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Alpha-fetoprotein-producing carcinoma (AFPC)/hepatoid adenocarcinoma (HAC) and neuroendocrine carcinoma (NEC) are uncommon in the stomach. Composite tumors consisting of these carcinomas and their histologic phenotypes are not well known. Between 2002 and 2007, to estimate the prevalence of composite tumors consisting of tubular adenocarcinoma, AFPC/HAC and NEC, we reviewed specimens obtained from294 consecutive patients treated surgically for gastric cancer. We examined histological phenotype of tumors of AFPC or NEC containing the composite tumor by evaluating immunohistochemical expressions of MUC2, MUC5AC,MUC6, CDX2, and SOX2. Immunohistochemically, AFPC/HAC dominantly showed the intestinal ormixed phenotype, and NEC frequently showed the gastric phenotype. In the composite tumor, the tubular and hepatoid components showed the gastric phenotype, and the neuroendocrine component showed the mixed type. The unique composite tumor predominantly showed the gastric phenotype, and the hepatoid and neuroendocrine components were considered to be differentiated from the tubular component. [ABSTRACT FROM AUTHOR]

Objective Neutrophil extracellular traps (NETs) are composed of DNA and antimicrobial proteins, including myeloperoxidase (MPO). Recent studies have demonstrated that impaired regulation of NETs could trigger an autoimmune response. Propylthiouracil (PTU), an antithyroid drug, is associated with a risk of MPO antineutrophil cytoplasmic antibody (ANCA) production and MPO ANCA-associated vasculitis (MPO AAV). This study was undertaken to clarify the mechanism of MPO ANCA production, using the PTU-induced model of MPO AAV. Methods NETs were induced by treating human neutrophils with phorbol myristate acetate (PMA) in vitro. We examined whether the addition of PTU influenced the NET formation induced by PMA and the degradation of NETs by DNase I, which is regarded as a regulator of NETs. Furthermore, we examined whether NETs generated by the combination of PMA and PTU induced MPO ANCA and MPO AAV in vivo in rats. Results When NETs were induced by PMA with PTU using human neutrophils in vitro, abnormal conformation of NETs was observed. Interestingly, the abnormal NETs were hardly digested by DNase I. Moreover, rats immunized with the abnormal NETs, which had been induced by PMA with PTU using rat neutrophils, produced MPO ANCA and developed pulmonary capillaritis. When rats were given oral PTU with intraperitoneal injection of PMA, pauci-immune glomerulonephritis and pulmonary capillaritis occurred with MPO ANCA production in the serum. Conclusion Our findings indicate that abnormal conformation and impaired degradation of NETs induced by PTU are involved in the pathogenesis of PTU-induced MPO ANCA production and MPO AAV. These findings suggest that disordered NETs can be critically implicated in the pathogenesis of MPO AAV. [ABSTRACT FROM AUTHOR]

The article reports on the results of a study of inter-subspecies hybrid dikaryons of oyster mushroom independently isolated in Vietnam and Japan. A description of the experimental set-up and measurement methods is presented. The study concluded that the asexual reproduction might allow stable maintenance of a particular pair of nuclei.

Business continuity plans (BCPs) can be effective and proactive countermeasures to respond flexibly to crises caused by unexpected natural disasters such as large tsunamis. BCP guidelines for fisheries are being issued by the Fisheries Agency (Japan) and the utilization of such BCPs has been spreading in Japan. Despite the need to promote the social implementation of BCPs in the fisheries industry, there is a lack of quantitative criteria for the tsunami damage threshold of various fishing ports and facilities. In this research, we surveyed the damage to the fishing facilities from the tsunami generated by the 2011 Tohoku-oki earthquake. Data were collected on the tsunami damage for various fishery facilities and used to establish criteria for tsunami damage thresholds. In addition, tsunami damage inferred from 1506 scenarios of tsunami computations was predicted probabilistically for a model region as the Nachi Katsu'ura Fishery Port in Wakayama Prefecture. The method we developed in this research makes it possible to assess the probabilistic tsunami damage by combining a tsunami hazard assessment method with criteria for damage occurrence for fishery port facilities and equipment. [ABSTRACT FROM AUTHOR]