1. Structural characterization of novel phospholipid lipid nanoparticles for controlled drug delivery
- Author
-
Wang, Qi, Gong, Tao, Sun, Xun, and Zhang, Zhirong
- Subjects
- *
PHOSPHOLIPIDS , *NANOPARTICLES , *MICROSTRUCTURE , *DRUG delivery systems , *X-ray diffraction , *CONFOCAL microscopy , *FLUORESCENCE spectroscopy , *ELECTRON paramagnetic resonance spectroscopy - Abstract
Abstract: Drug–phospholipid lipid nanoparticles (DPLNs) are prepared by incorporating drug–phospholipid complexes (DPCs) with a liquid lipid. DPLNs demonstrated interesting properties including increased encapsulation capacity, improved stability and controlled drug release profile. A comprehensive characterization of DPLNs was presented and then a schematic model was suggested according to the characterization results. Transmission electron microscopy and scanning electron microscope measurements showed the morphology of DPLNs. X-ray diffraction exhibited a predominantly amorphous structure for DPCs and totally amorphous for DPLNs. Laser confocal scanning microscopy revealed the relative position of DPCs and liquid lipid, showing that DPLNs formed a homogeneous system. Fluorescence spectra and electron spin resonance further confirmed the chemical environment inside the DPLNs in a non-invasive way. [Copyright &y& Elsevier]
- Published
- 2011
- Full Text
- View/download PDF