUTICS, CELL culture, AMYLOID beta-protein
Abstract

Copper (Cu) has been implicated in the progression of Alzheimer's disease (AD), and aggregation of Cu and amyloid β peptide (Aβ) are considered key pathological features of AD. Metal chelators are considered to be potential therapeutic agents for AD because of their capacity to reduce metal ion-induced Aβ aggregation through the regulation of metal ion distribution. Here, we used phage display technology to screen, synthesize, and evaluate a novel Cu(II)-binding peptide that specifically blocked Cu-triggered Aβ aggregation. The Cu(II)-binding peptide (S-A-Q-I-A-P-H, PCu) identified from the phage display heptapeptide library was used to explore the mechanism of PCu inhibition of Cu2+-mediated Aβ aggregation and Aβ production. In vitro experiments revealed that PCu directly inhibited Cu2+-mediated Aβ aggregation and regulated copper levels to reduce biological toxicity. Furthermore, PCu reduced the production of Aβ by inhibiting Cu2+-induced BACE1 expression and improving Cu(II)-mediated cell oxidative damage. Cell culture experiments further demonstrated that PCu had relatively low toxicity. This Cu(II)-binding peptide that we have identified using phage display technology provides a potential therapeutic approach to prevent or treat AD. [ABSTRACT FROM AUTHOR]

Published
2021
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