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Your search keyword '"Zhou, Zong-Guang"' showing total 338 results
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338 results on '"Zhou, Zong-Guang"'

9. Deciphering the Clinical Significance and Kinase Functions of GSK3α in Colon Cancer by Proteomics and Phosphoproteomics

Author

Gao, Li, primary, Lu, Ying, additional, Chen, Hai-Ning, additional, Li, Zhigui, additional, Hu, Meng, additional, Zhang, Rou, additional, Wang, Xiuxuan, additional, Xu, Zhiqiang, additional, Gong, Yanqiu, additional, Wang, Rui, additional, Du, Dan, additional, Hai, Shan, additional, Li, Shuangqing, additional, Su, Dan, additional, Li, Yuan, additional, Xu, Heng, additional, Zhou, Zong-Guang, additional, and Dai, Lunzhi, additional

Published
2023
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10. Phenotypic Heterogeneity Analysis of APC-Mutant Colon Cancer by Proteomics and Phosphoproteomics Identifies RAI14 as a Key Prognostic Determinant in East Asians and Westerners

Author

Zhang, Rou, primary, Hu, Meng, additional, Chen, Hai-Ning, additional, Wang, Xiuxuan, additional, Xia, Zhili, additional, Liu, Yu, additional, Wang, Rui, additional, Xia, Xuyang, additional, Shu, Yang, additional, Du, Dan, additional, Meng, Wenbo, additional, Qi, Shiqian, additional, Li, Yuan, additional, Xu, Heng, additional, Zhou, Zong-Guang, additional, and Dai, Lunzhi, additional

Published
2023
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20. Application of Gross Tissue Response System in Gastric Cancer After Neoadjuvant Chemotherapy: A Primary Report of a Prospective Cohort Study

Author

Yang, Hua, primary, Zhang, Wei-Han, additional, Ge, Rui, additional, Peng, Bo-Qiang, additional, Chen, Xin-Zu, additional, Yang, Kun, additional, Liu, Kai, additional, Chen, Xiao-Long, additional, He, Du, additional, Liu, Jian-Ping, additional, Zhang, Wei-Wei, additional, Qin, Yun, additional, Zhou, Zong-Guang, additional, and Hu, Jian-Kun, additional

Published
2021
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32. Expressions of miR-302a, miR-105, and miR-888 Play Critical Roles in Pathogenesis, Radiotherapy, and Prognosis on Rectal Cancer Patients : A Study From Rectal Cancer Patients in a Swedish Rectal Cancer Trial of Preoperative Radiotherapy to Big Database Analyses

Author

Meng, Wen-Jian, Pathak, Surajit, Zhang, Xueli, Adell, Gunnar, Jarlsfelt, Ingvar, Holmlund, Birgitta, Wang, Zi-Qiang, Zhang, Alexander S., Zhang, Hong, Zhou, Zong-Guang, and Sun, Xiao-Feng

Subjects
Cancer och onkologi, Cancer and Oncology, miRNAs, pathogenesis, radiotherapy, prognosis, rectal cancer
Abstract

Differential expressions and functions of various micoRNAs (miRNAs) have been intensively studied in both colon and rectal cancers. However, the importance of miRNAs on radiotherapy (RT) response and clinical outcome in rectal cancer patients remains unclear. In this study, we used real-time polymerase chain reaction to examine the expressions of miR-302a, miR-105, and miR-888 in normal mucosa and cancer tissue from rectal cancer patients with and without preoperative RT. The biological function of miR-302a, miR-105, and miR-888 expression was further analyzed and identified through the public databases: TCGA (The Cancer Genome Atlas) and GEPIA (Gene Expression Profiling Interactive Analysis). The results showed that the expression of miR-105 in rectal cancer was higher than that in normal mucosa in RT (P= 0.042) and non-RT patients (P= 0.003) and was associated with mucinous histological type (P= 0.004), COX-2 (P= 0.042), and p73 expression (P= 0.030). The expression of miR-302a was shown more frequently in cancers with necrosis (P= 0.033) and with WRAP53 expression (P= 0.015), whereas miR-888 expression occurred more frequently in tumors with protein the expression of survivin (P= 0.015), AEG-1 (astrocyte elevated gene-1) (P= 0.003), and SATB1 (special AT-rich sequence binding protein 1) (P= 0.036). Moreover, TargetScan also predicted AEG-1 and SATB1 as putative targets for miR-888. The miRNA-gene network analysis showed that ABI2 was associated with all the three miRNAs, with lower expression and good diagnostic value in rectal cancers. The TCGA database demonstrated the association of miR-105 expression with high carcinoembryonic antigen level (P= 0.048). RT reduced the expressions of miR-302a, miR-105, and miR-888. Prognostic analysis showed that miR-888 expression was independently associated with worse survival of patients without RT [overall survival,P= 0.001; disease-free survival,P= 0.009]. Analysis of biological function revealed that the protein serine/threonine kinase activity and PI3K-AKT signaling pathway were the most significantly enriched functions and pathways, respectively. Our findings suggest that miR-105 is involved in rectal cancer pathogenesis and miR-888 is associated with prognosis. MiR-302a, miR-105, and miR-888 have potential influence on the pathogenesis, RT, and prognosis of rectal cancer. Funding Agencies|Swedish Cancer Foundation; Swedish Research CouncilSwedish Research Council; Health Research Council in the South-East of Sweden [1921-B91-08XBC]

