1. Neonatal Bilirubin Levels and Childhood Asthma in the US Collaborative Perinatal Project, 1959–1965.
- Author
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Huang, Lisu, Bao, Yixiao, Xu, Zongli, Lei, Xiaoping, Chen, Yan, Zhang, Yongjun, and Zhang, Jun
- Subjects
ASTHMA risk factors ,RESEARCH ,BILIRUBIN ,CHI-squared test ,CONFIDENCE intervals ,EPIDEMIOLOGY ,LONGITUDINAL method ,MEDICAL cooperation ,RESEARCH funding ,SPECTROPHOTOMETRY ,DATA analysis ,SECONDARY analysis ,REPEATED measures design ,DISEASE prevalence ,DESCRIPTIVE statistics ,CHILDREN - Abstract
Evidence shows that asthma originates in early life. Studies have found that phototherapy and/or neonatal jaundice may be associated with asthma. We investigated the association between neonatal bilirubin levels and childhood asthma without phototherapy intervention in the Collaborative Perinatal Project, a multicenter prospective cohort study conducted in the United States from 1959 to 1965. A total of 54,795 livebirths were included, and 40,063 children were followed up until 7 years of age or older. Total serum bilirubin (TSB) levels were examined at 48 hours postpartum in newborns with birthweights of 2,250 g or more. Information on asthma and other diseases through age 7 years was summarized and confirmed by a group of pediatricians and child neurologists. Among 28,807 term infants, the overall prevalence of asthma was 5.26%. Risks of asthma increased with both maximum TSB levels and TSB levels at 48 hours postpartum (P for trend < 0.01). Neonatal maximum TSB levels greater than 15 mg/dL were associated with a 61% increase in the risk of childhood asthma (odds ratio = 1.61, 95% confidence interval: 1.04, 2.08) after adjustment for confounders. In this prospective cohort study of infants born at a time when phototherapy was unavailable, neonatal hyperbilirubinemia was associated with an increased risk of childhood asthma. [ABSTRACT FROM PUBLISHER]
- Published
- 2013
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