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Simple Summary: Lepidoptera species have higher growth rates than Blattodea species. The different growth rates lead to different strategies to allocate energy to biosynthesis and somatic maintenance under free-feeding and low-food-availability conditions. Moreover, Lepidoptera and Blattodea spend sharply different amounts of energy on synthesizing one unit of bio-tissue, which, in turn, leads to different cellular qualities and abilities to resist stress, and may have effect on their adult lifespan. Based on this evidence, we postulate that the capability of maintaining homeostasis not only depends on the amount of energy allocated to maintenance, but also depends on the quality of the tissue, and that the tissue quality is at least partially due to the energetic investments in biosynthesis. In short, materials that are cheap to synthesize deteriorate faster, and allocating more energy to biosynthesis enhances somatic maintenance. Different life histories result in different strategies to allocate energy in biosynthesis, including growth and reproduction, and somatic maintenance. One of the most notable life history differences between Lepidoptera and Blattodea species is that the former grow much faster than the latter, and during metamorphosis, a large amount of tissue in Lepidoptera species disintegrates. In this review, using Lepidoptera caterpillars and cockroach nymphs as examples, we show that, due to these differences in growth processes, cockroach nymphs spend 20 times more energy on synthesizing one unit of biomass (indirect cost of growth) than butterfly caterpillars. Because of the low indirect cost of growth in caterpillars, the fraction of metabolic energy allocated to growth is six times lower, and that for maintenance is seven times higher in caterpillars, compared to cockroach nymphs, despite caterpillar's higher growth rates. Moreover, due to the higher biosynthetic energy cost in cockroach nymphs, they have better cellular qualities, including higher proteasomal activity for protein quality control and higher resistance to oxidative stress. We also show that under food restriction conditions, the fraction of assimilated energy allocated to growth was reduced by 120% in cockroach nymphs, as they lost body weight under food restriction, while this reduction was only 14% in hornworms, and the body mass increased at a lower rate. Finaly, we discuss future research, especially the difference in adult lifespans associated with the energetic differences. [ABSTRACT FROM AUTHOR]

Although sexual selection can be a powerful evolutionary force in shaping the phenotype, sexually selected traits do not evolve in isolation of other traits or without influence from other selective pressures. Expensive tissues, such as brains, can constrain the evolution of sexually selected traits, such as testes, as can other energetically expensive processes, like the costs of locomotion. However, simple linear or binary analyses of specific traits of interest can prevent detection of important links within the integrated phenotype and obfuscate the importance of multiple selective forces. We used phylogenetically informed path analysis to determine causal links among mating system type, pace of life history, costs of locomotion, brain size, and testis size across 48 mammal species that exhibit a wide range of body sizes, life-history strategies, and types of locomotion. We found species with non-monogamous mating systems were associated with larger testes, faster life histories, and lower costs of locomotion compared to monogamous species. Having a larger brain was associated with a slower life history and, surprisingly, larger testes. In addition to highlighting the non-intuitive nature of certain causal relationships, our results also emphasize the utility of including multiple traits in studies of sexually selected traits, as well as considering the constraints imposed by linked traits and selection on those linked traits. [ABSTRACT FROM AUTHOR]

Society as a whole faces a host of economic tradeoffs, many of which emerge around economic policies. An example of tradeoffs that any society faces in many economic realms is the tradeoff between economic efficiency and income equality (aka the efficiency-equality tradeoff). This tradeoff has been called "the Big Tradeoff" by the esteemed economist Arthur Okun, who also termed it "the Double Standard of a Capitalist Democracy." Although the efficiency-equality tradeoff is more or less an inevitable tradeoff in most societal settings and economic contexts, there are still some special circumstances in which this tradeoff can be avoided. This paper identifies five such avenues and elaborates on why and how the tradeoff between these two somewhat contradictory societal goals—efficiency and equality—can be deftly averted under the mentioned circumstances. These avenues with their transformative potential can and should be used so that a capitalist society as an integrated whole can promote both efficiency and equality at the same time under these scenarios and avoid facing the Big Tradeoff in cases where it is evitable. Static and dynamic economic models are developed, solved, and applied to facilitate the articulation and exposition of the main points of each solution with formal rigor and logical coherence. Finally, policy implications are discussed. [ABSTRACT FROM AUTHOR]

Group living has well-known costs and benefits. Large groups may experience greater competition for resources, while simultaneously benefit from reduced risk through predator dilution. When there is a tradeoff between forage acquisition and predation risk, the ability to congregate into large groups may unlock access to previously unavailable habitat with high risk of predation, thereby increasing forage available to the population. We evaluated whether forage availability increased with population size and how it was mediated through changes in group size. There was a tradeoff between forage availability and predation risk. Larger groups used areas with more forage biomass and greater predation risk than smaller groups. Group size also increased with population abundance, meaning bighorn sheep used gentler terrain and areas with more forage biomass at greater population abundance. Group size functionally increased carrying capacity by yielding access to more resources for growing populations of gregarious ungulates. [ABSTRACT FROM AUTHOR]

Predator–prey interactions drive the evolution of prey visual camouflage, but prey species also must remain conspicuous to their conspecifics for social signaling purposes. Whether rapid body color change can help to balance conspecific visibility and predator concealment, in the eyes of each group's respective visual systems, remains poorly understood. We tested this question using water anoles (Anolis aquaticus), a small lizard that uses rapid dark-to-light body color change to visually camouflage itself from its avian predators across diverse microhabitats. We used digital image analysis and visual modeling to assess the effectiveness of color-matching camouflage in dark- and light-phase A. aquaticus, as perceived by anoles and avian predators. Our findings reveal that A. aquaticus body coloration was perceived similarly by both groups. However, sex-specific differences in overall conspicuousness emerged, with males more consistently color matching their microhabitats compared to females. Females were less likely to color match their backgrounds in their lighter phase, suggesting a sex difference in preferred conspicuity in more exposed habitats. We highlight the context-dependence of color change, with sex-specific differences and microhabitat potentially affecting its function. Significance statement: Predator and prey visual systems influence prey species' visual camouflage evolution, but whether rapid body color changes allow animals to dynamically balance conspecific visibility with predator concealment is not well known. We used visual modeling techniques to examine if water anoles (Anolis aquaticus), small lizards that employ rapid body color changes to evade their avian predators, appear differently to their predators and conspecifics depending on color phase. Our findings reveal that A. aquaticus body coloration is perceived similarly by both groups. However, we observed sex-specific differences: males and larger individuals displayed more consistent color matching across different microhabitats, whereas females showed reduced matching in their lighter phase. Our study underscores the context-dependence of the function of color change in relation to factors including sex and microhabitat. [ABSTRACT FROM AUTHOR]

The comparative studies of aging have established a negative correlation between Gompertz postnatal growth constant and maximum lifespan across mammalian species, but the underlying physiological mechanism remains unclear. This study shows that the Gompertz growth constant can be decomposed into two energetic components, mass-specific metabolic rate and the energetic cost of biosynthesis, and that after controlling the former as a confounder, the negative correlation between growth constant and lifespan still exists due to a 100-fold variation in the latter, revealing that the energetic cost of biosynthesis is a link between growth and longevity in mammals. Previously, the energetic cost of biosynthesis has been thought to be a constant across species and therefore was not considered a contributor to the variation in any life history traits, such as growth and lifespan. This study employs a recently proposed model based on energy conservation to explain the physiological effect of the variation in this energetic cost on the aging process and illustrates its role in linking growth and lifespan. The conventional life history theory suggested a tradeoff between growth and somatic maintenance, but the findings in this study suggest that allocating more energy to biosynthesis may enhance the somatic maintenance and extend lifespan and, hence, reveal a more complex nature of the tradeoff. [ABSTRACT FROM AUTHOR]

