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2 results on '"Lee, Sunyoung"'

1. Complete remission of advanced hepatocellular carcinoma by sorafenib: A case report

Author

Youngsoo Kim, Lee Sunyoung, Min Su Kim, Young-Joo Jin, Jung-Il Lee, Myoung Hun Chae, and Jin-Woo Lee

Subjects
Sorafenib, medicine.medical_specialty, Cirrhosis, business.industry, Gastroenterology, Complete remission, Case Report, Disease, medicine.disease, digestive system diseases, Malignant disease, Portal vein thrombosis, Surgery, Discontinuation, Oncology, Hepatocellular carcinoma, medicine, business, neoplasms, medicine.drug
Abstract

Hepatocellular carcinoma (HCC) is the fifth most common malignant disease worldwide, and curative treatment remains difficult because the majority of cases are diagnosed in the advanced stage. Sorafenib is the only known effective systemic treatment, but patients rarely achieve complete remission (CR). A 66-year-old man with a history of alcoholic liver cirrhosis with a diagnosis of advanced HCC, was initially treated with transarterial chemoembolization on four occasions. However, the disease progressed with portal vein thrombosis. Therefore, sorafenib was started, and 4 mo later, the patient achieved CR. The treatment was continued for 12 mo, and CR was maintained up to 4 mo after sorafenib discontinuation.

Published
2013

2. Detection of Hepatocellular Carcinoma in a High-Risk Population by a Mass Spectrometry-Based Test.

Author

Mahalingam, Devalingam, Chelis, Leonidas, Nizamuddin, Imran, Lee, Sunyoung S., Kakolyris, Stylianos, Halff, Glenn, Washburn, Ken, Attwood, Kristopher, Fahad, Ibnshamsah, Grigorieva, Julia, Asmellash, Senait, Meyer, Krista, Oliveira, Carlos, Roder, Heinrich, Roder, Joanna, and Iyer, Renuka

Subjects
ALPHA fetoproteins, EARLY detection of cancer, MACHINE learning, PROTEOMICS, MASS spectrometry, TUMOR markers, HEPATOCELLULAR carcinoma, ALGORITHMS
Abstract

Simple Summary: Liver cancer is one of the most common causes of cancer worldwide, but unfortunately, current technology has a limited ability to detect it early in high-risk patients. This study investigates a machine learning algorithm based on protein levels in the blood that can be used to help with diagnosis. The test shows promising results, especially in patients with smaller tumors and compared to current blood detection tests. This research suggests an important role in the future for machine learning algorithm-based blood detection tests. Hepatocellular carcinoma (HCC) is one of the fastest growing causes of cancer-related death. Guidelines recommend obtaining a screening ultrasound with or without alpha-fetoprotein (AFP) every 6 months in at-risk adults. AFP as a screening biomarker is plagued by low sensitivity/specificity, prompting interest in discovering alternatives. Mass spectrometry-based techniques are promising in their ability to identify potential biomarkers. This study aimed to use machine learning utilizing spectral data and AFP to create a model for early detection. Serum samples were collected from three separate cohorts, and data were compiled to make Development, Internal Validation, and Independent Validation sets. AFP levels were measured, and Deep MALDI® analysis was used to generate mass spectra. Spectral data were input into the VeriStrat® classification algorithm. Machine learning techniques then classified each sample as "Cancer" or "No Cancer". Sensitivity and specificity of the test were >80% to detect HCC. High specificity of the test was independent of cause and severity of underlying disease. When compared to AFP, there was improved cancer detection for all tumor sizes, especially small lesions. Overall, a machine learning algorithm incorporating mass spectral data and AFP values from serum samples offers a novel approach to diagnose HCC. Given the small sample size of the Independent Validation set, a further independent, prospective study is warranted. [ABSTRACT FROM AUTHOR]

Published
2021
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