101. Mechanobiology in Cells and Tissues.
- Author
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Martino, Sabata
- Subjects
TRP channels ,BONE mechanics ,STEM cell niches ,CELL physiology ,NEURAL stem cells ,TISSUES ,CELL morphology - Abstract
They demonstrated an increase in cell proliferation in Wharton's jelly-derived mesenchymal stem cells exposed to pressure stimuli during the primary step of culture without causing alteration changes in the stemness biology [[21]]. The papers in the Special Issue "Mechanobiology in Cells and Tissues" explored the multidisciplinary aspects of mechanobiology and highlighted the role of cell mechanobiology in physiology and pathology. Mechanobiology pathways are also essential for cardiac cells' function over their lifespan [[11]], and therefore, innovative therapeutic approaches attempt to regenerate the damaged tissue by re-establishing the mechanical microenvironment (e.g., stiffness range, topography, and viscoelasticity). Our group also provided an overview of the molecular basis of mechanosensing and mechanotransduction pathways, and of their role in the cross-talk between stem cells and microenvironments, and how these dynamic interplays are critical in the control of stem cell identity and function, including their therapeutic application in regenerative medicine [[2]]. [Extracted from the article]
- Published
- 2023
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