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9 results on '"Oliveira, Maria Leonor Sarno"'

2. Systems analysis of subjects acutely infected with the Chikungunya virus

Author

Soares-Schanoski, Alessandra, primary, Baptista Cruz, Natália, additional, de Castro-Jorge, Luíza Antunes, additional, de Carvalho, Renan Villanova Homem, additional, Santos, Cliomar Alves dos, additional, Rós, Nancy da, additional, Oliveira, Úrsula, additional, Costa, Danuza Duarte, additional, Santos, Cecília Luíza Simões dos, additional, Cunha, Marielton dos Passos, additional, Oliveira, Maria Leonor Sarno, additional, Alves, Juliana Cardoso, additional, Océa, Regina Adalva de Lucena Couto, additional, Ribeiro, Danielle Rodrigues, additional, Gonçalves, André Nicolau Aquime, additional, Gonzalez-Dias, Patricia, additional, Suhrbier, Andreas, additional, Zanotto, Paolo Marinho de Andrade, additional, Azevedo, Inácio Junqueira de, additional, Zamboni, Dario S., additional, Almeida, Roque Pacheco, additional, Ho, Paulo Lee, additional, Kalil, Jorge, additional, Nishiyama, Milton Yutaka, additional, and Nakaya, Helder I., additional

Published
2019
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5. Induction of systemic and mucosal immune response and decrease in Streptococcus pneumoniae colonization by nasal inoculation of mice with recombinant lactic acid bacteria expressing pneumococcal surface antigen A

Author

Oliveira, Maria Leonor Sarno, primary, Arêas, Ana Paula Mattos, additional, Campos, Ivana Barros, additional, Monedero, Vicente, additional, Perez-Martínez, Gaspar, additional, Miyaji, Eliane Namie, additional, Leite, Luciana Cezar Cerqueira, additional, Aires, Karina Araújo, additional, and Lee Ho, Paulo, additional

Published
2006
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8. Economical Value of Vaccines for the Developing Countries—The Case of Instituto Butantan, a Public Institution in Brazil.

Author

Paulo Lee Ho, Miyaji, Eliane Namie, Oliveira, Maria Leonor Sarno, de Oliveira Dias, Waldely, Kubrusly, Flavia Saldanha, Tanizaki, Martha Massako, Martins, Elizabeth Angélica Leme, and Raw, Isaias

Subjects
VACCINES, IMMUNIZATION, DEVELOPED countries, BRAZIL. Ministry of Health, TECHNOLOGY transfer, PARTNERSHIP agreements
Abstract

The article discusses the economic value of vaccine for developed countries particularly in Brazil. It notes the success of the national immunization program launched by the Ministry of Health (MH) in 1985 that has allowed the MH to purchase vaccines from domestic public vaccine production institutes at prices comparable to those obtained by Pan American Health Organization (PAHO) and UNICEF. It presents several methods on how to obtain new vaccine technology in Brazil as employed by Butantan Institute including technology transfer from for-profit vaccine producers, independent development and partnerships with for-profit vaccine producer.

Published
2011
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9. Production of Human Papillomavirus Type 16 L1 Virus-Like Particles by Recombinant Lactobacillus casei Cells.

Author

Aires, Karina Araujo, Cianciarullo, Aurora Marques, Carneiro, Sylvia Mendes, Villa, Luisa Lina, Boccardo, Enrique, Pérez-Martinez, Gaspar, Perez-Arellano, Isabel, Oliveira, Maria Leonor Sarno, and Ho, Paulo Lee

Subjects
*LACTOBACILLUS casei, *PAPILLOMAVIRUSES, *LACTOBACILLUS, *INFECTION, *CERVICAL cancer, *DEATH, *CANCER in women, *VACCINATION, *IMMUNOFLUORESCENCE
Abstract

Infections with human papillomavirus type 16 (HPV-16) are closely associated with the development of human cervical carcinoma, which is one of the most common causes of cancer death in women worldwide. At present, the most promising vaccine against HPV-16 infection is based on the Li major capsid protein, which self-assembles in virus-like particles (VLPs). In this work, we used a lactose-inducible system based on the Lactobacillus casei lactose operon promoter (plac) for expression of the HPV-16 L1 protein in L. casei. Expression was confirmed by Western blotting, and an electron microscopy analysis of L. casei expressing L1 showed that the protein was able to self-assemble into VLPs intracellularly. The presence of conformational epitopes on the L. casei-produced VLPs was confirmed by immunofluorescence using the anti-HPV-16 VLP conformational antibody H16.V5. Moreover, sera from mice that were subcutaneously immunized with L. casei expressing L1 reacted with Spodoptera frugiperda-produced HPV-16 L1 VLPs, as determined by an enzyme-linked immunosorbent assay. The production of L1 VLPs by Lactobacillus opens the possibility for development of new live mucosal prophylactic vaccines. [ABSTRACT FROM AUTHOR]

Published
2006
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