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Strontium has been widely used in bone repair materials due to its roles in promoting osteoclast apoptosis and enhancing osteoblast proliferation. In this work, synthesis and the effects of Sr2+ doping α-tricalcium phosphate at low-temperature was studied. The setting time and the mechanical properties of α-tricalcium phosphate were controlled by varying the content of Sr2+. The synthesized compounds were evaluated by XRD, SEM, XPS, setting time, compressive strength, SBF immersion, and colorimetric CCK-8 assay. The results showed that Sr2+ can improve the compressive strength and cell activity of calcium phosphate bone cement. [ABSTRACT FROM AUTHOR]

Strontium has been widely used in bone repair materials due to its roles in promoting osteoclast apoptosis and enhancing osteoblast proliferation. In this work, synthesis and the effects of Sr2+ doping α-tricalcium phosphate at low-temperature was studied. The setting time and the mechanical properties of α-tricalcium phosphate were controlled by varying the content of Sr2+. The synthesized compounds were evaluated by XRD, SEM, XPS, setting time, compressive strength, SBF immersion, and colorimetric CCK-8 assay. The results showed that Sr2+ can improve the compressive strength and cell activity of calcium phosphate bone cement. [ABSTRACT FROM AUTHOR]

Improving the mechanical properties of calcium phosphate cement (CPC) will be helpful for expanding its application range in the treatment of bone defect. In this work, reduced graphene oxide (RGO), which has two-dimensional structure and excellent mechanical properties, and carbon nanotubes (CNTs) were used as toughening materials collectively, to enhance the mechanical properties of CPC. Setting time, morphology and mechanical properties of CPC were analyzed. The two dimensional structure of RGO could increase the interface area between RGO and substrate, which achieved an effective transfer of load between substrate and RGO. Moreover, by reasons of bridging cracks, preventing crack extension, pulling out from substrate and interface debonding, the flexural strength and compressive strength of CPC were increased by 67.1% ± 4.8% and 76.4% ± 10.6% respectively. Therefore, the CPC composite we studied has potential to be used as load-bearing substitution in bone defects. [ABSTRACT FROM AUTHOR]