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[Display omitted] • A Water-economy-ecology concept framework is established. • An evaluation index system of 3 aspects including 15 indicators is constructed. • EFAST-Cloud model is innovatively proposed and applied in regional WRCC evaluation. • The WRCC of Henan Province is evaluated at the watershed scale and municipal scale. Water is the basic need for human survival and the development of economy and ecology. Water resources carrying capacity (WRCC) modelling is a fundamental task to explore the interaction mechanism between economy-ecology development and water resources carrying system. To reasonably quantify the regional WRCC, an evaluation method based on Water-economy-ecology (WEE) concept framework and EFAST-Cloud model is proposed in this study, and Henan Province of China is selected as a typical study area. It can both identify the inter-feeding relationships between sub-systems and evaluate the proportion of each grade in detail by reflecting the randomness and fuzziness of the evaluation. A total of 15 indicators including water system, economy system, and ecology system are constructed. The study analyzes the sensitivity of indicators by using Simlab software and then calculates the weight of indicators by using EFAST method. Compared with other traditional methods, EFAST algorithm is a special method for model sensitivity analysis, which can fully consider the coupling effect between indicators. According to the statistical data of 2010, 2015, and 2020, the WRCC at the watershed scale and municipal scale in Henan Province are evaluated through the EFAST-Cloud model. At the watershed scale, the ecology system criterion layer performs best over the multiple years, the Huaihe and Yangtze River basin have better WRCC at the target layer. At the municipal scale, Xuchang, Luohe, and Zhumadian have better WRCC, Puyang, Zhoukou, and Jiaozuo are slightly worse. The results show that WRCC of the study area has shown an overall improvement, but there is still much space for its development. Therefore, targeted recommendations are made for the water, economy, and ecology system respectively. The conclusion of this paper can provide a reference for the government in making water resources management policies. [ABSTRACT FROM AUTHOR]