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Nanotechnology, contrary to its name, has massively revolutionized industries around the world. This paper predominantly deals with data regarding the applications of nanotechnology in the modernization of several industries. A comprehensive research strategy is adopted to incorporate the latest data driven from major science platforms. Resultantly, a broad-spectrum overview is presented which comprises the diverse applications of nanotechnology in modern industries. This study reveals that nanotechnology is not limited to research labs or small-scale manufacturing units of nanomedicine, but instead has taken a major share in different industries. Companies around the world are now trying to make their innovations more efficient in terms of structuring, working, and designing outlook and productivity by taking advantage of nanotechnology. From small-scale manufacturing and processing units such as those in agriculture, food, and medicine industries to larger-scale production units such as those operating in industries of automobiles, civil engineering, and environmental management, nanotechnology has manifested the modernization of almost every industrial domain on a global scale. With pronounced cooperation among researchers, industrialists, scientists, technologists, environmentalists, and educationists, the more sustainable development of nano-based industries can be predicted in the future. [ABSTRACT FROM AUTHOR]

The paper describes quantitative and qualitative dimensions of nanomedicine research studies in India. The study is based on research publications data in nanomedicine research (1491 publications) as covered in Scopus data base for the period 2002-20. The study finds that nanomedicine research in India registered a high 73.7% growth with an average of 22.93 citations per paper. The nano-oncology subfield accounted for the highest share (48.49% share) in the national output, followed by seven other nanomedicine subfields. Jamia Hamdard University, Delhi, Panjab University, Chandigarh and Banaras Hindu University, Varanasi lead as the most productive organizations in the country. The paper also lists the most productive authors in nanomedicine research. The most productive research journals that reported nanomedicine research in India include Nanomedicine, International Journal of Nanomedicine and Current Pharmaceutical Design. In addition, International Journal of Pharmaceutics, International Journal of Nanomedicine and Drug Delivery Today topped in the list of most cited research journals. [ABSTRACT FROM AUTHOR]

Background Participant selection for first-in-human (FIH) trials involves complex decisions. The trial design makes it unlikely that participants will receive clinically relevant therapeutic benefit, but they are likely to experience risks of various magnitudes and types. The aim of the present paper was to describe and discuss the views of investigators and ethics committee members about the choice of trial participants for FIH trials in cancer nanomedicine. Methods We drew insights from an exploratory qualitative study involving thematic analysis of 46 in-depth interviews with key stakeholders in Europe and North America involved in FIH nanomedicine trials. The present work draws on subset of 21 interviews with investigators and ethics committee members who have either conducted or reviewed a FIH cancer nanomedicine trial or are planning one. Results Investigators and ethics committee members are aware of the ethics standards for recruiting patients with end-stage cancer into FIH trials, but they nonetheless question the practice and provide reasons against it. Conclusions Although it is a standard and ethically accepted practice to enrol patients with end-stage cancer and no treatment options into FIH trials of investigational chemotherapeutic molecules, doing so can threaten the validity and generalizability of the trials, thereby weakening translational research. Another possibility is to stratify and include patients with less advanced disease who demonstrate certain biomarkers or cancer genotypes and who have a disease profile similar to that tested in preclinical studies. The latter approach could be a step toward personalized medical research and targeted drug development. Such a patient selection approach requires multi-stakeholder discussion to reach scientific and ethics consensus. [ABSTRACT FROM AUTHOR]

Abstract: Nanofibers prepared from poly (vinyl alcohol) (PVA) using the electrospinning process have received a great deal of attention over the past decade due to their outstanding characteristics and their applicability in the field of biomedicine, coupled with their innovative preparation. However, the success of the electrospinning process depends strongly on the parameters of the source polymer solution. Of these parameters the majority of published papers routinely examine the viscosity, conductivity and surface tension, while other, indeed crucial, physical characteristics are only rarely investigated. In the present work, the emphasis was also on a comprehensive investigation of the bulk and interfacial rheology as well as on the small-angle X-ray scattering (SAXS) of PVA solutions. A detailed analysis revealed rearrangements of the molecules in the solutions depending on the polymer concentration proved by measured surface tension, determined apparent specific volume and radius of gyration. Further, we found out that smooth nanofibers are formed only from those PVA solutions, where properly firm internal polymer structures that can be oriented in the direction of an applied electric field, enable complete polymer elongation during the electrospinning. It is important to note that this is the first time that such an extensive study has been made and, our findings provide a better insight into the physical properties of the solutions for electrospinning as well as their decisive influence on the formation of the nanofibers. [Copyright &y& Elsevier]

Always have been told that: there is not tiny enemies, this statement couldn't be more true when we are talking about the fight between the body and different pathogen agents, cellular mutations, and dangerous substances. Right now our knowledge allow us to handle the matter at nanoscale (1/1.000'000.000 m) sizes. The nanotechnology develop this knowledge and be able to improve things as new materials, small amount of material to build devices, better performance with maximal efficiency of devices, and others [1], [2]. Using nanotechnology to solve health problems is call nanomedicine [2], [3]. This paper review nanotechnologic develops apply to diseases with high mortality and treatments that doesn't solve the problem deeply they just handle the disease with partial solutions. Therefore, nanomedicine will have greater impact in the future, improving the health issues of humanity. [ABSTRACT FROM AUTHOR]

The human nature of curiosity, wonder, and ingenuity date back to the age of humankind. In parallel with our history of civilization, interest in scientific approaches to unravel mechanisms underlying natural phenomena has been developing. Recent years have witnessed unprecedented growth in research in the area of pharmaceuticals and medicine. The optimism that nanotechnology (NT) applied to medicine and drugs is taking serious steps to bring about significant advances in diagnosing, treating, and preventing disease—a shift from fantasy to reality. The growing interest in the future medical applications of NT leads to the emergence of a new field for nanomaterials (NMs) and biomedicine. In recent years, NMs have emerged as essential game players in modern medicine, with clinical applications ranging from contrast agents in imaging to carriers for drug and gene delivery into tumors. Indeed, there are instances where nanoparticles (NPs) enable analyses and therapies that cannot be performed otherwise. However, NPs also bring unique environmental and societal challenges, particularly concerning toxicity. Thus, clinical applications of NPs should be revisited, and a deep understanding of the effects of NPs from the pathophysiologic basis of a disease may bring more sophisticated diagnostic opportunities and yield more effective therapies and preventive features. Correspondingly, this review highlights the significant contributions of NPs to modern medicine and drug delivery systems. This study also attempted to glimpse the future impact of NT in medicine and pharmaceuticals. [ABSTRACT FROM AUTHOR]