The evolution of interspecific mimicry does not always result in perfect resemblance between mimics and models. Differences between members of a mimicry complex can be explained by genetic or developmental constraints. Alternatively, imperfect mimicry might be the outcome of a tradeoff between multiple selective pressures. In this study, we explored the evolutionary conflict between mimicry and hybridization in woodpeckers. Based on the selective tradeoff hypothesis, we expected that mimicry complexes will start to evolve once the constraint of maladaptive hybridization is relaxed. Hence, we predicted limited overlap in the divergence times between hybridizing species pairs and members of a mimicry complex. This prediction was supported by clear tipping point in the probability of hybridization and mimicry at ca 9 million years of divergence. Around this timepoint, the probability of hybridization approaches zero while the probability of belonging to a mimicry complex increases. This finding is only correlational and remains to be confirmed in other taxonomic groups. Nonetheless, our results suggest a selective tradeoff between evolving interspecific mimicry and avoiding maladaptive hybridization in woodpeckers. [ABSTRACT FROM AUTHOR]

Although sexual selection can be a powerful evolutionary force in shaping the phenotype, sexually selected traits do not evolve in isolation of other traits or without influence from other selective pressures. Expensive tissues, such as brains, can constrain the evolution of sexually selected traits, such as testes, as can other energetically expensive processes, like the costs of locomotion. However, simple linear or binary analyses of specific traits of interest can prevent detection of important links within the integrated phenotype and obfuscate the importance of multiple selective forces. We used phylogenetically informed path analysis to determine causal links among mating system type, pace of life history, costs of locomotion, brain size, and testis size across 48 mammal species that exhibit a wide range of body sizes, life-history strategies, and types of locomotion. We found species with non-monogamous mating systems were associated with larger testes, faster life histories, and lower costs of locomotion compared to monogamous species. Having a larger brain was associated with a slower life history and, surprisingly, larger testes. In addition to highlighting the non-intuitive nature of certain causal relationships, our results also emphasize the utility of including multiple traits in studies of sexually selected traits, as well as considering the constraints imposed by linked traits and selection on those linked traits.

Non-alcoholic alternatives are gaining growing significance within the German beverage sector. In this context, the German wine industry is increasingly focusing on non-alcoholic wines, whose market has developed dynamically in recent years. While the technologies used, the sensory characteristics and the marketing of the products are frequently addressed in the literature, the consideration of sustainability impacts has so far been largely neglected. This applies in particular to the view of all three dimensions of sustainability. These are examined more closely in this review with regard to tradeoffs, which indicate that positive aspects in one dimension go hand in hand with a loss in the other. It can be shown that tradeoffs in the production and marketing of non-alcoholic wines arise both within and between the three sustainability dimensions. Exemplary of this is the increased use of resources in the course of alcohol removal. At the same time, an emerging market segment holds positive aspects from an economic perspective. Ultimately, the consideration of social sustainability is marked by the health science and political debate around the reduction in alcohol consumption and the simultaneous increase in the consumption of non-alcoholic alternatives. [ABSTRACT FROM AUTHOR]

Males and females often differ in use of antipredator behaviors, particularly when antipredator behavior comes at the cost of missed mating opportunities or territory defense. When using thermally suboptimal refugia, ectotherms are especially vulnerable to these costs, as their performance is linked to body temperature. To flee from predators, semi-aquatic Anolis lizards dive underwater for long periods and rebreathe from a bubble of air. We hypothesized that using aquatic refugia would result in body heat loss, that dive duration is influenced by sex, and that oxygen consumption when diving would help explain sex differences. We tested these hypotheses by measuring dive length and body temperatures in A. aquaticus, and by recording oxygen consumption and final oxygen partial pressure during controlled dives in several semi-aquatic Anolis species. Not only was there a significant thermal cost to diving, but A. aquaticus males and females appeared to tolerate different levels of this cost: males re-emerged from water more quickly and at higher body temperatures than did females. Body temperature decreased according to an exponential decay function, dropping up to 6 °C in 5 min. Oxygen consumption rates in semi-aquatic anoles were primarily explained by the expected allometric scaling relationship with mass and, therefore, are unlikely to lead to sex differences in physiological limits to dive times. Instead, shorter male dives may help them maintain physiological performance, mating opportunities or territory defense. Antipredator diving behavior is physiologically costly but undoubtedly beneficial to both sexes, highlighting the need for further study of sex-based antipredator optimization. Significance statement: To avoid predators, semi-aquatic Anolis lizards can dive underwater and remain there for an extended time by rebreathing a bubble of air over their heads. In this study, we reveal that diving to escape predators also comes with a cost: submersion in water reduces lizard body temperatures. Reduced body temperature can impair a lizard’s ability to move quickly and defend mates or territories, suggesting that there may be divergent diving behaviors in males and females. Our findings confirm that males do indeed spend less time underwater than females. We measured oxygen consumption during dives, and our data suggest that sex differences in diving behavior are unrelated to oxygen use. This study sheds light on the sex-specific balance of antipredator behaviors and the maintenance of optimal body temperatures, and more broadly contributes insight into adaptive responses to environmental challenges. [ABSTRACT FROM AUTHOR]

The evolution of interspecific mimicry does not always result in perfect resemblance between mimics and models. Differences between members of a mimicry complex can be explained by genetic or developmental constraints. Alternatively, imperfect mimicry might be the outcome of a tradeoff between multiple selective pressures. In this study, we explored the evolutionary conflict between mimicry and hybridization in woodpeckers. Based on the selective tradeoff hypothesis, we expected that mimicry complexes will start to evolve once the constraint of maladaptive hybridization is relaxed. Hence, we predicted limited overlap in the divergence times between hybridizing species pairs and members of a mimicry complex. This prediction was supported by clear tipping point in the probability of hybridization and mimicry at ca 9 million years of divergence. Around this timepoint, the probability of hybridization approaches zero while the probability of belonging to a mimicry complex increases. This finding is only correlational and remains to be confirmed in other taxonomic groups. Nonetheless, our results suggest a selective tradeoff between evolving interspecific mimicry and avoiding maladaptive hybridization in woodpeckers.

In free-space optical satellite networks (FSOSNs), satellites can have different laser inter-satellite link (LISL) ranges for connectivity. As the LISL range increases, the number of satellites from among all the satellites in the constellation that will be needed on the shortest path between a source and a destination ground station decrease, and thereby the number of the LISLs on the shortest path decreases. Greater LISL ranges can reduce network latency of the path but can also result in an increase in transmission power for satellites on the path. Consequently, this tradeoff between satellite transmission power and network latency should be investigated, and in this work we examine it in FSOSNs drawing on the Starlink Phase 1 Version 3 (i.e., the latest version of Starlink's Phase 1) and Kuiper Shell 2 (i.e., Kuiper's biggest shell) constellations for different LISL ranges and different inter-continental connections. We use appropriate system models for calculating the average satellite transmission power (i.e., the average of the transmission power of all satellites on the shortest path) and network latency (i.e., the end-to-end latency of the shortest path). The results show that the mean network latency (i.e., the mean of network latency over all time slots) decreases and mean average satellite transmission power (i.e., the mean of average satellite transmission power over all time slots) increases with an increase in LISL range. For the Toronto–Sydney inter-continental connection in an FSOSN with Starlink's Phase 1 Version 3 constellation, when the LISL range is approximately 2,900 km, the mean network latency and mean average satellite transmission power intersect are approximately 135 ms and 380 mW, respectively. For an FSOSN with the Kuiper Shell 2 constellation in this inter-continental connection, this LISL range is around 3,800 km, and the two parameters are approximately 120 ms and 700 mW, respectively. For the Toronto–Istanbul and Toronto–London inter-continental connections, the LISL ranges at the intersection are different and vary from 2,600 km to 3,400 km. Furthermore, we analyze outage probability performance of optical uplink/downlink due to atmosphere attenuation and turbulence.

