Search

Your search keyword '"Ł. Kłopotowski"' showing total 3 results
Start Over Author "Ł. Kłopotowski" Search Limiters Full Text
3 results on '"Ł. Kłopotowski"'

1. Interlayer excitons in MoSe2/2D perovskite hybrid heterostructures – the interplay between charge and energy transfer

Author

M. Karpińska, J. Jasiński, R. Kempt, J. D. Ziegler, H. Sansom, T. Taniguchi, K. Watanabe, H. J. Snaith, A. Surrente, M. Dyksik, D. K. Maude, Ł. Kłopotowski, A. Chernikov, A. Kuc, M. Baranowski, P. Plochocka, Laboratoire national des champs magnétiques intenses - Grenoble (LNCMI-G ), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Laboratoire national des champs magnétiques intenses - Toulouse (LNCMI-T), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Polish Academy of Sciences (PAN), Wroclaw University of Science and Technology, Technische Universität Dresden = Dresden University of Technology (TU Dresden), Fakultät für Physik [Regensburg], Universität Regensburg (UR), Clarendon Laboratory [Oxford], University of Oxford, Université de Tsukuba = University of Tsukuba, University of Regensburg, Universität Leipzig, and ANR-17-EURE-0009,NanoX,Science et Ingénierie à l'Echelle Nano(2017)

Subjects
Condensed Matter::Materials Science, transition metal dichalcogenides, General Materials Science, [PHYS.PHYS.PHYS-CHEM-PH]Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph], [CHIM.MATE]Chemical Sciences/Material chemistry, Metal halide perovskites, Metal halide perovskites, transition metal dichalcogenides, 2D perovskites/transition metal dichalcogenide heterostructures, Condensed Matter::Mesoscopic Systems and Quantum Hall Effect, Computer Science::Distributed, Parallel, and Cluster Computing, 2D perovskites/transition metal dichalcogenide heterostructures
Abstract

Van der Waals crystals have opened a new and exciting chapter in heterostructure research, removing lattice matching constraints characteristic of epitaxial semiconductors. They provide unprecedented flexibility for heterostructure design. Combining 2D perovskites with other 2D materials, in particular transition metal dichalcogenides (TMDs) has recently emerged as an intriguing way to design hybrid opto- electronic devices. However, the excitation transfer mechanism between the layers (charge or energy transfer) remains to be elucidated. Here we investigate PEA2PbI4/MoSe2 and (BA)2PbI4/MoSe2 heterostructures by combining optical spectroscopy and density functional theory (DFT) calculations. We show that the band alignment facilitates charge transfer. Namely, holes are transferred from the TMD to the 2D perovskite, while the electron transfer is blocked, resulting in the formation of inter-layer excitons. Moreover, we show that the energy transfer mechanism can be turned on by an appropriate alignment of the excitonic states, providing a rule of thumb for the deterministic control of the excitation transfer mechanism in TMD/2D-perovskite heterostructures.

Published
2022
Full Text
View/download PDF

2. CdTe Quantum Dots in a Field Effect Structure: Photoluminescence Lineshape Analysis

Author

Ł. Kłopotowski, A. Kudelski, P. Wojnar, A. I. Tartakovskii, M. S. Skolnick, O. Krebs, P. Voisin, S. Kret, P. Dłużewski, G. Karczewski, T. Wojtowicz, Marília Caldas, and Nelson Studart

Subjects
Physics, Condensed Matter::Materials Science, symbols.namesake, Photoluminescence, Condensed matter physics, Stark effect, Quantum dot laser, Quantum dot, symbols, Semiclassical physics, Field effect, Cadmium telluride photovoltaics, Quantum tunnelling
Abstract

We study an photoluminescence line of a single, self assembled CdTe quantum dot embedded in a field‐effect structure. As a reverse bias is applied the line becomes broader and its intensity is decreased as a result of enhanced escape of the photocreated carriers. We account for the observed effects in a semiclassical model.

3. Coumarin Derivative Hybrids: Novel Dual Inhibitors Targeting Acetylcholinesterase and Monoamine Oxidases for Alzheimer's Therapy.

Author

Żołek T, Purgatorio R, Kłopotowski Ł, Catto M, and Ostrowska K

Subjects
Humans, Molecular Dynamics Simulation, Structure-Activity Relationship, Protein Binding, Coumarins chemistry, Coumarins pharmacology, Cholinesterase Inhibitors chemistry, Cholinesterase Inhibitors pharmacology, Cholinesterase Inhibitors therapeutic use, Alzheimer Disease drug therapy, Alzheimer Disease metabolism, Monoamine Oxidase Inhibitors chemistry, Monoamine Oxidase Inhibitors pharmacology, Monoamine Oxidase Inhibitors therapeutic use, Monoamine Oxidase metabolism, Monoamine Oxidase chemistry, Molecular Docking Simulation, Acetylcholinesterase metabolism, Acetylcholinesterase chemistry
Abstract

Multi-target-directed ligands (MTDLs) represent a promising frontier in tackling the complexity of multifactorial pathologies like Alzheimer's disease (AD). The synergistic inhibition of MAO-B, MAO-A, and AChE is believed to enhance treatment efficacy. A novel coumarin-based molecule substituted with O -phenylpiperazine via three- and four-carbon linkers at the 5- and 7-positions, has been identified as an effective MTDL against AD. Employing a medicinal chemistry approach, combined with molecular docking, molecular dynamic simulation, and ΔG bind estimation, two series of derivatives emerged as potent MTDLs: 8-acetyl-7-hydroxy-4-methylcoumarin (IC 50 : 1.52-4.95 μM for hAChE, 6.97-7.65 μM for hMAO-A) and 4,7-dimethyl-5-hydroxycoumarin (IC 50 : 1.88-4.76 μM for hMAO-B). They displayed binding free energy (ΔG bind ) of -76.32 kcal/mol ( 11 ) and -70.12 kcal/mol ( 12 ) against AChE and -66.27 kcal/mol ( 11 ) and -62.89 kcal/mol ( 12 ) against MAO-A. It is noteworthy that compounds 11 and 12 demonstrated efficient binding to both AChE and MAO-A, while compounds 3 and 10 significantly reduced MAO-B and AChE aggregation in vitro. These findings provide structural templates for the development of dual MAO and AChE inhibitors for the treatment of neurodegenerative diseases.

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results