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Our aim is to investigate a relationship between trichogram findings and demographic/ clinical features in psoriasis and seborrheic dermatitis patients. Trichogram method may be instructive in differentiation of these two diseases and may reduce the necessity of biopsy in presence of specific trichogram findings. Material and Methods: Thirty one psoriasis and 26 seborrheic dermatitis patients and 21 healthy controls were included in the study. Hairs were counted and classified as anagen, telogen, catagen and dysplastic hair. Results: In psoriasis and seborrheic dermatitis patients, a statistically significant increase was determined in telogen and dysplastic hair rates both in the areas with or without lesions comparing to healthy control group. Whereas no significant difference in terms of catagen hair rate was determined in all three groups. Anagen hair rates were significantly decreased in psoriasis and seborrheic dermatitis patient groups comparing to control group. When trichogram findings of psoriasis patients' areas with and without lesion; in areas with lesion, an increase was determined in dysplastic and telogen hair rate and a decrease was determined in catagen and anagen hair rates comparing to areas without lesion. These differences were statistically significant. When trichogram findings of seborrheic dermatitis patients' areas with and without lesion; in areas with lesion an increase was determined in dysplastic hair rate, a decrease was determined in anagen hair rate. While these differences were found statistically significant, no significant difference was found in catagen and telogen hair rates. Conclusion: In psoriasis and seborrheic dermatitis patients' scalp involvement, increased telogen and dysplastic hair rates and decreased anagen hair rates are seen in terms of trichogram findings comparing to healthy control groups. There was no statistically significant difference between psoriasis and seborrheic dermatitis. As a result of this study psoriasis and seborrheic dermatitis cause a decrease in the anagen/ telogen rate and both increase the dysplastic hair count. © 2017 by Tör ki ye Klinikleri.

Objective: Standard KOH preparation and fungal culture are the most preferred methods used for the diagnosis of onychomycosis. Alternatively used methods are histopathological examination and KOH preparation for 24 hours. Our aim was to assess the sensitivity of standard KOH preparation, KOH preparation for 24 hours, fungal culture and histopathological examination for the diagnosis of onychomycosis. Material and Methods: Nail samples were taken from 58 patients with a clinical suspicion of onychomycosis. Standard KOH preparation, KOH preparation for 24 hours, fungal culture and histopathological examination were searched for presence of fungal elements. Results: Onychomycosis was diagnosed in 46 samples. Samples of 8 patients were negative by all methods. Fungal elements were observed by standard KOH preparation in 27 patients (50%), by KOH preparation for 24 hours in 37 patients (68.5%), by culture method in 14 patients (25.9%) and by histopathological examination in 40 (74.1%) patients. The sensitivity values of these methods were 58%, 80.4%, 30.4%, and 87% respectively. Conclusion: This study showed that histopathological examination and KOH preparation for 24 hours methods are more sensitive than the KOH preparation and fungal culture.

Karlikaya, Geysu/0000-0002-5021-1880 WOS: 000261497700005 Background and Design: It has been known that isotretinoin may cause rabdomyolysis besides its many side affects. The purpose of our study was to evaluate the effect of isotretinoin therapy with a cumulative dose of 120 mg/kg on serum creatine phosphokinase levels and muscle physiology in patients with acne vulgaris. Material and Method: A total of 66 patients with severe acne vulgaris were enrolled in the study and treated with isotretinoin twice daily at the dose of 0.6-0.8 mg/kg/day and for approximately 6.1 +/- 0.54 (3-7) months. Thirty-seven female (71.2%) and 15 male (28.8%) patients completed the study. The change in serum creatine kinase levels was measured before and monthly during the treatment course. Electromyography was performed in patients with a high serum CPK level and myalgia for the exclusion myopathy. All patients were evaluated with their laboratory findings and they were questioned for exercise habits and intramuscular injections. Results: The mean age and body weight was 24.6 +/- 6.1 years and 62.3 +/- 11.9 kg respectively. We have detected 7 patients having elevated (13.5%) serum CPK levels. Three of them had associating myalgia and muscle tenderness. The evaluation of these patients with EMG revealed no myopathy sign. (CPK values = 1000, 880,726 respectively) Only one patient with an elevated serum CPK was performing exercise. There was no history of intramuscular injection history in any of these patients. Conclusion: The use of standard isotretinoin therapy appears to have a relation with marked hyperCKemia with or without muscle-related complaints. Isotretinoin could have a potentializing effect on other myotoxicity inducers (drugs, infection, fever, muscular exertion). Although this phenomenon in isotretinoin-treated patients with acne appears to be validated as benign in nature, the clinicians must keep this side affect in mind and should monitorize serum CPK levels since there are some patients who had severe or persistent signs. (Turkderm 2008; 42: 56-9)