Spectral efficiency (SE) and energy efficiency (EE) are two main metrics for the transmit design in Visible Light Communications (VLC). However, the SE-optimal and EE-optimal strategies may be in conflict with each other to some extent. In this paper, we investigate the the tradeoff between EE and SE in rate splitting multiple access (RSMA)-aided VLC systems to maximize the system resource efficiency (RE) taking both perfect and imperfect channel state information (CSI) into consideration. For the scenarios with perfect CSI, we explore the joint precoding design and common rate allocation to maximize the RE of RSMA-aided VLC systems under the constraints of quality of service (QoS) and linear operation region (LoR) of LED, and propose a primal-dual-gradient-based precoding strategy. Furthermore, in the presence of CSI estimation errors, we propose a worst-case robust precoding design by exploiting quadratic transform and $\mathcal {S}$-Procedure. Numerical results indicate that the proposed resource efficient RSMA algorithm achieves the tradeoff between EE and SE.

The mechanisms underlying diversity-functioning relationships have been a consistent area of inquiry in biogeochemistry since the 1950s. Though these mechanisms remain unresolved in soil microbiomes, many approaches at varying scales have pointed to the same notion—composition matters. Confronting the methodological challenge arising from the complexity of microbiomes, this study used the model DEMENTpy, a trait-based modeling framework, to explore trait-based drivers of microbiome-dependent litter decomposition. We parameterized DEMENTpy for five sites along a climate gradient in Southern California, United States, and conducted reciprocal transplant simulations analogous to a prior empirical study. The simulations demonstrated climate-dependent legacy effects of microbial communities on plant litter decomposition across the gradient. This result is consistent with the previous empirical study across the same gradient. An analysis of community-level traits further suggests that a 3-way tradeoff among resource acquisition, stress tolerance, and yield strategies influences community assembly. Simulated litter decomposition was predictable with two community traits (indicative of two of the three strategies) plus local environment, regardless of the system state (transient vs. equilibrium). Although more empirical confirmation is still needed, community traits plus local environmental factors (e.g., environment and litter chemistry) may robustly predict litter decomposition across spatial-temporal scales. In conclusion, this study offers a potential trait-based explanation for climate-dependent community effects on litter decomposition with implications for improved understanding of whole-ecosystem functioning across scales.

Parasites reduce the fitness of their hosts, and different causes of this damage have fundamentally different consequences for the evolution of immune defences. Damage to the host may result from the parasite directly harming its host, often due to the production of virulence factors that manipulate host physiology. Alternatively, the host may be harmed by the activation of its own immune defences, as these can be energetically demanding or cause self-harm. A well-studied model of the cost of infection is Drosophila melanogaster and its common natural enemy, parasitoid wasps. Infected Drosophila larvae rely on humoral and cellular immune mechanisms to form a capsule around the parasitoid egg and kill it. Infection results in a developmental delay and reduced adult body size. To disentangle the effects of virulence factors and immune defences on these costs, we artificially activated anti-parasitoid immune defences in the absence of virulence factors. Despite immune activation triggering extensive differentiation and proliferation of immune cells together with hyperglycaemia, it did not result in a developmental delay or reduced body size. We conclude that the costs of infection do not result from these aspects of the immune response and may instead result from the parasite directly damaging the host. [ABSTRACT FROM AUTHOR]

Simple Summary: The circadian clock plays a crucial role in helping plants to effectively acclimate to ever-changing environmental conditions. The proper functioning of the circadian clock is integral to the growth and development of plants. In crops, the circadian clock system exerts a multifaceted influence on yield and the response to abiotic stress. This review provides a comprehensive overview of the mechanisms through which the components of a crop's circadian clock impact its response to abiotic stress and yield. We propose that the circadian clock may orchestrate the balance between abiotic stresses and yield in crops, which is useful for the future molecular design of crop breeding. Plants have evolved a circadian clock to adapt to ever-changing diel and seasonal environmental conditions. The circadian clock is generally considered an internal system that has evolved to adapt to cyclic environmental cues, especially diel light and temperature changes, which is essential for higher plants as they are sessile organisms. This system receives environmental signals as input pathways which are integrated by circadian core oscillators to synchronize numerous output pathways, such as photosynthesis, the abiotic stress response, metabolism, and development. Extreme temperatures, salinity, and drought stresses cause huge crop losses worldwide, imposing severe pressure on areas of agricultural land. In crop production, the circadian system plays a significant role in determining flowering time and responding to external abiotic stresses. Extensive studies over the last two decades have revealed that the circadian clock can help balance the tradeoff between crop yield-related agronomic traits and adaptation to stress. Herein, we focus on summarizing how the circadian clock coordinates abiotic stress responses and crop yield. We also propose that there might be an urgent need to better utilize circadian biology in the future design of crop breeding to achieve high yields under stress conditions. [ABSTRACT FROM AUTHOR]

Non-orthogonal multiple access (NOMA) with successive interference cancellation (SIC) detection, known as SIC NOMA, enjoys higher spectral efficiency (SE), but suffers increased processing complexity and additional error propagation compared to Non-SIC NOMA, in which the receivers directly detect their own signals from the superposed signal without SIC detection. We propose a joint Mode Selection and Power Allocation (MSPA) scheme that can flexibly realize different kinds of tradeoffs while guaranteeing minimum rate requirements (MRRs) for two-user MISO-NOMA downlink. Specifically, we first obtain rate region boundaries that guarantee two users’ MRRs for two candidate modes: maximum-ratio transmission (MRT)/SIC NOMA and minimum mean square error beamforming (MMSE-BF)/Non-SIC NOMA. We then construct an expression of power allocation factors (transmit power factors) that can satisfy the two users’ MRRs for MRT/SIC NOMA (MMSE-BF/Non-SIC NOMA) by introducing a parameter λ. Finally, we achieve outer boundary of the union of the two modes' rate regions by mode selection and derive expected users' rates on it. Numerical results demonstrate that the proposed MSPA can improve SE and flexibly achieve different kinds of tradeoffs by adjusting λ, while guaranteeing the two users’ MRRs simultaneously for high signal to noise ratio (SNR) scenario and alternately guaranteeing the two users’ MRRs for low SNR scenario.

Parasites reduce the fitness of their hosts, and different causes of this damage have fundamentally different consequences for the evolution of immune defences. Damage to the host may result from the parasite directly harming its host, often due to the production of virulence factors that manipulate host physiology. Alternatively, the host may be harmed by the activation of its own immune defences, as these can be energetically demanding or cause self-harm. A well-studied model of the cost of infection is Drosophila melanogaster and its common natural enemy, parasitoid wasps. Infected Drosophila larvae rely on humoral and cellular immune mechanisms to form a capsule around the parasitoid egg and kill it. Infection results in a developmental delay and reduced adult body size. To disentangle the effects of virulence factors and immune defences on these costs, we artificially activated anti-parasitoid immune defences in the absence of virulence factors. Despite immune activation triggering extensive differentiation and proliferation of immune cells together with hyperglycaemia, it did not result in a developmental delay or reduced body size. We conclude that the costs of infection do not result from these aspects of the immune response and may instead result from the parasite directly damaging the host.

