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Additional file 1: Figure S1. SEM images of nanoparticles. Figure S2. The release profiles of Ce6 (a) and BEZ235 (b) from H-APBC at pH 7.4, 6.5 and 5.6 PBS. Figure S3. Absorption spectrum and calibration curve of component. a Vis-NIR spectra of H-APBC NPs at various concentrations. b Calibration curve of H-APBC NPs at 808 nm. Figure S4. CLSM images of 4T1 cells after 6 h incubation with H-APBC under hypoxia. Scale bar: 25 μm. Figure S5. Images of migrated 4T1 cells incubated with different treatment under normoxia. Scale bar: 50 μm. Figure S6. Flow cytometry analysis of the proportions of 4T1 cells co-stained with Annexin V-FITC and PI in different treatments during the normoxic experiment. (n = 3). *p < 0.05, **p < 0.01, and ***p < 0.001. Figure S7. Viability of 4T1 cells in different groups under the normoxic condition. (n = 3). *p < 0.05, **p < 0.01, and ***p < 0.001. Figure S8. Immunofluorescence images of ROS detection in ABS, BEZ235, H-APBC and HT groups. Scale bar: 80 μm. Figure S9. Treatment effects of H-APBC. H&E (a), TUNEL (b), Ki67 (c) staining of tumor tissues in HD and HT groups. Scale bar: 80 μm. Figure S10. Images of expression on HIF-1α and CD31 in HD and HT groups. Scale bar: 80 μm (HIF-1α), 120 μm (CD31). Figure S11. Physiological function assessment of liver and kidney toxicity from the treated mice. a–f Total bilirubin (TBIL), direct bilirubin (DBIL), total bile acids (TBA), creatinine (CR), blood urea nitrogen (BUN) and uric acid (UA) levels recorded for mice in the treatment groups. The error bars are based on the SD of five mice. Figure S12. H&E staining of the main organs. Scale bar: 80 μm.

Additional file 1. Fig. S1. TEM corresponding size distribution histogram of ZIF67/Ola/Lapa. Fig. S2. SEM image and corresponding size distribution histogram of ZIF67/Ola/Lapa nanoparticles. Fig. S3. Hydrodynamic diameters of ZIF67/Ola/Lapa dispersed in saline and DMEM. Fig. S4. XPS high-resolution spectrum of Co 2p and F1s. Fig. S5. UV–vis absorption spectra of the solutions containing ZIF67, ZIF67/Ola, ZIF67/Lapa and ZIF67/Ola/Lapa. Fig. S6. UV–vis absorption spectra of the solutions containing different concentrations of Ola and its standard curve. Fig. S7. UV–vis absorption spectra of the solutions containing different concentrations of Lapa and its standard curve. Fig. S8. UV-vis absorbance spectra of Ola, and Lapa before and after loading. Fig. S9. Drug release behavior of Lapa and Ola at different pH. Fig. S10. CLSM images of MDA-MB-231 cells incubated with ZIF67/Ola/Lapa for different time periods. Fig. S11. Flow cytometry of MDA-MB-231 cells incubated with ZIF67/Ola/Lapa for different time periods. Fig. S12. CLSM images of intracellular ROS generation treated with ZIF67/Ola/Lapa in HBL-100 normal cells. Fig. S13. PCR analysis of NQO1 expression level of HBL-100 normal cells and MDA-MB-231 breast cancer cells. Fig. S14. The cytotoxicity of ZIF67, Ola and ZIF67/Ola towards MDA-MB-231 cells. Fig. S15. The cytotoxicity of ZIF67/Ola/Lapa towards A549 cells or A549 cells pretreated with Dicoumarol. Fig. S16. The cytotoxicity of ZIF67/Ola/Lapa towards HBL-100 normal cells. Fig. S17. Body weight of MDA-MB-231 tumor-bearing mice under different treatments. Fig. S18. H&E stained images of major organs obtained from different groups. Fig. S19. Blood biochemistry data including numbers of ALT, CREA, WBC, and HGB. Table S1: The detailed data of drug loading capacity.

Accumulating evidence indicates that long non-coding RNAs (lncRNAs) play a key role in the development of many human cancers. MT1JP is a lncRNA that is reportedly involved in gastric cancer development, but a biological role and mechanism for MT1JP in breast cancer is unknown. Here, we found that MT1JP expression was significantly down-regulated in breast cancer tissues and cell lines, and that decreased MT1JP expression was associated with breast cancer progression and poor survival of breast cancer patients. Additionally, we found that overexpression of MT1JP in breast cancer cells significantly inhibited cell proliferation and invasion, and also enhanced the cisplatin sensitivity of breast cancer cells. We then investigated a possible mechanism for these results, finding that MT1JP binds to and negatively regulates miR-24-3p, which is known to be an oncogene in some human cancers. Our rescue experiments showed that the tumor suppressive and cisplatin-sensitizing functions of MT1JP were mediated by negative regulation of miR-24-3p. Finally, western blot results showed that MT1JP inhibited the Wnt/β-catenin signaling pathway. Collectively, our data indicate that MT1JP functions as an anti-tumor lncRNA, enhances cisplatin sensitivity in breast cancer, and may serve as a novel diagnostic and therapeutic marker of breast cancer.

Although the long non-coding RNA (lncRNA) SUMO1P3, small ubiquitin-like modifier 1 pseudogene 3, has been shown to play a role in human cancer, the biological function and mechanism of SUMO1P3 in breast cancer remained unclear. In this study, we showed that SUMO1P3 expression was higher in breast cancer tissues when compared to adjacent normal tissues and we found that high levels of SUMO1P3 expression associated significantly with tumor progression and poor survival of breast cancer patients. Moreover, we found that knockdown of SUMO1P3 suppressed proliferation, migration, and invasion of breast cancer cells. Bioinformatics analysis and luciferase reporter assays confirmed that SUMO1P3 binds to miR-320a, which has been identified as a tumor suppressor in various cancers, including breast cancer. We also confirmed that the tumor-promoting effects of SUMO1P3 in breast cancer are partly mediated by negative regulation of miR-320a. Our data indicates that SUMO1P3 functions as an oncogenic lncRNA in breast cancer and may serve as a novel diagnostic and biological target for breast cancer diagnosis and treatment.

We report SHRIMP U‐Pb, rare earth element, Hf isotope, and laser Raman spectroscopic data on zircons from ultrahigh‐temperature (UHT) granulites from the Jining Complex of the Khondalite Belt in the Western Block of the North China Craton (NCC). These UHT rocks form part of an ultrahot orogen that formed along the collisional margin of the NCC associated with the tectonics of assembly of the Paleoproterozoic supercontinent Columbia. Despite the core‐rim textures displayed by some of the UHT zircons, their age values sharply converge within error, yielding weighted mean 207Pb/206Pb ages of ca. 1.92 Ga, indicating growth by recrystallization under extreme thermal conditions. In general, the zircons show moderate heavy rare earth element enrichment with sharp positive Ce and negative Eu anomalies. The Hf isotope data from the UHT zircons also display a fairly uniform character, with the majority of them characterized by positive eHf values, without any indication of mixing between reworked crust and...