6 results on '"Meng, Lu"'
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2. Phylogeography Reveals Association between Swine Trade and the Spread of Porcine Epidemic Diarrhea Virus in China and across the World
- Author
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Wan-Ting He, Nena Bollen, Yi Xu, Jin Zhao, Simon Dellicour, Ziqing Yan, Wenjie Gong, Cheng Zhang, Letian Zhang, Meng Lu, Alexander Lai, Marc A Suchard, Xiang Ji, Changchun Tu, Philippe Lemey, Guy Baele, Shuo Su, and Barlow, Miriam
- Subjects
Swine Diseases ,China ,Evolutionary Biology ,Swine ,Coronaviridae ,Porcine epidemic diarrhea virus ,Prevention ,BEAST ,Bayesian inference ,phylogeography ,United States ,Coronavirus ,Vaccine Related ,Phylogeography ,Infectious Diseases ,Emerging Infectious Diseases ,generalized linear model ,Genetics ,Animals ,Biochemistry and Cell Biology ,Infection ,Molecular Biology ,Pandemics ,Ecology, Evolution, Behavior and Systematics ,Phylogeny - Abstract
The ongoing SARS (severe acute respiratory syndrome)-CoV (coronavirus)-2 pandemic has exposed major gaps in our knowledge on the origin, ecology, evolution, and spread of animal coronaviruses. Porcine epidemic diarrhea virus (PEDV) is a member of the genus Alphacoronavirus in the family Coronaviridae that may have originated from bats and leads to significant hazards and widespread epidemics in the swine population. The role of local and global trade of live swine and swine-related products in disseminating PEDV remains unclear, especially in developing countries with complex swine production systems. Here, we undertake an in-depth phylogeographic analysis of PEDV sequence data (including 247 newly sequenced samples) and employ an extension of this inference framework that enables formally testing the contribution of a range of predictor variables to the geographic spread of PEDV. Within China, the provinces of Guangdong and Henan were identified as primary hubs for the spread of PEDV, for which we estimate live swine trade to play a very important role. On a global scale, the United States and China maintain the highest number of PEDV lineages. We estimate that, after an initial introduction out of China, the United States acted as an important source of PEDV introductions into Japan, Korea, China, and Mexico. Live swine trade also explains the dispersal of PEDV on a global scale. Given the increasingly global trade of live swine, our findings have important implications for designing prevention and containment measures to combat a wide range of livestock coronaviruses. ispartof: MOLECULAR BIOLOGY AND EVOLUTION vol:39 issue:2 ispartof: location:United States status: published
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- 2022
3. Virome characterization of game animals in China reveals a spectrum of emerging pathogens
- Author
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Wan-Ting He, Xin Hou, Jin Zhao, Jiumeng Sun, Haijian He, Wei Si, Jing Wang, Zhiwen Jiang, Ziqing Yan, Gang Xing, Meng Lu, Marc A. Suchard, Xiang Ji, Wenjie Gong, Biao He, Jun Li, Philippe Lemey, Deyin Guo, Changchun Tu, Edward C. Holmes, Mang Shi, and Shuo Su
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Mammals ,China ,Virome ,viruses ,COVID-19 ,Animals, Wild ,Communicable Diseases, Emerging ,Article ,General Biochemistry, Genetics and Molecular Biology ,Coronavirus ,Zoonoses ,Animals ,Phylogeny ,Disease Reservoirs - Abstract
Game animals are wildlife species traded and consumed as food and are potential reservoirs for SARS-CoV and SARS-CoV-2. We performed a meta-transcriptomic analysis of 1,941 game animals, representing 18 species and five mammalian orders, sampled across China. From this, we identified 102 mammalian-infecting viruses, with 65 described for the first time. Twenty-one viruses were considered as potentially high risk to humans and domestic animals. Civets (Paguma larvata) carried the highest number of potentially high-risk viruses. We inferred the transmission of bat-associated coronavirus from bats to civets, as well as cross-species jumps of coronaviruses from bats to hedgehogs, from birds to porcupines, and from dogs to raccoon dogs. Of note, we identified avian Influenza A virus H9N2 in civets and Asian badgers, with the latter displaying respiratory symptoms, as well as cases of likely human-to-wildlife virus transmission. These data highlight the importance of game animals as potential drivers of disease emergence.