Ethiopia’s government has created a number of policies and programs to address the urgent issue of rising food prices. Extension and regulation initiatives aiming at influencing the production and marketing are frequently used in conjunction with them. However, lack of indices on relative importance of individual crops results poor policy outcomes. Analyzing household decision dynamics and how household decisions respond to policies is crucial to reduce persistent complaints from recipients and avoid negative policy outcomes. For this study, data from 392 randomly chosen households of Kewot woreda was used. Sorghum found with higher calorie index per profit while mung bean was found higher profit index. Crop diversification found inefficient that arise from profitability differences and return to scale. Additionally multiple objectives could be met using tradeoffs among different crop benefits. This study also summarizes major findings from previous crop-related policies and linked them to specific crop characteristics. It is advised that policies be adjusted to reflect the value, character, and utility of crops.

Ethiopia's government has created a number of policies and programs to address the urgent issue of rising food prices. Extension and regulation initiatives aiming at influencing the production and marketing are frequently used in conjunction with them. However, lack of indices on relative importance of individual crops results poor policy outcomes. Analyzing household decision dynamics and how household decisions respond to policies is crucial to reduce persistent complaints from recipients and avoid negative policy outcomes. For this study, data from 392 randomly chosen households of Kewot woreda was used. Sorghum found with higher calorie index per profit while mung bean was found higher profit index. Crop diversification found inefficient that arise from profitability differences and return to scale. Additionally multiple objectives could be met using tradeoffs among different crop benefits. This study also summarizes major findings from previous crop-related policies and linked them to specific crop characteristics. It is advised that policies be adjusted to reflect the value, character, and utility of crops. [ABSTRACT FROM AUTHOR]

The invasive plant species, Solidago canadensis, often shares a common mycorrhizal network (CMN) with native plant species in southeast China. We ask whether the transfer of carbon (C) and nitrogen (N) among the invasive S. canadensis, the native Kummerowia striata and their CMN could contribute to the invasiveness of S. canadensis.We conducted a microcosm experiment in which a CMN was established on S. canadensis and K. striata. We used 13CO2 pulse‐labelling to quantify the relative contribution of recently fixed C from the two host species to the CMN. We also calculated the relative N distribution to each host species from the CMN.We found that 89% of the recently fixed C in the CMN originated from S. canadensis, while 11% originated from K. striata. We also found that the CMN distributed 77% of the N it absorbed to S. canadensis and 23% to K. striata.Our results suggest that the unequal distribution of N from a CMN to the invasive and native plant species is related to the unequal contribution of C from the plant species. This mechanism could contribute to invasion of native communities by alien species when there is a stoichiometric exchange of limiting nutrients for C, and when alien species contribute more C to the CMN than natives. Read the free Plain Language Summary for this article on the Journal blog. [ABSTRACT FROM AUTHOR]

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Understanding the tradeoffs/synergies between ecosystems is crucial to effective watershed ecosystem management and sustainable development. In this study, the Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST) and Carnegie Ames Stanford Approach (CASA) models were utilized to estimate four ecosystem services (ESs), including water conservation capacity, soil retention, habitat quality, and carbon storage services, in Qinghai Lake Basin between 2000 and 2018. Local Indicators of Spatial Association (LISA) and tradeoffs/synergies criterion (TSC) were used to reveal the relationships between the ESs. The results show that the water conservation capacity, soil retention, habitat quality, and carbon storage service in Qinghai Lake Basin all increased between 2000 and 2018. TSC and LISA revealed that carbon storage and habitat quality, habitat quality and water conservation capacity, and carbon storage and soil retention had the same relationship, as did habitat quality and soil retention. In addition, LISA showed that the relationships between ESs are mainly based on high high clusters that concentrate in the middle of the basin. The analysis also revealed obvious spatial heterogeneity. This study aims to compensate the research deficiencies that affected previous studies of the Qinghai Lake Basin and provide a point of reference for the sustainable development of the basin. [ABSTRACT FROM AUTHOR]

Abstract Plasmid fitness is directed by two orthogonal processes—vertical transfer through cell division and horizontal transfer through conjugation. When considered individually, improvements in either mode of transfer can promote how well a plasmid spreads and persists. Together, however, the metabolic cost of conjugation could create a tradeoff that constrains plasmid evolution. Here, we present evidence for the presence, consequences, and molecular basis of a conjugation‐growth tradeoff across 40 plasmids derived from clinical Escherichia coli pathogens. We discover that most plasmids operate below a conjugation efficiency threshold for major growth effects, indicating strong natural selection for vertical transfer. Below this threshold, E. coli demonstrates a remarkable growth tolerance to over four orders of magnitude change in conjugation efficiency. This tolerance fades as nutrients become scarce and horizontal transfer attracts a greater share of host resources. Our results provide insight into evolutionary constraints directing plasmid fitness and strategies to combat the spread of antibiotic resistance.

Purpose: Startups have significant differences compared to other companies. They have many intangible assets (e.g., team tenure and experience of founders), are risky, and tend not to generate profits in their initial years (Heirman & Clarysse, 2007; Weber & Zulehner, 2009). Does the startups’ financing choice also differ from that of traditional companies? We analyzed the capital structure of startups in their first years of life based on the classic tradeoff and pecking order theories. Methodology/approach: We collected data on 40 startups in the city of Ribeirão Preto, São Paulo, Brazil, through a questionnaire on the profiles of the founders, company characteristics, bottom-line performance and financing sources. The data collected covered the year of founding and the three subsequent years. Findings: The results indicated that these startups mainly financed themselves through the founders’ capital in all four years covered. Only in the third year did they start using resources generated internally, indicating pecking order adherence. However, the presence of angel investors and government subsidies contrasted with the absence of bank debt. In line with the tradeoff theory, bank debt was not a viable financing option in the early years of these firms since they had low profitability and high risk. Theoretical/methodological contributions: We offer a theoretical contribution by analyzing the adequacy of traditional financial theories in the specific context of startups. Originality: The finance literature about startups is scarce, and few studies have analyzed these companies from the capital structure theoretical perspective. Social contributions / for management: We provide a panorama of the financing of startups to support their financial planning regarding fundraising.

IntroductionChina has initiated national price negotiations to improve access to innovative drugs. Learning the factors that contributed to the time gap from marketing authorization to reimbursement leads to more clarity to decision-making, which remains under-researched in China.MethodsWe collected new oncology drug approvals that were marketed before 30 Jun 2022, using the Listed Drug Database of the Chinese drug agency. Major information of each approval was obtained from the published review report, including the first approval region (China or the US) and the receipt of expedited review pathways (priority review and conditional approval). The reimbursement lists issued by China National Healthcare Security Administration from 2015 to 2023 were used to determine the reimbursement status of drugs. The duration from marketing authorization to reimbursement was defined as the reimbursement decision speed, and the Cox regression was performed to explore the underlying factors.ResultsA total of 186 oncology approvals were included. More than half of the approvals qualified for reimbursement (110[59.14%]), and the median reimbursement decision speed was accelerated from 540.5 days in the third-round negotiation to 448 days in the seventh-round. Domestic new drugs had a higher probability of being adopted by the Chinese payer than drugs developed by foreign companies (adjusted HR = 3.73, 95% CI 2.42 to 5.75; P < 0.001). Furthermore, new drug applications receiving the regular review pathway were more likely to be reimbursed (adjusted HR = 2.15, 95% CI 1.13 to 4.08; P = 0.020) compared to those approved under the conditional approval pathway.DiscussionThese findings indicate that the Chinese government is actively working toward improving access to new oncology drugs. The faster reimbursement decision speed for domestic drugs might be attributed to their pricing advantages and the regulator's efforts to stimulate innovation in the domestic pharmaceutical industry. However, concerns about the uncertainty in drug benefits can affect the reimbursement decision-making, which suggests the delicate tradeoff between drug accessibility and risk involved in the reimbursement process.

