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The concept of cultural community has been firstly or more obviously embodied in the works of the minority/minoritized literature or writers from marginalized countries and approached from different perspectives, such as small and enduring spiritual bonds, aspiration and an ideal, or self-deconstruction due to heterogeneity, conflict, and difference. However, most researchers explore the cultural community in the works of merely one racial group, such as American Indian, Chinese, Korean, or African. There has been comparatively little research on the construction of a cultural community across races. Focusing on Molefi Kete Asante's Afrocentricity and Tu Wei-ming's embodied Confucianism, two cultural movements that fully embody a "new cosmopolitanism" and have the potential to dialog and complement each other, this study compares the views of transcendence of these two philosophies in terms of sense, the ultimate goal, orientation of time, vehicle for realization, and thinking pattern in the hope of the construction of a Sino-African cultural community, which reflects mutual understanding, coexistence, harmony without uniformity, and the contact, conflict, and intermingling of heterogeneous cultures. [ABSTRACT FROM AUTHOR]

The MYC oncoprotein activates and represses gene expression in a transcription‐dependent or transcription‐independent manner. Modification of mRNA emerges as a key gene expression regulatory nexus. We sought to determine whether MYC alters mRNA modifications and report here that MYC promotes cancer progression by down‐regulating N6‐methyladenosine (m6A) preferentially in transcripts of a subset of MYC‐repressed genes (MRGs). We find that MYC activates the expression of ALKBH5 and reduces m6A levels in the mRNA of the selected MRGs SPI1 and PHF12. We also show that MYC‐regulated m6A controls the translation of MRG mRNA via the specific m6A reader YTHDF3. Finally, we find that inhibition of ALKBH5, or overexpression of SPI1 or PHF12, effectively suppresses the growth of MYC‐deregulated B‐cell lymphomas, both in vitro and in vivo. Our findings uncover a novel mechanism by which MYC suppresses gene expression by altering m6A modifications in selected MRG transcripts promotes cancer progression. SYNOPSIS: MYC suppresses gene expression by indirectly altering m6A modifications in transcripts of MYC‐repressed genes via ALKBH5 to promote cancer progression. MYC indirectly down‐regulates m6A levels in mRNA and inhibits protein expression of selected MRG transcripts.MYC transcriptionally activates the m6A demethylases ALKBH5 and FTO.ALKBH5 removes m6A and YTHDF3 binds m6A‐modified mRNAs to regulate the translation of SPI1/PHF12.The MYC‐ALKBH5‐m6A‐SPI1/PHF12 axis is critical for cancer progression. [ABSTRACT FROM AUTHOR]