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Adverse Event: Warfarin‐related nephropathy. Drug Implicated: Warfarin. The Patient: A 31‐year‐old female, managed with warfarin for rheumatic heart disease with atrial fibrillation. Evidence that Links the Drug to the Event: There were no alternative causes of nephropathy that could have caused the adverse event in this patient. Management: Shifting the drug from warfarin to acenocoumarol. Mechanism: Difference in renal elimination between warfarin and acenocoumarol. Implication for Therapy: Clinicians should be aware of this rare adverse effect of warfarin, and acenocoumarol can be considered as an alternative therapy for this condition. Hypotheses to be Tested: Further prospectively designed studies are needed to consider acenocoumarol as an alternative therapy in warfarin‐related nephropathy. [ABSTRACT FROM AUTHOR]

To the Editor, Amphotericin B is often used in the therapeutics of potentially fatal fungal infections. The patient was extubated and put on oral K+ supplementation 40 mEq/day in divided doses, with close monitoring of serum K+ and Mg++ levels, while amphotericin B therapy was continued into the postoperative period. [Extracted from the article]