Bacteriophages have received recent attention for their therapeutic potential to treat antibiotic-resistant bacterial infections. One particular idea in phage therapy is to use phages that not only directly kill their bacterial hosts but also rely on particular bacterial receptors, such as proteins involved in virulence or antibiotic resistance. In such cases, the evolution of phage resistance would correspond to the loss of those receptors, an approach termed evolutionary steering. We previously found that during experimental evolution, phage U136B can exert selection pressure on Escherichia coli to lose or modify its receptor, the antibiotic efflux protein TolC, often resulting in reduced antibiotic resistance. However, for TolC-reliant phages like U136B to be used therapeutically, we also need to study their own evolutionary potential. Understanding phage evolution is critical for the development of improved phage therapies as well as the tracking of phage populations during infection. Here, we characterized phage U136B evolution in 10 replicate experimental populations. We quantified phage dynamics that resulted in five surviving phage populations at the end of the 10-day experiment. We found that phages from all five surviving populations had evolved higher rates of adsorption on either ancestral or coevolved E. coli hosts. Using whole-genome and whole-population sequencing, we established that these higher rates of adsorption were associated with parallel molecular evolution in phage tail protein genes. These findings will be useful in future studies to predict how key phage genotypes and phenotypes influence phage efficacy and survival despite the evolution of host resistance. IMPORTANCE Antibiotic resistance is a persistent problem in health care and a factor that may help maintain bacterial diversity in natural environments. Bacteriophages ("phages") are viruses that specifically infect bacteria. We previously discovered and characterized a phage called U136B, which infects bacteria through TolC. TolC is an antibiotic resistance protein that helps bacteria pump antibiotics out of the cell. Over short timescales, phage U136B can be used to evolutionarily "steer" bacterial populations to lose or modify the TolC protein, sometimes reducing antibiotic resistance. In this study, we investigate whether U136B itself evolves to better infect bacterial cells. We discovered that the phage can readily evolve specific mutations that increase its infection rate. This work will be useful for understanding how phages can be used to treat bacterial infections. [ABSTRACT FROM AUTHOR]

Natural ecosystems of the West Liao River basin (WLRB) in northeast China have been damaged by both natural and human factors from the 1990s. Since 2000, China's Grain-for-Green Program (GFGP) has been widely adopted with the aim of improving ecosystem services. An accurate evaluation of the eco-hydrological effects for policy implementation is essential to provide references for further restoration of ecosystem services. This study quantified and characterized the ecosystem services and their trade-offs/synergies using models and statistical methods in the WLRB from 1990 to 2020. Moreover, the impact of key drivers on ecosystem services was evaluated by the difference-in-differences model. Among them, the study mainly investigated how GFGP affects ecosystem services. The results confirmed that the water yield, carbon sequestration, habitat quality, and total ecosystem service of the WLRB decreased in the pre-GFGP period (1990–2000). However, this tendency was reversed in the regions where the GFGP was implemented during the period of 2001–2020. Furthermore, a synergistic relationship was shown among carbon sequestration, soil conservation, and habitat quality. Additionally, there were tradeoffs between water yield and the other three ecosystem services, especially in mountain areas. The GFGP could restore carbon sequestration, habitat quality, and total ecosystem services by 1.3%, 2.1%, and 0.6%, respectively. Nevertheless, GFCP may enlarge the tradeoff and imbalance between water yield and habitat quality. Results highlight the need for the governance of ecosystem protection and suggest natural restoration in the mountain area for maintaining water yield and helping ecosystem restoration. Timely adjustment of the policy implementation areas is the key to improving and balancing multiple ecosystem services in the future. [ABSTRACT FROM AUTHOR]

Ecological restoration is becoming increasingly important in addressing the global crisis of ecosystem degradation. Ecosystem services, as a concept that connects people and natural ecosystems, can be incorporated into the design, practice and evaluation of restoration projects to promote both the socioeconomic and ecological effects of restoration. However, the full incorporation of ecosystem services in landscape-scale restoration projects is still greatly lacking. In this study, we used the Dashihe mine tailings restoration project in Hebei, China, as a case study and analyzed data from field surveys, remote sensing and literature reviews to study the following two questions: 1) How would multiple ecosystem service supply capabilities and their tradeoffs change after ecological restoration; 2) How can multiple ecosystem service supply capabilities be maximized while minimizing their tradeoffs? The supply capabilities of four important ecosystem services (i.e., soil retention, dust deposition, carbon sequestration and habitat maintenance) and their tradeoff intensities under six restoration scenarios were quantified and compared. The results showed that restored ecosystems outperformed unrestored and even the reference conditions in terms of ecosystem service supply enhancement. However, there is still much room for improvement compared to the recommended restoration scenario. The recommended scenario could result in both higher service supplies and lower tradeoff intensities among the services. On this basis, we call for more incorporation of ecosystem service supply and tradeoff analysis in future ecological restoration projects to reverse the declining trends of ecosystem services across the globe.

Invasive species have profound negative impacts on native ranges. Unraveling the mechanisms employed by invasive plant species is crucial to controlling invasions. One important approach that invasive plants use to outcompete native plants is to disrupt mutualistic interactions between native roots and mycorrhizal fungi. However, it remains unclear how differences in the competitive ability of invasive plants affect native plant associations with mycorrhizae. Here, we examined how a native plant, Xanthium strumarium, responds to invasive plants that differed in competitive abilities (i.e., as represented by aboveground plant biomass) by measuring changes in root nitrogen concentration (root nutrient acquisition) and mycorrhizal colonization rate. We found that both root nitrogen concentration and mycorrhizal colonization rate in the native plant were reduced by invasive plants. The change in mycorrhizal colonization rate of the native plant was negatively correlated with both aboveground plant biomass of the invasive plants and the change in aboveground plant biomass of the native plant in monocultures relative to mixed plantings. In contrast, the change in root nitrogen concentration of the native plant was positively correlated with aboveground plant biomass of the invasive plants and the change in aboveground plant biomass of the native plant. When we compared the changes in mycorrhizal colonization rate and root nitrogen concentration in the native plant grown in monocultures with those of native plants grown with invasive plants, we observed a significant tradeoff. Our study shows that invasive plants can suppress native plants by reducing root nutrient acquisition rather than by disrupting symbiotic mycorrhizal associations, a novel finding likely attributable to a low dependence of the native plant on mycorrhizal fungi.

Many measures of international policies and support have dictated developing countries to upscale land areas of intact forestry, special biodiversity conservation site, and other wild reserves to half the land territory of the nation by 2050 for resulting environmental, and other benefits to global societies. The international initiations and work urged scholars to assess the potential impacts of the aggressive policy on forest-based communities and especially those living in institutionally and geo ecologically vulnerable areas. This study compiled the impacts of such international policy interventions on diverse affairs of the local community and national economies in Nepal and drew some conclusions on the well-being future of such forest-based communities. It explained that the international interventions in managing community-based resources induced serious disturbances in many local systems and resulted in vicious circles of emigration, income losses, social problems, psychological stresses, and food insecurities. The interventions have placed some communities and especially indigenous ethnic groups in the position either to be displaced from their ancestors’ homelands or suffer for generations. This study also explained some reinforcing phenomena that emerged from the external interventions which have placed situations of the resource impacting local communities adversely for years. It also investigated whether support of international agencies in policy formation and implementation for resource management safeguards the well-being of the resource-based communities. The agencies resulted in the best environmental and other benefits to foreign societies which have aggravated the misery of local communities, particularly the poor people, women, and indigenous ethnic communities. The adverse impacts on the local societies are not repercussions (accidentally or unknowingly happened). All these findings infer that the international policies of upscaling forests and wilderness areas or making conservation areas in half of their land territory, especially in developing societies for the global benefit, may place the lives of the forest-based communities in peril of suffering for generations or extirpating.

