1. Two new sesquiterpene lactone glycosides from Cnicus benedictus
- Author
-
Xiong Cai, Bin Li, Wei Wang, Kaiqiang Zhang, Ying Peng, Ali Zulfiqar, Yuqing Jian, Fei Long, Caiyun Peng, and Ikhlas A. Khan
- Subjects
Antifungal Agents ,Stereochemistry ,Chemical structure ,Cnicus ,Centaurea ,Plant Science ,Sesquiterpene lactone ,01 natural sciences ,Biochemistry ,Analytical Chemistry ,Aspergillus fumigatus ,Inhibitory Concentration 50 ,Lactones ,Organic chemistry ,Moiety ,Glycosides ,Medicinal plants ,chemistry.chemical_classification ,biology ,Molecular Structure ,010405 organic chemistry ,Organic Chemistry ,Glycoside ,Asteraceae ,biology.organism_classification ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,chemistry ,Sesquiterpenes - Abstract
Two new sesquiterpene lactone glycosides, namely melitensin 15-O-β-D-glucoside (1) and 11β,13-dihydrosalonitenolide 15-O-β-D-glucoside (2), along with eight known compounds (3–10) were isolated from the aerial part of Cnicus benedictus L. Their structures were elucidated from analyses of extensive spectroscopic data. Compounds 1–6 all possessed an α-methyl-γ-lactone moiety. Moreover, compound 5 exhibited moderate activity against the growth of Aspergillus fumigatus, with IC50 values of 17.67 μg mL−1.
- Published
- 2017