1. Atypical Cells in Lymphomatoid Papulosis Express the Hodgkin Cell-Associated Antigen Ki-1.
- Author
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Kaudewitz, Peter, Stein, Harald, Burg, Günter, Mason, David Y., and Braun-Falco, Otto
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IMMUNOHISTOCHEMISTRY , *LYMPHOMAS , *PHYTOHEMAGGLUTININS , *HODGKIN'S disease , *ANTIGEN presenting cells , *MONOCLONAL antibodies - Abstract
Lymphomatoid papulosis (LyP) is characterized by the presence of large multinucleated cells resembling Reed- Sternberg (RS) cells. Evidence of antigenic similarity between these two cell types has been sought by immunohistologic labeling of 10 biopsies from cases of LyP with monoclonal antibodies against Ki-I and other RS and Hodgkin (H) cell-associated antigens. In all cases studied, a proportion of the large atypical cells expressed the Ki-1 antigen. On the contrary, in 20 biopsies of benign skin lesions or cutaneous T-cell lymphomas, Ki-1-positive cells were absent or only occasionally present. Furthermore the large atypical cells of LyP also expressed antigens (e.g., T3, T4, HLA-DR, IL-2 receptors) which we have previously demonstrated on RS cells in the majority of cases of Hodgkin's disease (HD). These findings, in conjunction with the observation that Ki-1 antigen expression can be induced on peripheral blood lymphocytes following exposure to phytohemagglutinin or HTLV 1, provide evidence that the Ki-1 positive cells in LyP represent activated T cells as RS cells do in many cases of HD. [ABSTRACT FROM AUTHOR]
- Published
- 1986
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