Animals select habitats based on food, water, space, and cover. Each of those components are essential to the ability of an individual to survive and reproduce in a particular habitat. Selection of resources is linked to reproductive fitness and individuals likely vary in how they select resources relative to their reproductive state: during pregnancy, while provisioning young when nutritional needs of the mother are high, but offspring are vulnerable to predation, or if they lose young to mortality. We investigated the effects of reproductive state on selection of resources by maternal female desert bighorn sheep (Ovis canadensis nelsoni) by comparing selection during the last trimester of gestation, following parturition when females were provisioning dependent young, and if the female lost an offspring. We captured, and recaptured each year, 32 female bighorn sheep at Lone Mountain, Nevada, during 2016–2018. Captured females were fit with GPS collars and those that were pregnant received vaginal implant transmitters. We used a Bayesian approach to estimate differences in selection between females provisioning and not provisioning offspring, as well as the length of time it took for females with offspring to return levels of selection similar to that observed prior to parturition. Females that were not provisioning offspring selected areas with higher risk of predation, but greater nutritional resources than those that were provisioning dependent young. When females were provisioning young immediately following parturition, females selected areas that were safe from predators, but had lower nutritional resources. Females displayed varying rates of return to selection strategies associated with access to nutritional resources as young grew and became more agile and less dependent on mothers. We observed clear and substantial shifts in selection of resources associated with reproductive state, and females exhibited tradeoffs in favor of areas that were safer from predators when provisioning dependent young despite loss of nutritional resources to support lactation. As young grew and became less vulnerable to predators, females returned to levels of selection that provided access to nutritional resources to restore somatic reserves lost during lactation. [ABSTRACT FROM AUTHOR]

We consider a between-host model for a single epidemic outbreak of an infectious disease. According to the progression of the disease, hosts are classified in regard to the pathogen load. Specifically, we are assuming four phases: non-infectious asymptomatic phase, infectious asymptomatic phase (key-feature of the model where individuals show up mild or no symptoms), infectious symptomatic phase and finally an immune phase. The system takes the form of a non-linear Markov chain in discrete time where linear transitions are based on geometric (main model) or negative-binomial (enhanced model) probability distributions. The whole system is reduced to a single non-linear renewal equation. Moreover, after linearization, at least two meaningful definitions of the basic reproduction number arise: firstly as the expected secondary asymptomatic cases produced by an asymptomatic primary case, and secondly as the expected number of symptomatic individuals that a symptomatic individual will produce. We study the evolution of infection transmission before and after symptom onset. Provided that individuals can develop symptoms and die from the disease, we take disease-induced mortality as a measure of virulence and it is assumed to be positively correlated with a weighted average transmission rate. According to our findings, transmission rate of the infection is always higher in the symptomatic phase yet under a suitable condition, most of the infections take place prior to symptom onset. [ABSTRACT FROM AUTHOR]

Plasmid fitness is directed by two orthogonal processes—vertical transfer through cell division and horizontal transfer through conjugation. When considered individually, improvements in either mode of transfer can promote how well a plasmid spreads and persists. Together, however, the metabolic cost of conjugation could create a tradeoff that constrains plasmid evolution. Here, we present evidence for the presence, consequences, and molecular basis of a conjugation‐growth tradeoff across 40 plasmids derived from clinical Escherichia coli pathogens. We discover that most plasmids operate below a conjugation efficiency threshold for major growth effects, indicating strong natural selection for vertical transfer. Below this threshold, E. coli demonstrates a remarkable growth tolerance to over four orders of magnitude change in conjugation efficiency. This tolerance fades as nutrients become scarce and horizontal transfer attracts a greater share of host resources. Our results provide insight into evolutionary constraints directing plasmid fitness and strategies to combat the spread of antibiotic resistance. Synopsis: Quantification of natural plasmid transfer rates reveals a tradeoff between conjugation and cell division that constrains plasmid evolution. Conjugation spreads multidrug‐resistant plasmids at a metabolic cost that can slow host growth.A wide range of conjugation efficiencies can be tolerated before incurring a transfer tradeoff.Intermediate conjugation efficiencies yield the highest plasmid abundance.Conjugation attracts a greater share of resources from nutrient‐starved hosts. [ABSTRACT FROM AUTHOR]

Mobile cloud computing (MCC) brings rich computational resources to mobile users, network operators, and cloud computing providers. The battery capacity of mobile devices poses several complex challenges, hence it is necessary to save energy by offloading applications to the remote cloud resources, especially when the scheduling is in a dynamic mobile cloud computing environment. To make a tradeoff decision involving energy consumption, deadline, and the system load, we proposed an iterated greedy taboo-mechanism algorithm (IGTMA) to solve the above issues in MCC environment. Compared to state-of-art approaches such as Adaptive First Come First Served (AFCFS), Minimize Execution Time (MINET), and tradeoff decisions for code offloading (TRADEOFF), the simulation experiment results show that our proposed IGTMA reduces energy consumption and enhances the number of finished jobs.

Earth's temperature is rising, and with this increase, fungal communities are responding and affecting soil carbon processes. At a long-term soil-warming experiment in a boreal forest in interior Alaska, warming and warming-associated drying alters the function of microbes, and thus, decomposition of carbon. But what genetic mechanisms and resource allocation strategies are behind these community shifts and soil carbon changes? Here, we evaluate fungal resource allocation efforts under long-term experimental warming (including associated drying) using soil metatranscriptomics. We profiled resource allocation efforts toward decomposition and cell metabolic maintenance, and we characterized community composition. We found that under the warming treatment, fungi allocate resources to cell metabolic maintenance at the expense of allocating resources to decomposition. In addition, we found that fungal orders that house taxa with stress-tolerant traits were more abundant under the warmed treatment compared to control conditions. Our results suggest that the warming treatment elicits an ecological tradeoff in resource allocation in the fungal communities, with potential to change ecosystem-scale carbon dynamics. Fungi preferentially invest in mechanisms that will ensure survival under warming and drying, such as cell metabolic maintenance, rather than in decomposition. Through metatranscriptomes, we provide mechanistic insight behind the response of fungi to climate change and consequences to soil carbon processes.

Abstract Background For better understanding the mechanism of Reaumuria soongarica community formation in a salt stressed grassland ecosystem, we designed a field experiment to test how leaves salt secretion changes the competitive relationship between species in this plant communities. Results Among the three species (R. soongarica, Stipa glareosa and Allium polyrhizum) of the salt stressed grassland ecosystem, the conductivity of R. soongarica rhizosphere soil was the highest in five soil layers (0–55 cm depth). The high soil conductivity can increase the daily salt secretion rate of plant leaves of R. soongarica. In addition, we found the canopy size of R. soongarica was positively related to the distance from S. glareosa or A. polyrhizum. The salt-tolerance of R. soongarica was significantly higher than the other two herbs (S. glareosa and A. polyrhizum). Moreover, there was a threshold (600 µS/cm) for interspecific competition of plants mediated by soil conductivity. When the soil conductivity was lower than 600 µS/cm, the relative biomass of R. soongarica increased with the soil conductivity increase. Conclusions The efficient salt secretion ability of leaves increases soil conductivity under the canopy. This leads the formation of a “saline island” of R. soongarica. Meanwhile R. soongarica have stronger salt tolerance than S. glareosa and A. polyrhizum. These promote the competitiveness of R. soongarica and inhibit interspecies competition advantage of the other two herbs (S. glareosa and A. polyrhizum) in the plant community. It is beneficial for R. soongarica to establish dominant communities in saline regions of desert grassland.