Published
2020

33. Prognostic Heterogeneity of MRE11 Based on the Location of Primary Colorectal Cancer Is Caused by Activation of Different Immune Signals

Author

Fan, Chuanwen, Kopsida, Maria, Liu, Youbin, Zhang, Hong, Gao, Jingfang, Arbman, Gunnar, Cao, Si-Yu-Wei, Li, Yuan, Zhou, Zong-Guang, and Sun, Xiao-Feng

Subjects
enzymes and coenzymes (carbohydrates), Cancer och onkologi, colorectal cancer (CRC), left-sided colon and rectal cancer (LSCRC), MRE11, tumor-infiltrating inflammatory cells (TIICs), survival or prognosis, Cancer and Oncology
Abstract

Background: MRE11 plays an important role in DNA damage response for the maintenance of genome stability, and is becoming a prognostic marker for cancers, including colorectal cancer (CRC). However, the correlations of MRE11 to prognosis and tumor-infiltrating inflammatory cells (TIICs) in different locations of CRC remains unclear. Methods: Among Swedish and TCGA-COREAD patients, we investigated the association of MRE11 expression, tumor-infiltrating inflammatory cells (TIICs) and microsatellite status with survival in right-sided colon cancer (RSCC) and left-sided colon and rectal cancer (LSCRC). The signaling of MRE11-related was further analyzed using weighted gene co-expression network analysis and ClueGO. Results: High MRE11 expression alone or combination of high MRE11 expression with high TIICs was related to favorable prognosis in LSCRC. Moreover, high MRE11 expression was associated with favorable prognosis in LSCRC with microsatellite stability. The relationships above were adjusted for tumor stage, differentiation, and/or TIICs. However, no such evidence was observed in RSCC. Several signaling pathways involving MRE11 were found to be associated with cell cycle and DNA repair in RSCC and LSCRC, whereas, the activation of the immune response and necrotic cell death were specifically correlated with LSCRC. Conclusions: High MRE11 expression is an independent prognostic marker in LSCRC and enhanced prognostic potency of combining high MRE11 with high TIICs in LSCRC, mainly due to differential immune signaling activated by MRE11 in RSCC and LSCRC, respectively. Funding Agencies|Swedish Cancer Foundation; Swedish Research CouncilSwedish Research Council; Oncology Clinics in Linkoping; National Science Foundation of ChinaNational Natural Science Foundation of China [81402446]; Research Foundation of Health and Family Planning Commission of Sichuan Province, China [150136]

Published
2020

35. Expressions of miR-302a, miR-105, and miR-888 Play Critical Roles in Pathogenesis, Radiotherapy, and Prognosis on Rectal Cancer Patients: A Study From Rectal Cancer Patients in a Swedish Rectal Cancer Trial of Preoperative Radiotherapy to Big Database Analyses

Author

Meng, Wen-Jian, primary, Pathak, Surajit, additional, Zhang, Xueli, additional, Adell, Gunnar, additional, Jarlsfelt, Ingvar, additional, Holmlund, Birgitta, additional, Wang, Zi-Qiang, additional, Zhang, Alexander S., additional, Zhang, Hong, additional, Zhou, Zong-Guang, additional, and Sun, Xiao-Feng, additional

Published
2020
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45. Repurposing Brigatinib for the Treatment of Colorectal Cancer Based on Inhibition of ER-phagy

Author

Zhang, Zhe, primary, Gao, Wei, additional, Zhou, Li, additional, Chen, Yan, additional, Qin, Siyuan, additional, Zhang, Lu, additional, Liu, Jiayang, additional, He, Yujia, additional, Lei, Yunlong, additional, Chen, Hai-Ning, additional, Han, Junhong, additional, Zhou, Zong-Guang, additional, Nice, Edouard C., additional, Li, Changlong, additional, Huang, Canhua, additional, and Wei, Xiawei, additional

Published
2019
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46. Comparison between gastric and esophageal classification system among adenocarcinomas of esophagogastric junction according to AJCC 8th edition: a retrospective observational study from two high-volume institutions in China

