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【目的】分析引起反复早期自然流产的主要影响因素, 为临床诊断和治疗提供依据。【方法】收集在本院自然流 产专科诊治的患者共69 例, 筛查她们关于遗传、内分泌、解剖、感染、免疫, 毒物接触史和代谢等7 个方面的发病因素, 并对其 进行统计分析。【结果】在引起反复自然流产的以上7 个方面的因素中, 分析由于单因素异常的流产患者, 发现其中免疫因素 引起的反复自然流产占86.2 %, 远高于其他6 个方面的因素。并且免疫因素在不同年龄组的反复早期自然流产患者中存在 显著性差别。【结论】免疫因素异常在早期反复自然流产的发生中占重要地位, 而且随着流产次数的增多, 其在发病因素中占 有的比重显著增加。

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Objective To investigate the protective effect of Platycodin D (PD) on renal ischemia-reperfusion injury in rats. Methods The rats were divided into sham group, model group, low, middle and high-dose groups with 10 animals in each. The rat model of ischemia reperfusion injury was established by clamping the bilateral renal pedicles in model group, low, middle and high-dose group. The rats in sham group underwent the same modeling operation but did not clamp the renal pedicles. Before 5 minutes of modeling, the rats of low, middle and high-dose group were intra-peritoneally injected with 12.5, 25 and 50 mg/kg PD, respectively. After 24 h of modeling, the serum creatinine (Cr) and blood urea nitrogen (BUN) levels, as well as antioxidant markers[superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) ] levels in kidney tissues were measured. HE staining was used to evaluate renal tissue lesions. Immuno-histochemical staining was used to detect the expression of caspase-3 in renal tissue, the apoptosis index of renal tubular epithelial cells was evaluated by the counting of caspase-3 positive cells. RT-qPCR was used to detect the expression of interleukin-1β (IL-1β), IL-6 and IL-10 mRNA in renal tissues. Western blot was used to detect the expression of Toll-like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), p65, p-p65, inhibitor of nuclear factor kappa B (NF-κB) (IκB) and p-IκB. Results Compared with sham group, the kidney lesions, serum Cr and BUN levels, apoptosis index of renal tubular epithelial cells in model group were all increased (P＜0.05) . Compared with model group, the kidney lesions, serum Cr and BUN levels, apoptosis index of renal tubular epithelial cells in low, middle and high-dose group were decreased (P＜0.05) . Compared with sham group, the level of MDA and mRNA of IL-1β and IL-6, the protein expression of TLR4/MyD88/NF-κB signaling pathway in kidney tissue in model group were all significantly increased while the level of SOD and GSH-Px and mRNA of IL-10 in rat kidney tissue were decreased (P＜0.05) . Compared with model group, the level of MDA, mRNA of IL-1β and IL-6, the protein expression of TLR4/MyD88/NF-κB signaling pathway in kidney tissue in low, middle and high-dose group were all decreased, SOD and GSH-Px and IL-10 mRNA in rat kidney tissue were increased (P＜0.05) . Conclusions Platycodin D has a protective effect on renal ischemia-reperfusion injury in rats, and the underlying mechanism may be related to the improvement of antioxidant capacity and inhibition of TLR4/MyD88/NF-κB signaling pathway. [ABSTRACT FROM AUTHOR]

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Copyright of Basic & Clinical Medicine is the property of Editorial Office of Basic & Clinical Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Coal Science & Technology (0253-2336) is the property of Coal Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的: 提高人工流产负压吸引术(以下简称人工流产术)质量,减轻受术者痛苦, 防止手术并发症。 方法: 选择 88 例妊娠 6～ 8周的未产妇, 其中对照组28 例, 服药组60 例。服药组中于术前1～ 2 h 口服奥湿克2 片有31例, 口服喜克溃(米索 前列醇) 0. 4 mg, 有29例, 观察两药的临床效果。结果: 奥湿克可使宫口松弛扩张促进子宫收缩,降低人工流产综合征的发生, 且具有一定的止痛效果。结论: 口服奥湿克使人工流产术更易操作, 平均手术时间缩短, 并发症减少, 可以作为一种安全、可 靠、有效的人工流产术前常规用药。