ABSTRACT When microbes grow in foreign nutritional environments, selection may enrich mutations in unexpected pathways connecting growth and homeostasis. An evolution experiment designed to identify beneficial mutations in Burkholderia cenocepacia captured six independent nonsynonymous substitutions in the essential gene tilS, which modifies tRNAIle2 by adding a lysine to the anticodon for faithful AUA recognition. Further, five additional mutants acquired mutations in tRNAIle2, which strongly suggests that disrupting the TilS-tRNAIle2 interaction was subject to strong positive selection. Mutated TilS incurred greatly reduced enzymatic function but retained capacity for tRNAIle2 binding. However, both mutant sets outcompeted the wild type by decreasing the lag phase duration by ~3.5 h. We hypothesized that lysine demand could underlie fitness in the experimental conditions. As predicted, supplemental lysine complemented the ancestral fitness deficit, but so did the additions of several other amino acids. Mutant fitness advantages were also specific to rapid growth on galactose using oxidative overflow metabolism that generates redox imbalance, not resources favoring more balanced metabolism. Remarkably, 13 tilS mutations also evolved in the long-term evolution experiment with Escherichia coli, including four fixed mutations. These results suggest that TilS or unknown binding partners contribute to improved growth under conditions of rapid sugar oxidation at the predicted expense of translational accuracy. IMPORTANCE There is growing evidence that the fundamental components of protein translation can play multiple roles in maintaining cellular homeostasis. Enzymes that interact with transfer RNAs not only ensure faithful decoding of the genetic code but also help signal the metabolic state by reacting to imbalances in essential building blocks like free amino acids and cofactors. Here, we present evidence of a secondary function for the essential enzyme TilS, whose only prior known function is to modify tRNAIle(CAU) to ensure accurate translation. Multiple nonsynonymous substitutions in tilS, as well as its cognate tRNA, were selected in evolution experiments favoring rapid, redox-imbalanced growth. These mutations alone decreased lag phase and created a competitive advantage, but at the expense of most primary enzyme function. These results imply that TilS interacts with other factors related to the timing of exponential growth and that tRNA-modifying enzymes may serve multiple roles in monitoring metabolic health.

Plants utilize different strategies in different environments to maximize population expansion. Understanding plant reproductive strategies in heterogeneous habitats is therefore important for explaining plant ecological adaptability, and for effectively managing and conserving ecosystems. We wanted to explore the reproductive strategy transformation of D. angustifolia in heterogeneous habitats, as well as the environmental factors driving and affecting its reproductive characteristics. To do this we measured the reproductive characteristics of D. angustifolia, as well as the soil physical and chemical properties of these heterogeneous habitats. The density, biomass per unit area, and proportion of aboveground biomass in swampy meadows were significantly higher compared to other habitats. The proportion of rhizome node buds gradually increased from swampy to typical to miscellaneous grass meadows, while the proportion of tillering node buds decreased. The allocation of sexual reproduction within D. angustifolia populations was significantly and positively correlated with plant rhizome biomass and negatively correlated with the number of tillering node buds. The propagation strategies of D. angustifolia in heterogeneous habitats were consistent with CSR theory (Competitor, Stress-tolerator, and Ruderal). The proportions of inflorescence (2.07 ± 0.52%; 1.01 ± 0.15%) and root (23.8 ± 1.5%; 19.6 ± 1.4%) biomass in miscellaneous and typical meadows were high, which tended toward the “Ruderal” adaptation strategy. In swampy meadow, D. angustifolia invested mostly in vegetative growth to produce tiller node buds (14426.67 buds/m2; 46%) and ramets (1327.11 ± 102.10 plants/m2), which is characteristic of the “Competitor” strategy. Swamp D. angustifolia resisted flooding by maintaining a resource balance in its body, and was therefore biased toward the “Stress-tolerator” strategy. Environmental factors accounted for 74.63% of reproductive characteristic variation, in which the interpretative proportions of soil water content, dissolved organic carbon, ammonia nitrogen, and nitrate nitrogen were significant (p

Evidence for adaptation to different climates in the model species Arabidopsis thaliana is seen in reciprocal transplant experiments, but the genetic basis of this adaptation remains poorly understood. Field-based quantitative trait locus (QTL) studies provide direct but low-resolution evidence for the genetic basis of local adaptation. Using high-resolution population genomic approaches, we examine local adaptation along previously identified genetic trade-off (GT) and conditionally neutral (CN) QTLs for fitness between locally adapted Italian and Swedish A. thaliana populations [Ågren J, et al. (2013) Proc Natl Acad Sci USA 110:21077-21082]. We find that genomic regions enriched in high FST SNPs colocalize with GT QTL peaks. Many of these high FST regions also colocalize with regions enriched for SNPs significantly correlated to climate in Eurasia and evidence of recent selective sweeps in Sweden. Examining unfolded site frequency spectra across genes containing high FST SNPs suggests GTs may be due to more recent adaptation in Sweden than Italy. Finally, we collapse a list of thousands of genes spanning GT QTLs to 42 genes that likely underlie the observed GTs and explore potential biological processes driving these trade-offs, from protein phosphorylation, to seed dormancy and longevity. Our analyses link population genomic analyses and field-based QTL studies of local adaptation, and emphasize that GTs play an important role in the process of local adaptation.

An endfire periodic leaky-wave antenna (LWA) with high gain is presented in this communication, which consists of a series of rhombic elements based on double-sided parallel stripline (DSPSL). The endfire mechanism of the proposed antenna is illustrated by the phase difference of the far field of each arm in the rhombic element. Meanwhile, a tradeoff between the tilted angle $\theta _{0}$ and the width $w$ is found, which assures an optimum transverse aperture for achieving high-gain endfire radiation. Moreover, the improved Hansen–Woodyard (IHW) condition is applied to predict the optimum endfire phase constant. Finally, a prototype is fabricated and tested. The maximum endfire gain of 19.8 dBi is measured at 11.4 GHz, which is close to the simulated and predicted results. The proposed periodic rhombic antenna provides more choice for the modern communication system. [ABSTRACT FROM AUTHOR]

The offloading method is important when there are multiple mobile nodes and multiple edge servers. In the environment, those mobile nodes connect with edge servers with different bandwidths, thus taking different time and energy for offloading tasks. Considering the system load of edge servers and the attributes (the number of instructions, the size of files, deadlines, and so on) of tasks, the energy-aware offloading problem becomes difficult under our mobile edge environment (MCE). Most of the past work mainly offloads tasks by judging where the job consumes less energy. But sometimes, one task needs more energy because the preferred edge servers have been overloaded. Those methods always do not pay attention to the influence of the scheduling on the future tasks. In this paper, first, we try to execute the job locally when the job costs a lower energy consumption executed on the MD. We suppose that every task is submitted to the mobile server which has the highest bandwidth efficiency. Bandwidth efficiency is defined by the sending ratio, the receiving ratio, and their related power consumption. We sort the task in the descending order of the ratio between the energy consumption executed on the mobile server node and on the MD. Then, we give a "suffrage" definition for the energy consumption executed on different mobile servers for offloading tasks. The task selects the mobile server with the largest suffrage. Simulations show that our method reduces the execution time and the related energy consumption, while keeping a lower value in the number of uncompleted tasks. [ABSTRACT FROM AUTHOR]