Author

Liu, Kai, primary, Feng, Fan, additional, Chen, Xin-zu, additional, Zhou, Xin-yi, additional, Zhang, Jing-yu, additional, Chen, Xiao-long, additional, Zhang, Wei-han, additional, Yang, Kun, additional, Zhang, Bo, additional, Zhang, Hong-wei, additional, Zhou, Zong-guang, additional, and Hu, Jian-kun, additional

Published
2018
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47. Suppression of microRNA-31 increases sensitivity to 5-FU at an early stage, and affects cell migration and invasion in HCT-116 colon cancer cells

Author

Sun Xiao-Feng, Zhou Zong-Guang, Stratmann Johannes, and Wang Chao-Jie

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background MicroRNAs (miRNAs) are endogenously expressed noncoding RNAs with important biological and pathological functions. Although several studies have shown that microRNA-31 (miR-31) is obviously up-regulated in colorectal cancer (CRC), there is no study on the functional roles of miR-31 in CRC. Methods Anti-miR™ miRNA 31 inhibitor (anti-miR-31) is a sequence-specific and chemically modified oligonucleotide to specifically target and knockdown miR-31 molecule. The effect of anti-miR-31 transfection was investigated by real-time PCR. HCT-116p53+/+ and HCT-116p53-/-colon cancer cells were treated by anti-miR-31 with or without 5-fluorouracil (5-FU), cell proliferation was determined by MTT assay; apoptosis was detected by DAPI staining; cell cycle was evaluated by flow cytometry; colony formation, migration and invasion assays were performed to investigate the effect of suppression of miR-31 on the cell lines. Results Real-time PCR results showed that anti-miR-31 was efficiently introduced into the cells and reduced miR-31 levels to 44.1% in HCT-116p53+/+ and 67.8% in HCT-116p53-/-cell line (p = 0.042 and 0.046). MTT results showed that anti-miR-31 alone had no effect on the proliferation of HCT-116p53+/+ or HCT-116p53-/-. However, when combined with 5-FU, anti-miR-31 inhibited the proliferation of the two cell lines as early as 24 h after exposure to 5-FU (p = 0.038 and 0.044). Suppression of miR-31 caused a reduction of the migratory cells by nearly 50% compared with the negative control in both HCT-116p53+/+ and HCT-116p53-/-(p = 0.040 and 0.001). The invasive ability of the cells were increased by 8-fold in HCT-116p53+/+ and 2-fold in HCT-116p53-/- (p = 0.045 and 0.009). Suppression of miR-31 had no effect on cell cycle and colony formation (p > 0.05). Conclusions Suppression of miR-31 increases sensitivity to 5-FU at an early stage, and affects cell migration and invasion in HCT-116 colon cancer cells.

Published
2010
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48. The Survival Benefit and Safety of Splenectomy for Gastric Cancer With Total Gastrectomy: Updated Results †.

Author

Yang, Kun, Zang, Zhi-Yun, Niu, Kai-Fan, Sun, Li-Fei, Zhang, Wei-Han, Zhang, Yue-Xin, Chen, Xiao-Long, Zhou, Zong-Guang, and Hu, Jian-Kun

Subjects
SPLENECTOMY, STOMACH cancer, GASTRECTOMY, SURGICAL complications, DATA extraction, LYMPH nodes
Abstract

Background: Splenectomy was traditionally performed to dissect the splenic hilar lymph nodes. Considering the important functions of spleen, whether splenectomy would bring beneficial to gastric cancer patients is debatable. This meta-analysis aimed to make an updated evaluation on the effectiveness and safety of splenectomy. Methods: Literature searches were performed to identify eligible RCTs concerning effectiveness or safety of splenectomy with gastrectomy from PubMed, MEDLINE, CBMdisc, EMBASE, and Cochrane Central Register of Controlled Trials. Two reviewers completed the study selection, data extraction, and quality assessment independently. The meta-analyses were performed by RevMan 5.3. Results: A total of 971 patients from four studies were included (485 in splenectomy group and 486 in spleen preservation group). Splenectomy did not increase 5-year overall survival rate (RR=1.05, 95% CI: 0.96, 1.16) or increase postoperative mortality (RR=1.21, 95% CI: 0.41, 3.54). However, the analysis demonstrated that gastrectomy with splenectomy had significantly higher incidence of postoperative complications (RR=1.80, 95% CI: 1.33, 2.45). No significant differences were found in terms of the number of resected lymph nodes and reoperation rate; however, splenectomy had a tendency to prolong the duration of surgery and hospital stays. Subgroup analyses indicated that splenectomy could not increase overall survival rate for either whole or proximal gastric cancer. Sensitivity analyses also found similar results compared to the primary analyses. Conclusions: Splenectomy cannot benefit the survival of patients with tumor located at lesser curvature, and it could instead increase postoperative morbidity. [ABSTRACT FROM AUTHOR]

Published
2021
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