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Background: The authors compare the effectiveness and safety of endovascular treatment (EVT) versus best medical management (BMM) in strokes attributable to acute basilar artery occlusion (BAO).Methods: The present analysis was based on the ongoing, prospective, multicenter ATTENTION (Endovascular Treatment for Acute Basilar Artery Occlusion) trial registry in China. Our analytic sample comprised 2134 patients recruited at 48 sites between 2017 and 2021 and included 462 patients who received BMM and 1672 patients who received EVT. We performed an inversed probability of treatment weighting analysis. Qualifying patients had to present within 24 hours of estimated BAO. The primary clinical outcome was favorable functional outcome (modified Rankin Scale score, 0-3) at 90 days. We also performed a sensitivity analysis with the propensity score matching-based and the instrumental variable-based analysis.Results: In our primary analysis using the inversed probability of treatment weighting-based analysis, there was a significantly higher rate of favorable outcome at 90 days among EVT patients compared with BMM-treated patients (adjusted relative risk, 1.42 [95% CI, 1.19-1.65]; absolute risk difference, 11.8% [95% CI, 6.9-16.7]). The mortality was significantly lower (adjusted relative risk, 0.78 [95% CI, 0.69-0.88]; absolute risk difference, -10.3% [95% CI, -15.8 to -4.9]) in patients undergoing EVT. Results were generally consistent across the secondary end points. Similar associations were seen in the propensity score matching-based and instrumental variable-based analysis.Conclusions: In this real-world study, EVT was associated with significantly better functional outcomes and survival at 90 days. Well-designed randomized studies comparing EVT with BMM in the acute BAO are needed.Registration: URL: www.chictr.org.cn; Unique identifier: ChiCTR2000041117. [ABSTRACT FROM AUTHOR]

As a key component in mitigating global warming and achieving sustainable development strategies, wind power has received widespread attention and support from governments around the world. Numerous countries are engineering ambitious programs to map and project the mitigation potential of wind energy expansion to combat future global warming. Here, using the global installed wind capacity data, we identity that a total of 837 GW of wind energy installed capacity (WEIC) in 31 countries generated about 2186 TWh of electricity, that is 1311 Mt of CO 2 mitigation, in 2021. Considering power mix transformation, wind power could account for more than 30% of total global electricity generation by the mid-21st century, when many countries expect to realize carbon neutrality, and could reduce CO 2 emission up to 14871 Mt by 2050 and 32864 Mt by 2100. Meanwhile, the global phenomenon of the future southward shift of wind energy resources makes the wind energy development in low-latitude countries, such as Brazil, Vietnam, and Central African, more confident. Combined with the Shared Socio-economic Pathways (SSPs), we find that the mitigation benefits of wind energy expansion are significant and will directly reduce global warming by up to 0.64 °C by the end of the century (NZE deployment scenario, SSP3-7.0). For China and the United States, the share of renewable energy will reach 78% and 84% by 2050 (APS scenario) and the cumulative climate mitigation by wind power will be 0.12 °C and 0.11 °C during 2020–2100, respectively. The findings strongly support the development and practice of global climate mitigation energy solutions. • This study quantifies wind energy's impact on CO 2 and temperatures reduction. • Global wind energy can currently mitigate 1311 Mt CO 2 , up to 32864 Mt by 2100. • Wind energy expansion could mitigate global warming by up to 0.64 °C in 2100. • China and the U.S. lead global CO 2 reductions in wind power. [ABSTRACT FROM AUTHOR]