1. Lean Mass Improvement from Nutrition Education and Protein Supplementation among Rural Indian Women Living with HIV/AIDS: Results from Cluster Randomized Factorial Trial at 18-Month Follow-Up
- Author
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Carpenter, Catherine L, Kapur, Kavita, Ramakrishna, Padma, Pamujula, Suresh, Yadav, Kartik, Giovanni, Jennifer E, Julian, Olivia, Ekstrand, Maria L, Sinha, Sanjeev, and Nyamathi, Adeline M
- Subjects
Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Clinical Research ,Clinical Trials and Supportive Activities ,Prevention ,Behavioral and Social Science ,Nutrition ,HIV/AIDS ,Infectious Diseases ,Acquired Immunodeficiency Syndrome ,Body Composition ,Counseling ,Dietary Proteins ,Dietary Supplements ,Female ,Follow-Up Studies ,Health Education ,Humans ,India ,Nutrition Therapy ,Nutritional Physiological Phenomena ,Rural Population ,Time Factors ,lean mass ,HIV ,AIDS ,protein ,nutrition ,cluster-randomized trial ,Food Sciences ,Nutrition and Dietetics ,Clinical sciences ,Nutrition and dietetics ,Public health - Abstract
Loss of lean muscle mass impairs immunity and increases mortality risk among individuals with HIV/AIDS. We evaluated the relative contributions of protein supplementation and nutrition education on body composition among 600 women living with HIV/AIDS in rural Andhra Pradesh, India. We conducted a cluster randomized controlled 2 × 2 factorial trial lasting six months with follow up at twelve and eighteen months. Interventions occurred in the Nellore and Prakasam regions of Andhra Pradesh by trained village women, ASHA (Accredited Social Health Activists), and included: (1) the usual supportive care from ASHA (UC); (2) UC plus nutrition education (NE); (3) UC plus nutritional protein supplementation (NS); (4) combined UC plus NE plus NS. A Bioimpedance Analyzer Model 310e measured body composition. SAS 9.4 analyzed all data. Mixed models using repeated measures evaluated lean mass change from baseline as primary and fat weight and total weight as secondary outcomes. Lean mass change was significantly associated with NS (p = 0.0001), NE (p = 0.0001), and combined NS plus NE (p = 0.0001), with similar associations for secondary outcomes. Stronger associations for total weight were observed with greater ART adherence. Nutritional interventions may improve physiologic response to HIV. Significant increases in lean mass resulted from independent and combined protein supplementation and nutrition education.
- Published
- 2022