ABSTRACT Hydrophobins are small amphipathic surface proteins found exclusively in fungi. In filamentous ascomycetes, one conserved role of a subset of hydrophobins is their requirement for spore dispersal. Other contributions of these proteins to fungal biology are less clear and vary across genera. To determine the functions of hydrophobins in the biology and virulence of this fungus, we created seven single mutants and a septuple-deletion mutant (Δsep) of the entire putative P. expansum hydrophobin gene family. One spore hydrophobin, HfbA, shared 72.56% sequence identity to the Aspergillus fumigatus spore hydrophobin RodA and was required for efficient spore dispersion in P. expansum. The Δsep mutant was likewise reduced in spore dispersal, hypothesized to be due to the aberrant shape and clumping of the Δsep conidia and conidiophores. Additionally, the Δsep mutant presented several differences in physiological traits, including decreased survival in extreme cold temperatures and increased production of several toxic secondary metabolites. Most striking was the unexpected fitness advantage that the Δsep strain displayed in competitive passaging with the wild-type strain on host apple where the mutant significantly increased in percentage of the colonizing population. This work uncovers potential ecological trade-offs of hydrophobin presence in filamentous fungi. IMPORTANCE Hydrophobins are amphipathic secreted proteins uniquely found in filamentous fungi. These proteins self-assemble and constitute the outer most layer of fungal surfaces thus mediating multiple aspects of fungal interactions with their environments. Hydrophobins facilitate spore dispersal, yet a full understanding of the function and need for multiple hydrophobins in fungal species remains elusive. To address the role of this protein family in Penicillium expansum, the causative agent of blue mold disease in pome fruit, all seven putative hydrophobin genes were deleted and the mutant assessed for numerous physiological traits and virulence on fruit. Despite showing a decrease in spore dispersal, the septuple-deletion mutant was more fit than the wild type in competitive pathogenicity tests on apple. Our findings suggest this gene family illustrates a functional trade-off between dispersal and host colonization in P. expansum.

Plants have evolved a circadian clock to adapt to ever-changing diel and seasonal environmental conditions. The circadian clock is generally considered an internal system that has evolved to adapt to cyclic environmental cues, especially diel light and temperature changes, which is essential for higher plants as they are sessile organisms. This system receives environmental signals as input pathways which are integrated by circadian core oscillators to synchronize numerous output pathways, such as photosynthesis, the abiotic stress response, metabolism, and development. Extreme temperatures, salinity, and drought stresses cause huge crop losses worldwide, imposing severe pressure on areas of agricultural land. In crop production, the circadian system plays a significant role in determining flowering time and responding to external abiotic stresses. Extensive studies over the last two decades have revealed that the circadian clock can help balance the tradeoff between crop yield-related agronomic traits and adaptation to stress. Herein, we focus on summarizing how the circadian clock coordinates abiotic stress responses and crop yield. We also propose that there might be an urgent need to better utilize circadian biology in the future design of crop breeding to achieve high yields under stress conditions.

SUMMARY: Zea mays (maize) makes phytoalexins such as sesquiterpenoid zealexins, to combat invading pathogens. Zealexins are produced from farnesyl diphosphate in microgram per gram fresh weight quantities. As farnesyl diphosphate is also a precursor for many compounds essential for plant growth, the question arises as to how Z. mays produces high levels of zealexins without negatively affecting vital plant systems. To examine if specific pools of farnesyl diphosphate are made for zealexin synthesis we made CRISPR/Cas9 knockouts of each of the three farnesyl diphosphate synthases (FPS) in Z. mays and examined the resultant impacts on different farnesyl diphosphate‐derived metabolites. We found that FPS3 (GRMZM2G098569) produced most of the farnesyl diphosphate for zealexins, while FPS1 (GRMZM2G168681) made most of the farnesyl diphosphate for the vital respiratory co‐factor ubiquinone. Indeed, fps1 mutants had strong developmental phenotypes such as reduced stature and development of chlorosis. The replication and evolution of the fps gene family in Z. mays enabled it to produce dedicated FPSs for developmentally related ubiquinone production (FPS1) or defense‐related zealexin production (FPS3). This partitioning of farnesyl diphosphate production between growth and defense could contribute to the ability of Z. mays to produce high levels of phytoalexins without negatively impacting its growth. Significance Statement: A major goal for agricultural research is to develop crops that have both good yield and pest resistance. Often improving one of these traits has negative impact on the other, the so‐called growth‐defense tradeoff. In this study we uncover a mechanism in maize that allows the production of high levels of defense compounds using dedicated enzymes for shared precursor production. These findings can be used to guide synthetic biology approaches for agricultural improvement. [ABSTRACT FROM AUTHOR]

Input subsidy programs (ISP) often have two conflicting targeting goals: selecting individuals with the highest marginal return to inputs on efficiency grounds, or the poorest individuals on equity grounds, allowing for a secondary market to restore efficiency gains. To study this targeting dilemma, we implement a field experiment where beneficiaries of an ISP were selected via a lottery or a local committee. In lottery villages, we find evidence of displacement of private fertilizer and of a secondary market as beneficiaries are more likely to sell inputs to non‐beneficiaries. In contrast, in non‐lottery villages we find no evidence of displacement nor of elite capture. The impacts of the ISP on agricultural productivity and welfare are limited, suggesting that resources should be directed at complementary investments, such as improving soil quality and irrigation. [ABSTRACT FROM AUTHOR]

Emerging evidence suggests white matter network abnormalities in patients with schizophrenia (SZ) and bipolar disorder (BD), but the alterations in dynamics of the white matter network in patients with SZ and BD are largely unknown. The white matter network of patients with SZ (n = 45) and BD (n = 47) and that of healthy controls (HC, n = 105) were constructed. We used dynamics network control theory to quantify the dynamics metrics of the network, including controllability and synchronizability, to measure the ability to transfer between different states. Experiments show that the patients with SZ and BD showed decreasing modal controllability and synchronizability and increasing average controllability. The correlations between the average controllability and synchronizability of patients were broken, especially for those with SZ. The patients also showed alterations in brain regions with supercontroller roles and their distribution in the cognitive system. Finally, we were able to accurately discriminate and predict patients with SZ and BD. Our findings provide novel dynamic metrics evidence that patients with SZ and BD are characterized by a selective disruption of brain network controllability, potentially leading to reduced brain state transfer capacity, and offer new guidance for the clinical diagnosis of mental illness. [ABSTRACT FROM AUTHOR]

Many measures of international policies and support have dictated developing countries to upscale land areas of intact forestry, special biodiversity conservation site, and other wild reserves to half the land territory of the nation by 2050 for resulting environmental, and other benefits to global societies. The international initiations and work urged scholars to assess the potential impacts of the aggressive policy on forest-based communities and especially those living in institutionally and geo ecologically vulnerable areas. This study compiled the impacts of such international policy interventions on diverse affairs of the local community and national economies in Nepal and drew some conclusions on the well-being future of such forest-based communities. It explained that the international interventions in managing community-based resources induced serious disturbances in many local systems and resulted in vicious circles of emigration, income losses, social problems, psychological stresses, and food insecurities. The interventions have placed some communities and especially indigenous ethnic groups in the position either to be displaced from their ancestors' homelands or suffer for generations. This study also explained some reinforcing phenomena that emerged from the external interventions which have placed situations of the resource impacting local communities adversely for years. It also investigated whether support of international agencies in policy formation and implementation for resource management safeguards the well-being of the resource-based communities. The agencies resulted in the best environmental and other benefits to foreign societies which have aggravated the misery of local communities, particularly the poor people, women, and indigenous ethnic communities. The adverse impacts on the local societies are not repercussions (accidentally or unknowingly happened). All these findings infer that the international policies of upscaling forests and wilderness areas or making conservation areas in half of their land territory, especially in developing societies for the global benefit, may place the lives of the forest-based communities in peril of suffering for generations or extirpating. [ABSTRACT FROM AUTHOR]