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It is essential to design multifunctional contact lenses for selective recognition and utilization of the eye drop ofloxacin (OFL). Modified silicone hydrogel (MSL) contact lenses were firstly synthesized via ultraviolet curing by using (hydroxymethyl)methyl aminomethane, polydimethylsiloxane, methacryloxypropyl terminated polydimethylsiloxane, and N,N-dimethylacrylamide as monomers and N-vinyl-2-pyrrolidinone (NVP) as a modifier. The synthesized MSL contact lenses were characterized via Fourier transform infrared spectroscopy, scanning electron microscopy, and contact angle and mechanical property tests. The results showed that compared with silicone hydrogel (SL) contact lenses, the MSL contact lenses had a more porous structure and good swelling and mechanical properties. The molecularly imprinted polymer/ofloxacin-modified silicone hydrogel (MIP/OFL-MSL) contact lenses were firstly synthesized via free radical polymerization, using ofloxacin (OFL) as the template molecule. Moreover, compared with chlorogenic acid and myricetin molecule, the MIP/OFL-MSL contact lenses exhibited an adsorption capacity for OFL that reached 2.86 mg/g. The antibacterial test showed that the MIP/OFL-MSL contact lenses displayed an inhibition ring size of 15.2 mm and 17.8 mm for Staphylococcus aureus and Escherichia coli, respectively. [ABSTRACT FROM AUTHOR]

The high hydrophilicity of alginate materials makes delivering a high load of hydrophobic drug difficult. To overcome this drawback, sodium alginate (SA) was modified using octylamine (OA), and then kaempferol (KP) was combined with the alginate solution through the hydrophobic interaction between OA and KP. The modified SA/KP (MSA/KP) hydrogel films were ionically cross-linked by immersing in calcium chloride solution. Subsequently, the products were analyzed via Fourier transform infrared spectroscopy, scanning electron microscopy, contact angle test, thermogravimetric analysis, swelling analysis, water vapor transmission, and mechanical property test. Results showed that compared with the SA hydrogel films, the MSA/KP hydrogel films exhibited an interporous structure, good swelling, and mechanical properties. Moreover, the drug release experiments demonstrated that the MSA/KP hydrogel films achieved a KP encapsulation efficiency of 70.4%, with a sustained KP release of up to 80 h. The cell viability experiments demonstrated that the MSA/KP hydrogel films posed no evident cytotoxicity to human umbilical vein endothelial cells. [ABSTRACT FROM AUTHOR]