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36 results on '"Zhu, Yaowu"'

6. Identification and Validation of T-Cell Exhaustion Signature for Predicting Prognosis and Immune Response in Pancreatic Cancer by Integrated Analysis of Single-Cell and Bulk RNA Sequencing Data.

Author

Zhu, Yaowu, Tan, Li, Luo, Danju, and Wang, Xiong

Subjects
*T-cell exhaustion, *PANCREATIC cancer, *IMMUNE response, *RNA sequencing, *PROGNOSIS
Abstract

Purpose: Pancreatic cancer (PACA) is one of the most fatal malignancies worldwide. Immunotherapy is largely ineffective in patients with PACA. T-cell exhaustion contributes to immunotherapy resistance. We investigated the prognostic potential of T-cell exhaustion-related genes (TEXGs). Methods: A single-cell RNA (scRNA) sequencing dataset from Tumor Immune Single-Cell Hub (TISCH) and bulk sequencing datasets from the Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) were used to screen differentially expressed TEXGs. Kaplan–Meier survival, LASSO regression, and univariate/multivariate Cox regression analyses were performed to construct a TEXG risk model. This model was used to predict the prognosis, tumor immune microenvironment, and immunotherapy response. The PACA cohorts from the ICGC and GSE71729 datasets were used to validate the risk model. Pan-cancer expression of SPOCK2 was determined using the TISCH database. Results: A six-gene (SPOCK2, MT1X, LIPH, RARRES3, EMP1, and MEG3) risk model was constructed. Patients with low risk had prolonged survival times in both the training (TCGA-PAAD, n = 178) and validation (ICGC-PACA-CA, ICGC-PAAD-US, and GSE71729, n = 412) datasets. Multivariate Cox regression analysis demonstrated that the risk score was an independent prognostic variable for PACA. High-risk patients correlated with their immunosuppressive status. Immunohistochemical staining confirmed the changes in TEXGs in clinical samples. Moreover, pan-cancer scRNA sequencing datasets from TISCH analysis indicated that SPOCK2 may be a novel marker of exhausted CD8+ T-cells. Conclusion: We established and validated a T-cell exhaustion-related prognostic signature for patients with PACA. Moreover, our study suggests that SPOCK2 is a novel marker of exhausted CD8+ T cells. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Lymphocyte-Related Immunological Indicators for Stratifying Mycobacterium tuberculosis Infection

Author

Luo, Ying, primary, Xue, Ying, additional, Tang, Guoxing, additional, Cai, Yimin, additional, Yuan, Xu, additional, Lin, Qun, additional, Song, Huijuan, additional, Liu, Wei, additional, Mao, Liyan, additional, Zhou, Yu, additional, Chen, Zhongju, additional, Zhu, Yaowu, additional, Liu, Weiyong, additional, Wu, Shiji, additional, Wang, Feng, additional, and Sun, Ziyong, additional

Published
2021
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11. Using Routine Laboratory Markers and Immunological Indicators for Predicting Pneumocystis jiroveci Pneumonia in Immunocompromised Patients

Author

Tang, Guoxing, primary, Tong, Shutao, additional, Yuan, Xu, additional, Lin, Qun, additional, Luo, Ying, additional, Song, Huijuan, additional, Liu, Wei, additional, Wu, Shiji, additional, Mao, Liyan, additional, Liu, Weiyong, additional, Zhu, Yaowu, additional, Sun, Ziyong, additional, and Wang, Feng, additional

Published
2021
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12. Harnessing Big Data to Optimize an Algorithm for Rapid Diagnosis of Pulmonary Tuberculosis in a Real-World Setting

Author

Peng, Jing, primary, Song, Juan, additional, Wang, Feng, additional, Zuo, Peng, additional, Lu, Yanjun, additional, Liu, Weiyong, additional, Tian, Lei, additional, Chen, Zhongju, additional, Zhu, Yaowu, additional, Wang, Xiong, additional, Shen, Na, additional, Wang, Xu, additional, Wu, Shiji, additional, Yu, Qin, additional, Vallance, Bruce A., additional, Jacobson, Kevan, additional, Sun, Ziyong, additional, and Yu, Hong Bing, additional

Published
2021
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25. Lack of association between FOXO1 polymorphisms and bacteremia

Author

Yu, Jing, Wang, Xiong, Zhu, Yaowu, Lu, Yanjun, and Sun, Ziyong

Subjects
Original Article
Abstract

Increasing evidence suggests that FOXO1, one critical gene related to the human immune system, probable is closely to the human infection. In the present study we aimed to investigate genetic association of FOXO1 with bacteremia in Han Chinese. 188 patients with bacteremia diagnosed with blood culture and 250 healthy blood donors without signs of infection were studied, two tagging SNPs of FOXO1 (rs9532571, rs3751436) were selected and genotyped using predesigned TaqMan allelic discrimination assays. The results showed that the allele frequency of rs9532571 and rs3751436 in FOXO1 was not associated with an increased risk of bacteremia (P=0.762, OR=1.05, 95% CI 0.77-1.43; P=0.059, OR=1.34, 95% CI 0.99-1.81 respectively), the genotype distribution of these two SNPs was also not significantly different between bacteremia patients and control groups (P=0.9; P=0.16). Haplotypes in this block were not significantly associated with bacteremia risk. Conclusion: the association between FOXO1 genetic polymorphism and bacteremia has not been observed in the study, maybe a larger sample population and more SNPs in the FOXO1 need to reveal the role in bacteremia in the future.

Published
2015

34. The SNP rs402710 in 5p15.33 Is Associated with Lung Cancer Risk: A Replication Study in Chinese Population and a Meta-Analysis

Author

Lu, Xuzai, primary, Ke, Juntao, additional, Luo, Xia, additional, Zhu, Yaowu, additional, Zou, Li, additional, Li, Huijun, additional, Zhu, Beibei, additional, Xiong, Zhigang, additional, Chen, Wei, additional, Deng, Lingyan, additional, Lou, Jiao, additional, Wang, Xianxiu, additional, Zhang, Yu, additional, Wang, Zhenling, additional, Miao, Xiaoping, additional, and Cheng, Liming, additional

Published
2013
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36. Lack of association between FOXO1 polymorphisms and bacteremia.

Author

Yu J, Wang X, Zhu Y, Lu Y, and Sun Z

Abstract

Unlabelled: Increasing evidence suggests that FOXO1, one critical gene related to the human immune system, probable is closely to the human infection. In the present study we aimed to investigate genetic association of FOXO1 with bacteremia in Han Chinese. 188 patients with bacteremia diagnosed with blood culture and 250 healthy blood donors without signs of infection were studied, two tagging SNPs of FOXO1 (rs9532571, rs3751436) were selected and genotyped using predesigned TaqMan allelic discrimination assays. The results showed that the allele frequency of rs9532571 and rs3751436 in FOXO1 was not associated with an increased risk of bacteremia (P=0.762, OR=1.05, 95% CI 0.77-1.43; P=0.059, OR=1.34, 95% CI 0.99-1.81 respectively), the genotype distribution of these two SNPs was also not significantly different between bacteremia patients and control groups (P=0.9; P=0.16). Haplotypes in this block were not significantly associated with bacteremia risk., Conclusion: the association between FOXO1 genetic polymorphism and bacteremia has not been observed in the study, maybe a larger sample population and more SNPs in the FOXO1 need to reveal the role in bacteremia in the future.

Published
2015

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