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- 2022
4. Detection of Novel Coronavirus by RT-PCR in Stool Specimen from Asymptomatic Child, China
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Jie-nan Liu, Peng Li, Yaxin Dai, An Tang, Kefeng Li, Meng-lu Yu, Jian-Bo Yan, Hongling Wang, Wen-jie Wu, Zhendong Tong, and Chen Yuan
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Male ,Epidemiology ,viruses ,Expedited ,coronavirus ,lcsh:Medicine ,medicine.disease_cause ,asymptomatic child ,Feces ,0302 clinical medicine ,reverse transcription PCR ,030212 general & internal medicine ,stool ,Child ,Coronavirus ,biology ,Reverse Transcriptase Polymerase Chain Reaction ,novel coronavirus disease ,Patient Discharge ,Reverse transcription polymerase chain reaction ,Infectious Diseases ,Real-time polymerase chain reaction ,medicine.anatomical_structure ,Severe acute respiratory syndrome-related coronavirus ,RNA, Viral ,medicine.symptom ,Coronavirus Infections ,Article Commentary ,severe acute respiratory syndrome coronavirus 2 ,Microbiology (medical) ,China ,030231 tropical medicine ,Pneumonia, Viral ,novel coronavirus ,RT-PCR ,Asymptomatic ,Virus ,Detection of Novel Coronavirus by RT-PCR in Stool Specimen from Asymptomatic Child, China ,lcsh:Infectious and parasitic diseases ,2019 novel coronavirus disease ,03 medical and health sciences ,respiratory infections ,Betacoronavirus ,medicine ,Research Letter ,Humans ,lcsh:RC109-216 ,Pandemics ,business.industry ,SARS-CoV-2 ,lcsh:R ,COVID-19 ,biology.organism_classification ,Virology ,business ,Respiratory tract - Abstract
We report an asymptomatic child who was positive for a coronavirus by reverse transcription PCR in a stool specimen 17 days after the last virus exposure. The child was virus positive in stool specimens for at least an additional 9 days. Respiratory tract specimens were negative by reverse transcription PCR.
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- 2020
5. Using a Cloud-Based Machine Learning Classification Tree Analysis to Understand the Demographic Characteristics Associated With COVID-19 Booster Vaccination Among Adults in the United States.
- Author
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Meng, Lu, Fast, Hannah E, Saelee, Ryan, Zell, Elizabeth, Murthy, Bhavini Patel, Murthy, Neil Chandra, Lu, Peng-Jun, Shaw, Lauren, Harris, LaTreace, Gibbs-Scharf, Lynn, and Chorba, Terence
- Abstract
A tree model identified adults age ≤34 years, Johnson & Johnson primary series recipients, people from racial/ethnic minority groups, residents of nonlarge metro areas, and those living in socially vulnerable communities in the South as less likely to be boosted. These findings can guide clinical/public health outreach toward specific subpopulations. [ABSTRACT FROM AUTHOR]
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- 2022
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6. Etiology and genetic evolution of canine coronavirus circulating in five provinces of China, during 2018–2019
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Hai-Jian He, Wenyan Zhang, Jiawei Liang, Meng Lu, Ruyi Wang, Gairu Li, Jia-Wei He, Jun Chen, Gang Xing, and Ye Chen
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0301 basic medicine ,China ,030106 microbiology ,Population ,Genome, Viral ,Biology ,medicine.disease_cause ,Microbiology ,03 medical and health sciences ,Feces ,Dogs ,Coronavirus, Canine ,Phylogenetics ,medicine ,Animals ,Dog Diseases ,education ,Phylogeny ,Coronavirus ,education.field_of_study ,Phylogenetic tree ,Base Sequence ,Strain (biology) ,Canine parvovirus ,Outbreak ,Canine coronavirus ,Sequence Analysis, DNA ,biology.organism_classification ,Virology ,030104 developmental biology ,Infectious Diseases ,DNA, Viral ,Spike Glycoprotein, Coronavirus ,Coronavirus Infections - Abstract
As the outbreaks of COVID-19 in worldwide, coronavirus has once again caught the attention of people. Canine coronavirus is widespread among dog population, and sometimes causes even fatal cases. Here, to characterize the prevalence and evolution of current circulating canine coronavirus (CCoV) strains in China, we collected 213 fecal samples from diarrheic pet dogs between 2018 and 2019. Of the 213 samples, we found 51 (23.94%) were positive for CCoV. Co-infection with canine parvovirus (CPV), canine astrovirus (CaAstV), canine kobuvirus (CaKV), Torque teno canis virus (TTCaV) were ubiquitous existed. Mixed infection of different CCoV subtypes exists extensively. Considering the limited sequences data in recent years, we sequenced 7 nearly complete genomes and 10 complete spike gene. Phylogenetic analysis of spike gene revealed a new subtype CCoV-II Variant and CCoV-IIa was the most prevalent subtype currently circulating. Moreover, we identified strain B906_ZJ_2019 shared 93.24% nucleotide identifies with previous strain A76, and both of them clustered with CCoV-II Variant, which were not well clustered with the known subtypes. Recombination analysis of B906_ZJ_2019 indicated that strain B906_ZJ_2019 may a recombinant variant between CCoV-I and CCoV-II, which is consistent with strain A76. Furthermore, amino acid variations widely existed among current CCoV-IIa strains circulating in China and the classic CCoV-IIa strains, in spite of the unknown functions. In a word, we report a useful information as to the etiology and evolution of canine coronavirus in China based on the available sequences, which is urgent for the devise of future effective disease prevention and control strategies.
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- 2020
- Full Text
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